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Peer Reviewed Publications
Reviews and Book Chapters
Invited
Lectures
Posters
| Peer Reviewed Publications |
| Guiard, J., Paszkiewicz, E., Sadowska, J .M. and Bundle, D. R. Design and Synthesis of a Universal Antigen to Detect Brucellosis. Angew. Chem. Int. Ed., http://dx.doi.org/10.1002/anie.201302303.Published online 7th June 2013. |
| Jacobson, J. M., Kitov, P. I. and Bundle, D. R. The Synthesis of a Multivalent Heterobifunctional Ligand for Specific Interaction with Shiga toxin 2 produced by E. coli O157:H7. Carbohydr. Res., doi: http://dx.doi.org/10.1016/j.carres.2013.05.010. Published online 28 May 2013. |
| Iynkkaran, I. and Bundle, D. R. Synthesis of a trisaccharide repeat of the zwitterionic Sp1 capsular polysaccharide utilizing 2-azido-4-benzylamino-4N,3-O-carbonyl-2,4,6-trideoxy-D-galactopyranosyl trichloroacetimidate. Carbohydr. Res., doi:http://dx.doi.org/10.1016/j.carres.2013.05.005. Published online 21 May 2013. |
| Lipinski, T., Fitieh, A., St. Pierre, J., Ostergaard, H. L., Bundle, D. R. and Touret, N. Enhanced Immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to DCs via Dectin-1 by incorporating β-glucan. J. Immunol. in press, accepted Feb 21, 2013. |
| Johnson, M. A. and Bundle, D. R. Designing a new antifungal glycoconjugate vaccine. Chem. Soc. Rev., DOI: 10.1039/c2cs35382b. |
| Dang, A.-T., Johnson, M. A. and Bundle, D. R. Synthesis of a Candida albicans tetrasaccharide spanning the β1,2-mannan phosphodiester α-mannan junction. Org. Biomol. Chem., 10, 8348-8360, 2012. |
| Bundle, D. R., Nycholat, C., Costello, C., Rennie, R. and Lipinski, T. Design of a Candida albicans disaccharide conjugate vaccine by reverse engineering a protective monoclonal antibody. ACS Chem. Biol. 7, 1754-1763, 2012. |
| Lipinski, T., Wu, X., Sadowska, J., Kreiter, E., Yasui, Y., Cheriaparambil, S., Rennie, R. and Bundle, D. R. A trisaccharide conjugate vaccine induces high titer β-mannan specific antibodies that aid clearance of Candida albicans in immunocompromised rabbits. Vaccine, 30, 6263-6269, 2012. |
| Johnson, M. A., Cartmell, J., Weisser, N. E., Woods, R. J., and Bundle, D. R. Molecular recognition of Candida albicans (1→2)-β-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residue. J. Biol. Chem. 287, 18078-18090, 2012. |
| Xin, H., Cartmell, J., Bailey, J. J., Dziadek, S., Bundle, D. R. and Cutler, J. E. Self -adjuvanting Glycopeptide Conjugate Vaccine against Disseminated Candidiasis. PLoS One 7, e35106, 2012. |
| Costello, C. and Bundle, D. R. Synthesis of three trisaccharide congeners to investigate frame shifting of β1,2-mannan homo-oligomers in an antibody binding site. Carbohydr. Res., 357, 7-15, 2012. |
| Zhang,P., Razi, N., Eugenio, L., Fentabil, M., Kitova, E.N., Klassen, J.S., Bundle, D.R., Ng, K.K.-S. and Ling, C.-C. Unexpected structure of a Clostridium difficile toxin A ligand necessitates an annotation correction in a popular screening library. Chem. Comm. 47, 12397-12399, 2011. |
| Kitov, P. I., Paszkiewicz, E., Sadowska, J.M., Deng, Z., Ahmed, M., Narain, R., Griener, T., Mulvey, G. L., Armstrong, G. D., Bundle, D. R. Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate Shiga toxin and serum amyloid P component ternary complex formation. Toxins, 3, 1065-1088, 2011. |
| Sandbhor, M. S., Soya, N, Albohy, A., Zheng, R. B., Cartmell, J., Bundle, D. R., Klassen, J. S. and Cairo, C. W. Substrate recognition of the membrane-associated sialidase NEU3 requires a hydrophobic aglycone. Biochemistry, 50, 6753-5762, 2011. |
| Lipinski, T., Luu, T., Kitov, P. I., Szpacenko, A. and Bundle, D. R. A structurally diversified linker enhances the immune response to a small carbohydrate hapten. Glycoconj. J., 28, 149-164, 2011 |
| Cui, L., Kitov, P. I., Completo, G. C., Paulson, J. C. and Bundle. D. R. Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgM. Bioconjug. Chem., 22, 546-550, 2011. |
| Rademacher, C., Guiard, J., Kitov, P., Langpap, B., Dalton, K. P., Parra, F., Bundle, D. R. and Peters, P. Targeting Norovirus Infection – Multivalent Entry Inhibitor based on NMR Data. Chem. Eur. J., 17, 7442-7453, 2011. |
| Guiard, J., Langpap, B., Kitov, P., Peters, P. and Bundle, D. R. “Double-Click” Protocol for Synthesis of Heterobifunctional Multivalent Ligands: Toward a Focused Library of Specific Norovirus Inhibitors. Chem. Eur. J., 17, 7438-7441, 2011. |
| Tran, H.-A., Kitov,P. I., Paszkiewicz, E., Sadowska, J. M. and Bundle, D. R. Multifunctional multivalency: a focused library of polymeric cholera toxin antagonists. Org. Biomol. Chem., 9, 3658-3671, 2011. |
| Lipinski, T., Kitov, P., Szpacenko, A., Paszkiewicz, E. and Bundle, D. R. Synthesis and Immunogenicity of a Glycopolymer Conjugate. Bioconjug. Chem., 22, 274-281, 2011. |
Huang, J., Motto D. G., Bundle, D. R. and Sadler, J. E. Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. Blood, 116, 3653-3659, 2010 |
Iynkkaran, I. and Bundle, D. R., A novel glycosyl donor for synthesis of 2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactopranosides. Carbohydr. Res., 345, 2323-2327, 2010 |
| Wu, X., Cui, L., Lipinski, T. and Bundle, D.R. Synthesis of monomeric and
dimeric repeating units of the zwitterionic type 1 capsular polysaccharide
from Streptococcus pneumoniae. Chem. Eur. J., 16, 3476-3488, 2010. |
| 2009 |
Wu,
X., Cui, L., Lipinski, T., and Bundle, D.R. Synthesis of
monomeric and dimeric repeating units of the zwitterionic
type 1 capsular polysaccharide from Streptococcus pneumoniae.
Chem. Eur. J., in press, accepted October 14th 2009 |
Hu,
J., Huang, X., Ling, C.-C., Bundle, D.R., and Cheung, N.K.
Reducing Epitope Spread during Affinity Maturation of an
Anti-Ganglioside GD2 Antibody.
J. Immunol., 183, 5748 – 5755,
2009 |
Cai,
Y., Ling, C.-C., and Bundle, D.R. Efficient Synthesis of D-xylo and
D-ribo-Phytosphingosines from methyl 2-amino-2-deoxy-β-D-hexopyranosides.
Carbohydr. Res., 344, 2120-2126,
2009. |
Nycholat,
C.M., and Bundle, D.R. Synthesis of mono-deoxy and mono-O-methyl
congeners of methyl β-D-mannopyranosyl-(1®2)-β-D-mannopyranoside
for epitope mapping of anti-Candida albicans antibodies.
Carbohydr. Res., 344, 555-569, 2009 |
Cai,
Y., Ling, C.-C., and Bundle, D.R. Concise and efficient synthesis
of 2-acetamido-2-deoxy-β-D-hexopyranosides of diverse
aminosugars from 2-acetamido-2-deoxy-β-D-glucose.
J. Org. Chem., 74, 580–589, 2009 |
| 2008 |
Grant,
C.F., Kanda, V., Yu, H., Bundle, D.R., and McDermott, M.T.
Optimaization of Immobilized Bacterial Disaccharides for the
Surface Plasmon Resonance Immaging Measurements of Antibody
Binding.
Langmuir, 24,14125–14132, 2008 |
Kitov, P. I., Mulvey,
G. L., Griener, T., Lipinski, T., Solomon, D., Paszkiewicz,
E., Jacobson, J. , Sadowska, J. M., Suzuki, M., Yamamura, K.,
Armstrong, G. D., and Bundle, D. R.
In vivo supramolecular templating enhances the activity of
multivalent ligands: A potential therapeutic against the E.
coli O157 AB5 toxins.
Proc. Natl. Acad. Sci (USA), 105,
16837-16842, 2008 |
Xin
, H., Dziadek, S., Bundle, D. R. and Cutler, J. Synthetic
glycopeptide vaccines combining β-mannan and peptide epitopes
induce protection against candidiasis.
Proc. Natl. Acad. Sci (USA), 105, 13526-13531,
2008 |
Wu, X., Lipinski,
T., Paszkiewicz, E., and Bundle, D. R. Synthesis
and immunochemical characterization of S-linked glycoconjugate
vaccines against Candida albicans
Chem. Eur. J., 14, 6474-6482,
2008 |
Dziadek,S.,
Jacques, S. and Bundle, D. R. A novel linker methodology
for the synthesis of tailored conjugate vaccines composed of
complex carbohydrate antigens and specific TH-cell peptide
epitopes.
Chem. Eur. J., 14, 5908-5917,
2008 |
O’Reilly, M.
K., Collins, B. E., Han, S., Liao, L., Rillahan, C. Kitov,
P. I., Bundle, D. R., and Paulson, J. C. Bi-functional CD22
ligands use multimeric immunoglobulins as protein scaffolds
in assembly of immune complexes on B cells.
J. Am. Chem. Soc., 130, 7736-7745,
2008 |
Kitov,
P. I., Lipinski, T., Paszkiewicz, E., Solomon, D., Sadowska,
J. M., Grant, G. G. A., Mulvey, G. L., Kitova, E. N., Klassen,
J. S., Armstrong, G. D. and Bundle, D. R.
An Entropically Efficient Supramolecular Inhibition Strategy
for Shiga Toxins.
Angew. Chemie Intl. Ed., 47, 672-676,
2008 |
| |
| 2007 |
| Townson,
K., Greenshields, K. N., Veitch, J., Nicholl, D., Eckhardt,
M., Galanina, O., Bovin, N., Samain, E.,
Antoine, T., Bundle, D. R., Zhang, P., Ling, C.-C., and Willison,
H. J. Sulfatide binding properties of murine and human antiganglioside
antibodies. Glycobiology, 17, 1156 – 1166,
2007 |
Moore,
S. L., Uitz, C., Ling, C.-C., Bundle, D. R., Fusco P. C. and
Michon, F. Epitope Specificities
of the Groups Y and W-135 Polysaccharides of Neisseria
meningitides.
Clinical and Vaccine Immunology, 14,
1311-1317, 2007 |
Wu,
X., Lipinski, T., Carrell, F., Bailey, J. J., and Bundle,
D. R. Synthesis and Immunochemical Studies on a Candida
albicans Clustered Glycoconjugate Vaccine.
Org. Biomol. Chem., 5, 3477 – 3485,
2007 |
| Kitova,
E.N., Kitov, P.I., Paszkiewicz, E., Kim, J., Mulvey,
G.L., Armstrong, G.D., Bundle, D.R., and Klassen, J.S. Affinities
of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk Trisaccharide
Analogs Measured by Electrospray Ionization Mass Spectrometry. Glycobiology, 17,
1156-1166, 2007 |
Townson,
K., Boffey, J., Nicholl, D., Veitch, J., Bundle,
D.R., Zhang, P., Samain, E., Antoine, T., Bernardi, A.,
Arosio, D., Sonnino, S., Isaacs, N., and Willison, H.J. Solid
phase immunoadsorption for therapeutic and analytical studies
on neuropathy-associated anti-GM1 antibodies.
Glycobiology, 17, 294–303,
2007 |
Bundle,
D.R. Nitz, M., Wu, X., and Sadowska, J.M. A uniquely small,
protective carbohydrate epitope may yield a conjugate vaccine
for Candida albicans.
Amer. Chem. Soc., Symp. Ser., 989,
163-183, 2007 |
| 2006 |
Cai,
Y., Ling, C.-C., and Bundle, D.R. A general, efficient and
stereospecific route to sphingosine, sphinganines, phytosphingosines
and their analogs.
Org. Biomol. Chem., 4, 1140-1146,
2006. |
Jacques,
S., Rich, J.R., Ling, C.-C., and Bundle, D.R. Chemoenzymatic
synthesis of GM3 and GM2 gangliosides containing a truncated
ceramide functionalized for glycoconjugate synthesis and solid
phase applications.
Org. Biomol. Chem., 4, 142-154, 2006. |
Rich,
J.R., Wakarchuk, W.W., and Bundle, D.R. Chemical and chemoenzymatic
synthesis of S-linked ganglioside analogues and their
protein conjugates. Immunogens with improved in vivo
availability?
Chem. Eur. J., 12, 845-858,
2006. |
| 2005 |
Bundle,
D.R. Rich, J.R., Jacques, S., Yu, H.N., Nitz, M., and Ling,
C.-C. Thio-oligosaccharide conjugate vaccines evoke antibodies
specific for native antigens.
Angew. Chem. Int. Ed., 44,
7725-7729, 2005 |
Kanda, V. Kitov,
P.I., Bundle, D.R. and McDermott, M.T. Surface plasmon resonance
imaging measurements of the inhibition of Shiga-like toxin
by synthetic multivalent inhibitors.
Anal. Chem. 77, 7497-7504,
2005 |
Solomon,
D., Kitov, P. I., Paszkiewicz, E., Grant, G. A., Sadowska,
J. M.., and Bundle, D. R. Hetero-bifunctional multivalent
inhibitor-adaptors mediate specific aggregation between shiga
toxin and a pentraxin.
Org. Lett., 7, 4369-4372, 2005. |
Cai, Y., Ling,
C.-C., and Bundle, D. R. A facile approach to 2-acetamido-deoxy-b-D-glucopyranosides
via the furanosyl oxazoline.
Org. Lett., 7, 4021-4024, 2005 |
Wu,
X., and Bundle, D.R. Synthesis of glycoconjugate
vaccines for Candida albicans using novel linker methodology.
J. Org. Chem., 70, 7381-7388, 2005 |
Ho, J.G.S., Kitov,
P.I., Paszkiewicz, E., Sadowska, J., Bundle, D.R., and. Ng,
K.K.-S. Ligand-assisted aggregation of proteins: dimerization
of serum amyloid P component by bivalent ligands.
J. Biol. Chem., 280, 31999-32008,
2005 |
McGavin,
R.S. and Bundle, D.R. Developing high affinity oligosaccharide
inhibitors: conformational pre-organization paired with functional
group modification.
Org. Biomol. Chem., 3, 2733-2740, 2005 |
Gagne,
R.A., McGavin, R.S., Chervenak, M.C. and Bundle, D.R. The design,
synthesis and evaluation of high affinity macrocyclic carbohydrate
inhibitors.
Org. Biomol. Chem., 3, 2723-2732, 2005 |
| 2004 |
Wu, X., Ling,
C.-C., and Bundle, D.R. A New Homobifunctional p-Nitro
Phenyl Ester Coupling Reagent for the Preparation of Neoglycoproteins.
Org. Lett., 6(24), 4407-4410, 2004 |
Rich, J., and
Bundle, D.R. S-Linked ganglioside analogues for use in conjugate
vaccines.
Org. Lett., 6(6), 897-900, 2004 |
Kitova, E., Bundle,
D.R. and Klassen, J.S. Partitioning of solvent effects and
intrinsic interactions in biological recognition.
Angew. Chem. Int. Ed., 43, 4183-4186,
2004 |
Andersen, S.,
Ling, C.-C., Zhang, P., Townson, K., Willison, H.J., and Bundle,
D.R. Synthesis of ganglioside epitopes for oligosaccharide
specific immunoadsorption therapy of Guillian Barré syndrome.
Org. Biomol. Chem., 2, 1199 – 1212,
2004 |
Willison,
H.J., Townson, K., Veitch, J., Boffey, J., Isaacs, N., Andersen,
S., Zhang, P., Ling, C.-C., and Bundle, D.R. Synthetic disialylgalactose
immunoadsorbents deplete anti-GQ1b antibodies from neuropathy
sera.
Brain,127, 680-691,
2004 |
Rich, J.R., Szpacenko,
A., Palcic, M.M., and Bundle, D.R. Glycosyltransferase catalyzed
synthesis of thiooligosaccharides.
Angew. Chem. Int. Ed., 43,
613-615, 2004 |
| |
2003 |
Vyas,
N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M.,
and Quiocho, F.A. Structural basis of peptide-carbohydrate
mimicry in an antibody-combining site.
Proc. Natl. Acad. Sci (USA), 100, 15023-15028,
2003 |
Kitov, P.I. and
Bundle, D.R. On the Nature of the Multivalency Effect: A Statistical
Thermodynamic Model
J. Am. Chem. Soc., 125, 16271-16284,
2003 |
Yung, A.,Turnbull,
B., Kalverda, A., Thompson, G., Homans, S., Kitov, P.I. and
Bundle, D.R. Large scale millisecond inter-subunit dynamics
in the B subunit homopentamer of the toxin derived from E.
coli O157.
J. Am. Chem. Soc., 125, 13058-13062,
2003 |
Kamath, V., Sadowska,
J., Nilar, S., Bundle, D.R., Hindsgaul, O. Synthetic analogs
of the Lewisb-tetrasaccharide and their binding to the lectin
GS-IV – Part 1.
Synlett, 1327-1330, 2003 |
Kitov, P.I., Shimizu,
H., Homans, S.W., and Bundle, D.R. Optimization of Tether Length
in non-Glycosidically Linked Bivalent Ligands that Target Sites
2 and 1 of Shiga-like Toxin.
J. Am. Chem. Soc., 125, 3284-3294,
2003 |
Mulvey, G.L.,
Marcato, P., Kitov, P.I., Sadowska, J., Bundle, D.R., and Armstrong,
G.D. Assessment in Mice of the Therapeutic Potential of tailored,
Multivalent Shiga Toxin Carbohydrate Ligands.
J. Infect. Dis., 187, 640-649, 2003 |
| |
2002 |
Kitova, E.N.,
Wang, W., Bundle, D.R. and Klassen, J.S. Retention of
Bioactive Ligand Conformation in in a Gaseous Protein-Trisaccharide
Complex.
J. Am. Chem. Soc., 124, 13980-13981,
2002 |
Kitova, E.N.,
Bundle, D.R. and Klassen, J.S. Evidence for the Preservation
of Specific Intermolecular Interactions in Gaseous Protein-Oligosaccharide
Complexes.
J. Am. Chem. Soc., 124, 9340-9341,
2002 |
Vyas, N.K., Vyas,
M.N., Chervenak, M.C., Johnson, M.A., Pinto, B.M., Bundle,
D.R., and Quiocho, F.A. Molecular Recognition of Oligosaccharide
Epitopes by a Monoclonal Fab Specific for Shigella flexneri Y
Lipopolysaccharide: X-ray Structures and Thermodynamics.
Biochemistry 41, 13575-13586, 2002 |
Uhrín,
D., Prasad, A.V.K., Brisson, J.R. and Bundle, D.R. Carbohydrate-Antibody
Interactions by NMR. Antibody interactions by NMR.
Canad. J. Chem. 80, 904-907, 2002 |
Yu, H.N., Ling,
C.-C. and Bundle, D.R. Probing Carbohydrate-Antibody Interactions:
Synthesis of Three Salmonella Epitopes for SPR Studies.
Canad. J. Chem. 80, 1131-1140 2002 |
Lowary, T.L.,
Eichler, E. and Bundle, D.R.. Oligosaccharide recognition by
antibodies: synthesis and evaluation of talose oligosaccharide
analogues.
Canad. J. Chem. 80, 1112-1130, 2002 |
Zhang, P., Appleton,
J.A., Ling, C.C. and Bundle, D.R. Synthesis of disaccharide
congeners of the Trichinella spiralis glycan and binding
site mapping of two protective antibodies.
Canad. J. Chem. 80, 1141-1161, 2002 |
Kitova, E.N.,
Bundle, D.R. and Klassen, J.S. Thermal Dissociation of Protein-Oligosaccharide
Complexes in the Gas Phase: Mapping the Intrinsic Intermolecular
Interactions.
J. Am. Chem. Soc., 124, 5902-5913, 2002 |
Soltyk, A. M.,
MacKenzie, C. R., Wolski, V. M., Hirama, T., Kitov, P. I.,
Bundle, D. R., and Brunton, J. L. A mutational analysis of
the globotriaosylceramide binding sites of verotoxin VT1.
J. Biol Chem., 277, 5351-5359, 2002 |
Nitz, M., Ling,
C. C., Otter, A., Cutler, J. E. and Bundle, D. R. The unique
solution structure and immunochemistry of the Candida albicans b-1,2-mannopyranan
cell wall antigen.
J. Biol. Chem. 277, 3440-3446, 2002 |
| |
| 2001 |
Appleton,
J.A., Dell, A., Nitz, M., and Bundle, D.R. Novel N-glycans
of the parasitic nematode Trichinella spiralis.
Trends in Glycoscience and Glycotechnology, 13,
481-492 (2001 |
Nitz, M. and Bundle,
D.R. Synthesis of di- to hexasaccharide 1,2-linked b-mannopyranan
oligomers, a terminal S-linked tetrasaccharide congenerand
the corresponding BSA glycoconjugates.
J. Org. Chem., 66, 8411- 8423, 2001 |
G.
Mulvey, P.I. Kitov, P. Marcato, D.R. Bundle and G.D. Armstrong.
Glycan mimicry as a basis for novel anti-infective drugs.
Biochimie, 83, 841-847, 2001 |
Kitov, P.I. and
Bundle, D.R. Mild oxidative one-pot allyl group cleavage.
Org. Let.,3, 2835-2838, 2001 |
Wacowich-Sgarbi,
S.A., Ling, C.C., Otter, A. and Bundle, D.R. A tethered disaccharide
trapped as its anti conformer calibrates the Karplus
relationship for 3JC,H coupling constants.
J. Am. Chem. Soc., 123, 4362-4363, 2001 |
Kitova, E.N.,
Kitov, P.I., Bundle D.R., and Klassen, J.S. The observation
of multivalent complexes of Shiga-like toxin with globotrioside
and the determination of their stoichiometry by nanoelectrospray
Fourier-transform ion cyclotron resonance mass spectrometry.
Glycobiology, 11, 605-611, 2001 |
Kitov,
P.I. and Bundle, D.R. Synthesis and structure-activity relationships
of di- and trisaccharide inhibitors for Shiga-like
toxin Type 1.
JCS Perkin 1, 838-853, 2001 |
Yu,
H.N., Ling, C.-C. and Bundle, D.R. Efficient
stereoselective synthesis of 1-thio-b-mannopyranosides.
JCS Perkin 1, 832-837, 2001
|
2000
|
Nitz,
M., Purse B.W. and Bundle, D.R. Synthesis of a b1,2-mannopyranosyl
tetrasaccharide found in the phosphomannan antigen of Candida
albicans.
Org. Let.,2, 2939-2942, 2000 |
Nitz,
M. and Bundle, D.R. Efficient synthesis of 3,6-dideoxy-b-D-arabinohexopyranosyl
terminated LacdiNac glycan chains of the Trichinella
spiralis parasite.
J. Org. Chem.,65, 3064-3073, 2000 |
Alexander,
J., del Guercio, M-F., Maewal, A., Qiao, L., Filkes, J. Chesnut,
R.W., Paulson, J.C., Bundle, D,R., DeFrees, S. and Sette,
A. Linear PADRE T Helper Epitope and Carbohydrate B
Cell Epitope Conjugates Induce Specific High Titer IgG Antibody
Responses.
J. Immunol. 164, 1625-1633, 2000 |
Kitov,
P.I., Sadowska, J.M., Mulvey, G., Armstrong, G.D., Ling,
H., Pannu, N.S., Read, R.J. and Bundle, D.R. Shiga-like
toxins neutralized by tailored multivalent carbohydrate ligands.
Nature, 403, 669-672, 2000 |
Yu,
H.N., Zhang, P., Ling, C.-C. and Bundle, D.R. A practical
route to 3,6-dideoxyhexoses.
Tetrahedron Asymmetry, 11, 465-479,
2000 |
Zhang,
P. and Bundle, D.R. Synthesis of three tethered trisaccharides
to probe entropy contributions in carbohydrate-protein interactions.
Israel J. Chem., 40, 189-207, 2000 |
|
1999
|
Wacowich-Sgarbi,
S.A. and Bundle, D.R. Constrained H-Type 2 Blood Group
Trisaccharide Synthesized in a Bioactive Conformation via
Intramolecular Glycosylation
J. Org. Chem., 64, 9080-9089, 1999 |
Young,
N.M., Gidney, M.A.J., Gudmundsson, B.M.E., MacKenzie, C.R.,
To, R., Watson, D.C. and Bundle, D.R. Molecular basis
for the lack of mimicry of Brucella polysaccharide
antigens by Ab2g antibodies.
Mol. Immunol., 36, 339-347, 1999 |
Seto,
N.O.L., Compston, C.A., Evans, S. V., Bundle, D.R., Narang,
S.A. and Palcic, M.M. Donor Substrate Specificity
of Recombinant Human Blood Group A, B and Hybrid A/B Glycosyltransferases
Expressed In Escherichia coli.
Eur. J. Biochem. 259, 770-775,
1999 |
Schriemer,
D.C., Bundle, D.R., Li, L., and Hindsgaul, O. Micro-scale
frontal affinity chromatography: a new method for screening
of compound libraries.
Angew. Chem. Int. Ed. 37, 3383-3387,
1999 |
Otter,
A., Lemieux, R.U., Ball, R.G., Venot, A.P., Hindsgaul, O.,
and Bundle, D.R. Crystal State and Solution Conformation
of the Blood Group B Trisaccharide a-L-Fucp-(1®2)-[
a -D-Galp]-(1 ® 3)]-b-D-Galp-OCH3
Eur. J. Biochem., 259, 295-303, 1999 |
1998
|
Milton,
M.J. and Bundle D.R. Observation of the anti-
conformation of a glycosidic linkage in an antibody bound
oligosaccharide.
J. Am. Chem. Soc., 120, 10547-10548,
1998 |
Alibes,
R. and Bundle, D.R. Synthesis of tethered trisaccharides
to probe inter-saccharide flexibility in carbohydrate-protein
interactions.
J. Org. Chem., 63, 6288-6301, 1998 |
Bundle,
D.R., Alibes, R., Nilar, S., Otter, A., Warwas, M., and Zhang,
P. Thermodynamic and conformational implications of glycosidic
rotamers pre-organized for binding.
J. Am. Chem. Soc., 120, 5317-5318,
1998 |
Kitov,
P.I., Railton, C. and Bundle, D.R. The synthesis of
16-mercaptohexadecanyl glycosides for biosensor applications.
Carbohydr. Res., 307, 361-369,
1998 |
Stangier,
K., Palcic, M.M., Bundle, D.R., Hindsgaul, O., and Thiem,
J. Fucosyltransferase-catalyzed formation of L-galactosylated
Lewis structures.
Carbohydr. Res., 305, 511-515, 1998 |
|
Seto,
N.O.L., Palcic, M.M., Compston, C.A., Li, H., Bundle, D.R.
and Narang, S.A. Sequential interchange of four amino acids
from blood group B to blood group A glycosyltransferase boosts
catalytic activity and progressively modifies substrate recognition
in human recombinant enzymes.
J. Biol. Chem.,272, 14133-14138, 1997 |
Ellis,
L.A., McVay, C.S., Probert, M.A., Zhang, J., Bundle, D.R.,
and Appleton J.A. Terminal b-linked tyvelose creates unique
epitopes in Trichinella spiralis glycan antigens.
Glycobiology, 7, 383-390, 1997 |
|
Probert,
M.A., Zhang, J. and Bundle D.R. Synthesis of a-and
b-linked Tyvelose Epitopes of the Trichinella spiralis glycan;
2-Acetamido-2-deoxy-3-O-(3,6-dideoxy-D-arabino-hexopyranosyl)-b-D-galactopyranosides.
Carbohydr. Res., 296, 149-170, 1996 |
Zhang,
J., Otter A. and Bundle D.R. Synthesis and Conformational
Studies of the Tyvelose Capped, Lewis-x Like Tetrasaccharide
Epitope of Trichinella spiralis.
Bioorgan. Med. Chem., 4, 1989-2001,
1996 |
MacKenzie,
C.R., Hirama, T., Deng, S.-J., Bundle, D.R., Narang S.A.,
and Young, N.M. Analysis by surface plasmon resonance
of the influence of valence on the ligand binding affinity
and kinetics of an anti-carbohydrate antibody.
J. Biol. Chem., 271, 1527-1533, 1996 |
1995 |
Seto,
N.O.L., Palcic, M.M., Hindsgaul, O., Bundle, D.R., and Narang,
S.A. Expression of a recombinant human glycosyltransferase
from a synthetic gene and its utilization for synthesis of
the human blood group B trisaccharide.
Eur. J. Biochem., 234, 323-328,
1995 |
MacKenzie,
C.R., Clark, I.D., Evans, S.V., Hill, I.E., MacManus, J.P.,
Dubuc, G., Bundle, D.R., Narang S.A., Young, N.M., and Szabo,
A.G. Bifunctional fusion proteins consisting of a single-chain
antibody and an engineered lanthanide-binding protein. Immunotechnology, 1,
139-150, 1995 |
Lowary,
T., Eichler, E., and Bundle, D.R. Synthesis of a pentasaccharide
epitope for the investigation of carbohydrate-protein interactions.
J. Org. Chem., 60, 7316-7327, 1995 |
Otter
A., and Bundle, D.R., Long Range 4J and 5J Including Inter-Glycosidic
Correlations in Gradient-Enhanced Homonuclear COSY Experiments
of Oligosaccharides.
J. Mag. Reson. Ser. B, 109, 194-201,
1995 |
Otter,
A., Hindsgaul, O., and Bundle, D. R. Gradient-enhanced homonuclear
2D NMR techniques applied to oligosaccharides containing
manno-hexoses provide improved correlations for protons coupled
by small 3J.
Carbohydr. Res., 275, 381-389, 1995 |
Deng,
S.-J., MacKenzie, C.R., Hirama, T., Brousseau, R., Lowary,
T., Young, N.M., Bundle, D.R., and Narang S.A. Basis
for selection of improved carbohydrate-binding single-chain
antibodies from synthetic gene libraries.
Proc. Natl. Acad. Sci (USA), 92, 4992-4996,
1995 |
Evans,
S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R.,
To, R., Altman, E., Frosch, M., Weisgerber, C., Kratzin,
H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R.,
Young, N.M., and Bundle, D.R. The 2.8Å resolution
structure, and thermodynamics of ligand binding, of an Fab
specific for a(2®8)-polysialic acid.
Biochemistry, 34, 6737-6744, 1995 |
Stangier,
P., Palcic, M.M., and Bundle, D.R. 2-(Dimethyloctylsilyl)ethyl
lactoside: a versatile intermediate for chemical and enzymic
ganglioside synthesis.
Carbohydr. Res., 267, 153-159, 1995 |
|
Marsden,
B.J., Bundle, D.R., and Perry, M.B. Serological and
structural relationships between Escherichia coli O:98
and Yersinia enterocolitica O:11,23 and O:11,24
lipopolysaccharide O-antigens.
Biochem. Cell Biol., 72, 163-168,
1994 |
Lowary,
T.L., and Bundle, D.R. Nucleophile Induced Rearrangements
of Thioglycosides: Formation of 6-Thio Glycosides and 1,6
Thioanhydrosugars
Tetrahedron: Asymmetry, 5, 2397-2404,
1994 |
Bundle,
D.R., and Eichler, E. Modulation of antibody affinity
by synthetic modifications of the most exposed pyranose residue
of a trisaccharide epitope.
Bioorgan. Med. Chem., 2, 1221-1229,
1994 |
Evans,
S.V., Rose, D.R., To, R., Young, N.M., and Bundle, D.R. Exploring
the mimicry of polysaccharide antigens by anti-idiotypic
antibodies: The crystallization, molecular replacement, and
refinement to 2.8Å resolution of an idiotope-anti-idiotope-Fab
complex and of the unliganded-anti-idiotype Fab.
J. Mol. Biol., 241, 691-705, 1994 |
Zdanov,
A., Li, Y., Bundle, D.R., Deng, S.-J., MacKenzie, C.R., Narang
S.A., Young, N.M., and Cygler, M. Structure of a single-chain
Fv fragment complexed with a carbohydrate antigen at 1.7Å resolution.
Proc. Natl. Acad. Sci (USA), 91,
6423-6427, 1994 |
MacKenzie,
C.R., Sharma, V., Brummell, D.A., Bilous, D., Dubuc, G.,
Sadowska, J., Young, N.M., Bundle, D.R., and Narang, S.A. Effect
of Cl-Ck domain switching on Fab activity and yield
in Escherichia coli: synthesis and expression of
genes encoding two anti-carbohydrate Fabs.
Biotechnology, 12, 390-395, 1994 |
Deng,
S.-J., MacKenzie, C.R., Sadowska, J., Michniewicz, J., Young,
N.M., Bundle, D.R., and Narang, S.A. Selection of antibody
single-chain Fvs with improved carbohydrate-binding by phage
display.
J. Biol. Chem., 269, 9533-9538, 1994 |
Bundle,
D.R., Baumann, H., Brisson, J.-R., Gagne, S.M., Zdanov, A.,
and Cygler, M. The Solution Structure of a Trisaccharide-Antibody
Complex: Comparison of NMR Measurements with a Crystal
Structure.
Biochemistry, 33, 5183-5192, 1994 |
Bundle,
D.R., Eichler, E., Gidney, M.A.J., Meldal, M., Ragauskas,
A., Sigurskjold, B.W., Sinnott, B., Watson, D.C., Yaguchi,
M., and Young, N.M. Molecular Recognition of a Salmonella Trisaccharide
Epitope by Monoclonal Antibody SE155-4.
Biochemistry, 33, 5172-5182, 1994 |
|
Uhrin,
D., Brisson, J.-R., and Bundle, D.R. Pseudo-3D NMR
spectroscopy: Application to oligo- and polysaccharides.
J. Biomolecular NMR, 3, 367-373, 1993 |
Rose,
D.R., Przybylska, M., To, R.J., Kayden, C.S., Oomen, R. P.,
Vorberg, E., Young, N.M., and Bundle, D.R. Crystal
structure to 2.45Å resolution of a monoclonal Fab specific
for the Brucella A cell wall polysaccharide antigen.
Protein Science, 2, 1106-1113, 1993 |
Auzanneau,
F.-I., and Bundle, D.R. Synthesis of chlorodeoxy trisaccharides
related to the Shigella flexneri Y polysaccharide.
Carbohydr. Res., 247, 195-209,
1993 |
Baumann,
H., Altman, E., and Bundle, D. R. Controlled acid hydrolysis
of an O-antigen fragment yields univalent heptasaccharide
haptens containing one 3,6-dideoxyhexose epitope.
Carbohydr. Res., 247, 347-354,
1993 |
Auzanneau,
F.-I., and Bundle, D. R. Application of thioglycoside
chemistry to the synthesis of trisaccharides and deoxy-trisaccharides
related to the Shigella flexneri Y polysaccharide.
Can. J. Chem., 71, 534-548, 1993 |
Vyas,
M.N., Vyas, N.K. Meikle, P.J., Sinnott, B., Pinto, B.M.,
Bundle, D.R., and Quiocho, F.A. Preliminary crystallographic
analysis of a Fab specific for the O-antigen of Shigella
flexneri cell surface lipopolysaccharide with and without
bound saccharides.
J. Mol. Biol., 231, 133-136, 1993 |
Brummell,
D.A., Sharma, V.P., Anand, N.N., Bilous, D., Dubuc, G., Michniewicz,
J., MacKenzie, C.R., Sadowska, J., Sigurskjold, B.W., Sinnott,
B., Young, N.M., Bundle, D.R., Narang, S.A. Probing
the combining site of an anti-carbohydrate antibody by saturation-mutagenesis:
role of the heavy chain CDR3 residues.
Biochemistry, 32, 1180-1187, 1993 |
Auzanneau,
F.-I., Hanna, H.R., and Bundle, D.R. The synthesis
of chemically modified disaccharide derivatives of the Shigella
flexneri Y polysaccharide antigen.
Carbohydr. Res., 240, 161-181,
1993 |
Hanna,
H.R., and Bundle, D.R. Antibody-oligosaccharide interactions:
The synthesis of 2-deoxy-a-L-rhamnose containing oligosaccharide
haptens related to Shigella flexneri variant Y antigen.
Can. J. Chem., 71, 125-134, 1993 |
|
Reimer,
K.B., Gidney, M.A.J., Bundle, D.R., and Pinto, B.M. Immunochemical
characterization of polyclonal and monoclonal streptococcus group
A antibodies by chemically defined glycoconjugates and
synthetic oligosaccharides.
Carbohydr. Res., 232, 131-142, 1992 |
Sigurskjold,
B., and Bundle, D.R. Thermodynamics of oligosaccharide
binding to a monoclonal antibody specific for a Salmonella
O-antigen point to hydrophobic interactions in the binding
site.
J. Biol. Chem., 267, 8371-8376, 1992 |
|
Narang,
S.A., Brummell, D.A., Sharma, V., Bilous, D., Dubuc, G.,
MacKenzie, C.R., Michniewicz, J., Sadowska, J., Anand, N.N.,
Young, N.M., and Bundle, D.R. Scanning of key residues
in antibody binding sites by two saturation-mutagenesis approaches. Nucleic
Acid Res., 24, 173-179, 1991 |
Anand,
N.N., Mandal, S., MacKenzie, C.R., Sadowska, J., Sigurskjold,
B., Young, N.M., Bundle, D.R., and Narang, S.A. Bacterial
Expression and Secretion of Various Single-Chain Fv Genes
Encoding Proteins Specific for a Salmonella Serotype
B O-Antigen.
J. Biol. Chem., 266, 21874-21879,
1991 |
Cygler,
M., Rose, D.R., and Bundle, D.R. Recognition of a cell
surface oligosaccharide epitope of pathogenic Salmonella by
an antibody Fab fragment.
Science, 253, 442-446, 1991 |
Anand,
N.N., Dubuc, G., Phipps, J., MacKenzie, C.R., Sadowska, J.,
Young, N.M., Bundle, D.R., and Narang, S.A. Synthesis
and expression in Escherichia coli of cistronic
DNA encoding an antibody fragment specific for a Salmonella serotype
B O-antigen.
Gene, 100, 39-44,
1991 |
Kihlberg,
J., and Bundle, D.R. The synthesis of antibody binding
site probes: A hexasaccharide and two pentasaccharides
related to the Brucella A antigen prepared by in
situ activation of thioglycosides with bromine.
Carbohydr. Res., 216, 67-78, 1991 |
Eichler,
E., Kihlberg, J., and Bundle, D.R. Access to fluorescent
probes via allyl glycosides; the synthesis of a Brucella trisaccharide
epitope linked to a coumarin.
Glycoconjugate J., 8, 69-74, 1991 |
Auzanneau,
F.-I., and Bundle, D.R. Incidence and avoidance of
stereospecific 1,2-thioethyl migration during the synthesis
of ethyl 1-thio-a-L-rhamnopyranoside 2,3-orthoester.
Carbohydr. Res., 212, 13-24, 1991 |
Oomen,
R., Young, N.M., and Bundle, D.R. Molecular modeling
of antibody-antigen complexes between the Brucella abortus
O-chain polysaccharide and a specific monoclonal antibody.
Protein Engineering, 4, 427-433, 1991 |
Sigurskjold,
B.W., Altman, E., and Bundle, D.R. Sensitive titration
microcalorimetric study of the binding of Salmonella O-antigenic
oligosaccharide by a monoclonal antibody.
Eur. J. Biochem., 197, 239-246, 1991 |
Kihlberg,
J., Eichler, E., and Bundle, D.R. The design and synthesis
of antibody binding site probes: three pentasaccharide
analogues of the Brucella A antigen prepared by in
situ activation of thioglycosides with bromine.
Carbohydr. Res., 211, 59-75, 1991 |
|
Rose,
D.R., Cygler, M., To, R.J., Przybylska, M., Sinnott, B.,
and Bundle, D.R. Preliminary crystal structure determination
of an Fab specific for a Salmonella O-polysaccharide
antigen.
J. Mol. Biol., 215, 489-492, 1990 |
Meikle,
P.J., Young, N.M., and Bundle, D.R. O-antigen biotin
conjugates: Preparation and use in direct competitive
enzyme immunoassays.
J. Immunol. Meth., 132, 255-261, 1990 |
Meikle,
P.J., and Bundle, D.R. Preparation of polysaccharide
enzyme conjugates for competitive binding assays.
Glycoconjugate J., 7, 207-218, 1990 |
Vorberg,
E., and Bundle, D.R. Carbohydrate-enzyme conjugates
for competitive EIA.
J. Immunol. Meth., 132, 81-89, 1990 |
Beynon,
L.M., Bundle, D.R., and Perry, M.B. The structure
of the antigenic lipopolysaccharide O-chain produced by Escherichia
hermanii ATCC 33650 and 33652.
Can. J. Chem., 68, 1456-1466, 1990 |
Anand,
N.N., Dubuc, G., Mandal, S., Phipps, J., Gidney, M.A.J.,
Sinnott, B., Young, N.M., MacKenzie, C.R., Bundle, D.R.,
and Narang, S.A. Synthesis and expression in Escherichia
coli of DNA encoding the murine l1 chain of a monoclonal
antibody specific for Salmonella serotype B O-antigen.
Protein Engineering, 3, 541-546, 1990 |
Kihlberg,
J.O., Leigh, D.A., and Bundle, D.R. The in situ activation
of thioglycosides with bromine: An improved glycosylation
method.
J. Org. Chem., 55, 2860-2863, 1990 |
Peters,
T., Brisson, J.-R., and Bundle, D.R. Conformational
analysis of key disaccharide components of Brucella A
and M antigens.
Can. J. Chem., 68, 979-988, 1990 |
Perry,
M.B., and Bundle, D.R. Antigenic relationships in
the lipopolysaccharides of strains of Escherichia hermannii with Escherichia
coli 0157:H7, Brucella melitensis and Brucella
abortus.
Infect. Immun. 58, 1391-1395, 1990 |
Pinto,
B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Synthesis
and 2D-n.m.r. analysis of a pentasaccharide glycoside of
the biological repeating units of Shigella flexneri variant
Y polysaccharide and the preparation of a synthetic antigen.
Carbohydr. Res., 196, 156-166, 1990 |
Pinto,
B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Oligosaccharides
corresponding to biological repeating units of Shigella
flexneri variant Y polysaccharide: Part III. Synthesis
and 2D NMR analysis of a heptasaccharide hapten.
J. Chem. Soc. Perkin I, 293-299, 1990 |
|
Meikle, P.J.,
Perry, M.B., Cherwonogrodzky, J.W., and Bundle, D.R. Fine
structure of A and M antigens from Brucella biovars.
Infect. Immun., 57, 2820-2828, 1989
|
Bundle,
D.R., Cherwonogrodzky, J.W., Gidney, M.A.J., Meikle, P.J.,
Perry, M.B., and Peters, T. Definition of Brucella A
and M epitopes by monoclonal typing reagents and synthetic
oligosaccharides.
Infect. Immun., 57, 2829-2836, 1989 |
Nielsen, K.,
Cherwonogrodzky, J.W., Duncan, J.R., and Bundle, D.R. Enzyme-linked
immunosorbent assay for differentiation of the antibody
response of cattle naturally infected with Brucella abortus
or vaccinated with strain 19.
Am. J. Vet. Res., 50, 5-9, 1989
|
Pinto,
B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Oligosaccharides
corresponding to biological repeating units of Shigella
flexneri variant Y polysaccharide. Synthesis
and two-dimensional NMR analysis of a hexasaccharide hapten.
J. Org. Chem., 54, 2650-2656, 1989 |
Peters, T.,
and Bundle, D.R. Block synthesis of two pentasaccharide
determinants of the Brucella M antigen using thioglycoside
methodologies.
Can. J. Chem., 67, 497-502, 1989
|
Peters,
T., and Bundle. D.R. Synthetic antigenic determinants
of the Brucella A polysaccharide; a disaccharide
thioglycoside for block synthesis of pentasaccharide and
lower homologues of a1,2-linked 4,6-dideoxy-4-formamido-a-D-mannose.
Can. J. Chem., 67, 491-496, 1989 |
Bundle, D.R. Antibody
combining sites and oligosaccharide determinants studied
by competitive binding, sequencing and X-ray crystallography.
Pure and Applied Chem., 61, 1171-1180, 1989
|
|
Zygmunt,
M.S., Dubray, G., Bundle, D.R., and Perry, M.B. Purified
native haptens of Brucella abortus B19 and B. melitensis 16
M reveal the lipopolysaccharide origin of the antigens.
Ann. Inst. Pasteur/Microbiol., 139,
421-433, 1988 |
Kulakowska,
M., Lugowski, C., Romanowska, E., and Bundle, D.R. The
comparison of monoclonal-antibodies specific for 2 general
epitopes located on citrobacter-036 lipopolysaccharide.
Carbohydr. Res., 178, 233-241, 1988 |
Perry,
M.B., Bundle, D.R., Gidney, M. A.J., and Lior, H. Identification
of Escherichia coli serotype 0157 strains by using
monoconal antibody.
J. Clin. Microbiol., 26, 2391-2394,
1988 |
Todd,
E.C.D., Szabo, R.A., Peterkin, P., Sharpe, A.N, Parrington,
L., Bundle, D.R., Gidney, M.A.J., and Perry, M.B. Rapid
hydrophobic grid membrane filter -enzyme labeled antibody
procedure for identification and enumeration of Escherichia
coli 0157 in foods.
Applied and Environmental Microbiology, 54,
2536-2540, 1988 |
Kramer,
J.K.G., Sauer, F.D., and Bundle, D.R. The presence
of tightly bound Na+ or K+ in glycolipids in Methanobacterium
thermoautotrophicum.
Biochim. Biophys. Acta., 961,
285-292, 1988 |
Bundle,
D.R., Cherwonogrodzky, J.W., and Perry, M.B. Characterization
of Brucella polysaccharide B.
Infect. Immun., 56, 1101-1106, 1988 |
Bundle,
D.R., Gerken, M., and Peters, T. Synthesis of antigenic
determinants of the Brucella A antigen utilizing
methyl 4-azido-4,6-dideoxy-a-D-mannopyranoside efficiently
derived from D-mannose.
Carbohydr. Res., 174, 239-251,
1988 |
|
Peters,
T., and Bundle, D.R. Synthesis of 4,6-dideoxy-4-formamido-a-D-
mannose containing tri- tetra- and pentasaccharides, antigenic
determinants of the Brucella A and M antigens.
J. Chem. Soc. Chem. Comm., 1648-1650, 1987 |
Gerken,
M., and Bundle, D.R. Synthesis of immunologically active
oligosaccharide determinants of the Brucella A antigen: utilization
of intermediates derived from methyl 4-azido-4,6-dideoxy-a-D-mannopyranoside.
Tet. Lett., 28, 5067-5070, 1987 |
Bundle,
D.R., Cherwonogrodzky, J.W., and Perry, M.B. Structural
elucidation of the Brucella melitensis M antigen
by high resolution NMR at 500 MHz.
Biochemistry, 26, 8717-8726, 1987 |
Di
Fabio, J.L., Perry, M.B., and Bundle, D.R. Analysis
of the lipopolysaccharide of Pseudomonas maltophilia 555.
Biochem. Cell. Biol., 65, 968-977,
1987 |
Altman,
E., Brisson, J.-R., Bundle, D.R., and Perry, M.B. Structural
studies of the O-chain of the phenol-phase soluble lipopolysaccharide
from Haemophilus pleuropneumoniae serotype 2.
Biochem. Cell Biol., 65, 876-889,
1987 |
Cherwonogrodzky,
J.W., Perry, M.B., and Bundle, D.R. Identification
of the A and M antigens of Brucella as the O-polysaccharides
of smooth lipopolysaccharides.
Can. J. Microbiol., 33, 979-981, 1987 |
Carlin,
N.I.A., Bundle, D.R., and Lindberg, A.A. Characterization
of five Shigella flexneri variant Y - specific monoclonal
antibodies using defined saccharides and glycoconjugate antigens.
J. Immunol., 138, 4419-4427, 1987 |
Bundle,
D.R., Cherwonogrodzky, J.W., and Perry, M.B. The structure
of the lipopolysaccharide O-chain (M antigen) and polysaccharide
B produced by Brucella melitensis 16M.
FEBS Letters, 216, 261-264, 1987 |
Sugden,
E.A., Samagh, B.S., Bundle, D.R., and Duncan, J.R. Lipoarabinomannan
and lipid-free arabinomannan antigens of Mycobacterium
paratuberculosis.
Infect. Immun.. 55, 762-770, 1987 |
Bundle,
D.R., Cherwonogrodzky, J.W., Caroff, M., and Perry, M.B. The
lipopolysaccharides of Brucella abortus and B.
melitensis.
Ann. Inst. Pasteur/Microbiol., 138, 92-98,
19 |
Pinto,
B.M., Morrisette, D.G., and Bundle, D.R. Synthesis
of oligosaccharides corresponding to biological repeating
units of Shigella flexneri Y polysaccharide. Part
1. Overall strategy, synthesis of a key trisaccharide
intermediate, and synthesis of a pentasaccharide.
J. Chem. Soc. Perkin I, 9-14, 1987 |
|
Carlin,
N.I.A., Gidney, M.A.J., Lindberg, A.A., and Bundle, D.R. Characterization
of Shigella flexneri specific murine monoclonal
antibodies by chemically defined glycoconjugates.
J. Immunol., 137, 2361-2366, 1986 |
Perry,
M.B., Bundle, D.R., MacLean, L., Perry, J.A., and Griffith,
D.W. The structure of the antigenic lipopolysaccharide
O-chains produced by Salmonella urbana and Salmonella
godesberg.
Carbohydr. Res., 156, 107-122,
1986 |
Bundle,
D.R., Gerken, M., and Perry, M.B. Two dimensional NMR
at 500 MHz: The structural elucidation of a Salmonella serogroup
N polysaccharide antigen.
Can. J. Chem., 64, 255-264, 1986 |
|
Lemieux,
R.U., Venot, A.P., Spohr, U., Bird, P., Mandal, G., Morishima,
N., Hindsgaul, O., and Bundle, D.R. Molecular recognition.
V. The binding of the B human blood group determinant
by hybridoma monoclonal antibodies.
Can. J. Chem., 63, 2664-2668, 1985 |
Emmrich,
F., Bundle, D.R., van der Zee, J., Out, T., Zenke, G., and
Eichmann, K. Two human IgM myeloma proteins with unusual
specificities for streptococcal carbohydrate-associated epitopes.
Scand. J. Immunol., 21, 119-126, 1985 |
Wessel,
H.P., and Bundle, D.R. Strategies for the synthesis
of branched oligosaccharides of the Shigella flexneri 5a,
5b and variant X serogroups employing a multifunctional rhamnose
precursor.
J. Chem. Soc., Perkin I, 2251-2260, 1985 |
Wessel,
H.P., Iversen, T., and Bundle, D.R. Acid-catalyzed
benzylation and allylation by alkyl trichloroacetimidates.
J. Chem. Soc., Perkin I, 2247-2250, 1985 |
Gidney,
M.A.J., Bundle, D.R., Godard, A., and Griffiths, B.W. Development
and characterization of monoclonal antibodies to pregnancy-specific
b1-glycoprotein.
Can. J. Biochem., 63, 737-742,
1985 |
Birnbaum,
G.I., and Bundle, D.R. Conformation of methyl 3,6-dideoxy-a-D-arabino-hexopyranoside,
the immunodominant sugar of Salmonella serogroup
D1: Crystal structure, 1H NMR analysis and semi-empirical
calculations.
Can. J. Chem., 63, 739-744, 1985 |
|
Pinto,
B.M., and Bundle, D.R. Antigenic determinant of Salmonella serogroup
B. Synthesis of a trisaccharide glycoside for use as an artificial
antigen.
Carbohydr. Res., 133, 333-338, 1984 |
Bundle,
D.R., Gidney, M.A.J., Perry, M.B., Duncan, J.R., and Cherwonogrodzky,
J.W. Serological confirmation of Brucella abortus and Yersinia
enterocolitica O:9 O-antigens by monoclonal antibodies.
Infect. Immun., 46, 389-393, 1984 |
Caroff,
M., Bundle, D.R., Perry, M.B., Cherwonogrodsky, J.W., and
Duncan, J.R. Antigenic S-type lipopolysaccharide of Brucella
abortus 1119-3.
Infect. Immun., 46, 384-388, 1984 |
Bock,
K., Meldal, M., Bundle, D.R., Iversen, T., Pinto, B.M., Garegg,
P.J., Kvanström, I., Norberg, T., Lindberg, A.A., and
Svenson, S.B. The conformation of Salmonella O-antigenic
oligosaccharides of serogroups A, B and D1 inferred
from 1H and 13C nuclear magnetic resonance spectroscopy.
Carbohydr. Res., 130, 35-53, 1984 |
Bock,
K., Meldal, M., Bundle, D.R., Iversen, T., Garegg, P.J.,
Norberg, T., Lindberg, A.A., and Svenson, S.B. The
conformation of Salmonella O-antigenic polysaccharide
chains of serogroups A, B and D1 predicted by semi-empirical
hard sphere (HSEA) calculations.
Carbohydr. Res., 130, 23-34, 1984 |
Carlin,
N. I. A., Lindberg, A. A., Bock, K., and Bundle, D. R. The Shigella
flexneri O-antigenic polysaccharide chain: Nature
of the biological repeating unit.
Eur. J. Biochem., 139, 189-194,
1984 |
Shearman,
P.J., Bundle, D.R., Romanowska, E., Lugowski, C., and Bogulska,
M. Characterization of anti-Citrobacter 036-specific
polysaccharide monoclonal antibodies.
Can. J. Microbiol., 30, 91-97,
1984 |
Caroff,
M., Bundle, D. R., and Perry, M. B. Structure of the
O-chain of the phenol-phase soluble cellular lipopolysaccharide
of Yersinia enterocolitica serotype O:9.
Eur. J. Biochem., 139, 195-200,
1984 |
Wessel,
H.P., Iversen, T., and Bundle, D.R. Synthesis of the
trisaccharide moiety of gangliotriosylceramide, Asialo GM2.
Carbohydr. Res., 130, 5-21, 1984 |
|
Wessel,
H.P., and Bundle, D.R. Artificial carbohydrate antigens: A
block synthesis of a linear tetrasaccharide repeating unit
of the Shigella flexneri variant Y polysaccharide.
Carbohydr. Res., 124, 301-311, 1983 |
Pinto,
B.M., and Bundle, D.R. Preparation of glycoconjugates
for use as artificial antigens: A simplified procedure.
Carbohydr. Res., 124, 313-318, 1983 |
Kenne,
L., Lindberg, B., Soderholm, E., Bundle, D.R., and Griffith,
D.W. Structural studies of the O-antigens from Salmonella
greenside and Salmonella adelaide.
Carbohydr. Res., 111, 289-296,
1983 |
Bhattacharjee,
A.K., Bennett, J.E., Bundle, D.R., and Glaudemans, C.P.J.
Anticryptococcal type D antibodies raised in rabbits.
Mol. Immunol., 20, 351-359, 1983 |
|
Bundle,
D.R., Gidney, M.A.J., Kassam, N., and Rahman, A.F.R. Hybridomas
specific for carbohydrates; synthetic human blood-group antigens
for the production, selection and characterization of monoclonal
typing reagents.
J. Immunol., 129, 678-682, 1982 |
Neurohr,
K.J., Bundle, D.R., Young, N.M., and Mantsch, H.H. Binding
of disaccharides by peanut agglutinin as studied by ultraviolet
difference spectroscopy.
Eur. J. Biochem., 123, 305-310,
1982 |
Iversen,
T., and Bundle, D.R. Synthesis of the colitose determinant
of Escherichia coli 0111 and 3,6-di-O-(a-D-galactopyranosyl)-a-D-glucopyranoside.
Can. J. Chem., 60, 299-303, 1982 |
Iversen,
T., and Bundle, D.R. Antigenic Determinants of Salmonella A
and D1 synthesis of trisaccharide glycosides for use
as artificial antigens.
Carbohydr. Res., 103, 29-40, 1982 |
Bock,
K., Josephson, S., and Bundle, D.R. Lipopolysaccharide
solution conformation: Antigen shape inferred from high resolution
1H and 13C nuclear magnetic resonance spectroscopy and hard-sphere
calculations.
J. Chem. Soc., Perkin II, 59-70, 1982 |
Perry,
M.B., Bundle, D.R. Daoust, V., and Carlo D.J. The
specific capsular polysaccharide of Streptococcus pneumoniae type
15F.
Mol. Immunol., 19, 235-246, 1982 |
Neurohr,
K.J., Mantsch, H.H., Young, N.M., and Bundle, D.R. Carbon-13
nuclear magnetic resonance studies on lectin-carbohydrate
interactions: Binding of specifically 13C-labeled methyl
b-D-lactoside to peanut agglutinin.
Biochemistry, 21, 498-503, 1982 |
|
Iversen,
T., and Bundle. D.R. A direct and efficient synthesis
of β-L-rhamnopyranosides.
J. Org. Chem., 46, 5389-5393, 1981 |
Iversen,
T., and Bundle, D.R. Benzyl trichloroacetimidate, a
versatile reagent for acid-catalyzed benzylation of hydroxy-groups.
Chem. Comm., 1240-1241, 1981 |
Iversen,
T., Josephson, S., and Bundle, D.R. The synthesis of
streptococcal groups A, C and variant-A antigenic determinants.
J. Chem. Soc, Perkin I. 2379-2385, 1981 |
|
Bundle,
D.R., and Josephson, S. Chlorosulphation of amino sugars: Synthesis
of methyl 2-acetamido-4-amino-2,4,6-trideoxy-b-D-glucopyranoside
(bacillosamine) from a D-glucosamine derivative.
Can. J. Chem., 58, 2679-2685, 1980 |
Iversen,
T., and Bundle, D.R. A new and efficient synthesis
of β-L-rhamnopyranosides.
Carbohydr. Res., 84, C13-C15, 1980 |
Josephson,
S., and Bundle, D.R. Artificial carbohydrate antigens: The
synthesis of rhamnose trisaccharide and disaccharide haptens
common to Shigella flexneri O-antigens.
J. Chem. Soc., Perkin I. 297-301, 1980 |
Bundle,
D.R., and Josephson, S. Artificial carbohydrate antigens: The
synthesis of tetra-saccharide hapten, a Shigella flexneri O-antigen
repeating unit.
Carbohydr. Res., 80, 75-85, 1980 |
|
Josephson,
S., and Bundle, D.R. Artificial carbohydrate antigens: The
synthesis of the tetrasaccharide repeating unit of Shigella
flexneri O-antigen.
Can. J. Chem., 57, 3073-3079, 1979 |
Unemura,
J., Birnbaum, G.I., Bundle, D.R., Murphy, W.F., Bernstein,
H.J., and Mantsch, H.H. The correlation between O-H
stretching frequencies and hydrogen bond distances in a crystalline
sugar monohydrate.
Can. J. Chem., 57, 2640-2645, 1979 |
Banoub,
J., and Bundle, D.R. 1,2-orthoacetate intermediates
in silver trifluoro-methanesulphonate promoted Koenigs-Knorr
synthesis of disaccharide glycosides.
Can. J. Chem., 57, 2091-2097, 1979 |
Banoub,
J., and Bundle, D.R. Stannic tetrachloride catalyzed
glycosylation of 8-ethoxy-carbonyloctanol by cellobiose,
lactose and maltose octaacetates; synthesis of a and b glycosidic
linkages.
Can. J. Chem., 57, 2085-2090,
1979 |
Bundle,
D.R. Antibody to an artificial disaccharide antigen
cross-reactive with Neisseria gonorrhoeae lipopolysaccharide.
Can. J. Biochem., 57, 367-371, 1979 |
Bundle,
D.R. Displacement of sugar chlorosulphates by bromide,
azide and acetate; a facile synthesis of methyl, 3,6-dideoxy-b-D-ribo-hexopyranoside.
J. Chem. Soc., Perkin I, 2751-2755, 1979 |
Bundle,
D.R., and Josephson, S. Artificial carbohydrate antigens: The
synthesis and conformation of a Shigella flexneri trisaccharide
hapten.
J. Chem. Soc., Perkin I, 2736-2739, 1979 |
Bundle,
D.R., and Josephson, S. Artificial carbohydrate antigen:
Synthesis of rhamnose disaccharides common to Shigella
flexneri O-antigen determinants.
Can. J. Chem., 57, 662-668, 1979 |
Birnbaum,
G.I., and Bundle, D.R. Solution conformation and crystal
structure of methyl 3,6-dideoxy-b-D-ribo-hexopyranoside,
an immunodominant sugar of O-antigens.
Biochim. Biophys. Acta, 582, 515-524,
1979 |
|
Bundle,
D.R., and Josephson, S. A facile synthesis of methyl
3,6-dideoxy-L-xylo-hexopyranoside (colitose).
Can. J. Chem., 56, 2686-2690, 1978 |
Lemieux, R.U., Boullanger, P.A., Bundle,
D.R., Baker, D.A., and Venot, A. Binding studies of
b-D-galactopyranosyl antibodies. Intramolecular hydrogen
bonding effects.
Nouveau. J. Chimie, 2, 321-329, 1978 |
|
Jennings,
H.J., Bhattacharjee, A.K., Bundle, D.R., Kenny, C.P., Martin,
A., and Smith, I.C.P. Structures of the capsular polysaccharides
of Neisseria meningitidis as determined by C-13
nuclear magnetic resonance spectroscopy.
J. Infectious Diseases, 136, S78-S83,
1977 |
Lemieux,
R.U., Baker, D.A., and Bundle, D.R. A methodology for
the production of carbohydrate-specific antibody.
Can. J. Biochem., 55, 507-512,
1977 |
Lemieux,
R.U., Bundle, D.R., and Baker, D.A. The properties
of a synthetic antigen related to the human blood group Lewis-a.
J. Am. Chem. Soc., 97, 4076-4083,
1975 |
Bundle,
D.R., and Jennings, H.J. The synthesis of 2-acetamido-2-deoxy-a-D-glucopyranose
4-phosphate.
Can. J. Biochem., 52, 723-725,
1974 |
Bundle,
D.R., Jennings, H.J., and Kenny, C.P. Studies on the
group-specific polysaccharide of Neisseria meningitidis serogroup
X and an improved procedure for its isolation.
J. Biol. Chem., 249, 4797-4801,
1974 |
Bundle,
D.R., Smith I.C.P., and Jennings, H.J. Determination
of the structure and conformation of bacterial polysaccharides
by carbon-13 nuclear magnetic resonance.
J. Biol. Chem., 249, 2275-2281, 1974 |
Bundle,
D.R., Jennings, H.J., and Smith, I.C.P. The carbon-13
nuclear magnetic resonance spectra of 2-acetamido-2-deoxy-D-hexoses
and some specifically deuterated, O-acetylated,
and phosphorylated derivatives.
Can. J. Chem., 51, 3812-3819, 1973 |
Bundle,
D.R., Jennings, H.J., and Kenny, C.P. An improved procedure
for the isolation of meningococcal, polysaccharide antigens,
and the structural determination of the antigen from serogroup
X.
Carbohydr. Res., 26, 268-270, 1973 |
Bundle,
D.R., and Shaw, N. Synthesis of 2-acetamido-6-O-(2-acetamido-2-deoxy-ß-D-glucopyranosyl)-2-deoxy-D-glucopyranose.
Carbohydr. Res., 21, 211-217, 1972 |
return to top
| Reviews and Book Chapters |
| Bundle, D.R. Costello, C., Nycholat, C., Lipinski, T., and Rennie, R. “Designing a Candida albicans Conjugate Vaccine by Reverse Engineering Protective Monoclonal Antibodies” in Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application, edited by P. Kosma and S. Muller-Loennies Springer, pp 121-146, January 2012. |
|
| Ling, C.-C. and Bundle, D.R. Eliciting carbohydrate-specific immune response against sialosides: success and challenges. Future Medicinal Chemistry 3, 519-534, 2011. |
|
| Bundle, D.R. “New frontiers in the Chemistry of Glycoconjugate Vaccines,” in Vaccine Design: Innovative Approaches and Novel Strategies, edited by F. Bagnoli and R. Rappuoli, Caister Academic Press, pp 69-107, February 2011. |
|
Kitov, P.I. and Bundle, D.R. "Thermodynamic
models of multivalency effect," in
Carbohydrate-based Drug Discovery, edited by Chi-Huey
Wong Wiley-VCH Weinheim, Germany Carbohydrate-based Drug
Discovery, Vol. 2, 541-574, 2003 |
|
Kitov, P.I., Paszkiewicz,
E., Wakarchuk, W.W. and Bundle, D.R.“Preparative scale
chemo-enzymatic synthesis of large carbohydrate assemblies
using a(1-4)-galactosyltransferase/UDP-4-gal-epimerase fusion
protein”.
Methods in Enzymology (Academic Press), 362, 86-105,
2003 |
|
Nitz, M. and Bundle, D.R. “The
unique solution structure and immunochemistry of the Candida
albicans b1,2-mannopyranan cell wall antigen,” in
NMR of Glyco-Conjugates Edited by: J. Jimenez-Barbero, T. Peters,
Wilet-VCHVerlag, Weinheim, Germany, pp. 145-187, October 2002 |
|
Nitz, M. and Bundle, D.R. “The
Historical and Contemporary Role of Glycosyl Halides in Oligosaccharide
Synthesis,” in
Glycoscience: Chemistry and Chemical Biology. Edited
by: B. Fraser-Reid, K. Tatsuta, J. Thiem, Springer–Verlag,
Heidelberg, Germany. pp. 1498-1542, July 2001 |
|
Feizi, T. and Bundle, D. “The
coming of age for oligosaccharide ligands and databases for
saccharide structures.”
[Review] [14 refs]. Current Opinion in Structural Biology. 6,
659-62; 1996 Oct |
|
McVay, C., Ellis, L., Bundle,
D. and Appleton, J.A. "Structural Analysis of TSL-1
Glycans of Trichinella spiralis".
Proceedings of the Ninth International Conference on Trichinellosis,
Mexico City, Edited by G. Otega-Pierres, R. Gamble,
F. van Knapen and D. Wakelin. pp: 205-210, August 1996 |
|
"Recognition of carbohydrate
antigens by antibody binding sites " in
Carbohydrates edited by S. Hecht, Oxford University Press Inc.,
Oxford, pp. 370-440, 1998 |
|
"Antibody-Oligosaccharide
Interactions Determined by Crystallography" in
Glycosciences: Status and Perspectives edited by H.-J. Gabius
and S. Gabius, Chapman and Hall, Weinheim, Germany.
pp. 311-331, 1997 |
|
Bundle, D.R. and Feizi, T.
editors of multi-author review "Carbohydrates and Glycoconjugates" in
Current Opinion in Structural Biology, 6,
659-720, 1996 |
|
Bundle, D.R. “The Recognition
of Carbohydrate Antigens by Antibody at Atomic Resolution” in
Carbohydrates in Europe, pp. 22-30, 1994 |
|
Altman, E., and Bundle, D.R. “Polysaccharide
Affinity Columns for Purification of Lipopolysaccharide-Specific
Murine Monoclonal Antibodies”.
Meth. Enzymol., 247, 243-253, 1994 |
|
Bundle, D.R., and Sigurskjold,
B.W. “Determination of Accurate Thermodynamics
of Binding by Titration Microcalorimetry”.
Meth. Enzymol., 247, 288-305, 1994 |
|
Bundle, D.R. and Feizi, T.
editors of multi-author review "Carbohydrates and Glycoconjugates" in
Current Opinion in Structural Biology, 4,
673-728, 1994 |
|
Bundle, D.R. “Carbohydrate
Antigens” in
Molecular Biology and Biotechnology A Comprehensive Desk Reference
edited by R.A. Meyers, VCH Publishers Inc., pp. 141-146, 1995 |
|
Bundle, D.R.,
Altman, E., Auzanneau, F.-I., Baumann, H., Eichler, E., and
Sigurskjold, B.W. “The structure of oligosaccharide-antibody
complexes and improved inhibitors of carbohydrate-protein binding” in
Complex Carbohydrates in Drug Research, Alfred Benzon Symposium
No. 36, eds K. Bock and H. Clausen, Munksgaard, Copenhagen, 1994 |
|
Cygler,
M., Wu, S., Zdanov, A., Bundle, D.R., and Rose, D.R. “Recognition
of a carbohydrate antigenic determinant of Salmonella by
an antibody”.
Biochemical Society Transactions, 21,
437-441, 1993 |
|
Bundle D.R. and Young, N.M. “Carbohydrate-protein
interactions in antibodies and lectins” in
Current Opinion in Structural Biology, 2,
pp: 666-673, 1992 |
|
Ashton,
F.E., Michon, F., Bundle, D.R., Gidney, M.A.J., Gamian, A.
and Jennings, H.J. “Immunological properties of
monoclonal antibodies to the N-propionyl derivative
of group B meningococcal polysaccharide”
(Achtman, M., Kohl, P., Marchal, C., Morelli, G., Seiler, A.,
Thiesen, B., eds.), Neisseria 1990. Proc. of the Seventh
Int. Pathogenic Neisseria Conference, Berlin, Germany,
September 9-14, 1990. Walter de Gruyter, pgs. 187-191,
1991 |
|
Perry, M.B., and Bundle, D.R. “Lipopolysaccharide
antigens and carbohydrates of Brucella” in
Advances in Brucellosis Research (Adams, L.G., ed.), Texas
A and M Univ. Press), pp. 76-88, 1990 |
|
Bundle,
D.R. “Synthesis of oligosaccharides related to
bacterial O-antigens”.
Topics in Current Chemistry, Springer Verlag, Heidelberg 154,
1-37, 1990 |
|
Bundle, D.R., Cherwonogrodzky,
J.W., and Perry, M.B. “Monoclonal antibodies in
the identification and characterization of Brucella species” in
Nucleic Acid and Monoclonal Antibody Probes: Applications
in Diagnostic Microbiology, (Prakash, G., and Swaminathan,
B., eds.), Marcel Dekker, New York, pp. 581-597, 1989 |
|
Bundle,
D.R. “Structural analysis by high resolution 1H
and 13C nuclear magnetic resonance spectroscopy”. In
Bacterial Cell Surface Techniques (Hancock, I., and Poxton,
I., eds.), John Wiley and Sons, pp. 146-158, 1988 |
|
Bundle, D.R. “Monoclonal
antibodies to bacterial O-antigens in combination with synthetic
glycoconjugates for mapping the combining site”.
Protein-Carbohydrate Interactions in Biological Systems. Academic
Press, pp. 165-171, 1986 |
|
Bundle,
D.R., and Perry, M.B. “Structure and serology of
the Brucella abortus O-antigen”.
Biochemical Society Transactions, 13,
980-982, 1985 |
|
Bundle, D.R., Gidney, M.A.J.,
Josephson, S., and Wessel, H.-P. “ Synthesis of Shigella
flexneri O-antigen repeating units: Conformational probes and
aids to monoclonal antibody production” in
American Chem. Soc. 83, pp. 49-63
, 1983 |
|
Bundle,
D.R., Iversen, T., and Josephson, S. “Preparative
medium and high pressure chromatography”.
American Laboratory. 93-98, 1980 |
|
Pazur, J.H.,
Dreher, K.L., and Bundle, D.R. “Interaction of glycosyl
immunogens with immunocyte receptor sites in the synthesis
of anti-glycosyl” edited by Goldstein I.J., in
ACS Symposium Series, 88, pp.102-115,
1979 |
|
Bundle,
D.R., and Lemieux, R.U. “Determination of anomeric
configuration by NMR”.
Methods in Carbohydr. Chem., 7, 79-86,
1976 |
|
return to top
Invited Lectures
1985 - 2013 |
Targetted Delivery of Conjugate Vaccines to Dendritc Cells
ACS Symposium, New Orleans, April 2013 |
New Approaches to Carbohydrate Vaccines
Department of Pediatrics, Louisiana State University Health Sciences Center, April 2013 |
New Approaches to Carbohydrate Vaccines
Free University of Berlin, November 2012 |
New Approaches to Carbohydrate Vaccines
Haworth Memorial Lecture, University of Birmingham, UK, November 2012 |
Supramolecular
heterobifunctional ligand-protein complexes: a
strategy for enhancing drug efficacy
University of Luebeck, Germany, September 2009 |
A Candida
albicans Conjugate Vaccine.
Society for General Microbiology, UK- Autumn 2009 Meeting – Heriot-Watt
University, Edinburgh, September 2009 |
Supramolecular
heterobifunctional ligand-protein complexes: a
strategy for enhancing drug efficacy
Gordon Research Conference (Carbohydrates) – Tilton
School, New Hampshire, June
2009 |
A Candida
albicans Conjugate Vaccine
Claude S. Hudson Award Symposium, American Chemical Society,
Salt Lake City, Utah, March
2009 |
Mapping
the Protective Epitope of the β1,2-Mannan from Candida
albicansand the Prospects for a Conjugate
Vaccine
Institute for Biological Science, National Research Council,
Ottawa, October
2008 |
Neutralizing
Shiga toxin by ligand induced in vivo protein dimerization
Ontario Cancer Institute, University of Toronto, June
2008 |
Mapping
the Protective Epitope of the β1,2-Mannan from Candida
albicans
and the Prospects for a Conjugate Vaccine
Canadian Society for Chemistry Symposium:
Carbohydrate Chemistry and Glycobiology, May
2008 |
Unprecedented in
vitro Activity and in vivo Efficacy of
Pre‑ordered Polymeric Heterobifunctional Ligands
Canadian Society for Chemistry Symposium:
Chemical Biology; Molecular Probes and Organic Biomaterials,
May 2008 |
Supramolecular
heterobifunctional ligand-protein complexes: a strategy
for enhancing drug efficacy
Lectures in Biochemistry Seminar, University of Alberta,
May 2008 |
Supramolecular
heterobifunctional ligand-protein complexes: a strategy
for enhancing drug efficacy
NIH workshop:
Future Directions of Multivalent Agents in Therapeutic Development, May
2008 |
Supramolecular
and Multivalent Effects: A Novel Approach to High Avidity
Neutralization of Bacterial Toxins
Alberta Ingenuity Accelerator in Nanotechnology: Health & Medical
Technologies, May 2008 |
Unprecedented in
vitro Activity and in vivo Efficacy of
Pre‑ordered Polymeric Heterobifunctional Ligands
Glycobiology 2008, Society for Glycobiology, Boston, November
2007 |
Supramolecular
and Multivalent Effects: A Novel Approach to High Avidity
Ligands for Bacterial Toxins
Royal Society of Chemistry, Carbohydrate Group: Glycoarrays:
Synthesis and
Applications, University of Manchester, UK, October
2007 |
The
Prospects for a Synthetic Conjugate Vaccine Against Candida
albicans
Department of Chemistry, University of Toledo, September
2007 |
Synthesis
and mapping of the protective epitope contained in di-
and trisaccharide analogs of the (1®2)-β-mannan
from Candida albicans
Carbohydrate Moieties as Vaccine Candidates, NIH, Bethesda,
September 2007 |
Heterobivalent
ligands: examples of the utility of ligand induced protein
aggregation
Department of Chemistry Simon Fraser University, BC, January
2007 |
Synthetic
and chemo-enzymatic strategies to create ganglioside and
other
glycoconjugate vaccines
Novartis Vaccines & Diagnostics Siena, Italy, December
2006 |
Exploiting
Oligovalent Interactions with Low Molecular Weight Ligands
Pharmacenter, University of Basel, Switzerland, July
2006 |
Synthesis
and Application of Oligosaccharide Conjugate Vaccines
Laboratorium für Organische Chemie, ETH-Hönggerberg,
Zürich, Switzerland, July
2006 |
Exploiting
Oligovalent Interactions with Low Molecular Weight Ligands
Carlsberg Laboratory, Copenhagen, Denmark, June
2006 |
Synthesis
and Application of Oligosaccharide Conjugate Vaccines
CERMAV-CNRS, Universitaire Grenoble, June
2006 |
The
Prospects for a Conjugate Vaccine Against Candida albicans
Institute of Chemistry, University of Lübeck,
Germany, February
2006 |
Ligand
promoted protein dimerization
Mc Gill University, Montreal, Quebec, February
2006
|
Design
of multivalent carbohydrate inhibitors for microbial toxin
Half a Century at the Carbohydrate-Protein Interface: An
International Symposium
to Celebrate the Eightieth Birthday of Professor Nathan Sharon,
Weizmann Institute of Science, Israel, November
2005 |
New
Approaches to Conjugate Vaccines that Utilize Short Oligosaccharide
Epitopes
Gordon Research Conference on Carbohydrate Chemistry, Tilton
School, NH, June
2005 |
Structure
and Mechanism of Specific Aggregation of Serum Amyloid P
Component by a Novel Series of Bivalent Ligands
American Chemical Society, San Diego California, March
2005 |
Prospects
for an Oligosaccharide Conjugate Vaccine for Candida
albicans
American Chemical Society, San Diego California, March
2005 |
Oligosaccharide
Vaccines: Making Carbohydrates Presentable
Kaplan Award, University of Alberta, Edmonton, March
2005 |
Multivalent
Ligands and Oligomeric Proteins
Alnylam Pharmaceuticals, Cambridge, MA, USA, January
2005 |
Synthetic
Glycoconjugate Vaccines: Prospects for a Candida albicans vaccine
Harvard Medical School - Department of Microbiology and
Molecular Genetics,
Boston, USA, January
2005 |
Prospects
for a C. albicans vaccine: a uniquely small
and protective
carbohydrate epitope
NIH meeting, Bethesda, Maryland, USA, October
2004 |
Serendipity
in Synthesis and Conformational Analysis Creates a Potential
Vaccine against Candida albicans
Queens University, Kingston, Ontario, September
2004 |
Prospects
for an Oligosaccharide Conjugate Vaccine for Candida
albicans
Carlsberg Institute, Copenhagen, Denmark, June
2004 |
Prospects
for a Candida albicans Vaccine
FASEB Summer Research Conferences, Tuscon, Arizona, USA,
June 2004 |
Oligosaccharide
Conjugate Vaccines
University of Calgary, Department of Chemistry, February
2004 |
Immunogenicity
of carbohydrate antigens and their recognition by the
immune system
Seventh International Xenotransplantation Congress, Glasgow,
UK, August
2003 |
A
Thermodynamic Theory to Account for Multivalency Effects
Observed with Radially Symmetric Multi-Subunit Proteins
39th IUPAC Congress, Ottawa, August
2003 |
The
chemical biology of the carbohydrates and the importance
of glycopeptides
in glycobiology
Department of Chemistry, University of Umea, Sweden, May
2003 |
Empirical
observations and theoretical explanations of multivalency
effects
Department of Chemistry, University of Umea, Sweden, May
2003 |
Empirical observations
and theoretical explanations of multivalency effects
Hofmann La Roche, Basel, Switzerland, May
2003 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate ligands for Shiga-like toxins
Defense Science and Technology Laboratories, Ministry of
Defense,
Porton Down, UK, May
2003 |
Empirical
Observations and Theoretical Explanations of Multivalency Effects
The University of Georgia - Complex Carbohydrate Research Centre,
Athens, Georgia, USA, March 2003 |
A
New Class of Therapeutics: Starfsh neutralizes E.coli Toxin
Alberta Teachers Association – Science
Council Conference, Banff, Alberta, November
2002 |
The
search for high avidity ligands: Constrained univalent
oligosaccharides
and radially arranged multivalent oligosaccharides
XXI Int’l Carbohydrate Symposium, Cairns, Australia,
July 2002 |
Trichinella
spiralis glycan and the topology of the antigen
surface recognized
by protective antibody
Canadian Society for Chemistry Awards Lecture, Vancouver,
BC, June
2002 |
The
design, synthesis and mode of action of multivalent carbohydrate
ligands
that neutralize Shiga-like toxins
University of Wisconsin-Madison, USA, December
2001 |
STARFISH
takes the sting out of Shiga toxin
2nd International Symposium on Conformational
Control of Biomolecular Function,
VW-Foundation Meeting, Lübeck, Germany, October
2001 |
STARFISH takes
the sting out of Shiga toxin
2001 American Society for Nephrology World Congress,
San Francisco, USA, October
2001 |
Structural
basis for neutralization of Shiga-like toxins by synthetic
multivalent carbohydrate ligands
16th International Glycoconjugate Symposium, The Hague, Netherlands,
August 2001 |
Structural
basis for neutralization of Shiga-like toxins by synthetic
multivalent carbohydrate ligands
Natural Products Gordon Conference, Tilton, USA, July
2001 |
Tailored
Mutivalent Carbohydrate Ligands that Neutralize Shiga-like
Toxins
Canadian Society
for Chemistry, Montreal, Quebec, May
2001 |
Strafish
takes the sting out of Shiga toxins: design, synthesis and
mode of action of tailored
multivalent carbohydrate ligands
Glycobiology Gordon Conference, Ventura, California, USA, March
2001 |
Structural
basis for neutralization of Shiga-like toxins by synthetic
multivalent carbohydrate
Scripps Research Institute, La Jolla, California, USA, February
2001 |
Multivalent
Carbohydrate Ligands that Neutralize Shiga-like Toxin
University of Guelph, November 2000 |
Multivalent
Carbohydrate Ligands that Neutralize Shiga-like Toxin
Mc Master University, November 2000 |
Structure
and interactions in antibody-sugar antigen complexes and bacterial toxin-glycolipid
complexes
University of Glasgow, Glasgow, Scotland, October
2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate
ligands that neutralize Shiga-like toxins
Carlsberg Laboratories, Copenhagen, Denmark, October
2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate
ligands that neutralize Shiga-like toxins
Glycoconjugates in Biological Studies Annual Meeting, Tammsvik,
Sweden, October
2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate
ligands that neutralize Shiga-like toxins
Agricultural University of Uppsala, Sweden, October
2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate
ligands that neutralize Shiga-like toxins
Canadian Society for Chemistry Award Lecture, Calgary, Alberta,
May 2000 |
The Candida
albicans (1®2)-b-mannopyranan
antigen, a potential synthetic
glycoconjugate vaccine candidate. Ordered conformation
correlates with unique immunochemistry
Canadian Bacterial Diseases Network, AGM, Banff, Alberta,
May 2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate ligands that neutralize Shiga-like toxins
North American Vaccines, Washington, DC, USA, February
2000 |
The design,
synthesis and mode of action of tailored multivalent carbohydrate
ligands that neutralize Shiga-like toxins
University of Toronto/PENCE, Toronto, Ontario, February
2000 |
The
design, synthesis and mode of action of tailored multivalent
carbohydrate ligands that neutralize shiga-like toxins
Dept. of Chemistry, Duke University, Durham, NC, USA, February
2000 |
Rational
design of soluble sub-nanomolar inhibitors for Shiga toxins
15th International Glycoconjugate Meeting, Japan, August
1999 |
Design, synthesis
and crystal structure of soluble sub-nanomar inhibitors for
Shiga-like toxins
Gordon Research Conference on Carbohydrate Chemistry, Tilton
School, NH Jun
1999 |
Rational
design of soluble sub-nanomolar inhibitors for Shiga toxins
Canadian Bacterial Diseases Network, AGM, Banff, May
1999 |
Oligosaccharide
interactions with protein receptors
Royal Society of Chemistry, Carbohydrate Group, York University,
March 1999 |
Non-glycosidically
linked oligosaccharide clusters
University of Virginia 1998 Alfred Burger Lecturer, October
1998 |
StrStructure
and interactions in antibody-sugar antigen complexes
International Carbohydrate Symposium, San Diego, California,
August 1998 |
Binding energy
and the conformation of oligosaccharides in the bound state
International Carbohydrate Symposium, San Diego, California,
August 1998 |
How
antibodies bind oligosaccharide epitopes
Silver Jubilee FEBS Meeting, Copenhagen, Denmark, July
1998 |
How antibodies
bind oligosaccharide epitopes
Neose Technologies Inc., Horsham, Pennsylvania, March
1998 |
Structure
and interactions in antibody-sugar antigen complexes
DuPont, Wilmington, Delaware, March
1998 |
Structure and
interactions in antibody-sugar antigen complexes
GlycoBio Technology Symposium, Braunschweig, Germany, May1998 |
Structure
and interactions in antibody-sugar antigen complexes
University of Lübeck, Lübeck, Germany, April/May
1998 |
Structure
and interactions between carbohydrate antigens and antibody
binding sites
Lectures in Modern Chemistry: Department of Chemistry, University
of British
Columbia, Vancouver, BC, October
1997 |
Structure and
interactions between carbohydrate antigens and antibody
binding sites
Department of Chemistry Simon Fraser University, British Columbia,
October 1997 |
Structure and
interactions between carbohydrate antigens and antibody binding
sites
Department of Chemistry, University of Victoria, British
Columbia, October
1997 |
Carbohydrate-recognition:
Probing antibodies from all angles
Glycoconjugates and Matrix Molecules in Health and Disease
NIH,
Bethesda, Maryland, August
1997 |
The three dimensional
structures of bacterial polysaccharide-antibody complexes
FASEB meeting: Microbial Polysaccharides of Medical, Agricultural
and Industrial
Importance, Copper Mountain, Colorado, June
1997 |
The
conformation of tethered oligosaccharide epitopes designed
to fit a monoclonal antibody
Nordic NMR Symposium, Copenhagen, Denmark, May
1997 |
A calorimetric
investigation of inhibitor modifications that enhance antibody
carbohydrate-binding
American Chemical Society Semi Annual meeting, San Francisco,
April 1997 |
Interactions
in and adjacent to the antibody binding site for oligosaccharide
epitopes Genentech, San Francisco, March
1997 |
A
calorimetric investigation of inhibitor modifications that
enhance antibody carbohydrate-binding
Annual Symposium of the Complex Carbohydrate Society, Boston,
November 1996 |
Synthesis
and immunochemical determination of the anomeric configuration
of a tyvelose capped, Lewis-X like tetrasaccharide epitope
of Trichinella Spiralis
International Carbohydrate Symposium, Milan, Italy, July
1996 |
Constraint of
glycosidic linkages fails to increase binding affnity; conformational
and binding studies of a trisaccharide with intramolecular
tether
International Carbohydrate Symposium, Milan, Italy, July
1996 |
Synthesis
of a conformationally constrained trisaccharide epitope
via an
intramolecular tether
International Carbohydrate Symposium, Milan, Italy, July
1996 |
Conformational
and binding studies of tethered trisaccharides by NMR and
enzyme immunoassay
Intl. Carbohydrate Symposium Satellite Meeting on Conformational
studies of
carbohydrates, La Thuile, Italy, July
1996 |
Oligosaccharide
epitopes and antibody binding
sites of Fab and Single Chain Fv Molecules
Keystone Meeting on Antibodies and the Immunoglobulin Superfamily,
Taos, NM, March 1996 |
How
antibodies bind oligosaccharide epitopes
8th European Carbohydrate Symposium, Seville, Spain, July
1995 |
Ligand and protein
engineering of carbohydrate antibodies
Canadian Federation of Biological Societies, Saskatoon, June
1995 |
Three dimensional
structures of carbohydrate antigens complexed with antibody
Canadian Federation of Biological Societies, Saskatoon, June
1995 |
Binding motifs
in oligosaccharide-antibody complexes
Gordon Research Conference on Carbohydrate Chemistry, Tilton
School, NH, June
1995 |
The role of water
on antibody-oligosaccharide complexes
78th Canadian Society for Chemistry Conference and Exhibition,
Guelph, May 1995 |
The influence
of water on oligosaccharide conformations in complexes with
antibodies
XVIIth International Carbohydrate Symposium, Ottawa, July
1994 |
Synthesis and
NMR Studies of a terisaccharide analogue of the Shigella
Felxneri y O-antigen
XVIIth International Carbohydrate Symposium, Ottawa, July
1994 |
Three
dimensional structures of oligosaccharide-antibody complexes Glycoconjugates:
structure, metabolism and molecular biology
Jacques Monod Conference, La Londe-les-Maures, France, April
1994 |
Antigen-antibody
interactions by the isotope-filtered 1H nmr spectroscopy
Bundle Intl. Carbohydrate Symposium Satellite Meeting on
Conformational studies of carbohydrates, Far Hills, Quebec, July
1994 |
The
structures of oligosaccharide complexes with native antibody
Fab, E. coli
expressed Fab and single chain variants
The New Biology of Carbohydrates, 9th Annual Symposium on
Biotechnology,
University College, London, December
1993 |
Carbohydrate
antigen-antibody interactions: Crystal structures, thermodynamics
and molecular modeling
Department of Biochemistry, University of Oxford, England,
December 1993 |
Oligosaccharide
antibody interactions studied by protein engineering, ligand
modification and crystallography
Institut for Biophysical Chemistry, J. W. Goethe University
of Frankfurt, Germany, December
1993 |
Ligand
engineering and antibody engineering applied to carbohydrate
specific antibodies
Central Research Laboratory, Ciba, Basel, Switzerland, December
1993 |
The
structure of oligosaccharide complexes and improved inhibitors
of carbohydrate-protein binding
MerckFrosst Centre for Therapeutic Research, Ponte-Claire-Dorval, October
1993 |
The
structure of oligosaccharide complexes and improved inhibitors
of
carbohydrate-protein binding
Alfred Benzon Symposium, Complex Carbohydrates in Drug Research,
Copenhagen, Denmark, June
1993 |
Carbohydrate
ligands & their protein receptors: Biological function &
molecular interactions
Keystone Symposium Colorado, January
1993 |
Oligosaccharide-antibody
interactions
University of Bonn, Germany, November
1992 |
Synthetic oligosaccharide
chemistry in the study of antibody binding sites
University of Hamburg, Hamburg, Germany, November
1992 |
The
crystal studies of oligosaccharide antibody complexes
Forschunginstitut Borstal, Borstal, Germany, November
1992 |
The
structure of oligosaccharide-antibody complexes
Carlsberg Institute, Denmark, October
1992 |
The
structure of an oligosaccharide-antibody complex
International Carbohydrate Symposium, Paris, July
1992 |
The
atomic detail of oligosaccharide antibody complexes
Table Ronde no 73 Roussel Uclaf, Frontiers in Glycosciences,
July 1992 |
Molecular
recognition and antibody engineering studies of antibody-carbohydrate
interactions
Bio Recognition, Montreal, June
1992 |
The structure
of a carbohydrate-antibody complex
75th Canadian Chemical Conference, Edmonton, June
1992 |
Antibodies
that bind carbohydrate antigens
American Chemical Society: National Meeting Emil Fischer
Centennial Symposium
San Francisco, California, April
1992 |
Synthetic
oligosaccharides, NMR and microcalorimetry as tools to study
antibody-carbohydrate interactions
Keystone Glycobiology II Symposium, Park City, Utah, March
1992 |
A comparison
of ligand mapping studies with a high resolution crystal
structure
4th American Chemical Society Congress of North America,
New York, N.Y., August
1991 |
The
crystal structure of an oligosaccharide - Fab complex and
binding activities
of site specific mutants expressed in E. coli
4th American Chemical Society Congress of North America,
New York, N.Y., August
1991 |
The
crystal structure of a dodecasaccharide - antibody Fab
complex
11th International Symposium on Glycoconjugates, Toronto,
July 1991 |
Synthetic
oligosaccharides and the antibody binding site for the Salmonella serogroup
B polysaccharide: A comparison of ligand mapping
studies with a high resolution crystal structure
Society for Complex Carbohydrates, San Diego, California,
October 1990 |
Crystallographic
and modeling studies of antibody binding sites for bacterial
O-antigens
5th Bratislava Symposium on Saccharides, Bratislava, Czechoslovakia,
August 1990 |
Structural
analysis of bacterial O‑antigens; integration of
high resolution
NMR and classical approaches
Society for Complex Carbohydrates, Ann Arbour, Michigan,
November 1989 |
Crystal
structure and modeling studies of antibody binding sites
specific for
bacterial O‑antigens
F. Hoffmann La Roche, Basel, Switzerland, September
1989 |
Investigation
of antibody binding sites by synthetic oligosaccharides,
X‑ray crystallography and model building
Gordon Research Conference on Carbohydrates, New Hampshire,
June 1989 |
Oligosaccharide‑protein
interactions: Studies of antibody combining sites
by competitive binding, sequence analysis and X‑ray
crystallography
XIVth International Carbohydrate Symposium, Stockholm, Sweden,
August 1988 |
The identification
and structural elucidation of Brucella
melitensis M antigen
XIIIth International Carbohydrate Symposium, Cornell University,
Ithaca, August
1986 |
Synthesis
of oligosaccharides for studies of the antibody combining
site
Royal Society of Chemistry Carbohydrate Group Meeting. Sheffield,
England, April
1986 |
The structure
of a Salmonella serogroup N O-antigen determined by two dimensional
NMR methods at 500 MHz
European Symposium on Carbohydrates, Grenoble, France, September
1985 |
The
chemical synthesis of a trisaccharide corresponding to
the Brucella abortus O-antigen
European Symposium on Carbohydrates, Grenoble, France, September
1985 |
Monoclonal
antibodies to bacterial O‑antigens as a model for
protein‑carbohydrate interactions. Molecular
Biology and Microbial Pathogenicity, Role of Protein‑Carbohydrate
Interactions
FEMS and Swedish Society for Microbiology, Lulea, Sweden,
June 1985 |
return to top
Posters
2013
Gordon Conference on Carbohydrates
Mount Snow, VT - June 2013 |
Design of an HIV-1 Glycoconjugate Vaccine using a Filamentous Phage Carrier. J.J. Bailey, Bela Reiz, Kevin Henry, J.K. Scott, D.R. Bundle |
|
Alberta Glycomics Centre 9th National Carbohydrate Symposium
Banff, Alberta - May, 2013 |
A Simplified Novel Ligand for Shiga Toxin Type 1 Eugenia Paszkiewicz, Dennis Wilhelm, Joanna Sadowska, Pavel I. Kitov, and David R. Bundle |
|
Grow Big or Go Home: How to Turn Elisa Plate into an Affinity Farm.
Somnath Dasgupta, Pavel I. Kitov, and David R. Bundle |
|
| An HIV-1 Glycoconjugate Vaccine utilizing Filamentous Phage as an Immunogenic Carrier. J. Bailey, Bela Reiz, Kevin Henry, J.K. Scott, D.R. Bundle. |
|
Annual Meeting of the Canadian Society for Immunology
Whistler, BC, April 2013 |
An HIV-1 Glycoconjugate Vaccine utilizing Filamentous Phage as an Immunogenic Carrier
J.J. Bailey, Bela Reiz, Kevin Henry J.K. Scott, D.R. Bundle |
|
8th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
Amsterdam, Netherlands, May 2012 |
Lipopolysacchride-Sensitized Transgenic Mice Constitutively Expressing Human Serum Amyloid P Component are Protected from Stx2 by Polymeric Heterobifunctional Ligands
Mulvey, G. L., Griener, T. P., Bundle, D. R., and Armstrong, G. D. |
|
Journee Rhone-Alpes des Biomolecules
Grenoble, France, June, 2012 |
Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands
Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle.
|
|
|
Alberta Glycomics Centre 8th National Carbohydrate Symposium
Banff, Alberta - May, 2012 |
Modelling and Crystallography of E. coli Stx2 Toxin with Bound Ligand: Design and Preliminary Evaluation of Inhibitors in a Transgenic Mouse Model of Disease
Jacobson, J. M., Yin, J., Kitov, P. I., Mulvey, G., James, M., Armstrong, G., and Bundle, D. R.
|
|
The design, synthesis and application of a chemically defined antigen to detect brucellosis
Wilhelm, D., Guiard, J., Paszkiewicz, E., Sadowska, J., Rennie, R., and Bundle, D. R. |
|
Synthesis of Candida Albicans β1,2-Mannan Phosphodiester Junction with the α-Mannan Backbone
Dang, A-T.; Sadowska, J. M.; Johnson, M. A.; Cartmell, J.; Bundle R. D. |
|
Immunodominance of internal epitopes in Candida mannans
Johnson MA, Cartmell J, Weisser NE, Woods RJ, Bundle DR. |
|
POLY(N-VINYL-2-PYRROLIDONE-CO-VINYL ALCOHOL): A VERSATILE POLYMERIC SCAFFOLD FOR BIOCHEMICAL APPLICATIONS
Eugenia Paszkiewicz, Yohei Kotsuchibashi, Dennis Wilhelm, Ravin Narain, Pavel I. Kitov,
and David R. Bundle |
|
Search for high affinity ligands for cholera toxin
Carlos A. Sanhueza, Pavel Kitov, Jonathan Cartmell, Joanna Sadowska and David. R. Bundle |
|
8th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
Amsterdam, Netherlands - May 2012 |
Lipopolysacchride-Sensitized Transgenic Mice Constitutively Expressing Human Serum Amyloid P Component are Protected from Stx2 by Polymeric Heterobifunctional Ligands
Mulvey, G. L., Griener, T. P., Bundle, D. R., and Armstrong, G. D. |
|
Journee Rhone-Alpes des Biomolecules
Grenoble, France, June, 2012 |
Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands
Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle.
|
|
2011
AICCS
Annual Meeting
Banff, Alberta - May, 2011 |
Multifunctional Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose Analogs of Pk Trisaccharide For Selective Binding to Shiga Toxin Type 2
Jacobson, J. M., Kitov, P. I., and Bundle, D. R. |
|
Multifunctional Multivalency: Defined Molecular Weight
Heterobifunctional Polymeric Inhibitors of Shiga Toxins
Eugenia Paszkiewicz, Pavel I. Kitov, Joanna Sadowska, Zhicheng Deng, Marya Ahmed, Ravin Narain, and David R. Bundle |
|
Design and synthesis of new Shiga Toxin 1 inhibitors
Wilhelm, D., Cartmell, J., and Bundle, D. R. |
|
Determination of specific binding epitopes of Brucella A and M antigens by STD-NMR
Wilhelm, D., Guiard, J., and Bundle, D. R. |
|
Synthesis of the β1,2-Mannan Phosphodiester to α-Mannan Backbone Junction of the Candida Albicans Phosphomannan
Dang, A-T.; Bundle, D. R. |
|
Antibody recognition of β-(1→2)-mannosides investigated by solution NMR spectroscopy
Johnson MA, Costello C, Sadowska J, Szpacenko A, Bundle DR. |
|
Identification of an important structural motif in the bacterial oligosaccharyltransferase for N-linked protein glycosylation
Barre Y, Nothaft H, Liu X, Johnson MA, Ng K, Li J, Szymanski CM |
|
Towards an Improved HIV Vaccine
Bailey, J.J.; Bundle, D.R. |
|
Design, synthesis and evaluation of heterobifunctional ligands for the inhibition of Clostridium difficile toxins
Carlos A. Sanhueza, Pavel Kitov, Jonathan Cartmell, Adam Szpacenko, Joanna Sadowska, Kenneth Ng, Elena Kitova, Rambod Daneshfar, Amr Elhawiet, John Klassen, and David. R. Bundle |
|
Gordons Research Conference for Carbohydrates
Waterville, MA, USA. - June 2011 |
Determination of binding epitopes of Brucella A and M antigens by STD-NMR
Wilhelm, D., Guiard, J., and Bundle, D. R. |
|
Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands
Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle
|
|
Journee du Groupe Lyonnais des Glyco-Sciences
Lyon, France, November, 2011 |
Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands
Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle
|
|
2010
AICCS
Annual Meeting
Banff, Alberta - May, 2010 |
Multifunctional
Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose
Analogs of PK Trisaccharide for More Effective Binding to Shiga
Toxin type 2
Jared Jacobson, Pavel I. Kitov and David R. Bundle
|
|
MULTIFUNCTIONAL MULTIVALENCY: Defined Molecular Weight Heterobifunctional Polymeric Inhibitors of Shiga Toxins Obtained by Raft Polymerization
Eugenia Paszkiewicz, Pavel I. Kitov, Zhicheng Deng, Marya Ahmed, Ravin Narain, and David R. Bundle |
|
Synthesis of Candida Albicans β1,2-Mannan Phosphodiester Junction with the α-Mannan Backbone
Dang, A-T.; Bundle, D. R. |
|
Molecular recognition of Candida albicans oligosaccharides by a protective antibody
Johnson MA, Sadowska J, Szpacenko A, Luu T, Bundle DR |
|
Advancements in the Synthesis of Mannose Antigens for use in a Phage Display Vaccine
Bailey, J.J.; Bundle, D.R. |
|
Functional characterization of the bacterial oligosaccharyltransferase for N-linked protein glycosylation
Barre Y, Nothaft H, Johnson MA, Liu X, Li J, Szymanski CM |
|
6th National Symposium on Recent Advances in Carbohydrate Science
Banff, AB, May 6-8, 2010 |
Functional characterization of the bacterial oligosaccharyltransferase for N-linked protein glycosylation
Barre Y, Nothaft H, Johnson MA, Liu X, Li J, Szymanski CM |
|
2009
AICCS
Annual Meeting
Banff, Alberta - May 13-16 |
Multifunctional
Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose
Analogs of PK Trisaccharide for More Effective Binding to Shiga
Toxin type 2
Jared Jacobson, Pavel I. Kitov and David R. Bundle
|
|
Synthesis
of Zwitterionic Oligosaccharides with the Potential to Stimulate
T-cell Responses
David R.Bundle, Chang-Chung Ling and Ithayavani Iynkkaran |
|
Synthesis
and Mapping of the Protective Epitope Contained in Trisaccharide
Analogues of the (1→2)-β-mannan from Candida
albicans
Casey Costello, Corwin M. Nycholat, and David R. Bundle |
|
Synthesis
of a Vaccine Against C. albicans Incorporating βMan3
, Fba, and Tetanus Toxoid
Jonathan Cartmell, Thanh Luu and David R Bundle |
|
Novel
Strategy for Protein-Ligand Conjugations
Tomasz Lipinski, Adam Szpacenko, Pavel Kitov, Julie Guiard
and David R. Bundle
|
|
| Versatile Synthesis of β1,3 Glucans for in vivo Targeting of Dendritic Cells and Micro-Patterned Ligand Arrays
Bailey, J.J.; Bundle, D.R. |
|
| Synthesis of Mannose Antigens for use in a Phage Display Vaccine
Bailey, J.J.; Bundle, D.R. |
|
19th International Symposium on Fluorine Chemistry
Jackson Hole, WY - Aug 2009 |
| Bailey, J.J.; Bundle, D.R., Development of a Fluorous Tag as an Anomeric Protecting Group, a Purification Aid and a Protein Linker |
|
2008
AICCS
Annual Meeting
Banff, Alberta - April 29-May 3 |
Synthesis
of a Zwitterionic Hexasaccharide Containing two Repeating Units
of the Streptococcus Pneumoniae Type 1 Capsular Polysaccharide
Xiangyang Wu, Lina Cui, and David R. Bundle
|
|
Synthesis
of Zwitterionic Oligosaccharides with the Potential to Stimulate
T-Cell Responses
Ithayavani Iynkkaran, Chang-Chung Ling, Xiangyang Wu and David.
R. Bundle
|
|
The
Convergent Synthesis of a-Galactosylceramide by Olefin Cross
Metathesis
Ye Cai and David R. Bundle
|
|
Synthesis
of Oligosaccharide Fragments of Lipoarabinomannan from Mycobacterium
Tuberculosis as Haptens for the Development of Anti-Tuberculosis
Vaccines
Yu Bai, Maju Joe, Jayant N. Tilekar and Todd L. Lowary
|
|
Design
and Synthesis of Aspergillus fumigatus Antigens
Vincent R. Bouvet, Feng Yang, Todd L. Lowary and David R. Bundle
|
|
Development
of Glycoconjugate Polymeric Vaccines for the Treatment of Candida
albicans
Thanh Luu, Pavel I. Kitov, Tomasz Lipinski and David R. Bundle
|
|
Investigating
synthetic techniques for a practical synthesis of ß-1,3
glucans as a preliminary backbone structure in a laminarin
based glycan library
J. James Bailey and David R. Bundle
|
|
In
Vivo Synthesis of Complex Ganglioside Analogues by Metabolically
Engineered Escherichia coli Strains
Sandra Jacques, Chang-Chun Ling, Eric Samain, and David R.
Bundle
|
|
Multifunctional Multivalency: Synthesis of Heterobifunctional
Polymeric Shiga Toxin Antagonists for in vivo Evaluation
P. I. Kitov, E. Paszkiewicz, Jared M. Jacobson, T. Lipinski
and D. R. Bundle
|
|
Multifunctional
Multivalency: Effect of Linker Length on the Activity of Heterobifunctional
Polymeric Shiga Toxin Antagonists
E. Paszkiewicz, P. I. Kitov, T. Lipinski and D. R. Bundle
|
|
Multifunctional
Multivalency: The Synthesis of the Inactive Diastereoisomer
of a Heterobifunctional Antagonist for Shiga Toxin
Jared M. Jacobson, Eugenia Paskiewicz, Pavel I. Kitov and David
R. Bundle
|
|
Multifunctional
Multivalency: Synthesis of Polyvalent Heterobifunctional Ligand
for Redirecting IgM to Siglec CD22
Lina Cui, Pavel I. Kitov, Gladys C. Completo, James C. Paulson,
and David R. Bundle |
|
2007
Gordon
Conference on Carbohydrates
Tilton, New Hampshire - June 17-22 |
Multifunctional
Multivalency: Synthesis of Shiga Toxin Antagonists Based on
Biocompatible N-(2-Hydroxypropyl) Methacrylamide (HPMA)
Eugenia Paszkiewicz, Pavel I. Kitov, David R. Bundle
|
|
Chemical
Mapping and STD NMR StudiesEstablish the Trichinella spiralis
Epitope Recognized by a Monoclonal Antibody
Lina Cui, Ping Zhang, Chang-Chun Ling and David Bundle
|
|
Multifunctional
Multivalency: A Novel Concept Capable of Delivering One Billion
Fold Avidity Gains
Pavel Kitov, Dmitry Solomon, Tomasz Lipinski, Eugenia Paszkiewicz,
Joanna Sadowska, George Mulvey, Glen Armstrong and David Bundle
|
|
Diversified
Synthesisof Phytoshingosines and Glycocermide Analogs
Ye Cai, Chang-Chun Ling and David Bundle
|
|
AICCS
Annual Meeting
Lake Louise, Alberta - May 3-5 |
Structure
and Carbohydrate Binding Properties of Toxins A and B from
Clostridium difficile
Antonio Greco, Pavel Kitov, David Bundle, Jiangxiao Sun, John
Klassen, Maja Rüpnik, Kenneth Ng
|
|
Multifunctional
Multivalency: Design, Synthesis and Preliminary Evaluation
of the Most Potent Shiga Toxin Inhibitor
D. Solomon, P. I. Kitov, T. Lipinski, E. Paszkiewicz, J.
M. Sadowska and D. R. Bundle
|
|
Multifunctional
Multivalency: Synthesis of Shiga Toxin Antagonists Based on
Biocompatible N-(2-Hydroxypropyl) Methacrylamide (HPMA)
Eugenia Paszkiewicz, Pavel I. Kitov and David R. Bundle
|
|
Immuno-Targeting
Malignant Cells Through Folate-GlcNAc Conjugated Ligands
Lina Cui, Pavel Kitov and David R. Bundle
|
|
Synthesis
of tailored conjugate vaccines composed of complex carbohydrate
antigens and specific TH-cell peptide epitopes employing a
novel linker methodology
Sebastian Dziadek, Sandra Jacques and David R. Bundle
|
|
Immune
Response to Small Oligosaccharide Enhanced by Copolymerization
with Acrylamide
T. Lipinski, P. Kitov, E. Paszkiewicz, X. Wu and D. R. Bundle
|
|
Synthesis
and mapping of the protective epitope contained in di- and
trisaccharide analogs of the (1-2)-ß-mannan from Candida
albicans
Corwin M. Nycholat, and David R. Bundle
|
|
Synthesis
of Glycosphingolipid-Derivatives for the Therapy of Autoimmune
Diseases
Birgit Kranke and David R. Bundle
|
|
Diversified
Synthesis of Phytosphingosines and Glycoceramide Analogs
Ye Cai and David R. Bundle
|
|
Synthesis
of ß-1,3 (laminarin) glucans as a preliminary backbone
structure in a laminarin based glycan library
J. James Bailey and David R. Bundle
|
|
Synthesis
of the Zwitterionic Hexasaccharide Containing two Repeating
Units of the Streptococcus pneumoniae Type 1 Capsular Polysaccharide
Xiangyang Wu and David R. Bundle
|
|
Synthesis
of Zwitterionic Oligosaccharides with the Potential to Stimulate
T-Cell Responses
Ithayavani Iynkkaran, Chang-Chung Ling and David R.Bundle
|
|
Synthesis
of Pk-Trisaccharide Deoxy Analogs and Mapping of the Carbohydrate
Binding sites in Shiga Toxins by FTICR Mass spectrometry
Jonghwa Kim, Pavel Kitov and David R. Bundle
|
|
Affinities
of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk
Trisaccharide Analogs Measured by Electrospray Ionization
Mass Spectrometry
E. N. Kitova, P. I. Kitov, E. Paszkiewicz, J. Kim, G. L.
Mulvey, G. D. Armstrong, D. R. Bundle and J. S. Klassen
|
|
Progress
toward the Synthesis of Galactomannan Antigens of Aspergillus
fumigatus
Vincent R. Bouvet, Feng Yang, Todd L. Lowary and David R. Bundle
|
|
2006
Glycobiology
2006
Los Angeles, California - November |
Heterobivalent
Ligands: A Versatile Approach to Ligand-Induced Protein Aggregation
Exemplified by the Structure-based Design of Shiga Toxin Antagonists
Pavel I. Kitov and David R. Bundle
|
|
23rd
International Carbohydrate Symposium
Whistler, Canada - July 23-28 |
Synthetic
Ganglioside Epitopes for Extracorporeal Removal of Antibodies
in Neuropathy
Birgit Kranke, Ping Zhang, Chang-Chun Ling, and David R. Bundle
|
|
A
Facile Approach to 2-Acetamido-2-deoxy-ß-D-glucopyranosides
Facilitates Convenient Syntheses of ?-Glycosides of Unusual
Aminosugars
Ye Cai, Chang-Chun Ling and David. R. Bundle
|
|
A
Comparison of STD NMR and Chemical Mapping Studies of a Trichinella
spiralis Antibody Binding Site
Lina Cui, Chang-Chun Ling, David R. Bundle
|
|
Ganglioside
Conjugate Vaccines Incorporating an in vivo-labile ß-Thiopropionate
Tether
S. Jacques, S. Dziadek, J. R. Rich, D. R. Bundle
|
|
Heterobivalent
Ligand Mediated Ternary Complex Formation between Shiga Toxin
and Serum Amyloid P Component
P. I. Kitov, G. Grant, E. Paszkiewicz, J. Sadowska and D. R.
Bundle
|
|
A
Concise Chemoenzymatic Synthetic Route to Natural Gangliosides
and Ganglioside Analogs for Cancer Immunotherapy
Ping Zhang, Chang-Chun Ling, Sandra Jacques, Blake Zheng,
and David R. Bundle
|
|
Synthesis
of a Dimeric Heterobifunctional Ligand Designed to Induce a
Complex Between Shiga Toxin and Serum Amyloid P Component
D. Solomon, P. I. Kitov and D. R. Bundle
|
|
Immunochemistry
of Thioanalogs of theTrisaccharide ß-Mannan Epitope
of Candida Albicans
T. Lipinski, X. Wu, E. Paszkiewicz and D.R. Bundle
|
|
Diastereoselective
Synthesis of Phytosphingosine and Preparation of Thioanalogs
of Galactosylceramide
Chang-Chun Ling, Ye Cai, Ping Zhang, and David R. Bundle
|
|
Synthesis
of the Trisaccharide Repeating Unit of the Type 1 Capsular
Polysaccharide from Streptococcus Pneumoniae (Sp1)
Xiangyang Wu and David R. Bundle
|
|
AICCS
Annual Meeting
Telus Centre, Edmonton, Alberta - June 8-9 |
Preliminary
Steps Towards the Identification of ß-Mannopyranosyl
Transferases from Candida albicans
Magali Buffet and David Bundle
|
|
Synthesis
of Glycoconjugate Vaccines on Clustered Modes against Candida
Albicans Using a Novel Methodology
Xiangyang Wu, Tomasz Lipinski, J. James Bailey, Frédéric
Carrel and David Bundle
|
|
Immune
Response to Thioanalogs of Trisaccharide Epitope of Candida
Albicans ß-Mannan in Mice
Tomasz Lipinski, Xiangyang Wu, Eugenia Paszkiewicz and David
Bundle
|
|
Synthesis
of disaccharide congeners of the (1-2)-ß-mannan from
the cell-wall phosphomannan of Candida albicans
Corwin Nycholat and David Bundle
|
|
Furanosyl
Oxazoline of D-GlcNAc Functionalized at O-3: Larg-Scale Synthesis
of ß-Glycosides of Unusual Aminosugars
Ye Cai, Chang-Chun Ling and David Bundle
|
|
Efficient
Synthesis of N-Acetylmuramic Acid and Muramyl Oligopeptide
Immuno- adjuvants
Ye Cai, Chang-Chun Ling and David Bundle
|
|
Diastereoselective
Synthesis of Phytosphingosine and Preparation of Thioanalogs
of Galactosylceramide
Chang-Chun Ling, Ye Cai, Ping Zhang, and David Bundle
|
|
A
Concise Chemoenzymatic Synthetic Route to Natural Gangliosides
and Ganglioside Analogs for Cancer Immunotherapy
Ping Zhang, Chang-Chun Ling, Sandra Jacques, Ruixiang Blake
Zheng, and David Bundle
|
|
Ganglioside
Conjugate Vaccines Incorporating an in vivo-labile ß-Thiopropionate
Tether
Sandra Jacques, Sebastian Dziadek, Jamie Rich, David Bundle
|
|
Synthesis
of a Dimeric Heterobifunctional Ligand Designed to Induce
a Complex Between Shiga Toxin and Serum Amyloid P Component
Dmitry Solomon, Pavel Kitov and David Bundle
|
|
Heterobivalent
Ligand Mediated Ternary Complex Formation between Shiga Toxin
and Serum Amyloid P Component
Pavel Kitov, Gordon Grant, Eugenia Paszkiewicz, Joanna Sadowska
and David Bundle
|
|
American
Society for Microbiology
Denver, Colorado - March 13-17 |
A
Synthetic Glycoconjugate Candida albicans Vaccine Confers Protection
in a Disseminated Candidiasis Rabbit Model
T. Lipinski, X. Wu, J. Sadowska, Y. Yasui, S. Cheriaparambil,
R. P. Rennie, D. R. Bundle
|
|
2005
Gordon Conference
on Carbohydrates
Tilton, New Hampshire, June 19-24, 2005 |
Synthesis
and Immunochemistry of Ganglioside Analogues
Jacques, S.; Rich, J.R.; Bundle, D. R.
|
|
Synthesis
of Multivalent Hetero-Bifunctional Inhibitors
Dmitry Solomon, Eugenia Paszkiewicz, Pavel Kitov, Gordon
A. Grant, and David R. Bundle
|
|
Evaluation
of synthetic vaccine for Candida albicans
Tomasz Lipinski, Xiangyang Wu, Joanna Sadowska, Shilton Cheriaparambil,
Robert Rennie, and David R. Bundle |
|
Single
Site Functional Group Replacement and Tethering of Trisaccharides
Yield Non-Linear Free Energy Gains Due to Changes in Bound
Ligand Orientation
McGavin, R.S., Peters, T. and Bundle, D.R. |
|
Synthesis
of Glycoconjugate Vaccines on Clustered Modes against Candida
Albicans Using the Novel Methodology
Xiangyang Wu, Tomasz Lipinski, J. James Bailey, Frédéric
Carrel and David R. Bundle |
PDF
file |
Single
Site Functional Group Replacement and Thethering of Trisaccharides
Yield Non-Linear Free Energy Gains Due to Changes in Bound
Ligand Orientation
Mc Gavin, R.S., Peters, T., and Bundle, D.R. |
PDF
file |
Synthesis
of Di- and Trisaccharide Congeners of the (1?2)-ß-Mannan
from the Cell-wall Phosphomannanof Candida Albicans
Corwin Nycholat and David R. Bundle
|
PDF
file |
88th Canadian
Chemistry Conference and Exhibition
Saskatoon, Saskatchewan, May 28-June 1, 2005 |
Synthesis
and Immunochemistry of Ganglioside Analogues
Jacques, S.; Rich, J.R.; Bundle, D. R.
|
|
A
Facile Route To Unprotected b-Glycopyranosides Of N-Acetylglucosamine
Via A Furanosyl Oxazoline Derivative
Ye Cai, Chang-Chun Lin, David R. Bundle
|
|
An
Iterative Approach to High Affinity Carbohydrate Ligand Design
Lina Cui, C.-C. Ling and David R. Bundle |
|
Synthesis
of Di- and Trisaccharide Congeners of the (1-2)-ß-Mannan
from the Cell-wall Phosphomannanof Candida Albicans
Corwin Nycholat and David R. Bundle
|
PDF
file |
AICCS
Annual Meeting and Symposium on Carbohydrate Science
Lake Louise, Alberta, April 28-30, 2005 |
In-vitro
Screening of Anti-adhesive Drugs that Complex with Serum Amyloid
P Component to Inhibit Shiga-like Toxins
Grant, G.A., Kitov, P.I, Solomon, D., Paszkiewicz, E., Sadowska,
J.M, Mulvey, G.L., Armstrong, G.D., and Bundle, D.R..
|
|
Preliminary
Comparison of the Epitope Maps of Ligands Directed Towards
Monoclonal Antibody SYA/J6
McGavin, R.S., Peters, T. and Bundle, D.R. |
PDF
file |
Synthesis
of Multivalent Ligands directed against Anti-ganglioside
Antibodies related to Autoimmune GBS Neuropathy
Frédéric Carrel and David Bundle
|
|
Chemoenzymatic
Synthesis of Functionalized Ganglioside Analogues
Jacques, S.; Rich, J.R.; Bundle, D. R.
|
|
Synthesis
of Multivalent Hetero-Bifunctional Inhibitors
Dmitry Solomon, Eugenia Paszkiewicz, Pavel Kitov, Gordon A.
Grant, and David R. Bundle
|
|
The
Immune Response To Glycoconjugate Vaccines for Candida albicans
and
in vivo Protection Experiments in Neutropenic Rabbits
Tomasz Lipinski, Joanna Sadowska, Shilton Cheriaparambil,
Robert Rennie, and David R. Bundle |
|
A
Facile Route To Unprotected b-Glycopyranosides Of N-Acetylglucosamine
Via A Furanosyl Oxazoline Derivative
Ye Cai, Chuang-chun Lin, and David R. Bundle |
|
A
Novel Synthesis of Phytosphingosines from 6-Iodo Aminosugars
Using a Zinc-mediated Reductive Elimination and Olefin Metathesis
Ye Cai, Chuang-chun Lin, and David R. Bundle
|
|
Synthesis
and Immunochemistry of S-Gangliosides
Jamie R. Rich, Sandra Jacques and David R. Bundle |
|
Synthesis
of Glycoconjugate Vaccines against Candida albicans Using
the Novel Linker Methodology
Xiangyang Wu, J. James Bailey, Eugenia Paszkiewicz and David
R. Bundle
|
PDF
file |
An
Iterative Approach to High Affinity Carbohydrate Ligand Design
Lina Cui, C.-C. Ling and David R. Bundle |
|
Chemical
and Chemo-Enzymatic Approach to the Synthesis of Pk-trisaccharide
Deoxy Analogues
Jonghwa Kim, Pavel Kitov and David R. Bundle
|
PDF
file |
Synthesis
of Di- and Trisaccharide Congeners of the (1-2)-ß-Mannan
from the Cell-wall Phosphomannanof Candida Albicans
Corwin Nycholat and David R. Bundle
|
|
Synthesis
of thio-analog of KRN7000
Chang-Chun Ling, Ping Zhang and David R. Bundle
|
|
Synthesis
of Ganglioside Epitopes for Oligosaccharide Specific Immunoadsorption
Therapy of GuillainBarré Syndrome
Ping Zhang, Chang-Chun Ling, Kate Townson, Hugh J. Willison
and David R. Bundle |
PDF
file |
2004
International
Carbohydrate Symposium
Glasgow, Scotland |
Molecular
Basis for Inhibition of Serum Amyloid P Component by New Multivalent
Ligands
Pavel I. Kitov, Eugenia Paszkiewicz, Joanna Sadowska, David
R. Bundle, Jason G.S. Ho, and Kenneth K.-S. Ng
|
|
Sulfur
Linked Analogues of Gangliosides GM3 and GM2 for Use in Conjugate
Vaccines
Jamie R. Rich, Sandra Jacques and David
R. Bundle
|
PDF
file (25k) |
2003
Eurocarb Symposium 2003
Grenoble, France |
Synthesis
of Phosphmannan Antigens found in the Candida albicans cell
wall
Stéphane Chambert and David R.
Bundle
|
PDF
file (50k) |
Synthesis
and Binding Analysis of Cyclic Oligosaccharide Inhibitors
of Monoclonal Antibody SYA/J6
Robert S. McGavin and David R. Bundle
|
PDF
file (53k) |
Understanding
Neuropathy Pathogenesis: Synthesis of Ganglioside BSA Glycoconjugates
and Immobilization on Sepharose Gel
Soren Andersen, Chang-Chun
Ling, Ping Zheng, Kate Townson, Jean Veitch, Hugh J. Willison,
David R. Bundle |
PDF
file (35k) |
Alberta
Ingenuity Centre for Carbohydrate Science - Annual Meeting
2003 Edmonton, Alberta |
An efficient route
to sphinganine, phytosphingosine and their analogs
Ye Cai, Chang-Chun Ling, and David R. Bundle |
PDF
file
|
Large Scale Synthesis
of an Analog of Azidosphingosine and Preparation of the Corresponding
GM2 Analog
Chang-Chun Ling, Ping Zhang, Corwin M. Nycholat and David R.
Bundle
|
PDF
file |
*Synthesis of Sulfur Containing
Ganglioside Analogues for Use as Immunogens
Jamie R. Rich, David R. Bundle
|
PDF
file |
*Synthesis and Binding Analysis
of Cyclic Oligosaccharide Inhibitors of Monoclonal Antibody
SYA/J6
Robert S. McGavin, and David R. Bundle
|
PDF
file |
*Chemical Synthesis and Adjuvant
Properties of Gentiobiosyl Diphytanyl Glycerol
Dean T. Williams and David R. Bundle
|
PDF
file |
*Towards
the Total Synthesis of SB1a, a Carbohydrate Hapten Associated
with Human Hepatocellular Carcinoma
Dmitry Solomon and David R. Bundle
|
PDF
file |
Banff
Symposium on Organic Chemistry 2003
Banff, Alberta |
An efficient route
to sphinganine, phytosphingosine and their analogs
Ye Cai, Chang-Chun Ling, and David R. Bundle |
PDF
file |
Annual
Conference of the Society for Glycobiology
San Diego, CA. - Dec. 2003 |
Glycosyltransferase
Catalyzed Synthesis of Thiooligosaccharides
Jamie R. Rich, Adam Szpacenko, Monica
M. Palcic and David R. Bundle
|
PDF
file (95k) |
2002
International
Carbohydrate Symposium
Cairns, Australia; August 7-12 2002 |
Candida
albicans b(1-2)-Mannans: Unique Solution Conformation and
the Immune Response to Their Glycoconjugates.
Mark Nitz, Chang-Chun Ling, Albin
Otter, Joanna Sadowska and David R. Bundle |
Poster Session I
PP273
PDF
file (203k) |
Canadian
Society for Chemistry Conference and Exhibition
Vancouver, B.C., Canada; June 1-5, 2002 |
Intramolecular
Pre-Organization of Oligosaccharides:The Synthesis of Cyclic
Inhibitors Towards Monoclonal Antibody SYA/J6.
Robert S. McGavin and David R. Bundle |
PDF
file (73k) |
Synthetic
Studies Toward Lewis Y Glycoconjugates.
Lesley Liu, Chang-Chun
Ling and David R. Bundle |
PDF
file (67k) |
Thio-linked
Oligosaccharides: Better Immunogens? Synthesis and Binding
Studies of S-linked Trisaccharides Related to Shigella flexneri
Variant Y LPS Antigens
Henry N. Yu, Chang-Chun
Ling and David R. Bundle |
PDF
file (75k) |
Synthesis
and conformational Studies of Ganglioside Analogues Containing
S-linked Neuraminic Aicd and a S-linked Ceramide.
J.R. Rich and D.R.
Bundle |
PDF
file (62k) |
Understanding
Neuropathy Pathogenesis: Synthesis of Ganglioside BSA Glycoconjugates
and Immobilization on Sepharose Gel
Soren M. Andersen,
Ping Zhang, Chang-Chun Ling and David R. Bundle |
Lecture |
Experimental NMR Conference 2002
Asilomar, California; April 14-19, 2002
|
Unique Helical
Solution Confirmation in Candida albicans β1-2)-Mannopyranan
Oligomers
Albin Otter, Mark
Nitz, Chang-Chun Ling and David R. Bundle |
Lecture |
2001
Gordon
Research Conference - 2001
Tilton, NH |
Determination
of the Binding Affinity of mAb B3 for Synthetic Derivatives
of Lewis Y Using FAC/MS
Lesley Liu, Chang-Chun
Ling and David R. Bundle |
PDF
file (82k) |
Construction
of 1-Thio-b-Mannopyranosyl and 1-Thio-b-Rhamnopyranosyl Linkages
via a Facile SN2 Reaction
Henry N. Yu, Chang-Chun
Ling and David R. Bundle |
PDF
file (76k) |
Allyl
Cleavage under Mild Oxidative Conditions
Pavel I. Kitov and
David R. Bundle |
PDF
file (407k) |
2000
Experimental NMR Conference 2000
Asilomar, California; April 9-14, 2000
|
Conformational
Analysis of a Tethered Disaccharide Trapped in the anit Conformation
Shirley A. Wachowich-Sgarbi,
Chang-Chun Ling, David R. Bundle and Albin Otter |
PDF
file (168k) |
Canadian Bacterial Diseases Network
Centre 2000
|
Pk-Starfish:
The Next Generation
P.I. Kitov, J.M. Sadowska,
P. Marcato, G.D. Armstrong and D.R. Bundle |
PDF
file (281k) |
Fourier-Transform
Ion Cyclotron Resonance Mass Spectrometry Studies of the
Homophilic Non-Covalent Interactions of Shiga-like Toxin
Subunits, as well as their Interactions with Carbohydrate
Ligands.
E.N. Kitova, J.S.
Klassen, P.I. Kitov, P. Marcatao, G.D. Armstrong and D.R.
Bundle |
PDF
file (103k) |
1999
Gordon
Research Conference, Carbohydrates 1999 |
Rational
Design of Soluable Sub-Nanomolar Inhibitors for Shiga Toxins
P.I. Kitov, J.M. Sadowska,
D.R. Bundle, Randy J. Read and G.D Armstrong |
PDF
file (372k) |
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