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Peer Reviewed Publications

 

2013
Guiard, J., Paszkiewicz, E., Sadowska, J .M. and Bundle, D. R. Design and Synthesis of a Universal Antigen to Detect Brucellosis. Angew. Chem. Int. Ed., http://dx.doi.org/10.1002/anie.201302303.Published online 7th June 2013.
Jacobson, J. M., Kitov, P. I. and Bundle, D. R. The Synthesis of a Multivalent Heterobifunctional Ligand for Specific Interaction with Shiga toxin 2 produced by E. coli O157:H7. Carbohydr. Res.,  doi: http://dx.doi.org/10.1016/j.carres.2013.05.010. Published online 28 May 2013.
Iynkkaran, I. and Bundle, D. R. Synthesis of a trisaccharide repeat of the zwitterionic Sp1 capsular polysaccharide utilizing 2-azido-4-benzylamino-4N,3-O-carbonyl-2,4,6-trideoxy-D-galactopyranosyl trichloroacetimidate. Carbohydr. Res., doi:http://dx.doi.org/10.1016/j.carres.2013.05.005. Published online 21 May 2013.
Lipinski, T., Fitieh, A., St. Pierre, J., Ostergaard, H. L., Bundle, D. R. and Touret, N. Enhanced Immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to DCs via Dectin-1 by incorporating β-glucan. J. Immunol. in press, accepted Feb 21, 2013.
Johnson, M. A. and Bundle, D. R. Designing a new antifungal glycoconjugate vaccine. Chem. Soc. Rev., DOI: 10.1039/c2cs35382b.

 

2012
Dang, A.-T., Johnson, M. A. and Bundle, D. R. Synthesis of a Candida albicans tetrasaccharide spanning the β1,2-mannan phosphodiester α-mannan junction. Org. Biomol. Chem., 10, 8348-8360, 2012.
Bundle, D. R., Nycholat, C., Costello, C., Rennie, R. and Lipinski, T.   Design of a Candida albicans disaccharide conjugate vaccine by reverse engineering a protective monoclonal antibody. ACS Chem. Biol. 7, 1754-1763, 2012. 
Lipinski, T., Wu, X., Sadowska, J., Kreiter, E., Yasui, Y., Cheriaparambil, S., Rennie, R. and Bundle, D. R. A trisaccharide conjugate vaccine induces high titer β-mannan specific antibodies that aid clearance of Candida albicans in immunocompromised rabbits. Vaccine, 30, 6263-6269, 2012.
Johnson, M. A., Cartmell, J., Weisser, N. E., Woods, R. J., and Bundle, D. R.  Molecular recognition of Candida albicans (1→2)-β-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residue. J. Biol. Chem. 287, 18078-18090, 2012.
Xin, H., Cartmell, J., Bailey, J. J., Dziadek, S., Bundle, D. R. and Cutler, J. E. Self -adjuvanting Glycopeptide Conjugate Vaccine against Disseminated Candidiasis. PLoS One 7, e35106, 2012.
Costello, C. and Bundle, D. R. Synthesis of three trisaccharide congeners to investigate frame shifting of β1,2-mannan homo-oligomers in an antibody binding site. Carbohydr. Res., 357, 7-15, 2012.

 

2011
Zhang,P., Razi, N., Eugenio, L., Fentabil, M., Kitova, E.N., Klassen, J.S., Bundle, D.R., Ng, K.K.-S. and Ling, C.-C. Unexpected structure of a Clostridium difficile toxin A ligand necessitates an annotation correction in a popular screening library. Chem. Comm. 47, 12397-12399, 2011.
Kitov, P. I., Paszkiewicz, E., Sadowska, J.M., Deng, Z., Ahmed, M., Narain, R., Griener, T., Mulvey, G. L., Armstrong, G. D., Bundle, D. R. Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate Shiga toxin and serum amyloid P component ternary complex formation. Toxins, 3, 1065-1088, 2011.
Sandbhor, M. S., Soya, N, Albohy, A., Zheng, R. B., Cartmell, J.,  Bundle, D. R., Klassen,  J. S. and Cairo, C. W. Substrate recognition of the membrane-associated sialidase NEU3 requires a hydrophobic aglycone. Biochemistry, 50, 6753-5762, 2011.
Lipinski, T., Luu, T., Kitov, P. I., Szpacenko, A. and Bundle, D. R. A structurally diversified linker enhances the immune response to a small carbohydrate hapten. Glycoconj. J., 28, 149-164, 2011
Cui, L., Kitov, P. I., Completo, G. C., Paulson, J. C. and Bundle. D. R. Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgM. Bioconjug. Chem., 22, 546-550, 2011.
Rademacher, C., Guiard, J., Kitov, P., Langpap, B., Dalton, K. P., Parra, F., Bundle, D. R. and Peters, P. Targeting Norovirus Infection – Multivalent Entry Inhibitor based on NMR Data. Chem. Eur. J., 17, 7442-7453, 2011.
Guiard, J., Langpap, B., Kitov, P., Peters, P. and Bundle, D. R. “Double-Click” Protocol for Synthesis of Heterobifunctional Multivalent Ligands: Toward a Focused Library of Specific Norovirus Inhibitors. Chem. Eur. J., 17, 7438-7441, 2011.
Tran, H.-A., Kitov,P. I., Paszkiewicz, E., Sadowska, J. M. and Bundle, D. R. Multifunctional multivalency: a focused library of polymeric cholera toxin antagonists. Org. Biomol. Chem., 9, 3658-3671, 2011.
Lipinski, T., Kitov, P., Szpacenko, A., Paszkiewicz, E. and Bundle, D. R. Synthesis and Immunogenicity of a Glycopolymer Conjugate. Bioconjug. Chem., 22, 274-281, 2011.

 

2010

Huang, J., Motto D. G., Bundle, D. R. and Sadler, J. E. Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. Blood, 116, 3653-3659, 2010

Iynkkaran, I. and Bundle, D. R., A novel glycosyl donor for synthesis of 2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactopranosides. Carbohydr. Res., 345, 2323-2327, 2010

Wu, X., Cui, L., Lipinski, T. and Bundle, D.R. Synthesis of monomeric and dimeric repeating units of the zwitterionic type 1 capsular polysaccharide from Streptococcus pneumoniae. Chem. Eur. J., 16, 3476-3488, 2010.

 

2009

Wu, X., Cui, L., Lipinski, T., and Bundle, D.R. Synthesis of monomeric and dimeric repeating units of the zwitterionic type 1 capsular polysaccharide from Streptococcus pneumoniae.
Chem. Eur. J
., in press, accepted October 14th 2009

Hu, J., Huang, X., Ling, C.-C., Bundle, D.R., and Cheung, N.K. Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody.
J. Immunol., 183, 5748 – 5755, 2009

Cai, Y., Ling, C.-C., and Bundle, D.R. Efficient Synthesis of D-xylo and D-ribo-Phytosphingosines from methyl 2-amino-2-deoxy-β-D-hexopyranosides.
Carbohydr. Res., 344, 2120-2126, 2009.
Nycholat, C.M.,  and Bundle, D.R. Synthesis of mono-deoxy and mono-O-methyl congeners of methyl β-D-mannopyranosyl-(1®2)-β-D-mannopyranoside for epitope mapping of anti-Candida albicans antibodies.
Carbohydr. Res
., 344, 555-569, 2009
Cai, Y., Ling, C.-C., and Bundle, D.R. Concise and efficient synthesis of 2-acetamido-2-deoxy-β-D-hexopyranosides of diverse aminosugars from 2-acetamido-2-deoxy-β-D-glucose.
J. Org. Chem., 74, 580–589, 2009

 

2008
Grant, C.F., Kanda, V., Yu, H., Bundle, D.R., and McDermott, M.T. Optimaization of Immobilized Bacterial Disaccharides for the Surface Plasmon Resonance Immaging Measurements of Antibody Binding.
Langmuir
, 24,14125–14132, 2008
Kitov, P. I.,  Mulvey, G. L., Griener, T., Lipinski, T., Solomon, D., Paszkiewicz, E., Jacobson, J. , Sadowska, J. M., Suzuki, M., Yamamura, K., Armstrong, G. D., and Bundle, D. R.
In vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the E. coli O157 AB5 toxins.
Proc. Natl. Acad. Sci (USA), 105, 16837-16842, 2008
Xin , H., Dziadek, S., Bundle, D. R.  and Cutler, J. Synthetic glycopeptide vaccines combining β-mannan and peptide epitopes induce protection against candidiasis.
Proc. Natl. Acad. Sci (USA
), 105, 13526-13531, 2008
Wu, X., Lipinski, T., Paszkiewicz, E., and Bundle, D. R. Synthesis and immunochemical characterization of S-linked glycoconjugate vaccines against Candida albicans
Chem. Eur. J., 14, 6474-6482, 2008
Dziadek,S., Jacques, S. and Bundle, D. R.  A novel linker methodology for the synthesis of tailored conjugate vaccines composed of complex carbohydrate antigens and specific TH-cell peptide epitopes.
Chem. Eur. J.
, 14, 5908-5917, 2008
O’Reilly,  M. K., Collins, B. E., Han, S., Liao, L., Rillahan, C.  Kitov, P. I., Bundle, D. R., and Paulson, J. C. Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells.
J. Am. Chem. Soc., 130, 7736-7745, 2008
Kitov, P. I., Lipinski, T., Paszkiewicz, E., Solomon, D., Sadowska, J. M., Grant, G. G. A., Mulvey, G. L., Kitova, E. N., Klassen, J. S., Armstrong, G. D. and Bundle, D. R. An Entropically Efficient Supramolecular Inhibition Strategy for Shiga Toxins.
Angew. Chemie Intl. Ed., 47, 672-676, 2008
 
2007
Townson, K., Greenshields, K. N., Veitch, J., Nicholl, D., Eckhardt, M., Galanina, O., Bovin, N.,  Samain, E., Antoine, T., Bundle, D. R., Zhang, P., Ling, C.-C., and Willison, H. J. Sulfatide binding properties of murine and human antiganglioside antibodies. Glycobiology, 17, 1156 – 1166, 2007
Moore, S. L., Uitz, C., Ling, C.-C., Bundle, D. R., Fusco P. C. and Michon, F. Epitope Specificities of the Groups Y and W-135 Polysaccharides of Neisseria meningitides.
Clinical and Vaccine Immunology
, 14, 1311-1317, 2007
Wu, X., Lipinski, T., Carrell, F., Bailey, J. J.,  and Bundle, D. R. Synthesis and Immunochemical Studies on a Candida albicans Clustered Glycoconjugate Vaccine.
Org. Biomol. Chem.,  5, 3477 – 3485, 2007
Kitova, E.N., Kitov, P.I., Paszkiewicz, E., Kim, J., Mulvey, G.L., Armstrong, G.D., Bundle, D.R., and Klassen, J.S. Affinities of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk Trisaccharide Analogs Measured by Electrospray Ionization Mass Spectrometry. Glycobiology, 17, 1156-1166, 2007
Townson, K., Boffey, J., Nicholl, D., Veitch, J.,  Bundle, D.R.,  Zhang, P., Samain, E., Antoine, T., Bernardi, A., Arosio, D., Sonnino, S., Isaacs, N., and Willison, H.J. Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies.
Glycobiology, 17, 294–303, 2007
Bundle, D.R. Nitz, M., Wu, X., and Sadowska, J.M. A uniquely small, protective carbohydrate epitope may yield a conjugate vaccine for Candida albicans.
Amer. Chem. Soc., Symp. Ser., 989, 163-183, 2007

 

2006
Cai, Y., Ling, C.-C., and Bundle, D.R. A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs.
Org. Biomol. Chem.
4, 1140-1146, 2006.
Jacques, S., Rich, J.R., Ling, C.-C., and Bundle, D.R. Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications.
Org. Biomol. Chem
., 4, 142-154, 2006.
Rich, J.R., Wakarchuk, W.W., and Bundle, D.R. Chemical and chemoenzymatic synthesis of S-linked ganglioside analogues and their protein conjugates.  Immunogens with improved in vivo availability?
Chem. Eur.  J., 12, 845-858, 2006.

 

2005
Bundle, D.R. Rich, J.R., Jacques, S., Yu, H.N., Nitz, M., and Ling, C.-C. Thio-oligosaccharide conjugate vaccines evoke antibodies specific for native antigens.
Angew. Chem. Int. Ed., 44, 7725-7729, 2005
Kanda, V. Kitov, P.I., Bundle, D.R. and McDermott, M.T. Surface plasmon resonance imaging measurements of the inhibition of Shiga-like toxin by synthetic multivalent inhibitors.
Anal. Chem.
77, 7497-7504, 2005
Solomon, D., Kitov, P. I., Paszkiewicz, E., Grant, G. A., Sadowska, J. M.., and Bundle, D. R.  Hetero-bifunctional multivalent inhibitor-adaptors mediate specific aggregation between shiga toxin and a pentraxin.
Org. Lett
., 7, 4369-4372, 2005.
Cai, Y., Ling, C.-C., and Bundle, D. R. A facile approach to 2-acetamido-deoxy-b-D-glucopyranosides via the furanosyl oxazoline.
Org. Lett., 7, 4021-4024, 2005
Wu, X., and Bundle, D.R. Synthesis of glycoconjugate vaccines for Candida albicans using novel linker methodology.
J. Org. Chem.,
70, 7381-7388, 2005
Ho, J.G.S., Kitov, P.I., Paszkiewicz, E., Sadowska, J., Bundle, D.R., and. Ng, K.K.-S. Ligand-assisted aggregation of proteins: dimerization of serum amyloid P component by bivalent ligands.
J. Biol. Chem., 280, 31999-32008, 2005
McGavin, R.S. and Bundle, D.R. Developing high affinity oligosaccharide inhibitors: conformational pre-organization paired with functional group modification.
Org. Biomol. Chem.
, 3, 2733-2740, 2005
Gagne, R.A., McGavin, R.S., Chervenak, M.C. and Bundle, D.R. The design, synthesis and evaluation of high affinity macrocyclic carbohydrate inhibitors.
Org. Biomol. Chem.
, 3, 2723-2732, 2005

 

2004
Wu, X., Ling, C.-C., and Bundle, D.R. A New Homobifunctional p-Nitro Phenyl Ester Coupling Reagent for the Preparation of Neoglycoproteins.
Org. Lett
., 6(24), 4407-4410, 2004
Rich, J., and Bundle, D.R. S-Linked ganglioside analogues for use in conjugate vaccines.
Org. Lett
., 6(6), 897-900, 2004
Kitova, E., Bundle, D.R. and Klassen, J.S. Partitioning of solvent effects and intrinsic interactions in biological recognition.
Angew. Chem.
Int. Ed., 43, 4183-4186, 2004
Andersen, S., Ling, C.-C., Zhang, P., Townson, K., Willison, H.J., and Bundle, D.R. Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian Barré syndrome.
Org. Biomol. Chem
., 2, 1199 – 1212, 2004
Willison, H.J., Townson, K., Veitch, J., Boffey, J., Isaacs, N., Andersen, S., Zhang, P., Ling, C.-C., and Bundle, D.R. Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies from neuropathy sera.
Brain,127, 680-691, 2004
Rich, J.R., Szpacenko, A., Palcic, M.M., and Bundle, D.R. Glycosyltransferase catalyzed synthesis of thiooligosaccharides. 
Angew. Chem. Int. Ed., 43, 613-615, 2004
 
2003
Vyas, N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M., and Quiocho, F.A. Structural basis of peptide-carbohydrate mimicry in an antibody-combining site.
Proc. Natl. Acad. Sci (USA)
, 100, 15023-15028, 2003
Kitov, P.I. and Bundle, D.R. On the Nature of the Multivalency Effect: A Statistical Thermodynamic Model
J. Am. Chem. Soc.,
125, 16271-16284, 2003
Yung, A.,Turnbull, B., Kalverda, A., Thompson, G., Homans, S., Kitov, P.I. and Bundle, D.R. Large scale millisecond inter-subunit dynamics in the B subunit homopentamer of the toxin derived from E. coli O157.
J. Am. Chem. Soc., 125, 13058-13062, 2003
Kamath, V., Sadowska, J., Nilar, S., Bundle, D.R., Hindsgaul, O. Synthetic analogs of the Lewisb-tetrasaccharide and their binding to the lectin GS-IV – Part 1.
Synlett, 1327-1330, 2003
Kitov, P.I., Shimizu, H., Homans, S.W., and Bundle, D.R. Optimization of Tether Length in non-Glycosidically Linked Bivalent Ligands that Target Sites 2 and 1 of Shiga-like Toxin.
J. Am. Chem. Soc., 125, 3284-3294, 2003
Mulvey, G.L., Marcato, P., Kitov, P.I., Sadowska, J., Bundle, D.R., and Armstrong, G.D. Assessment in Mice of the Therapeutic Potential of tailored, Multivalent Shiga Toxin Carbohydrate Ligands.
J. Infect. Dis.,
187, 640-649, 2003
 
2002
Kitova, E.N., Wang, W., Bundle, D.R. and Klassen, J.S.  Retention of Bioactive Ligand Conformation in in a Gaseous Protein-Trisaccharide Complex.
J. Am. Chem. Soc., 124, 13980-13981, 2002
Kitova, E.N., Bundle, D.R. and Klassen, J.S.  Evidence for the Preservation of Specific Intermolecular Interactions in Gaseous Protein-Oligosaccharide Complexes. 
J. Am. Chem. Soc., 124, 9340-9341, 2002
Vyas, N.K., Vyas, M.N., Chervenak, M.C., Johnson, M.A., Pinto, B.M., Bundle, D.R., and Quiocho, F.A. Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab Specific for Shigella flexneri Y Lipopolysaccharide: X-ray Structures and Thermodynamics.
Biochemistry 41, 13575-13586, 2002
Uhrín, D., Prasad, A.V.K., Brisson, J.R. and Bundle, D.R. Carbohydrate-Antibody Interactions by NMR. Antibody interactions by NMR.
Canad. J. Chem
. 80, 904-907, 2002
Yu, H.N., Ling, C.-C. and Bundle, D.R. Probing Carbohydrate-Antibody Interactions: Synthesis of Three Salmonella Epitopes for SPR Studies.
Canad. J. Chem
. 80, 1131-1140 2002
Lowary, T.L., Eichler, E. and Bundle, D.R.. Oligosaccharide recognition by antibodies: synthesis and evaluation of talose oligosaccharide analogues.
Canad. J. Chem
. 80, 1112-1130, 2002
Zhang, P., Appleton, J.A., Ling, C.C. and Bundle, D.R. Synthesis of disaccharide congeners of the Trichinella spiralis glycan and binding site mapping of two protective antibodies.
Canad. J. Chem
. 80, 1141-1161, 2002
Kitova, E.N., Bundle, D.R. and Klassen, J.S. Thermal Dissociation of Protein-Oligosaccharide Complexes in the Gas Phase: Mapping the Intrinsic Intermolecular Interactions.
J. Am. Chem. Soc.
, 124, 5902-5913, 2002
Soltyk, A. M., MacKenzie, C. R., Wolski, V. M., Hirama, T., Kitov, P. I., Bundle, D. R., and Brunton, J. L. A mutational analysis of the globotriaosylceramide binding sites of verotoxin VT1.
J. Biol Chem.,
277, 5351-5359, 2002
Nitz, M., Ling, C. C., Otter, A., Cutler, J. E. and Bundle, D. R. The unique solution structure and immunochemistry of the Candida albicans b-1,2-mannopyranan cell wall antigen.
J. Biol. Chem.
277, 3440-3446, 2002
 
2001
Appleton, J.A., Dell, A., Nitz, M., and Bundle, D.R. Novel N-glycans of the parasitic nematode Trichinella spiralis.
Trends in Glycoscience and Glycotechnology
, 13, 481-492 (2001
Nitz, M. and Bundle, D.R. Synthesis of di- to hexasaccharide 1,2-linked b-mannopyranan oligomers, a terminal S-linked tetrasaccharide congenerand the corresponding BSA glycoconjugates.
J. Org. Chem.
, 66, 8411- 8423, 2001
G. Mulvey, P.I. Kitov, P. Marcato, D.R. Bundle and G.D. Armstrong. Glycan mimicry as a basis for novel anti-infective drugs.  
Biochimie
, 83, 841-847, 2001
Kitov, P.I. and Bundle, D.R. Mild oxidative one-pot allyl group cleavage.
Org. Let.
,3, 2835-2838, 2001
Wacowich-Sgarbi, S.A., Ling, C.C., Otter, A. and Bundle, D.R. A tethered disaccharide trapped as its anti conformer calibrates the Karplus relationship for 3JC,H coupling constants.
J. Am. Chem. Soc.,
123, 4362-4363, 2001
Kitova, E.N., Kitov, P.I., Bundle D.R., and Klassen, J.S. The observation of multivalent complexes of Shiga-like toxin with globotrioside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry.
Glycobiology
, 11, 605-611, 2001
Kitov, P.I. and Bundle, D.R. Synthesis and structure-activity relationships of di- and trisaccharide inhibitors for Shiga-like toxin Type 1.
JCS Perkin 1, 838-853, 2001

Yu, H.N., Ling, C.-C. and Bundle, D.R. Efficient stereoselective synthesis of 1-thio-b-mannopyranosides.
JCS Perkin 1, 832-837, 2001

 


2000

Nitz, M., Purse B.W. and Bundle, D.R. Synthesis of a b1,2-mannopyranosyl tetrasaccharide found in the phosphomannan antigen of Candida albicans.
Org. Let.
,2, 2939-2942, 2000
Nitz, M. and Bundle, D.R. Efficient synthesis of 3,6-dideoxy-b-D-arabinohexopyranosyl terminated LacdiNac glycan chains of the Trichinella spiralis parasite.
J. Org. Chem.,65, 3064-3073, 2000
Alexander, J., del Guercio, M-F., Maewal, A., Qiao, L., Filkes, J. Chesnut, R.W., Paulson, J.C., Bundle, D,R., DeFrees, S. and Sette, A.  Linear PADRE T Helper Epitope and Carbohydrate B Cell Epitope Conjugates Induce Specific High Titer IgG Antibody Responses. 
J. Immunol.
164, 1625-1633, 2000
Kitov, P.I., Sadowska, J.M., Mulvey, G., Armstrong, G.D., Ling, H., Pannu, N.S., Read, R.J. and Bundle, D.R.  Shiga-like toxins neutralized by tailored multivalent carbohydrate ligands.
Nature
, 403, 669-672, 2000
Yu, H.N., Zhang, P., Ling, C.-C. and Bundle, D.R.  A practical route to 3,6-dideoxyhexoses.
Tetrahedron Asymmetry
, 11, 465-479, 2000
Zhang, P. and Bundle, D.R. Synthesis of three tethered trisaccharides to probe entropy contributions in carbohydrate-protein interactions.
Israel J. Chem.
, 40, 189-207, 2000

 


1999

Wacowich-Sgarbi, S.A. and Bundle, D.R.  Constrained H-Type 2 Blood Group Trisaccharide Synthesized in a Bioactive Conformation via Intramolecular Glycosylation
J. Org. Chem., 64, 9080-9089, 1999
Young, N.M., Gidney, M.A.J., Gudmundsson, B.M.E., MacKenzie, C.R., To, R., Watson, D.C. and Bundle, D.R.  Molecular basis for the lack of mimicry of Brucella polysaccharide antigens by Ab2g antibodies
Mol. Immunol.
, 36, 339-347, 1999
Seto, N.O.L., Compston, C.A., Evans, S. V., Bundle, D.R., Narang, S.A. and Palcic, M.M.  Donor Substrate Specificity of Recombinant Human Blood Group A, B and Hybrid A/B Glycosyltransferases Expressed In Escherichia coli.
Eur. J. Biochem. 259, 770-775, 1999
Schriemer, D.C., Bundle, D.R., Li, L., and Hindsgaul, O.  Micro-scale frontal affinity chromatography: a new method for screening of compound libraries.
Angew. Chem. Int. Ed.
37, 3383-3387, 1999

Otter, A., Lemieux, R.U., Ball, R.G., Venot, A.P., Hindsgaul, O., and Bundle, D.R. Crystal State and Solution Conformation of the Blood Group B Trisaccharide a-L-Fucp-(1®2)-[ a -D-Galp]-(1 ® 3)]-b-D-Galp-OCH3 
Eur. J. Biochem.,
259, 295-303, 1999

 

1998

Milton, M.J. and Bundle D.R.  Observation of the anti- conformation of a glycosidic linkage in an antibody bound oligosaccharide.
J. Am. Chem. Soc., 120, 10547-10548, 1998
Alibes, R. and Bundle, D.R. Synthesis of tethered trisaccharides to probe inter-saccharide flexibility in carbohydrate-protein interactions.
J. Org. Chem.,
63, 6288-6301, 1998
Bundle, D.R., Alibes, R., Nilar, S., Otter, A., Warwas, M., and Zhang, P. Thermodynamic and conformational implications of glycosidic rotamers pre-organized for binding.
J. Am. Chem. Soc., 120, 5317-5318, 1998
Kitov, P.I., Railton, C. and Bundle, D.R.  The synthesis of 16-mercaptohexadecanyl glycosides for biosensor applications.
Carbohydr. Res., 307, 361-369, 1998
Stangier, K., Palcic, M.M., Bundle, D.R., Hindsgaul, O., and Thiem, J. Fucosyltransferase-catalyzed formation of L-galactosylated Lewis structures.
Carbohydr. Res.
, 305, 511-515, 1998

 

1997

Seto, N.O.L., Palcic, M.M., Compston, C.A., Li, H., Bundle, D.R. and Narang, S.A. Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies substrate recognition in human recombinant enzymes.
J. Biol. Chem
.,272, 14133-14138, 1997

Ellis, L.A., McVay, C.S., Probert, M.A., Zhang, J., Bundle, D.R., and Appleton J.A. Terminal b-linked tyvelose creates unique epitopes in Trichinella spiralis glycan antigens.
Glycobiology
, 7, 383-390, 1997

1996

Probert, M.A., Zhang, J. and Bundle D.R.  Synthesis of a-and b-linked Tyvelose Epitopes of the Trichinella spiralis glycan; 2-Acetamido-2-deoxy-3-O-(3,6-dideoxy-D-arabino-hexopyranosyl)-b-D-galactopyranosides.
Carbohydr. Res
., 296, 149-170, 1996
Zhang, J., Otter A. and Bundle D.R.  Synthesis and Conformational Studies of the Tyvelose Capped, Lewis-x Like Tetrasaccharide Epitope of Trichinella spiralis.
Bioorgan. Med. Chem., 4, 1989-2001, 1996
MacKenzie, C.R., Hirama, T., Deng, S.-J., Bundle, D.R., Narang S.A., and Young, N.M.  Analysis by surface plasmon resonance of the influence of valence on the ligand binding affinity and kinetics of an anti-carbohydrate antibody.
J. Biol. Chem
., 271, 1527-1533, 1996

 

1995

Seto, N.O.L., Palcic, M.M., Hindsgaul, O., Bundle, D.R., and Narang, S.A.  Expression of a recombinant human glycosyltransferase from a synthetic gene and its utilization for synthesis of the human blood group B trisaccharide.
Eur. J. Biochem., 234, 323-328, 1995
MacKenzie, C.R., Clark, I.D., Evans, S.V., Hill, I.E., MacManus, J.P., Dubuc, G., Bundle, D.R., Narang S.A., Young, N.M., and Szabo, A.G. Bifunctional fusion proteins consisting of a single-chain antibody and an engineered lanthanide-binding protein. Immunotechnology, 1, 139-150, 1995
Lowary, T., Eichler, E., and Bundle, D.R. Synthesis of a pentasaccharide epitope for the investigation of carbohydrate-protein interactions.
J. Org. Chem
., 60, 7316-7327, 1995
Otter A., and Bundle, D.R., Long Range 4J and 5J Including Inter-Glycosidic Correlations in Gradient-Enhanced Homonuclear COSY Experiments of Oligosaccharides.
J. Mag. Reson. Ser. B
, 109, 194-201, 1995
Otter, A., Hindsgaul, O., and Bundle, D. R. Gradient-enhanced homonuclear 2D NMR techniques applied to oligosaccharides containing manno-hexoses provide improved correlations for protons coupled by small 3J.
Carbohydr. Res
., 275, 381-389, 1995
Deng, S.-J., MacKenzie, C.R., Hirama, T., Brousseau, R., Lowary, T., Young, N.M., Bundle, D.R., and  Narang S.A.  Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries. 
Proc. Natl. Acad. Sci (USA)
, 92, 4992-4996, 1995
Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R., To, R., Altman, E., Frosch, M., Weisgerber, C., Kratzin, H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R., Young, N.M., and Bundle, D.R.  The 2.8Å resolution structure, and thermodynamics of ligand binding, of an Fab specific for a(2®8)-polysialic acid.
Biochemistry
, 34, 6737-6744, 1995
Stangier, P., Palcic, M.M., and Bundle, D.R.  2-(Dimethyloctylsilyl)ethyl lactoside: a versatile intermediate for chemical and enzymic ganglioside synthesis.
Carbohydr. Res
., 267, 153-159, 1995

1994

Marsden, B.J., Bundle, D.R., and Perry, M.B.  Serological and structural relationships between Escherichia coli O:98 and Yersinia enterocolitica O:11,23 and O:11,24 lipopolysaccharide O-antigens.
Biochem. Cell Biol., 72, 163-168, 1994
Lowary, T.L., and Bundle, D.R.  Nucleophile Induced Rearrangements of Thioglycosides: Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars
Tetrahedron: Asymmetry, 5, 2397-2404, 1994
Bundle, D.R., and Eichler, E.  Modulation of antibody affinity by synthetic modifications of the most exposed pyranose residue of a trisaccharide epitope.
Bioorgan. Med. Chem
., 2, 1221-1229, 1994
Evans, S.V., Rose, D.R., To, R., Young, N.M., and Bundle, D.R.  Exploring the mimicry of polysaccharide antigens by anti-idiotypic antibodies: The crystallization, molecular replacement, and refinement to 2.8Å resolution of an idiotope-anti-idiotope-Fab complex and of the unliganded-anti-idiotype Fab.
J. Mol. Biol., 241, 691-705, 1994
Zdanov, A., Li, Y., Bundle, D.R., Deng, S.-J., MacKenzie, C.R., Narang S.A., Young, N.M., and Cygler, M.  Structure of a single-chain Fv fragment complexed with a carbohydrate antigen at 1.7Å resolution.
Proc. Natl. Acad. Sci (USA), 91, 6423-6427, 1994
MacKenzie, C.R., Sharma, V., Brummell, D.A., Bilous, D., Dubuc, G., Sadowska, J., Young, N.M., Bundle, D.R., and Narang, S.A.  Effect of Cl-Ck domain switching on Fab activity and yield in Escherichia coli: synthesis and expression of genes encoding two anti-carbohydrate Fabs.
Biotechnology, 12, 390-395, 1994
Deng, S.-J., MacKenzie, C.R., Sadowska, J., Michniewicz, J., Young, N.M., Bundle, D.R., and Narang, S.A.  Selection of antibody single-chain Fvs with improved carbohydrate-binding by phage display.
J. Biol. Chem
., 269, 9533-9538, 1994
Bundle, D.R., Baumann, H., Brisson, J.-R., Gagne, S.M., Zdanov, A., and Cygler, M.  The Solution Structure of a Trisaccharide-Antibody Complex:  Comparison of NMR Measurements with a Crystal Structure.
Biochemistry
, 33, 5183-5192, 1994
Bundle, D.R., Eichler, E., Gidney, M.A.J., Meldal, M., Ragauskas, A., Sigurskjold, B.W., Sinnott, B., Watson, D.C., Yaguchi, M., and Young, N.M.  Molecular Recognition of a Salmonella Trisaccharide Epitope by Monoclonal Antibody SE155-4. 
Biochemistry
, 33, 5172-5182, 1994

1993

Uhrin, D., Brisson, J.-R., and Bundle, D.R.  Pseudo-3D NMR spectroscopy: Application to oligo- and polysaccharides. 
J. Biomolecular NMR
, 3, 367-373, 1993
Rose, D.R., Przybylska, M., To, R.J., Kayden, C.S., Oomen, R. P., Vorberg, E., Young, N.M., and Bundle, D.R.  Crystal structure to 2.45Å resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen. 
Protein Science
, 2, 1106-1113, 1993
Auzanneau, F.-I., and Bundle, D.R.  Synthesis of chlorodeoxy trisaccharides related to the Shigella flexneri Y polysaccharide.
Carbohydr. Res., 247, 195-209, 1993
Baumann, H., Altman, E., and Bundle, D. R.  Controlled acid hydrolysis of an O-antigen fragment yields univalent heptasaccharide haptens containing one 3,6-dideoxyhexose epitope.
Carbohydr. Res., 247, 347-354, 1993
Auzanneau, F.-I., and Bundle, D. R.  Application of thioglycoside chemistry to the synthesis of trisaccharides and deoxy-trisaccharides related to the Shigella flexneri Y polysaccharide. 
Can. J. Chem
., 71, 534-548, 1993
Vyas, M.N., Vyas, N.K. Meikle, P.J., Sinnott, B., Pinto, B.M., Bundle, D.R., and Quiocho, F.A.  Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides.
J. Mol. Biol., 231, 133-136, 1993
Brummell, D.A., Sharma, V.P., Anand, N.N., Bilous, D., Dubuc, G., Michniewicz, J., MacKenzie, C.R., Sadowska, J., Sigurskjold, B.W., Sinnott, B., Young, N.M., Bundle, D.R., Narang, S.A.  Probing the combining site of an anti-carbohydrate antibody by saturation-mutagenesis: role of the heavy chain CDR3 residues.
Biochemistry, 32, 1180-1187, 1993
Auzanneau, F.-I., Hanna, H.R., and Bundle, D.R.  The synthesis of chemically modified disaccharide derivatives of the Shigella flexneri Y polysaccharide antigen. 
Carbohydr. Res., 240, 161-181, 1993
Hanna, H.R., and Bundle, D.R.  Antibody-oligosaccharide interactions: The synthesis of 2-deoxy-a-L-rhamnose containing oligosaccharide haptens related to Shigella flexneri variant Y antigen. 
Can. J. Chem
., 71, 125-134, 1993

1992

Reimer, K.B., Gidney, M.A.J., Bundle, D.R., and Pinto, B.M.  Immunochemical characterization of polyclonal and monoclonal streptococcus group A antibodies by chemically defined glycoconjugates and synthetic oligosaccharides. 
Carbohydr. Res
., 232, 131-142, 1992
Sigurskjold, B., and Bundle, D.R.  Thermodynamics of oligosaccharide binding to a monoclonal antibody specific for a Salmonella O-antigen point to hydrophobic interactions in the binding site. 
J. Biol. Chem
., 267, 8371-8376, 1992

1991

Narang, S.A., Brummell, D.A., Sharma, V., Bilous, D., Dubuc, G., MacKenzie, C.R., Michniewicz, J., Sadowska, J., Anand, N.N., Young, N.M., and Bundle, D.R.  Scanning of key residues in antibody binding sites by two saturation-mutagenesis approaches.  Nucleic Acid Res., 24, 173-179, 1991
Anand, N.N., Mandal, S., MacKenzie, C.R., Sadowska, J., Sigurskjold, B., Young, N.M., Bundle, D.R., and Narang, S.A.  Bacterial Expression and Secretion of Various Single-Chain Fv Genes Encoding Proteins Specific for a Salmonella Serotype B O-Antigen. 
J. Biol. Chem., 266, 21874-21879, 1991
Cygler, M., Rose, D.R., and Bundle, D.R.  Recognition of a cell surface oligosaccharide epitope of pathogenic Salmonella by an antibody Fab fragment. 
Science
, 253, 442-446, 1991
Anand, N.N., Dubuc, G., Phipps, J., MacKenzie, C.R., Sadowska, J., Young, N.M., Bundle, D.R., and Narang, S.A.  Synthesis and expression in Escherichia coli of cistronic DNA encoding an antibody fragment specific for a Salmonella serotype B O-antigen. 
Gene
, 100, 39-44, 1991
Kihlberg, J., and Bundle, D.R.  The synthesis of antibody binding site probes:  A hexasaccharide and two pentasaccharides related to the Brucella A antigen prepared by in situ activation of thioglycosides with bromine. 
Carbohydr. Res
., 216, 67-78, 1991
Eichler, E., Kihlberg, J., and Bundle, D.R.  Access to fluorescent probes via allyl glycosides; the synthesis of a Brucella trisaccharide epitope linked to a coumarin.
Glycoconjugate J
., 8, 69-74, 1991
Auzanneau, F.-I., and Bundle, D.R.  Incidence and avoidance of stereospecific 1,2-thioethyl migration during the synthesis of ethyl 1-thio-a-L-rhamnopyranoside 2,3-orthoester. 
Carbohydr. Res
., 212, 13-24, 1991
Oomen, R., Young, N.M., and Bundle, D.R.  Molecular modeling of antibody-antigen complexes between the Brucella abortus O-chain polysaccharide and a specific monoclonal antibody. 
Protein Engineering
, 4, 427-433, 1991
Sigurskjold, B.W., Altman, E., and Bundle, D.R.  Sensitive titration microcalorimetric study of the binding of Salmonella O-antigenic oligosaccharide by a monoclonal antibody. 
Eur. J. Biochem
., 197, 239-246, 1991
Kihlberg, J., Eichler, E., and Bundle, D.R.  The design and synthesis of antibody binding site probes:  three pentasaccharide analogues of the Brucella A antigen prepared by in situ activation of thioglycosides with bromine. 
Carbohydr. Res., 211, 59-75, 1991

1990

Rose, D.R., Cygler, M., To, R.J., Przybylska, M., Sinnott, B., and Bundle, D.R. Preliminary crystal structure determination of an Fab specific for a Salmonella O-polysaccharide antigen. 
J. Mol. Biol., 215, 489-492, 1990
Meikle, P.J., Young, N.M., and Bundle, D.R.  O-antigen biotin conjugates:  Preparation and use in direct competitive enzyme immunoassays.
J. Immunol. Meth., 132, 255-261, 1990
Meikle, P.J., and Bundle, D.R.  Preparation of polysaccharide enzyme conjugates for competitive binding assays. 
Glycoconjugate J., 7, 207-218, 1990
Vorberg, E., and Bundle, D.R.  Carbohydrate-enzyme conjugates for competitive EIA.
J. Immunol. Meth
., 132, 81-89, 1990
Beynon, L.M., Bundle, D.R., and Perry, M.B.  The structure of the antigenic lipopolysaccharide O-chain produced by Escherichia hermanii ATCC 33650 and 33652. 
Can. J. Chem
., 68, 1456-1466, 1990
Anand, N.N., Dubuc, G., Mandal, S., Phipps, J., Gidney, M.A.J., Sinnott, B., Young, N.M., MacKenzie, C.R., Bundle, D.R., and Narang, S.A.  Synthesis and expression in Escherichia coli of DNA encoding the murine l1 chain of a monoclonal antibody specific for Salmonella serotype B O-antigen. 
Protein Engineering, 3, 541-546, 1990
Kihlberg, J.O., Leigh, D.A., and Bundle, D.R.  The in situ activation of thioglycosides with bromine:  An improved glycosylation method. 
J. Org. Chem
., 55, 2860-2863, 1990
Peters, T., Brisson, J.-R., and Bundle, D.R.  Conformational analysis of key disaccharide components of Brucella A and M antigens. 
Can. J. Chem
., 68, 979-988, 1990
Perry, M.B., and Bundle, D.R.  Antigenic relationships in the lipopolysaccharides of strains of Escherichia hermannii with Escherichia coli 0157:H7, Brucella melitensis and Brucella abortus
Infect. Immun
. 58, 1391-1395, 1990
Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R.  Synthesis and 2D-n.m.r. analysis of a pentasaccharide glycoside of the biological repeating units of Shigella flexneri variant Y polysaccharide and the preparation of a synthetic antigen.
Carbohydr. Res
., 196, 156-166, 1990
Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R.  Oligosaccharides corresponding to biological repeating units of Shigella flexneri variant Y polysaccharide:  Part III.  Synthesis and 2D NMR analysis of a heptasaccharide hapten. 
J. Chem. Soc. Perkin I, 293-299, 1990

1989

Meikle, P.J., Perry, M.B., Cherwonogrodzky, J.W., and Bundle, D.R.  Fine structure of A and M antigens from Brucella biovars. 
Infect. Immun., 57, 2820-2828, 1989
Bundle, D.R., Cherwonogrodzky, J.W., Gidney, M.A.J., Meikle, P.J., Perry, M.B., and Peters, T.  Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides. 
Infect. Immun., 57, 2829-2836, 1989
Nielsen, K., Cherwonogrodzky, J.W., Duncan, J.R., and Bundle, D.R.  Enzyme-linked immunosorbent assay for differentiation of the antibody response of cattle naturally infected with Brucella abortus or vaccinated with strain 19. 
Am. J. Vet. Res., 50, 5-9, 1989
Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R.  Oligosaccharides corresponding to biological repeating units of Shigella flexneri variant Y polysaccharide.  Synthesis and two-dimensional NMR analysis of a hexasaccharide hapten. 
J. Org. Chem., 54, 2650-2656, 1989
Peters, T., and Bundle, D.R.  Block synthesis of two pentasaccharide determinants of the Brucella M antigen using thioglycoside methodologies.
Can. J. Chem., 67, 497-502, 1989
Peters, T., and Bundle. D.R.  Synthetic antigenic determinants of the Brucella A polysaccharide; a disaccharide thioglycoside for block synthesis of pentasaccharide and lower homologues of a1,2-linked 4,6-dideoxy-4-formamido-a-D-mannose.
Can. J. Chem
., 67, 491-496, 1989
Bundle, D.R.  Antibody combining sites and oligosaccharide determinants studied by competitive binding, sequencing and X-ray crystallography. 
Pure and Applied Chem., 61, 1171-1180, 1989

1988

Zygmunt, M.S., Dubray, G., Bundle, D.R., and Perry, M.B.  Purified native haptens of Brucella abortus B19 and B. melitensis 16 M reveal the lipopolysaccharide origin of the antigens. 
Ann. Inst. Pasteur/Microbiol., 139, 421-433, 1988
Kulakowska, M., Lugowski, C., Romanowska, E., and Bundle, D.R.  The comparison of monoclonal-antibodies specific for 2 general epitopes located on citrobacter-036 lipopolysaccharide. 
Carbohydr. Res
., 178, 233-241, 1988
Perry, M.B., Bundle, D.R., Gidney, M. A.J., and Lior, H.  Identification of Escherichia coli serotype 0157 strains by using monoconal antibody. 
J. Clin. Microbiol., 26, 2391-2394, 1988
Todd, E.C.D., Szabo, R.A., Peterkin, P., Sharpe, A.N, Parrington, L., Bundle, D.R., Gidney, M.A.J., and Perry, M.B.  Rapid hydrophobic grid membrane filter -enzyme labeled antibody procedure for identification and enumeration of Escherichia coli 0157 in foods. 
Applied and Environmental Microbiology, 54, 2536-2540, 1988
Kramer, J.K.G., Sauer, F.D., and Bundle, D.R.  The presence of tightly bound Na+ or K+ in glycolipids in Methanobacterium thermoautotrophicum
Biochim.  Biophys. Acta., 961, 285-292, 1988
Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B.  Characterization of Brucella polysaccharide B.  
Infect. Immun
., 56, 1101-1106, 1988
Bundle, D.R., Gerken, M., and Peters, T.  Synthesis of antigenic determinants of the Brucella A antigen utilizing methyl 4-azido-4,6-dideoxy-a-D-mannopyranoside efficiently derived from D-mannose. 
Carbohydr. Res., 174, 239-251, 1988

1987

Peters, T., and Bundle, D.R.  Synthesis of 4,6-dideoxy-4-formamido-a-D- mannose containing tri- tetra- and pentasaccharides, antigenic determinants of the Brucella A and M antigens.  
J. Chem. Soc. Chem. Comm
., 1648-1650, 1987
Gerken, M., and Bundle, D.R.  Synthesis of immunologically active oligosaccharide determinants of the Brucella A antigen:  utilization of intermediates derived from methyl 4-azido-4,6-dideoxy-a-D-mannopyranoside.
Tet. Lett
., 28, 5067-5070, 1987
Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B.   Structural elucidation of the Brucella melitensis M antigen by high resolution NMR at 500 MHz. 
Biochemistry, 26, 8717-8726, 1987
Di Fabio, J.L., Perry, M.B., and Bundle, D.R.  Analysis of the lipopolysaccharide of Pseudomonas maltophilia 555. 
Biochem. Cell. Biol
., 65, 968-977, 1987
Altman, E., Brisson, J.-R., Bundle, D.R., and Perry, M.B.   Structural studies of the O-chain of the phenol-phase soluble lipopolysaccharide from Haemophilus pleuropneumoniae serotype 2. 
Biochem. Cell Biol., 65, 876-889, 1987
Cherwonogrodzky, J.W., Perry, M.B., and Bundle, D.R.  Identification of the A and M antigens of Brucella as the O-polysaccharides of smooth lipopolysaccharides.
Can. J. Microbiol
., 33, 979-981, 1987
Carlin, N.I.A., Bundle, D.R., and Lindberg, A.A.  Characterization of five Shigella flexneri variant Y - specific monoclonal antibodies using defined saccharides and glycoconjugate antigens. 
J. Immunol
., 138, 4419-4427, 1987
Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B.  The structure of the lipopolysaccharide O-chain (M antigen) and polysaccharide B produced by Brucella melitensis 16M. 
FEBS Letters
, 216, 261-264, 1987
Sugden, E.A., Samagh, B.S., Bundle, D.R., and Duncan, J.R.  Lipoarabinomannan and lipid-free arabinomannan antigens of Mycobacterium paratuberculosis
Infect. Immun
.. 55, 762-770, 1987
Bundle, D.R., Cherwonogrodzky, J.W., Caroff, M., and Perry, M.B.  The lipopolysaccharides of Brucella abortus and B. melitensis
Ann. Inst. Pasteur/Microbiol
., 138,  92-98, 19
Pinto, B.M., Morrisette, D.G., and Bundle, D.R.  Synthesis of oligosaccharides corresponding to biological repeating units of Shigella flexneri Y polysaccharide. Part 1.  Overall strategy, synthesis of a key trisaccharide intermediate, and synthesis of a pentasaccharide. 
J. Chem. Soc. Perkin I, 9-14, 1987

1986

Carlin, N.I.A., Gidney, M.A.J., Lindberg, A.A., and Bundle, D.R.  Characterization of Shigella flexneri specific murine monoclonal antibodies by chemically defined glycoconjugates. 
J. Immunol., 137, 2361-2366, 1986
Perry, M.B., Bundle, D.R., MacLean, L., Perry, J.A., and Griffith, D.W.  The structure of the antigenic lipopolysaccharide O-chains produced by Salmonella urbana and Salmonella godesberg
Carbohydr. Res., 156, 107-122, 1986
Bundle, D.R., Gerken, M., and Perry, M.B.  Two dimensional NMR at 500 MHz:  The structural elucidation of a Salmonella serogroup N polysaccharide antigen. 
Can. J. Chem
., 64, 255-264, 1986

1985

Lemieux, R.U., Venot, A.P., Spohr, U., Bird, P., Mandal, G., Morishima, N., Hindsgaul, O., and Bundle, D.R.  Molecular recognition. V.  The binding of the B human blood group determinant by hybridoma monoclonal antibodies. 
Can. J. Chem
., 63, 2664-2668, 1985
Emmrich, F., Bundle, D.R., van der Zee, J., Out, T., Zenke, G., and Eichmann, K.  Two human IgM myeloma proteins with unusual specificities for streptococcal carbohydrate-associated epitopes. 
Scand. J. Immunol
., 21, 119-126, 1985
Wessel, H.P., and Bundle, D.R.  Strategies for the synthesis of branched oligosaccharides of the Shigella flexneri 5a, 5b and variant X serogroups employing a multifunctional rhamnose precursor. 
J. Chem. Soc., Perkin I, 2251-2260, 1985
Wessel, H.P., Iversen, T., and Bundle, D.R.  Acid-catalyzed benzylation and allylation by alkyl trichloroacetimidates. 
J. Chem. Soc., Perkin I, 2247-2250, 1985
Gidney, M.A.J., Bundle, D.R., Godard, A., and Griffiths, B.W.  Development and characterization of monoclonal antibodies to pregnancy-specific b1-glycoprotein.
Can. J. Biochem., 63, 737-742, 1985
Birnbaum, G.I., and Bundle, D.R.  Conformation of methyl 3,6-dideoxy-a-D-arabino-hexopyranoside, the immunodominant sugar of Salmonella serogroup D1: Crystal structure, 1H NMR analysis and semi-empirical calculations. 
Can. J. Chem
., 63, 739-744, 1985

1984

Pinto, B.M., and Bundle, D.R.  Antigenic determinant of Salmonella serogroup B. Synthesis of a trisaccharide glycoside for use as an artificial antigen. 
Carbohydr. Res
., 133, 333-338, 1984
Bundle, D.R., Gidney, M.A.J., Perry, M.B., Duncan, J.R., and Cherwonogrodzky, J.W. Serological confirmation of Brucella abortus and Yersinia enterocolitica O:9 O-antigens by monoclonal antibodies. 
Infect. Immun
., 46, 389-393, 1984
Caroff, M., Bundle, D.R., Perry, M.B., Cherwonogrodsky, J.W., and Duncan, J.R. Antigenic S-type lipopolysaccharide of Brucella abortus 1119-3. 
Infect. Immun., 46, 384-388, 1984
Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Pinto, B.M., Garegg, P.J., Kvanström, I., Norberg, T., Lindberg, A.A., and Svenson, S.B.  The conformation of Salmonella O-antigenic oligosaccharides of serogroups A, B and D1 inferred from 1H and 13C nuclear magnetic resonance spectroscopy. 
Carbohydr. Res
., 130, 35-53, 1984
Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Garegg, P.J., Norberg, T., Lindberg, A.A., and Svenson, S.B.  The conformation of Salmonella O-antigenic polysaccharide chains of serogroups A, B and D1 predicted by semi-empirical hard sphere (HSEA) calculations.
Carbohydr. Res
., 130, 23-34, 1984
Carlin, N. I. A., Lindberg, A. A., Bock, K., and Bundle, D. R.  The Shigella flexneri  O-antigenic polysaccharide chain:  Nature of the biological repeating unit. 
Eur. J. Biochem., 139, 189-194, 1984
Shearman, P.J., Bundle, D.R., Romanowska, E., Lugowski, C., and Bogulska, M. Characterization of anti-Citrobacter 036-specific polysaccharide monoclonal antibodies. 
Can. J. Microbiol., 30, 91-97, 1984
Caroff, M., Bundle, D. R., and Perry, M. B.  Structure of the O-chain of the phenol-phase soluble cellular lipopolysaccharide of Yersinia enterocolitica serotype O:9. 
Eur. J. Biochem., 139, 195-200, 1984
Wessel, H.P., Iversen, T., and Bundle, D.R.  Synthesis of the trisaccharide moiety of gangliotriosylceramide, Asialo GM2. 
Carbohydr. Res., 130, 5-21, 1984

1983

Wessel, H.P., and Bundle, D.R.  Artificial carbohydrate antigens:  A block synthesis of a linear tetrasaccharide repeating unit of the Shigella flexneri variant Y polysaccharide.
Carbohydr. Res
., 124, 301-311, 1983
Pinto, B.M., and Bundle, D.R.  Preparation of glycoconjugates for use as artificial antigens: A simplified procedure. 
Carbohydr. Res
., 124, 313-318, 1983
Kenne, L., Lindberg, B., Soderholm, E., Bundle, D.R., and Griffith, D.W.  Structural studies of the O-antigens from Salmonella greenside and Salmonella adelaide.
Carbohydr. Res., 111, 289-296, 1983
Bhattacharjee, A.K., Bennett, J.E., Bundle, D.R., and Glaudemans, C.P.J. Anticryptococcal type D antibodies raised in rabbits. 
Mol. Immunol., 20, 351-359, 1983

1982

Bundle, D.R., Gidney, M.A.J., Kassam, N., and Rahman, A.F.R.  Hybridomas specific for carbohydrates; synthetic human blood-group antigens for the production, selection and characterization of monoclonal typing reagents. 
J. Immunol., 129, 678-682, 1982
Neurohr, K.J., Bundle, D.R., Young, N.M., and Mantsch, H.H.  Binding of disaccharides by peanut agglutinin as studied by ultraviolet difference spectroscopy.
Eur. J. Biochem., 123, 305-310, 1982
Iversen, T., and Bundle, D.R.  Synthesis of the colitose determinant of Escherichia coli 0111 and 3,6-di-O-(a-D-galactopyranosyl)-a-D-glucopyranoside. 
Can. J. Chem., 60, 299-303, 1982
Iversen, T., and Bundle, D.R.  Antigenic Determinants of Salmonella A and D1 synthesis of trisaccharide glycosides for use as artificial antigens. 
Carbohydr. Res., 103, 29-40, 1982
Bock, K., Josephson, S., and Bundle, D.R.  Lipopolysaccharide solution conformation: Antigen shape inferred from high resolution 1H and 13C nuclear magnetic resonance spectroscopy and hard-sphere calculations.  
J. Chem. Soc., Perkin
II, 59-70, 1982
Perry, M.B., Bundle, D.R. Daoust, V., and Carlo D.J.   The specific capsular polysaccharide of Streptococcus pneumoniae type 15F. 
Mol. Immunol., 19, 235-246, 1982
Neurohr, K.J., Mantsch, H.H., Young, N.M., and Bundle, D.R.  Carbon-13 nuclear magnetic resonance studies on lectin-carbohydrate interactions:  Binding of specifically 13C-labeled methyl b-D-lactoside to peanut agglutinin.
Biochemistry, 21, 498-503, 1982

1981

Iversen, T., and Bundle. D.R.  A direct and efficient synthesis of β-L-rhamnopyranosides.
J. Org. Chem
., 46, 5389-5393, 1981
Iversen, T., and Bundle, D.R.  Benzyl trichloroacetimidate, a versatile reagent for acid-catalyzed benzylation of hydroxy-groups. 
Chem. Comm
., 1240-1241, 1981
Iversen, T., Josephson, S., and Bundle, D.R.  The synthesis of streptococcal groups A, C and variant-A antigenic determinants. 
J. Chem. Soc, Perkin I. 2379-2385, 1981

1980

Bundle, D.R., and Josephson, S.  Chlorosulphation of amino sugars:  Synthesis of methyl 2-acetamido-4-amino-2,4,6-trideoxy-b-D-glucopyranoside (bacillosamine) from a D-glucosamine derivative. 
Can. J. Chem., 58, 2679-2685, 1980
Iversen, T., and Bundle, D.R.  A new and efficient synthesis of β-L-rhamnopyranosides.
Carbohydr. Res
., 84, C13-C15, 1980
Josephson, S., and Bundle, D.R.  Artificial carbohydrate antigens:  The synthesis of rhamnose trisaccharide and disaccharide haptens common to Shigella flexneri O-antigens. 
J. Chem. Soc., Perkin I. 297-301, 1980
Bundle, D.R., and Josephson, S.  Artificial carbohydrate antigens:  The synthesis of tetra-saccharide hapten, a Shigella flexneri O-antigen repeating unit.
Carbohydr. Res., 80, 75-85, 1980

1979

Josephson, S., and Bundle, D.R.  Artificial carbohydrate antigens:  The synthesis of the tetrasaccharide repeating unit of Shigella flexneri O-antigen. 
Can. J. Chem., 57, 3073-3079, 1979
Unemura, J., Birnbaum, G.I., Bundle, D.R., Murphy, W.F., Bernstein, H.J., and Mantsch, H.H.  The correlation between O-H stretching frequencies and hydrogen bond distances in a crystalline sugar monohydrate. 
Can. J. Chem
., 57, 2640-2645, 1979
Banoub, J., and Bundle, D.R.  1,2-orthoacetate intermediates in silver trifluoro-methanesulphonate promoted Koenigs-Knorr synthesis of disaccharide glycosides. 
Can. J. Chem
., 57, 2091-2097, 1979
Banoub, J., and Bundle, D.R.  Stannic tetrachloride catalyzed glycosylation of 8-ethoxy-carbonyloctanol by cellobiose, lactose and maltose octaacetates; synthesis of a and b glycosidic linkages.
Can. J. Chem
., 57,  2085-2090, 1979
Bundle, D.R.  Antibody to an artificial disaccharide antigen cross-reactive with Neisseria gonorrhoeae lipopolysaccharide. 
Can. J. Biochem., 57, 367-371, 1979
Bundle, D.R.  Displacement of sugar chlorosulphates by bromide, azide and acetate; a facile synthesis of methyl, 3,6-dideoxy-b-D-ribo-hexopyranoside
J. Chem. Soc., Perkin
I, 2751-2755, 1979
Bundle, D.R., and Josephson, S.  Artificial carbohydrate antigens:  The synthesis and conformation of a Shigella flexneri trisaccharide hapten. 
J. Chem. Soc., Perkin I, 2736-2739, 1979
Bundle, D.R., and Josephson, S.  Artificial carbohydrate antigen: Synthesis of rhamnose disaccharides common to Shigella flexneri O-antigen determinants. 
Can. J. Chem., 57, 662-668, 1979
Birnbaum, G.I., and Bundle, D.R.  Solution conformation and crystal structure of methyl 3,6-dideoxy-b-D-ribo-hexopyranoside, an immunodominant sugar of O-antigens.
Biochim. Biophys. Acta, 582, 515-524, 1979

1978

Bundle, D.R., and Josephson, S.  A facile synthesis of methyl 3,6-dideoxy-L-xylo-hexopyranoside (colitose). 
Can. J. Chem.
, 56, 2686-2690, 1978
    Lemieux, R.U., Boullanger, P.A., Bundle, D.R., Baker, D.A., and Venot, A.  Binding studies of b-D-galactopyranosyl antibodies. Intramolecular hydrogen bonding effects.
    Nouveau. J. Chimie, 2, 321-329, 1978

1972 - 1977

Jennings, H.J., Bhattacharjee, A.K., Bundle, D.R., Kenny, C.P., Martin, A., and Smith, I.C.P.  Structures of the capsular polysaccharides of Neisseria meningitidis as determined by C-13 nuclear magnetic resonance spectroscopy. 
J. Infectious Diseases, 136, S78-S83, 1977
Lemieux, R.U., Baker, D.A., and Bundle, D.R.  A methodology for the production of carbohydrate-specific antibody. 
Can. J. Biochem., 55, 507-512, 1977
Lemieux, R.U., Bundle, D.R., and Baker, D.A.  The properties of a synthetic antigen related to the human blood group Lewis-a. 
J. Am. Chem. Soc., 97, 4076-4083, 1975
Bundle, D.R., and Jennings, H.J.  The synthesis of 2-acetamido-2-deoxy-a-D-glucopyranose 4-phosphate. 
Can. J. Biochem., 52, 723-725, 1974
Bundle, D.R., Jennings, H.J., and Kenny, C.P.  Studies on the group-specific polysaccharide of Neisseria meningitidis serogroup X and an improved procedure for its isolation.
J. Biol. Chem., 249, 4797-4801, 1974
Bundle, D.R., Smith I.C.P., and Jennings, H.J.  Determination of the structure and conformation of bacterial polysaccharides by carbon-13 nuclear magnetic resonance.
J. Biol. Chem
., 249, 2275-2281, 1974
Bundle, D.R., Jennings, H.J., and Smith, I.C.P.  The carbon-13 nuclear magnetic resonance spectra of 2-acetamido-2-deoxy-D-hexoses and some specifically deuterated, O-acetylated, and phosphorylated derivatives. 
Can. J. Chem
., 51, 3812-3819, 1973
Bundle, D.R., Jennings, H.J., and Kenny, C.P.  An improved procedure for the isolation of meningococcal, polysaccharide antigens, and the structural determination of the antigen from serogroup X. 
Carbohydr. Res
., 26, 268-270, 1973
Bundle, D.R., and Shaw, N.  Synthesis of 2-acetamido-6-O-(2-acetamido-2-deoxy-ß-D-glucopyranosyl)-2-deoxy-D-glucopyranose. 
Carbohydr. Res., 21, 211-217, 1972

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Reviews and Book Chapters
Bundle, D.R. Costello, C., Nycholat, C., Lipinski, T., and Rennie, R. “Designing a Candida albicans Conjugate Vaccine by Reverse Engineering Protective Monoclonal Antibodies” in Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application, edited by P. Kosma and S. Muller-Loennies Springer, pp 121-146, January 2012.  
Ling, C.-C. and Bundle, D.R. Eliciting carbohydrate-specific immune response against sialosides: success and challenges. Future Medicinal Chemistry 3, 519-534, 2011.  
Bundle, D.R. “New frontiers in the Chemistry of Glycoconjugate Vaccines,” in Vaccine Design: Innovative Approaches and Novel Strategies, edited by F. Bagnoli  and R. Rappuoli, Caister Academic Press, pp 69-107, February 2011.  
Kitov, P.I. and Bundle, D.R. "Thermodynamic models of multivalency effect," in
Carbohydrate-based Drug  Discovery, edited by Chi-Huey Wong Wiley-VCH Weinheim, Germany Carbohydrate-based Drug Discovery, Vol. 2, 541-574, 2003
 
Kitov, P.I., Paszkiewicz, E., Wakarchuk, W.W. and Bundle, D.R.“Preparative scale chemo-enzymatic synthesis of large carbohydrate assemblies using a(1-4)-galactosyltransferase/UDP-4-gal-epimerase fusion protein”.
Methods in Enzymology (Academic Press), 362, 86-105, 2003
 
Nitz, M. and Bundle, D.R. “The unique solution structure and immunochemistry of the Candida albicans b1,2-mannopyranan cell wall antigen,” in
NMR of Glyco-Conjugates Edited by: J. Jimenez-Barbero, T. Peters, Wilet-VCHVerlag, Weinheim, Germany, pp. 145-187, October 2002
 
Nitz, M. and Bundle, D.R.  “The Historical and Contemporary Role of Glycosyl Halides in Oligosaccharide Synthesis,” in
Glycoscience: Chemistry and Chemical Biology.  Edited by: B. Fraser-Reid, K. Tatsuta, J. Thiem, Springer–Verlag, Heidelberg, Germany. pp. 1498-1542, July 2001
 
Feizi, T. and Bundle, D. “The coming of age for oligosaccharide ligands and databases for saccharide structures.”
[Review] [14 refs]. Current Opinion in Structural Biology. 6, 659-62; 1996 Oct
 
McVay, C., Ellis, L., Bundle, D. and Appleton, J.A.  "Structural Analysis of TSL-1 Glycans of Trichinella spiralis". 
Proceedings of the Ninth International Conference on Trichinellosis, Mexico City,  Edited by G. Otega-Pierres, R. Gamble, F. van Knapen and D. Wakelin.  pp: 205-210, August 1996
 
"Recognition of carbohydrate antigens by antibody binding sites " in
Carbohydrates edited by S. Hecht, Oxford University Press Inc., Oxford, pp. 370-440, 1998
 
"Antibody-Oligosaccharide Interactions Determined by Crystallography" in
Glycosciences: Status and Perspectives edited by H.-J. Gabius and S. Gabius,  Chapman and Hall, Weinheim, Germany. pp. 311-331, 1997
 
Bundle, D.R. and Feizi, T. editors of multi-author review "Carbohydrates and Glycoconjugates" in
Current Opinion in Structural Biology, 6, 659-720, 1996
 
Bundle, D.R. “The Recognition of Carbohydrate Antigens by Antibody at Atomic Resolution” in
Carbohydrates in Europe, pp. 22-30, 1994
 
Altman, E., and Bundle, D.R.  “Polysaccharide Affinity Columns for Purification of Lipopolysaccharide-Specific Murine Monoclonal Antibodies”.
Meth. Enzymol., 247, 243-253, 1994
 
Bundle, D.R., and Sigurskjold, B.W.  “Determination of Accurate Thermodynamics of Binding by Titration Microcalorimetry”.
Meth. Enzymol., 247, 288-305, 1994
 
Bundle, D.R. and Feizi, T. editors of multi-author review "Carbohydrates and Glycoconjugates" in
Current Opinion in Structural Biology, 4, 673-728, 1994
 
Bundle, D.R. “Carbohydrate Antigens” in
Molecular Biology and Biotechnology A Comprehensive Desk Reference edited by R.A. Meyers, VCH Publishers Inc., pp. 141-146, 1995
 
Bundle, D.R., Altman, E., Auzanneau, F.-I., Baumann, H., Eichler, E., and Sigurskjold, B.W.  “The structure of oligosaccharide-antibody complexes and improved inhibitors of carbohydrate-protein binding”  in
Complex Carbohydrates in Drug Research, Alfred Benzon Symposium No. 36, eds K. Bock and H. Clausen, Munksgaard, Copenhagen,  1994
 
Cygler, M., Wu, S., Zdanov, A., Bundle, D.R., and Rose, D.R.  “Recognition of a carbohydrate antigenic determinant of Salmonella by an antibody”.
Biochemical Society Transactions, 21, 437-441, 1993
 
Bundle D.R. and Young, N.M. “Carbohydrate-protein interactions in antibodies and lectins” in
Current Opinion in Structural Biology, 2, pp: 666-673, 1992
 
Ashton, F.E., Michon, F., Bundle, D.R., Gidney, M.A.J., Gamian, A. and Jennings, H.J.  “Immunological properties of monoclonal antibodies to the N-propionyl derivative of group B meningococcal polysaccharide”
(Achtman, M., Kohl, P., Marchal, C., Morelli, G., Seiler, A., Thiesen, B., eds.), Neisseria 1990.  Proc. of the Seventh Int. Pathogenic Neisseria Conference, Berlin, Germany, September 9-14, 1990.  Walter de Gruyter, pgs. 187-191, 1991
 
Perry, M.B., and Bundle, D.R.  “Lipopolysaccharide antigens and carbohydrates of Brucella”  in
Advances in Brucellosis Research (Adams, L.G., ed.), Texas A and M Univ. Press), pp. 76-88, 1990
 
Bundle, D.R.  “Synthesis of oligosaccharides related to bacterial O-antigens”. 
Topics in Current Chemistry, Springer Verlag, Heidelberg 154, 1-37, 1990
 
Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B.  “Monoclonal antibodies in the identification and characterization of Brucella species” in
Nucleic Acid and Monoclonal Antibody Probes:  Applications in Diagnostic Microbiology, (Prakash, G., and Swaminathan, B., eds.), Marcel Dekker, New York, pp. 581-597, 1989
 
Bundle, D.R.  “Structural analysis by high resolution 1H and 13C nuclear magnetic resonance spectroscopy”.  In
Bacterial Cell Surface Techniques (Hancock, I., and Poxton, I., eds.), John Wiley and Sons, pp. 146-158, 1988
 
Bundle, D.R. “Monoclonal antibodies to bacterial O-antigens in combination with synthetic glycoconjugates for mapping the combining site”. 
Protein-Carbohydrate Interactions in Biological Systems.  Academic Press, pp. 165-171, 1986
 
Bundle, D.R., and Perry, M.B.  “Structure and serology of the Brucella abortus O-antigen”.
Biochemical Society Transactions, 13, 980-982, 1985
 
Bundle, D.R., Gidney, M.A.J., Josephson, S., and Wessel, H.-P. “ Synthesis of Shigella flexneri O-antigen repeating units: Conformational probes  and aids to monoclonal  antibody production” in
American Chem. Soc. 83, pp. 49-63 , 1983
 
Bundle, D.R., Iversen, T., and Josephson, S.  “Preparative medium and high pressure chromatography”. 
American Laboratory
. 93-98, 1980
 
Pazur, J.H., Dreher, K.L., and Bundle, D.R. “Interaction of glycosyl immunogens with immunocyte receptor sites in the synthesis of anti-glycosyl” edited by Goldstein I.J., in
ACS Symposium Series, 88, pp.102-115, 1979
 
Bundle, D.R., and Lemieux, R.U.  “Determination of anomeric configuration by NMR”.
Methods in Carbohydr. Chem., 7, 79-86, 1976
 

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Invited Lectures
1985 - 2013

Targetted Delivery of Conjugate Vaccines to Dendritc Cells
ACS Symposium, New Orleans, April 2013

New Approaches to Carbohydrate Vaccines
Department of Pediatrics, Louisiana State University Health Sciences Center, April 2013

New Approaches to Carbohydrate Vaccines
Free University of Berlin, November 2012

New Approaches to Carbohydrate Vaccines
Haworth Memorial Lecture, University of Birmingham, UK, November 2012

Supramolecular heterobifunctional ligand-protein complexes: a strategy for enhancing drug efficacy
University of Luebeck, Germany, September 2009

A Candida albicans Conjugate Vaccine.
Society for General Microbiology, UK- Autumn 2009 Meeting – Heriot-Watt University, Edinburgh, September 2009

Supramolecular heterobifunctional ligand-protein complexes: a strategy for enhancing drug efficacy
Gordon Research Conference (Carbohydrates) – Tilton School, New Hampshire, June 2009

A Candida albicans Conjugate Vaccine                                                                                      
Claude S. Hudson Award Symposium, American Chemical Society, Salt Lake City, Utah, March 2009

Mapping the Protective Epitope of the β1,2-Mannan from Candida albicansand the Prospects for a Conjugate Vaccine
Institute for Biological Science, National Research Council, Ottawa, October 2008

Neutralizing Shiga toxin by ligand induced in vivo protein dimerization
Ontario Cancer Institute, University of Toronto, June 2008

Mapping the Protective Epitope of the β1,2-Mannan from Candida albicans and the Prospects for a Conjugate Vaccine
Canadian Society for Chemistry Symposium: Carbohydrate Chemistry and Glycobiology, May 2008

Unprecedented in vitro Activity and in vivo Efficacy of Pre‑ordered Polymeric Heterobifunctional Ligands
Canadian Society for Chemistry Symposium: Chemical Biology; Molecular Probes and Organic Biomaterials, May 2008

Supramolecular heterobifunctional ligand-protein complexes: a strategy for enhancing drug efficacy
Lectures in Biochemistry Seminar, University of Alberta, May 2008

Supramolecular heterobifunctional ligand-protein complexes: a strategy for enhancing drug efficacy
NIH workshop: Future Directions of Multivalent Agents in Therapeutic Development, May 2008

Supramolecular and Multivalent Effects: A Novel Approach to High Avidity Neutralization of Bacterial Toxins
Alberta Ingenuity Accelerator in Nanotechnology: Health & Medical Technologies, May 2008

Unprecedented in vitro Activity and in vivo Efficacy of Pre‑ordered Polymeric Heterobifunctional Ligands
Glycobiology 2008, Society for Glycobiology, Boston, November 2007

Supramolecular and Multivalent Effects: A Novel Approach to High Avidity Ligands for Bacterial Toxins
Royal Society of Chemistry, Carbohydrate Group: Glycoarrays: Synthesis and Applications, University of Manchester, UK, October 2007

The Prospects for a Synthetic Conjugate Vaccine Against Candida albicans
Department of Chemistry, University of Toledo, September 2007

Synthesis and mapping of the protective epitope contained in di- and trisaccharide analogs of the (1®2)-β-mannan from Candida albicans
Carbohydrate Moieties as Vaccine Candidates, NIH, Bethesda, September 2007

Heterobivalent ligands: examples of the utility of ligand induced protein aggregation
Department of Chemistry Simon Fraser University, BC, January 2007

Synthetic and chemo-enzymatic strategies to create ganglioside and other glycoconjugate vaccines
Novartis Vaccines & Diagnostics Siena, Italy, December 2006

Exploiting Oligovalent Interactions with Low Molecular Weight Ligands
Pharmacenter, University of Basel, Switzerland, July 2006

Synthesis and Application of Oligosaccharide Conjugate Vaccines
Laboratorium für Organische Chemie, ETH-Hönggerberg, Zürich, Switzerland, July 2006

Exploiting Oligovalent Interactions with Low Molecular Weight Ligands
Carlsberg Laboratory, Copenhagen, Denmark, June 2006

Synthesis and Application of Oligosaccharide Conjugate Vaccines
CERMAV-CNRS, Universitaire Grenoble, June 2006

The Prospects for a Conjugate Vaccine Against Candida albicans
Institute of Chemistry, University of Lübeck, Germany, February 2006

Ligand promoted protein dimerization
Mc Gill University, Montreal, Quebec, February 2006

Design of multivalent carbohydrate inhibitors for microbial toxin Half a Century at the Carbohydrate-Protein Interface: An International Symposium
to Celebrate the Eightieth Birthday of Professor Nathan Sharon, Weizmann Institute of Science, Israel, November 2005

New Approaches to Conjugate Vaccines that Utilize Short Oligosaccharide Epitopes
Gordon Research Conference on Carbohydrate Chemistry, Tilton School, NH, June 2005

Structure and Mechanism of Specific Aggregation of Serum Amyloid P Component by a Novel Series of Bivalent Ligands
American Chemical Society, San Diego California, March 2005

Prospects for an Oligosaccharide Conjugate Vaccine for Candida albicans
American Chemical Society, San Diego California, March 2005

Oligosaccharide Vaccines: Making Carbohydrates Presentable
Kaplan Award, University of Alberta, Edmonton, March 2005

Multivalent Ligands and Oligomeric Proteins
Alnylam Pharmaceuticals, Cambridge, MA, USA, January 2005

Synthetic Glycoconjugate Vaccines: Prospects for a Candida albicans vaccine
Harvard Medical School - Department of Microbiology and Molecular Genetics, Boston, USA, January 2005

Prospects for a C. albicans  vaccine: a uniquely small and protective carbohydrate epitope
NIH meeting, Bethesda, Maryland, USA, October 2004

Serendipity in Synthesis and Conformational Analysis Creates a Potential Vaccine against Candida albicans
Queens University, Kingston, Ontario, September 2004

Prospects for an Oligosaccharide Conjugate Vaccine for Candida albicans
Carlsberg Institute, Copenhagen, Denmark, June 2004

Prospects for a Candida albicans Vaccine
FASEB Summer Research Conferences, Tuscon, Arizona, USA, June 2004

Oligosaccharide Conjugate Vaccines
University of Calgary, Department of Chemistry, February 2004

Immunogenicity of carbohydrate antigens and their recognition by the immune system
Seventh International Xenotransplantation Congress, Glasgow, UK, August 2003

A Thermodynamic Theory to Account for Multivalency Effects Observed with Radially Symmetric Multi-Subunit Proteins                                                     
39th IUPAC Congress, Ottawa, August 2003

The chemical biology of the carbohydrates and the importance of glycopeptides in glycobiology 
Department of Chemistry, University of Umea, Sweden, May 2003

Empirical observations and theoretical explanations of multivalency effects
Department of Chemistry, University of Umea, Sweden, May 2003

Empirical observations and theoretical explanations of multivalency effects
Hofmann La Roche, Basel, Switzerland, May 2003

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands for Shiga-like toxins
Defense Science and Technology Laboratories, Ministry of Defense, Porton Down, UK, May 2003

Empirical Observations and Theoretical Explanations of Multivalency Effects
The University of Georgia - Complex Carbohydrate Research Centre, Athens, Georgia, USA, March 2003
A New Class of Therapeutics: Starfsh neutralizes E.coli Toxin
Alberta Teachers Association – Science Council Conference, Banff, Alberta, November 2002

The search for high avidity ligands: Constrained univalent oligosaccharides and radially arranged multivalent oligosaccharides
XXI Int’l Carbohydrate Symposium, Cairns, Australia, July 2002

Trichinella spiralis glycan and the topology of the antigen surface recognized by protective antibody
Canadian Society for Chemistry Awards Lecture, Vancouver, BC, June 2002

The design, synthesis and mode of action of multivalent carbohydrate ligands that neutralize Shiga-like toxins
University of Wisconsin-Madison, USA, December 2001

STARFISH takes the sting out of Shiga toxin
2nd  International Symposium on Conformational Control of Biomolecular Function, VW-Foundation Meeting, Lübeck, Germany, October 2001

STARFISH takes the sting out of Shiga toxin
2001 American Society for Nephrology World Congress, San Francisco, USA, October 2001

Structural basis for neutralization of Shiga-like toxins by synthetic multivalent carbohydrate ligands
16th International Glycoconjugate Symposium, The Hague, Netherlands, August 2001

Structural basis for neutralization of Shiga-like toxins by synthetic multivalent carbohydrate ligands
Natural Products Gordon Conference, Tilton, USA, July 2001

Tailored Mutivalent Carbohydrate Ligands that Neutralize Shiga-like Toxins
Canadian Society for Chemistry, Montreal, Quebec, May 2001
Strafish takes the sting out of Shiga toxins: design, synthesis and mode of action of tailored multivalent carbohydrate ligands
Glycobiology Gordon Conference, Ventura, California, USA, March 2001

Structural basis for neutralization of Shiga-like toxins by synthetic multivalent carbohydrate
Scripps Research Institute, La Jolla, California, USA, February 2001

Multivalent Carbohydrate Ligands that Neutralize Shiga-like Toxin
University of Guelph, November 2000
Multivalent Carbohydrate Ligands that Neutralize Shiga-like Toxin
Mc Master University, November 2000
Structure and interactions in antibody-sugar antigen complexes and bacterial toxin-glycolipid complexes
University of Glasgow, Glasgow, Scotland, October 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
Carlsberg Laboratories, Copenhagen, Denmark, October 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
Glycoconjugates in Biological Studies Annual Meeting, Tammsvik, Sweden, October 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
Agricultural University of Uppsala, Sweden, October 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
Canadian Society for Chemistry Award Lecture, Calgary, Alberta, May 2000

The Candida albicans (1®2)-b-mannopyranan antigen, a potential synthetic glycoconjugate vaccine candidate. Ordered conformation correlates with unique immunochemistry
Canadian Bacterial Diseases Network, AGM, Banff, Alberta, May 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
North American Vaccines, Washington, DC, USA, February 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize Shiga-like toxins
University of Toronto/PENCE, Toronto, Ontario, February 2000

The design, synthesis and mode of action of tailored multivalent carbohydrate ligands that neutralize shiga-like toxins
Dept. of Chemistry, Duke University, Durham, NC, USA, February 2000

Rational design of soluble sub-nanomolar inhibitors for Shiga toxins
15th International Glycoconjugate Meeting, Japan, August 1999

Design, synthesis and crystal structure of soluble sub-nanomar inhibitors for Shiga-like toxins
Gordon Research Conference on Carbohydrate Chemistry, Tilton School, NH                 Jun 1999

Rational design of soluble sub-nanomolar inhibitors for Shiga toxins
Canadian Bacterial Diseases Network, AGM, Banff, May 1999

Oligosaccharide interactions with protein receptors
Royal Society of Chemistry, Carbohydrate Group, York University, March 1999
Non-glycosidically linked oligosaccharide clusters
University of Virginia 1998 Alfred Burger Lecturer, October 1998
StrStructure and interactions in antibody-sugar antigen complexes
International Carbohydrate Symposium, San Diego, California, August 1998
Binding energy and the conformation of oligosaccharides in the bound state
International Carbohydrate Symposium, San Diego, California, August 1998
How antibodies bind oligosaccharide epitopes
Silver Jubilee FEBS Meeting, Copenhagen, Denmark, July 1998
How antibodies bind oligosaccharide epitopes
Neose Technologies Inc., Horsham, Pennsylvania, March 1998
Structure and interactions in antibody-sugar antigen complexes
DuPont, Wilmington, Delaware, March 1998
Structure and interactions in antibody-sugar antigen complexes
GlycoBio Technology Symposium, Braunschweig, Germany, May1998

Structure and interactions in antibody-sugar antigen complexes
University of Lübeck, Lübeck, Germany,  April/May 1998

Structure and interactions between carbohydrate antigens and antibody binding sites
Lectures in Modern Chemistry: Department of Chemistry, University of British Columbia, Vancouver, BC, October 1997

Structure and interactions between carbohydrate antigens and antibody binding sites
Department of Chemistry Simon Fraser University, British Columbia, October 1997

Structure and interactions between carbohydrate antigens and antibody binding sites
Department of Chemistry, University of Victoria, British Columbia,  October 1997

Carbohydrate-recognition: Probing antibodies from all angles
Glycoconjugates and Matrix Molecules in Health and Disease NIH, Bethesda, Maryland,  August 1997

The three dimensional structures of bacterial polysaccharide-antibody complexes
FASEB meeting: Microbial Polysaccharides of Medical, Agricultural and Industrial Importance, Copper Mountain, Colorado, June 1997
The conformation of tethered oligosaccharide epitopes designed to fit a monoclonal antibody
Nordic NMR Symposium, Copenhagen, Denmark, May 1997

A calorimetric investigation of inhibitor modifications that enhance antibody carbohydrate-binding 
American Chemical Society Semi Annual meeting, San Francisco, April 1997

Interactions in and adjacent to the antibody binding site for oligosaccharide
epitopes Genentech, San Francisco, March 1997

A calorimetric investigation of inhibitor modifications that enhance antibody carbohydrate-binding 
Annual Symposium of the Complex Carbohydrate Society, Boston, November 1996

Synthesis and immunochemical determination of the anomeric configuration of a tyvelose capped, Lewis-X like tetrasaccharide epitope of Trichinella Spiralis
International Carbohydrate Symposium, Milan, Italy, July 1996

Constraint of glycosidic linkages fails to increase binding affnity; conformational and binding studies of a trisaccharide with intramolecular tether
International Carbohydrate Symposium, Milan, Italy, July 1996

Synthesis of a conformationally constrained trisaccharide epitope via an intramolecular tether
International Carbohydrate Symposium, Milan, Italy, July 1996

Conformational and binding studies of tethered trisaccharides by NMR and enzyme immunoassay
Intl. Carbohydrate Symposium Satellite Meeting on Conformational studies of carbohydrates, La Thuile, Italy, July 1996

Oligosaccharide epitopes and antibody binding sites of Fab and Single Chain Fv Molecules
Keystone Meeting on Antibodies and the Immunoglobulin Superfamily, Taos, NM, March 1996

How antibodies bind oligosaccharide epitopes
8th European Carbohydrate Symposium, Seville, Spain, July 1995

Ligand and protein engineering of carbohydrate antibodies
Canadian Federation of Biological Societies, Saskatoon, June 1995

Three dimensional structures of carbohydrate antigens complexed with antibody
Canadian Federation of Biological Societies, Saskatoon, June 1995

Binding motifs in oligosaccharide-antibody complexes
Gordon Research Conference on Carbohydrate Chemistry, Tilton School, NH, June 1995
The role of water on antibody-oligosaccharide complexes
78th Canadian Society for Chemistry Conference and Exhibition, Guelph, May 1995
The influence of water on oligosaccharide conformations in complexes with antibodies
XVIIth International Carbohydrate Symposium, Ottawa, July 1994
Synthesis and NMR Studies of a terisaccharide analogue of the Shigella Felxneri y O-antigen
XVIIth International Carbohydrate Symposium, Ottawa, July 1994

Three dimensional structures of oligosaccharide-antibody complexes Glycoconjugates: structure, metabolism and molecular biology                               
Jacques Monod Conference, La Londe-les-Maures, France, April 1994

Antigen-antibody interactions by the isotope-filtered 1H nmr spectroscopy
Bundle Intl. Carbohydrate Symposium Satellite Meeting on Conformational studies of carbohydrates, Far Hills, Quebec, July 1994

The structures of oligosaccharide complexes with native antibody Fab, E. coli   expressed Fab and single chain variants
The New Biology of Carbohydrates, 9th Annual Symposium on Biotechnology, University College, London, December 1993

Carbohydrate antigen-antibody interactions: Crystal structures, thermodynamics and molecular modeling
Department of Biochemistry, University of Oxford, England, December 1993

Oligosaccharide antibody interactions studied by protein engineering, ligand modification and crystallography
Institut for Biophysical Chemistry, J. W. Goethe University of Frankfurt, Germany, December 1993

Ligand engineering and antibody engineering applied to carbohydrate specific antibodies
Central Research Laboratory, Ciba, Basel, Switzerland, December 1993

The structure of oligosaccharide complexes and improved inhibitors of carbohydrate-protein binding
MerckFrosst Centre for Therapeutic Research, Ponte-Claire-Dorval, October 1993

The structure of oligosaccharide complexes and improved inhibitors of carbohydrate-protein binding
Alfred Benzon Symposium, Complex Carbohydrates in Drug Research, Copenhagen, Denmark, June 1993

Carbohydrate ligands & their protein receptors: Biological function & molecular interactions
Keystone Symposium Colorado, January 1993

Oligosaccharide-antibody interactions
University of Bonn, Germany, November 1992
Synthetic oligosaccharide chemistry in the study of antibody binding sites
University of Hamburg, Hamburg, Germany, November 1992

The crystal studies of oligosaccharide antibody complexes                                         
Forschunginstitut Borstal, Borstal, Germany, November 1992

The structure of oligosaccharide-antibody complexes
Carlsberg Institute, Denmark, October 1992

The structure of an oligosaccharide-antibody complex
 International Carbohydrate Symposium, Paris, July 1992

The atomic detail of oligosaccharide antibody complexes 
Table Ronde no 73 Roussel Uclaf, Frontiers in Glycosciences, July 1992

Molecular recognition and antibody engineering studies of antibody-carbohydrate interactions                              
Bio Recognition, Montreal, June 1992

The structure of a carbohydrate-antibody complex
75th Canadian Chemical Conference, Edmonton, June 1992

Antibodies that bind carbohydrate antigens
American Chemical Society: National Meeting Emil Fischer Centennial Symposium San Francisco, California, April 1992

Synthetic oligosaccharides, NMR and microcalorimetry as tools to study antibody-carbohydrate interactions
Keystone Glycobiology II Symposium, Park City, Utah, March 1992

A comparison of ligand mapping studies with a high resolution crystal structure
4th American Chemical Society Congress of North America, New York, N.Y., August 1991

The crystal structure of an oligosaccharide - Fab complex and binding activities of site specific mutants expressed in E. coli
4th American Chemical Society Congress of North America, New York, N.Y., August 1991

The crystal structure of a dodecasaccharide - antibody Fab complex
11th International Symposium on Glycoconjugates, Toronto, July 1991

Synthetic oligosaccharides and the antibody binding site for the Salmonella serogroup B polysaccharide:  A comparison of ligand mapping studies with a high resolution crystal structure                      
Society for Complex Carbohydrates, San Diego, California, October 1990

Crystallographic and modeling studies of antibody binding sites for bacterial O-antigens
5th Bratislava Symposium on Saccharides, Bratislava, Czechoslovakia, August 1990

Structural analysis of bacterial O‑antigens; integration of high resolution NMR and classical approaches
Society for Complex Carbohydrates, Ann Arbour, Michigan, November 1989

Crystal structure and modeling studies of antibody binding sites specific for bacterial O‑antigens 
F. Hoffmann La Roche, Basel, Switzerland, September 1989

Investigation of antibody binding sites by synthetic oligosaccharides, X‑ray crystallography and model building                       
Gordon Research Conference on Carbohydrates, New Hampshire, June 1989

Oligosaccharide‑protein interactions:  Studies of antibody combining sites by competitive binding, sequence analysis and X‑ray crystallography        
XIVth International Carbohydrate Symposium, Stockholm, Sweden, August 1988

The identification and structural elucidation of Brucella melitensis M antigen
XIIIth International Carbohydrate Symposium, Cornell University, Ithaca, August 1986

Synthesis of oligosaccharides for studies of the antibody combining site                                 
Royal Society of Chemistry Carbohydrate Group Meeting.  Sheffield, England, April 1986

The structure of a Salmonella serogroup N O-antigen determined by two dimensional NMR methods at 500 MHz
European Symposium on Carbohydrates, Grenoble, France, September 1985

The chemical synthesis of a trisaccharide corresponding to the Brucella abortus O-antigen
European Symposium on Carbohydrates, Grenoble, France, September 1985

Monoclonal antibodies to bacterial O‑antigens as a model for protein‑carbohydrate interactions.  Molecular Biology and Microbial Pathogenicity, Role of Protein‑Carbohydrate Interactions
FEMS and Swedish Society for Microbiology, Lulea, Sweden, June 1985

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Posters

2013

Gordon Conference on Carbohydrates
Mount Snow, VT - June 2013

Design of an HIV-1 Glycoconjugate Vaccine using a Filamentous Phage Carrier. J.J. Bailey, Bela Reiz, Kevin Henry, J.K. Scott, D.R. Bundle

 
Alberta Glycomics Centre 9th National Carbohydrate Symposium
Banff, Alberta - May, 2013

A Simplified Novel Ligand for Shiga Toxin Type 1 Eugenia Paszkiewicz, Dennis Wilhelm, Joanna Sadowska, Pavel I. Kitov, and David R. Bundle

 

Grow Big or Go Home: How to Turn Elisa Plate into an Affinity Farm. Somnath Dasgupta, Pavel I. Kitov, and David R. Bundle

 
An HIV-1 Glycoconjugate Vaccine utilizing Filamentous Phage as an Immunogenic Carrier. J. Bailey, Bela Reiz, Kevin Henry, J.K. Scott, D.R. Bundle.  
Annual Meeting of the Canadian Society for Immunology
Whistler, BC, April 2013

An HIV-1 Glycoconjugate Vaccine utilizing Filamentous Phage as an Immunogenic Carrier
J.J. Bailey, Bela Reiz, Kevin Henry J.K. Scott, D.R. Bundle

 
8th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
Amsterdam, Netherlands, May 2012

Lipopolysacchride-Sensitized Transgenic Mice Constitutively Expressing Human Serum Amyloid P Component are Protected from Stx2 by Polymeric Heterobifunctional Ligands

Mulvey, G. L., Griener, T. P., Bundle, D. R., and Armstrong, G. D.

 
Journee Rhone-Alpes des Biomolecules
Grenoble, France, June, 2012

Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands

Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle.

 

 

Alberta Glycomics Centre 8th National Carbohydrate Symposium
Banff, Alberta - May, 2012

Modelling and Crystallography of E. coli Stx2 Toxin with Bound Ligand: Design and Preliminary Evaluation of Inhibitors in a Transgenic Mouse Model of Disease

Jacobson, J. M., Yin, J., Kitov, P. I., Mulvey, G., James, M., Armstrong, G., and Bundle, D. R.
 

The design, synthesis and application of a chemically defined antigen to detect brucellosis

Wilhelm, D., Guiard, J., Paszkiewicz, E., Sadowska, J., Rennie, R., and Bundle, D. R.

 
Synthesis of Candida Albicans β1,2-Mannan Phosphodiester Junction with the α-Mannan Backbone

Dang, A-T.; Sadowska, J. M.; Johnson, M. A.; Cartmell, J.; Bundle R. D.
 
Immunodominance of internal epitopes in Candida mannans

Johnson MA, Cartmell J, Weisser NE, Woods RJ, Bundle DR.
 

POLY(N-VINYL-2-PYRROLIDONE-CO-VINYL ALCOHOL): A VERSATILE POLYMERIC SCAFFOLD FOR BIOCHEMICAL APPLICATIONS

Eugenia Paszkiewicz, Yohei Kotsuchibashi, Dennis Wilhelm, Ravin Narain, Pavel I. Kitov,
and David R. Bundle

 

Search for high affinity ligands for cholera toxin 

Carlos A. Sanhueza, Pavel Kitov, Jonathan Cartmell, Joanna Sadowska and David. R. Bundle

 
8th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
Amsterdam, Netherlands - May 2012

Lipopolysacchride-Sensitized Transgenic Mice Constitutively Expressing Human Serum Amyloid P Component are Protected from Stx2 by Polymeric Heterobifunctional Ligands

Mulvey, G. L., Griener, T. P., Bundle, D. R., and Armstrong, G. D.

 
Journee Rhone-Alpes des Biomolecules
Grenoble, France, June, 2012

Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands

Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle.

 

2011

AICCS Annual Meeting
Banff, Alberta - May, 2011

Multifunctional Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose Analogs of Pk Trisaccharide For Selective Binding to Shiga Toxin Type 2

Jacobson, J. M., Kitov, P. I., and Bundle, D. R.

 

Multifunctional Multivalency: Defined Molecular Weight
Heterobifunctional Polymeric Inhibitors of Shiga Toxins

Eugenia Paszkiewicz, Pavel I. Kitov, Joanna Sadowska, Zhicheng Deng, Marya Ahmed, Ravin Narain, and David R. Bundle
 

Design and synthesis of new Shiga Toxin 1 inhibitors

Wilhelm, D., Cartmell, J., and Bundle, D. R.

 

Determination of specific binding epitopes of Brucella A and M antigens by STD-NMR

Wilhelm, D., Guiard, J., and Bundle, D. R.

 
Synthesis of the β1,2-Mannan Phosphodiester to α-Mannan Backbone Junction of the Candida Albicans Phosphomannan

Dang, A-T.; Bundle, D. R.
 
Antibody recognition of β-(1→2)-mannosides investigated by solution NMR spectroscopy

Johnson MA, Costello C, Sadowska J, Szpacenko A, Bundle DR. 
 
 Identification of an important structural motif in the bacterial oligosaccharyltransferase for N-linked protein glycosylation

Barre Y, Nothaft H, Liu X, Johnson MA, Ng K, Li J, Szymanski CM
 
Towards an Improved HIV Vaccine

Bailey, J.J.; Bundle, D.R.
 

Design, synthesis and evaluation of heterobifunctional ligands for the inhibition of Clostridium difficile toxins

Carlos A. Sanhueza, Pavel Kitov, Jonathan Cartmell, Adam Szpacenko, Joanna Sadowska, Kenneth Ng, Elena Kitova, Rambod Daneshfar, Amr Elhawiet, John Klassen, and David. R. Bundle

 

Gordons Research Conference for Carbohydrates
Waterville, MA, USA. - June 2011

Determination of binding epitopes of Brucella A and M antigens by STD-NMR

Wilhelm, D., Guiard, J., and Bundle, D. R.

 
Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands

Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle
 

Journee du Groupe Lyonnais des Glyco-Sciences
Lyon, France, November, 2011

Design of specific Norovirus entry-inhibitors using a focused library of heterobifunctional multivalent ligands

Julie Guiard, Eugenia Paszkiewicz, Brigitte Fiege, Jonathan Cartmell, Pavel I. Kitov, Thomas Peters and David R. Bundle
 

2010

AICCS Annual Meeting
Banff, Alberta - May, 2010
Multifunctional Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose Analogs of PK Trisaccharide for More Effective Binding to Shiga Toxin type 2

Jared Jacobson, Pavel I. Kitov and David R. Bundle
 
MULTIFUNCTIONAL MULTIVALENCY: Defined Molecular Weight Heterobifunctional Polymeric Inhibitors of Shiga Toxins Obtained by Raft Polymerization 

Eugenia Paszkiewicz, Pavel I. Kitov, Zhicheng Deng, Marya Ahmed, Ravin Narain, and David R. Bundle
 
Synthesis of Candida Albicans β1,2-Mannan Phosphodiester Junction with the α-Mannan Backbone

Dang, A-T.; Bundle, D. R.
 
Molecular recognition of Candida albicans oligosaccharides by a protective antibody

Johnson MA, Sadowska J, Szpacenko A, Luu T, Bundle DR
 
Advancements in the Synthesis of Mannose Antigens for use in a Phage Display Vaccine

Bailey, J.J.; Bundle, D.R.
 
Functional characterization of the bacterial oligosaccharyltransferase for N-linked protein glycosylation

Barre Y, Nothaft H, Johnson MA, Liu X, Li J, Szymanski CM
 

6th National Symposium on Recent Advances in Carbohydrate Science
Banff, AB, May 6-8, 2010

Functional characterization of the bacterial oligosaccharyltransferase for N-linked protein glycosylation

Barre Y, Nothaft H, Johnson MA, Liu X, Li J, Szymanski CM
 

2009

AICCS Annual Meeting
Banff, Alberta - May 13-16
Multifunctional Multivalency: The Synthesis of 2-acetamido-2-deoxy-D-galactose Analogs of PK Trisaccharide for More Effective Binding to Shiga Toxin type 2

Jared Jacobson, Pavel I. Kitov and David R. Bundle
 
Synthesis of Zwitterionic Oligosaccharides with the Potential to Stimulate T-cell Responses

David R.Bundle, Chang-Chung Ling and Ithayavani Iynkkaran
 
Synthesis and Mapping of the Protective Epitope Contained in Trisaccharide Analogues of the (1→2)-β-mannan from Candida albicans 

Casey Costello, Corwin M. Nycholat, and David R. Bundle  
 
Synthesis of a Vaccine Against C. albicans Incorporating βMan3 , Fba, and Tetanus Toxoid

Jonathan Cartmell, Thanh Luu and David R Bundle
 
Novel Strategy for Protein-Ligand Conjugations

Tomasz Lipinski, Adam Szpacenko, Pavel Kitov, Julie Guiard and David R. Bundle

 

Versatile Synthesis of β1,3 Glucans for in vivo Targeting of Dendritic Cells and Micro-Patterned Ligand Arrays

Bailey, J.J.; Bundle, D.R.

 

Synthesis of Mannose Antigens for use in a Phage Display Vaccine

Bailey, J.J.; Bundle, D.R.

 
19th International Symposium on Fluorine Chemistry
Jackson Hole, WY - Aug 2009
Bailey, J.J.; Bundle, D.R., Development of a Fluorous Tag as an Anomeric Protecting Group, a Purification Aid and a Protein Linker  

2008

AICCS Annual Meeting
Banff, Alberta - April 29-May 3
Synthesis of a Zwitterionic Hexasaccharide Containing two Repeating Units of the Streptococcus Pneumoniae Type 1 Capsular Polysaccharide

Xiangyang Wu, Lina Cui, and David R. Bundle

 
Synthesis of Zwitterionic Oligosaccharides with the Potential to Stimulate T-Cell Responses

Ithayavani Iynkkaran, Chang-Chung Ling, Xiangyang Wu and David. R. Bundle

 
The Convergent Synthesis of a-Galactosylceramide by Olefin Cross Metathesis
Ye Cai and David R. Bundle

 
Synthesis of Oligosaccharide Fragments of Lipoarabinomannan from Mycobacterium Tuberculosis as Haptens for the Development of Anti-Tuberculosis Vaccines

Yu Bai, Maju Joe, Jayant N. Tilekar and Todd L. Lowary

 
Design and Synthesis of Aspergillus fumigatus Antigens

Vincent R. Bouvet, Feng Yang, Todd L. Lowary and David R. Bundle

 
Development of Glycoconjugate Polymeric Vaccines for the Treatment of Candida albicans

Thanh Luu, Pavel I. Kitov, Tomasz Lipinski and David R. Bundle

 
Investigating synthetic techniques for a practical synthesis of ß-1,3 glucans as a preliminary backbone structure in a laminarin based glycan library

J. James Bailey and David R. Bundle

 
In Vivo Synthesis of Complex Ganglioside Analogues by Metabolically Engineered Escherichia coli Strains

Sandra Jacques, Chang-Chun Ling, Eric Samain, and David R. Bundle

 

Multifunctional Multivalency: Synthesis of Heterobifunctional Polymeric Shiga Toxin Antagonists for in vivo Evaluation

P. I. Kitov, E. Paszkiewicz, Jared M. Jacobson, T. Lipinski and D. R. Bundle
 
Multifunctional Multivalency: Effect of Linker Length on the Activity of Heterobifunctional Polymeric Shiga Toxin Antagonists

E. Paszkiewicz, P. I. Kitov, T. Lipinski and D. R. Bundle

 
Multifunctional Multivalency: The Synthesis of the Inactive Diastereoisomer of a Heterobifunctional Antagonist for Shiga Toxin

Jared M. Jacobson, Eugenia Paskiewicz, Pavel I. Kitov and David R. Bundle

 
Multifunctional Multivalency: Synthesis of Polyvalent Heterobifunctional Ligand for Redirecting IgM to Siglec CD22

Lina Cui, Pavel I. Kitov, Gladys C. Completo, James C. Paulson, and David R. Bundle
 

2007

Gordon Conference on Carbohydrates
Tilton, New Hampshire - June 17-22
Multifunctional Multivalency: Synthesis of Shiga Toxin Antagonists Based on Biocompatible N-(2-Hydroxypropyl) Methacrylamide (HPMA)

Eugenia Paszkiewicz, Pavel I. Kitov, David R. Bundle

 
Chemical Mapping and STD NMR StudiesEstablish the Trichinella spiralis Epitope Recognized by a Monoclonal Antibody

Lina Cui, Ping Zhang, Chang-Chun Ling and David Bundle
 
Multifunctional Multivalency: A Novel Concept Capable of Delivering One Billion Fold Avidity Gains

Pavel Kitov, Dmitry Solomon, Tomasz Lipinski, Eugenia Paszkiewicz, Joanna Sadowska, George Mulvey, Glen Armstrong and David Bundle

 

Diversified Synthesisof Phytoshingosines and Glycocermide Analogs

Ye Cai, Chang-Chun Ling and David Bundle

 
AICCS Annual Meeting
Lake Louise, Alberta - May 3-5
Structure and Carbohydrate Binding Properties of Toxins A and B from Clostridium difficile

Antonio Greco, Pavel Kitov, David Bundle, Jiangxiao Sun, John Klassen, Maja Rüpnik, Kenneth Ng
 

Multifunctional Multivalency: Design, Synthesis and Preliminary Evaluation of the Most Potent Shiga Toxin Inhibitor

D. Solomon, P. I. Kitov, T. Lipinski, E. Paszkiewicz, J. M. Sadowska and D. R. Bundle

 
Multifunctional Multivalency: Synthesis of Shiga Toxin Antagonists Based on Biocompatible N-(2-Hydroxypropyl) Methacrylamide (HPMA)

Eugenia Paszkiewicz, Pavel I. Kitov and David R. Bundle
 

Immuno-Targeting Malignant Cells Through Folate-GlcNAc Conjugated Ligands

Lina Cui, Pavel Kitov and David R. Bundle

 
Synthesis of tailored conjugate vaccines composed of complex carbohydrate antigens and specific TH-cell peptide epitopes employing a novel linker methodology

Sebastian Dziadek, Sandra Jacques and David R. Bundle
 

Immune Response to Small Oligosaccharide Enhanced by Copolymerization with Acrylamide

T. Lipinski, P. Kitov, E. Paszkiewicz, X. Wu and D. R. Bundle

 
Synthesis and mapping of the protective epitope contained in di- and trisaccharide analogs of the (1-2)-ß-mannan from Candida albicans

Corwin M. Nycholat, and David R. Bundle
 

Synthesis of Glycosphingolipid-Derivatives for the Therapy of Autoimmune Diseases

Birgit Kranke and David R. Bundle

 
Diversified Synthesis of Phytosphingosines and Glycoceramide Analogs

Ye Cai and David R. Bundle
 

Synthesis of ß-1,3 (laminarin) glucans as a preliminary backbone structure in a laminarin based glycan library

J. James Bailey and David R. Bundle

 
Synthesis of the Zwitterionic Hexasaccharide Containing two Repeating Units of the Streptococcus pneumoniae Type 1 Capsular Polysaccharide

Xiangyang Wu and David R. Bundle
 

Synthesis of Zwitterionic Oligosaccharides with the Potential to Stimulate T-Cell Responses

Ithayavani Iynkkaran, Chang-Chung Ling and David R.Bundle

 
Synthesis of Pk-Trisaccharide Deoxy Analogs and Mapping of the Carbohydrate Binding sites in Shiga Toxins by FTICR Mass spectrometry

Jonghwa Kim, Pavel Kitov and David R. Bundle
 

Affinities of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk Trisaccharide Analogs Measured by Electrospray Ionization Mass Spectrometry

E. N. Kitova, P. I. Kitov, E. Paszkiewicz, J. Kim, G. L. Mulvey, G. D. Armstrong, D. R. Bundle and J. S. Klassen

 
Progress toward the Synthesis of Galactomannan Antigens of Aspergillus fumigatus

Vincent R. Bouvet, Feng Yang, Todd L. Lowary and David R. Bundle
 

2006

Glycobiology 2006
Los Angeles, California - November
Heterobivalent Ligands: A Versatile Approach to Ligand-Induced Protein Aggregation Exemplified by the Structure-based Design of Shiga Toxin Antagonists

Pavel I. Kitov and David R. Bundle
 
23rd International Carbohydrate Symposium
Whistler, Canada - July 23-28
Synthetic Ganglioside Epitopes for Extracorporeal Removal of Antibodies in Neuropathy

Birgit Kranke, Ping Zhang, Chang-Chun Ling, and David R. Bundle
 

A Facile Approach to 2-Acetamido-2-deoxy-ß-D-glucopyranosides Facilitates Convenient Syntheses of ?-Glycosides of Unusual Aminosugars

Ye Cai, Chang-Chun Ling and David. R. Bundle

 
A Comparison of STD NMR and Chemical Mapping Studies of a Trichinella spiralis Antibody Binding Site

Lina Cui, Chang-Chun Ling, David R. Bundle
 

Ganglioside Conjugate Vaccines Incorporating an in vivo-labile ß-Thiopropionate Tether

S. Jacques, S. Dziadek, J. R. Rich, D. R. Bundle

 
Heterobivalent Ligand Mediated Ternary Complex Formation between Shiga Toxin and Serum Amyloid P Component

P. I. Kitov, G. Grant, E. Paszkiewicz, J. Sadowska and D. R. Bundle
 

A Concise Chemoenzymatic Synthetic Route to Natural Gangliosides and Ganglioside Analogs for Cancer Immunotherapy

Ping Zhang, Chang-Chun Ling, Sandra Jacques, Blake Zheng, and David R. Bundle

 
Synthesis of a Dimeric Heterobifunctional Ligand Designed to Induce a Complex Between Shiga Toxin and Serum Amyloid P Component

D. Solomon, P. I. Kitov and D. R. Bundle
 

Immunochemistry of Thioanalogs of theTrisaccharide ß-Mannan Epitope of Candida Albicans

T. Lipinski, X. Wu, E. Paszkiewicz and D.R. Bundle

 
Diastereoselective Synthesis of Phytosphingosine and Preparation of Thioanalogs of Galactosylceramide

Chang-Chun Ling, Ye Cai, Ping Zhang, and David R. Bundle
 

Synthesis of the Trisaccharide Repeating Unit of the Type 1 Capsular Polysaccharide from Streptococcus Pneumoniae (Sp1)

Xiangyang Wu and David R. Bundle

 
AICCS Annual Meeting
Telus Centre, Edmonton, Alberta - June 8-9
Preliminary Steps Towards the Identification of ß-Mannopyranosyl Transferases from Candida albicans

Magali Buffet and David Bundle

 

Synthesis of Glycoconjugate Vaccines on Clustered Modes against Candida Albicans Using a Novel Methodology

Xiangyang Wu, Tomasz Lipinski, J. James Bailey, Frédéric Carrel and David Bundle

 
Immune Response to Thioanalogs of Trisaccharide Epitope of Candida Albicans ß-Mannan in Mice

Tomasz Lipinski, Xiangyang Wu, Eugenia Paszkiewicz and David Bundle
 

Synthesis of disaccharide congeners of the (1-2)-ß-mannan from the cell-wall phosphomannan of Candida albicans

Corwin Nycholat and David Bundle

 
Furanosyl Oxazoline of D-GlcNAc Functionalized at O-3: Larg-Scale Synthesis of ß-Glycosides of Unusual Aminosugars

Ye Cai, Chang-Chun Ling and David Bundle
 

Efficient Synthesis of N-Acetylmuramic Acid and Muramyl Oligopeptide Immuno- adjuvants

Ye Cai, Chang-Chun Ling and David Bundle

 
Diastereoselective Synthesis of Phytosphingosine and Preparation of Thioanalogs of Galactosylceramide

Chang-Chun Ling, Ye Cai, Ping Zhang, and David Bundle
 

A Concise Chemoenzymatic Synthetic Route to Natural Gangliosides and Ganglioside Analogs for Cancer Immunotherapy

Ping Zhang, Chang-Chun Ling, Sandra Jacques, Ruixiang Blake Zheng, and David Bundle

 
Ganglioside Conjugate Vaccines Incorporating an in vivo-labile ß-Thiopropionate Tether
Sandra Jacques, Sebastian Dziadek, Jamie Rich, David Bundle
 

Synthesis of a Dimeric Heterobifunctional Ligand Designed to Induce a Complex Between Shiga Toxin and Serum Amyloid P Component

Dmitry Solomon, Pavel Kitov and David Bundle

 
Heterobivalent Ligand Mediated Ternary Complex Formation between Shiga Toxin and Serum Amyloid P Component

Pavel Kitov, Gordon Grant, Eugenia Paszkiewicz, Joanna Sadowska and David Bundle
 
American Society for Microbiology
Denver, Colorado - March 13-17
A Synthetic Glycoconjugate Candida albicans Vaccine Confers Protection in a Disseminated Candidiasis Rabbit Model

T. Lipinski, X. Wu, J. Sadowska, Y. Yasui, S. Cheriaparambil, R. P. Rennie, D. R. Bundle
 

2005

Gordon Conference on Carbohydrates
Tilton, New Hampshire, June 19-24, 2005
Synthesis and Immunochemistry of Ganglioside Analogues

Jacques, S.; Rich, J.R.; Bundle, D. R.
 

Synthesis of Multivalent Hetero-Bifunctional Inhibitors

Dmitry Solomon, Eugenia Paszkiewicz, Pavel Kitov, Gordon A. Grant, and David R. Bundle

 

Evaluation of synthetic vaccine for Candida albicans

Tomasz Lipinski, Xiangyang Wu, Joanna Sadowska, Shilton Cheriaparambil, Robert Rennie, and David R. Bundle

 

Single Site Functional Group Replacement and Tethering of Trisaccharides Yield Non-Linear Free Energy Gains Due to Changes in Bound Ligand Orientation

McGavin, R.S., Peters, T. and Bundle, D.R.

 
Synthesis of Glycoconjugate Vaccines on Clustered Modes against Candida Albicans Using the Novel Methodology

Xiangyang Wu, Tomasz Lipinski, J. James Bailey, Frédéric Carrel and David R. Bundle
PDF file

Single Site Functional Group Replacement and Thethering of Trisaccharides Yield Non-Linear Free Energy Gains Due to Changes in Bound Ligand Orientation

Mc Gavin, R.S., Peters, T., and Bundle, D.R.

PDF file
Synthesis of Di- and Trisaccharide Congeners of the (1?2)-ß-Mannan from the Cell-wall Phosphomannanof Candida Albicans

Corwin Nycholat and David R. Bundle
PDF file
88th Canadian Chemistry Conference and Exhibition
Saskatoon, Saskatchewan, May 28-June 1, 2005
Synthesis and Immunochemistry of Ganglioside Analogues

Jacques, S.; Rich, J.R.; Bundle, D. R.
 

A Facile Route To Unprotected b-Glycopyranosides Of N-Acetylglucosamine Via A Furanosyl Oxazoline Derivative

Ye Cai, Chang-Chun Lin, David R. Bundle

 

An Iterative Approach to High Affinity Carbohydrate Ligand Design

Lina Cui, C.-C. Ling and David R. Bundle

 

Synthesis of Di- and Trisaccharide Congeners of the (1-2)-ß-Mannan from the Cell-wall Phosphomannanof Candida Albicans

Corwin Nycholat and David R. Bundle

PDF file
AICCS Annual Meeting and Symposium on Carbohydrate Science
Lake Louise, Alberta, April 28-30, 2005
In-vitro Screening of Anti-adhesive Drugs that Complex with Serum Amyloid P Component to Inhibit Shiga-like Toxins

Grant, G.A., Kitov, P.I, Solomon, D., Paszkiewicz, E., Sadowska, J.M, Mulvey, G.L., Armstrong, G.D., and Bundle, D.R..
 

Preliminary Comparison of the Epitope Maps of Ligands Directed Towards Monoclonal Antibody SYA/J6

McGavin, R.S., Peters, T. and Bundle, D.R.

PDF file

Synthesis of Multivalent Ligands directed against Anti-ganglioside Antibodies related to Autoimmune GBS Neuropathy

Frédéric Carrel and David Bundle

 

Chemoenzymatic Synthesis of Functionalized Ganglioside Analogues

Jacques, S.; Rich, J.R.; Bundle, D. R.

 
Synthesis of Multivalent Hetero-Bifunctional Inhibitors

Dmitry Solomon, Eugenia Paszkiewicz, Pavel Kitov, Gordon A. Grant, and David R. Bundle
 

The Immune Response To Glycoconjugate Vaccines for Candida albicans and
in vivo Protection Experiments in Neutropenic Rabbits

Tomasz Lipinski, Joanna Sadowska, Shilton Cheriaparambil, Robert Rennie, and David R. Bundle

 

A Facile Route To Unprotected b-Glycopyranosides Of N-Acetylglucosamine Via A Furanosyl Oxazoline Derivative

Ye Cai, Chuang-chun Lin, and David R. Bundle

 

A Novel Synthesis of Phytosphingosines from 6-Iodo Aminosugars Using a Zinc-mediated Reductive Elimination and Olefin Metathesis

Ye Cai, Chuang-chun Lin, and David R. Bundle

 

Synthesis and Immunochemistry of S-Gangliosides

Jamie R. Rich, Sandra Jacques and David R. Bundle

 

Synthesis of Glycoconjugate Vaccines against Candida albicans Using the Novel Linker Methodology

Xiangyang Wu, J. James Bailey, Eugenia Paszkiewicz and David R. Bundle

PDF file

An Iterative Approach to High Affinity Carbohydrate Ligand Design

Lina Cui, C.-C. Ling and David R. Bundle

 

Chemical and Chemo-Enzymatic Approach to the Synthesis of Pk-trisaccharide Deoxy Analogues

Jonghwa Kim, Pavel Kitov and David R. Bundle

PDF file

Synthesis of Di- and Trisaccharide Congeners of the (1-2)-ß-Mannan from the Cell-wall Phosphomannanof Candida Albicans

Corwin Nycholat and David R. Bundle

 

Synthesis of thio-analog of KRN7000

Chang-Chun Ling, Ping Zhang and David R. Bundle

 

Synthesis of Ganglioside Epitopes for Oligosaccharide Specific Immunoadsorption Therapy of GuillainBarré Syndrome

Ping Zhang, Chang-Chun Ling, Kate Townson, Hugh J. Willison and David R. Bundle

PDF file

2004

International Carbohydrate Symposium
Glasgow, Scotland
Molecular Basis for Inhibition of Serum Amyloid P Component by New Multivalent Ligands


Pavel I. Kitov, Eugenia Paszkiewicz, Joanna Sadowska, David R. Bundle, Jason G.S. Ho, and Kenneth K.-S. Ng
 

Sulfur Linked Analogues of Gangliosides GM3 and GM2 for Use in Conjugate Vaccines

Jamie R. Rich, Sandra Jacques and David R. Bundle

PDF file (25k)

 

2003

Eurocarb Symposium 2003
Grenoble, France

Synthesis of Phosphmannan Antigens found in the Candida albicans cell wall

Stéphane Chambert and David R. Bundle

PDF file (50k)

Synthesis and Binding Analysis of Cyclic Oligosaccharide Inhibitors of Monoclonal Antibody SYA/J6

Robert S. McGavin and David R. Bundle

PDF file (53k)

Understanding Neuropathy Pathogenesis: Synthesis of Ganglioside BSA Glycoconjugates and Immobilization on Sepharose Gel

Soren Andersen, Chang-Chun Ling, Ping Zheng, Kate Townson, Jean Veitch, Hugh J. Willison, David R. Bundle

PDF file (35k)
Alberta Ingenuity Centre for Carbohydrate Science - Annual Meeting 2003 Edmonton, Alberta
An efficient route to sphinganine, phytosphingosine and their analogs

Ye Cai, Chang-Chun Ling, and David R. Bundle
PDF file
Large Scale Synthesis of an Analog of Azidosphingosine and Preparation of the Corresponding GM2 Analog

Chang-Chun Ling, Ping Zhang, Corwin M. Nycholat and David R. Bundle
PDF file
*Synthesis of Sulfur Containing Ganglioside Analogues for Use as Immunogens

Jamie R. Rich, David R. Bundle
PDF file
*Synthesis and Binding Analysis of Cyclic Oligosaccharide Inhibitors of Monoclonal Antibody SYA/J6

Robert S. McGavin, and David R. Bundle
PDF file
*Chemical Synthesis and Adjuvant Properties of Gentiobiosyl Diphytanyl Glycerol

Dean T. Williams and David R. Bundle
PDF file
*Towards the Total Synthesis of SB1a, a Carbohydrate Hapten Associated with Human Hepatocellular Carcinoma

Dmitry Solomon and David R. Bundle
PDF file
Banff Symposium on Organic Chemistry 2003
Banff, Alberta
An efficient route to sphinganine, phytosphingosine and their analogs

Ye Cai, Chang-Chun Ling, and David R. Bundle
PDF file
Annual Conference of the Society for Glycobiology
San Diego, CA. - Dec. 2003

Glycosyltransferase Catalyzed Synthesis of Thiooligosaccharides

Jamie R. Rich, Adam Szpacenko, Monica M. Palcic and David R. Bundle

PDF file (95k)

 

2002

International Carbohydrate Symposium
Cairns, Australia; August 7-12 2002

Candida albicans b(1-2)-Mannans: Unique Solution Conformation and the Immune Response to Their Glycoconjugates.

Mark Nitz, Chang-Chun Ling, Albin Otter, Joanna Sadowska and David R. Bundle

Poster Session I

PP273

PDF file (203k)

Canadian Society for Chemistry Conference and Exhibition
Vancouver, B.C., Canada; June 1-5, 2002

Intramolecular Pre-Organization of Oligosaccharides:The Synthesis of Cyclic Inhibitors Towards Monoclonal Antibody SYA/J6.

Robert S. McGavin and David R. Bundle

PDF file (73k)

Synthetic Studies Toward Lewis Y Glycoconjugates.

Lesley Liu, Chang-Chun Ling and David R. Bundle

PDF file (67k)

Thio-linked Oligosaccharides: Better Immunogens? Synthesis and Binding Studies of S-linked Trisaccharides Related to Shigella flexneri Variant Y LPS Antigens

Henry N. Yu, Chang-Chun Ling and David R. Bundle

PDF file (75k)

Synthesis and conformational Studies of Ganglioside Analogues Containing S-linked Neuraminic Aicd and a S-linked Ceramide.

J.R. Rich and D.R. Bundle

PDF file (62k)

Understanding Neuropathy Pathogenesis: Synthesis of Ganglioside BSA Glycoconjugates and Immobilization on Sepharose Gel

Soren M. Andersen, Ping Zhang, Chang-Chun Ling and David R. Bundle

Lecture

Experimental NMR Conference 2002
Asilomar, California; April 14-19, 2002

Unique Helical Solution Confirmation in Candida albicans β1-2)-Mannopyranan Oligomers

Albin Otter, Mark Nitz, Chang-Chun Ling and David R. Bundle

Lecture

2001

Gordon Research Conference - 2001
Tilton, NH

Determination of the Binding Affinity of mAb B3 for Synthetic Derivatives of Lewis Y Using FAC/MS

Lesley Liu, Chang-Chun Ling and David R. Bundle

PDF file (82k)

Construction of 1-Thio-b-Mannopyranosyl and 1-Thio-b-Rhamnopyranosyl Linkages via a Facile SN2 Reaction

Henry N. Yu, Chang-Chun Ling and David R. Bundle

PDF file (76k)
Allyl Cleavage under Mild Oxidative Conditions

Pavel I. Kitov and David R. Bundle

PDF file (407k)

2000

Experimental NMR Conference 2000
Asilomar, California; April 9-14, 2000

Conformational Analysis of a Tethered Disaccharide Trapped in the anit Conformation

Shirley A. Wachowich-Sgarbi, Chang-Chun Ling, David R. Bundle and Albin Otter

PDF file (168k)

Canadian Bacterial Diseases Network Centre 2000

Pk-Starfish: The Next Generation

P.I. Kitov, J.M. Sadowska, P. Marcato, G.D. Armstrong and D.R. Bundle

PDF file (281k)

Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry Studies of the Homophilic Non-Covalent Interactions of Shiga-like Toxin Subunits, as well as their Interactions with Carbohydrate Ligands.

E.N. Kitova, J.S. Klassen, P.I. Kitov, P. Marcatao, G.D. Armstrong and D.R. Bundle

PDF file (103k)

1999

Gordon Research Conference, Carbohydrates 1999

Rational Design of Soluable Sub-Nanomolar Inhibitors for Shiga Toxins

P.I. Kitov, J.M. Sadowska, D.R. Bundle, Randy J. Read and G.D Armstrong

PDF file (372k)

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Bundle Research Group Department of Chemistry University of Alberta