Selected Publications

Selected Recent Publications (from over 400 total):

(click here for full list of publications)

Lamer, T.; Chen, P.; Catenza, K.; Perov, I.; Donnelly, B.L.; Hsiao, Y.-T.; Van Oers, T.J.; Lemieux, M.J.; Vederas, J.C. Structure and inhibition of diaminopimelic acid epimerase by slow-binding alpha-methyl amino acids. Protein Sci. 34:e70139. 1-15 (2025).

Perov, I.; Catenza, K..;Abucay, J.J.; Hsiao, Y.-T.; Vederas, J.C. Investigation and optimization of metal- and organocatalyzed decarboxylative radical addition of carboxylic acids to Seebach-Beckwith dehydroalanine towards optically pure nonnatural amino acids. Tetrahedron Lett. 159, 15507, 1-7 (2025).

Chen, P.; Van Oers. T.J.; Arutyunova, E.; Fischer, C.; Wang, C.; Lamer, T.; van Belkum, M.J.; Young, H.S.; Vederas, J.C.; Lemieux, M.J. A structural comparison of oral SARS-CoV-2 drug candidate ibuzatrelvir complexed with the main protease (Mpro) of SARS-CoV-2 and MERS-CoV JACS Au 4, 3217-3227 (2024).

Van Oers, T.J.; Piercey, A.; Belovodskiy, A.; Reiz, B.; Donnelly, B.L; Vuong, W.; Lemieux, M.J.; Nieman, J.A.; Auclair, K.; Vederas, J.C. Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Org. Lett. 25, 5885-5889 (2023)

Pascoe, C.A.; Engelhardt, D.B.; Rosana, A.R.R.; van Belkum, M.J.; Vederas, J.C. Methylene Analogues of Neopetrosiamide as Potential Antimetastatic Agents: Solid Supported Syntheses Using Diamino Diacids for Pre-Stapling of Peptides with Multiple Disulfides. Org. Lett. 23, 9216-9220 (2021)

Fernandez, K.X; Fischer, C.; Vu, Gheblawi, M.; Wang, W.; Gottschalk, S.; Iturrioz, X.; Llorens-Cortès, C.; Oudit, G.A.; Vederas, J.C. Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators RSC Med. Chem. 12, 1402–1413 (2021).

Vuong, W.; Khan, M.B; Fischer, C.; Arutyunova, E.; Lamer, T.; Shields, J.; Saffran, H.A.; McKay, R.T.; van Belkum, M.J.; Joyce, M.; Young, H.S.; Tyrrell, D.L.; Vederas, J.C.; Lemieux, M.J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Comm. 11, Article 4282, 1-8 (2020).

Acedo J.Z.; Chiorean, S.; Vederas, J.C.; van Belkum, M.J. The expanding structural variety among bacteriocins from Gram-positive bacteria. FEMS Microbiol. Rev., 42, 805–828 (2018).