The Vederas Group
Department of Chemistry
The University of Alberta

Selected Publications

Selected Recent Publications (from over 340 total):

(click here for full list of publications)

Vuong, W.; Khan, M.B; Fischer, C.; Arutyunova, E.; Lamer, T.; Shields, J.; Saffran, H.A.; McKay, R.T.; van Belkum, M.J.; Joyce, M.; Young, H.S.; Tyrrell, D.L.; Vederas, J.C.; Lemieux, M.J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Comm. 11, Article 4282, 1-8 (2020).

Fischer, C.; Lamer, T.; Fernandez, K.; Gheblawi, M.; Wang, W.; Pascoe, C.; Lambkin, G.; Iturrioz, X.l; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. PEG-extended apelin-17 analogues as cardioprotective drug leads: importance of the KFRR motif and aromatic head group for improved physiological activity. J. Med. Chem. 63, 12073−12082 (2020).

Antwi, I.; Chiorean, S.; van Belkum, M.J.; Vederas, J.C. Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production. RSC Med. Chem. 11, 528-531 (2020).

Chiorean, S.; Antwi, A.; Carney, D.W.; Kotsogianni, I.; Giltrap, A.M.; Alexander, F.M.; Cochrane, S.A.; Payne, R.J.; Martin, N.I.; Henninot, A.; Vederas, J.C. Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. ChemBioChem 21, 789-792 (2020).

Vuong, W.; Mosquera-Guagua, F.; Sanichar, R.; McDonald, T.R.; Ernst, O.P.; Wang, L.; Vederas, J.C. Synthesis of Chiral Spin-Labeled Amino Acids. Org. Lett. 21, 10149−10153 (2019).

Fischer, C.; Ahn, Y.-C.; Vederas, J.C. Catalytic Mechanism and Properties of Pyridoxal 5’-Phosphate Independent Racemases: How Enzymes Alter Mismatched Acidity and Basicity. Nat. Prod. Rep. 36, 1697-1705 (2019).

Acedo J.Z.; Chiorean, S.; Vederas, J.C.; van Belkum, M.J. The expanding structural variety among bacteriocins from Gram-positive bacteria. FEMS Microbiol. Rev., 42, 805–828 (2018).