The Vederas Group
Department of Chemistry
The University of Alberta
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Selected Publications


Selected Recent Publications (from over 375 total):

(click here for full list of publications)

 Van Oers, T.J.; Piercey, A.; Belovodskiy, A.; Reiz, B.; Donnelly, B.L; Vuong, W.; Lemieux, M.J.; Nieman, J.A.; Auclair, K.; Vederas, J.C. Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Org. Lett. 25, 5885-5889 (2023)

Fernandez, K.X; Pokorny, S.; Ishangulyeva, G.; Ullah, A.; Todorova, S.I.; Erbilgin, N.; Carroll, A.L.; Vederas, J.C. Beauveria bassiana exhibits strong virulence against Dendroctonus ponderosae in greenhouse and field experiments. Appl. Microbiol. Biotechnol. 107, 3341-3352 (2023). 

Pascoe, C.A.; Engelhardt, D.B.; Rosana, A.R.R.; van Belkum, M.J.; Vederas, J.C. Methylene Analogues of Neopetrosiamide as Potential Antimetastatic Agents: Solid Supported Syntheses Using Diamino Diacids for Pre-Stapling of Peptides with Multiple Disulfides. Org. Lett. 23, 9216-9220 (2021)

Hsiao, Y-.T.; Beadle, J.; Pascoe, C.; Annadate, R.; Vederas, J.C. Decarboxylative Radical Addition to Methylideneoxazolidinones for Stereocontrolled Synthesis of Selectively Protected Diamino Diacids. Org. Lett. 23, 7270-7273 (2021).

Fernandez, K.X; Fischer, C.; Vu, Gheblawi, M.; Wang, W.; Gottschalk, S.; Iturrioz, X.; Llorens-Cortès, C.; Oudit, G.A.; Vederas, J.C. Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators RSC Med. Chem. 12, 1402–1413 (2021).

Vuong, W.; Khan, M.B; Fischer, C.; Arutyunova, E.; Lamer, T.; Shields, J.; Saffran, H.A.; McKay, R.T.; van Belkum, M.J.; Joyce, M.; Young, H.S.; Tyrrell, D.L.; Vederas, J.C.; Lemieux, M.J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Comm. 11, Article 4282, 1-8 (2020).

Fischer, C.; Lamer, T.; Fernandez, K.; Gheblawi, M.; Wang, W.; Pascoe, C.; Lambkin, G.; Iturrioz, X.l; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. PEG-extended apelin-17 analogues as cardioprotective drug leads: importance of the KFRR motif and aromatic head group for improved physiological activity. J. Med. Chem. 63, 12073−12082 (2020).

Antwi, I.; Chiorean, S.; van Belkum, M.J.; Vederas, J.C. Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production. RSC Med. Chem. 11, 528-531 (2020).

Fischer, C.; Ahn, Y.-C.; Vederas, J.C. Catalytic Mechanism and Properties of Pyridoxal 5’-Phosphate Independent Racemases: How Enzymes Alter Mismatched Acidity and Basicity. Nat. Prod. Rep. 36, 1697-1705 (2019).

Acedo J.Z.; Chiorean, S.; Vederas, J.C.; van Belkum, M.J. The expanding structural variety among bacteriocins from Gram-positive bacteria. FEMS Microbiol. Rev., 42, 805–828 (2018).