Complete List of Publications

JOHN CHRISTOPHER VEDERAS
List of Publications and Patents

Van Belkum, M.J.; Aleksandrzak-Piekarczyk, T.; Lamer, T.; Vederas, J.C. Lactococcus lactis Mutants Resistant to Lactococcin A and Garvicin Q Reveal Missense Mutations in the Sugar Transport Domain of the Mannose Phosphotransferase System. Microbiol. Spectrum, 12, 1-13 (2024) doi 10.1128/spectrum03130-23 .

Arutyunova, E.; Belovodskiy, A.; Chen, P.; Joyce, M.; Saffran, H.; Lu, J.; Turner, Z.; Bai, B.; Lamer, T.; Vederas, J.C.; Tyrrell, D. L.; Lemieux, M. J.; Nieman, J. The effect of deuteration and homologation of the lactam ring of nirmatrelvir on its biochemical properties and oxidative metabolism. ACS Bio & Med Chem Au, 3, 529-541 (2023).

Van Oers, T.J.; Piercey, A.; Belovodskiy, A.; Reiz, B.; Donnelly, B.L; Vuong,   W.; Lemieux, M.J.; Nieman, J.A.; Auclair, K.; Vederas, J.C. Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Org. Lett. 25, 5885-5889 (2023).

Wong, J.Y.K.; Ekanayake, A. I.; Kharchenko, S.; Kirberger, S.E.; Qui, R.; Kelich, P.; Sarkar, S.; Li, J.; Fernandez, K.X.; Alvizo-Paez, E.R.; Miao, J.; Kalhor-Monfared, S.; Dwyer, J.J.; Kang, H.; Choi, H.; Nuss, J.M.; Vederas, J.C.; Lin, Y.-S.; Macauley, M.S.; Vukovic, L.; Pomerantz, W.C.K.; Derda, R. Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo. Nature Comm. doi.org/10.1038/s41467-023-41427-y  1-13 (2023).

Li, J.X.; Fernandez, K.X.; Ritland, C.; Jancsik, S.; Engelhardt, D.B.; Coombe, L.; Warren, R.L.; van Belkum, M.J.; Carroll, A.L.; Vederas, J.C.; Bohlmann, J.; Birol, I. Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population. BMC Genomics. 24, 390 doi.org/10.1186/s12864-023-09473-4(2023)

Kwon, M.; Hodgins, C.L.; Salama, E.; Dias, K.; Parikh, A.; Mackey, A.; Catenza, K.; Vederas, J.C.; Ro, D.-K. New insights into natural rubber biosynthesis from rubber-deficient lettuce mutants, expressing goldenrod and guayule cis-prenyltransferase. New Phytologist  239, 1098-1111 (2023).  doi 10.1111/ nph.18994

Fernandez, K.X; Pokorny, S.; Ishangulyeva, G.; Ullah, A.; Todorova, S.I.; Erbilgin, N.; Carroll, A.L.; Vederas, J.C. Beauveria bassiana exhibits strong virulence against Dendroctonus ponderosae in greenhouse and field experiments. Appl. Microbiol. Biotechnol. 107, 3341-3352 (2023).

Lamer, T. ; Vederas, J.C.  Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins. BMC Biotechnology 23, 1-11 doi.org/10.1186/s12896-023-00779-5  (2023).

Chen, A.A.; Arutyunova, E.; Lu, J.; Khan, M.B.; Rut, W.; Zmudzinski, M.; Shahbaz, S.; IyyathuraI, J.; Moussa, E.; Turner, Z.; Bai, B.; Lamer, T.; Nieman, J.A.; Vederas, J.C.; Julien, O.; Drag, M.; Elahi, S.; Young, H.S.; Lemieux, M.J. SARS-CoV-2 Mpro protease variants of concern display altered viral substrate and cell host target Gal8 processing but retain sensitivity towards antivirals.  ACS Central Sci. 9, 696-708(2023).

Li, Z.; Fernandez, K.X.; Vederas, J.C.; Gaenzle, M. Composition and activity of antifungal lipopeptides produced by Bacillus spp. in daqu fermentation. Food Microbiol.111,  article  10421, 1-10  (2023).

Rosana, A.R.R.; Klutsch, J.G.; Erbilgin, N.; Carroll, A.L.; Vederas, J.C. Dendroctonus ponderosae (Hopkins), Mountain Pine Beetle (Coleoptera: Curculionidae, Scolytinae) Biological Control Programmes in Canada, 6, in press (2023). 

Engelhardt, D.B.; Donnelly, B.L.; Beadle, J.; van Belkum, M.J; Vederas, J.C. Ring-opening reactions for the solid-phase synthesis of nisin lipopeptide analogues. Org Biomol. Chem. 20, 8989-8999   (2022). 

Lamer, T.; van Belkum, M.J. Vederas, J.C. Methods for recombinant production and purification of peptides as SUMO-peptide-intein fusion proteins to protect from degradation. Current Protocols. e571, 2, doi: 10.1002/cpz1.571, 1-28 (2022). 

Lamer, T.; van Belkum, M.J.; Wijewardane, A.; Chiorean, S.; Martin-Visscher, L.A.; Vederas, J.C. SPI “Sandwich”: combined SUMO-Peptide-Intein expression system and isolation procedure for improved stability and yield of peptides. Protein Sci. 31, e4316, 1-10 (2022). 

Lu, J.; Chen, S.; Khan, M.B.; Brassard, R.; Arutyunova, E.; Lamer, T.; Vuong, W.; Fisher, C.; Young, H.S.; Vederas, J.C.; Lemieux, J.M. Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition. Frontiers in Chem. 10, Article 85221, 1-10  (2022).

Kwan, M.; Utomo, J.C.; Park, K.; Pascoe, C.A.; Chiorean, S.; Ngo, I.; Pelot, K.A.; Pan, C.-H.; Kim, S.-W.; Zerbe, P.; Vederas, J.C.; Ro. D.-K. Cytochrome P450-catalyzed biosynthesis of a dihydrofuran neoclerodane in magic mint (Salvia divinorum). ACS Catalysis 12, 777-782 (2022) .

de Oliveira, A.A.; Vergara, A.; Wang, X.; Vederas, J.C.; Oudit, G.Y. Apelin Pathway in Cardiovascular, Kidney and Metabolic Diseases: Therapeutic Role of Apelin Analogs and Apelin Receptor Agonists. Peptides 147, 170697, 1-17 (2022).

Pascoe, C.A.; Engelhardt, D.B.; Rosana, A.R.R.; van Belkum, M.J.; Vederas, J.C. Methylene Analogues of Neopetrosiamide as Potential Antimetastatic Agents: Solid Supported Syntheses Using Diamino Diacids for Pre-Stapling of Peptides with Multiple Disulfides. Org. Lett. 23, 9216-9220 (2021).

Silva Francisco, M.; Lívio Varella Coelho, M.; Freitas de Souza Duarte, A.; Towle, K.M.; Chiorean, S.; Silva Almeida, G.; van Belkum, M.J.; Nes, I.F.; Vederas, J.C.; do Carmo de Freire Bastos, M. Draft genome sequence of Staphylococcus agnetis 4244, a strain with gene clusters coding for distinct post-translationally modified antimicrobial peptides. J. Global Antimicrob. Resist. 27, 239-243   (2021). 

Pablos, I.; Machado, Y.; Ramos de Jesus, H.C.; Mohamud, Y.; Kappelhoff, R.; Lindskog, C.; Vlok, M.; Bell, P.A.; Butler, G.S.; Grin, P.M.; Cao, Q.T.; Nguyen, J.P.; Solis, N.; Abbina, S.; Rut, W.; Vederas, J.C.; Szekely, L.; Szakos, A.; Drag, M.; Kizhakkedathu, J.N.; Mossman. K.; Hirota, J.A.; Jan, E.; Luo, H.; Banerjee, A.; Overall, C. Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome. Cell Peports 37, 109892, 1-20  (2021)

Hsiao, Y-.T.; Beadle, J.; Pascoe, C.; Annadate, R.; Vederas, J.C. Decarboxylative Radical Addition to Methylideneoxazolidinones for Stereocontrolled Synthesis of Selectively Protected Diamino Diacids. Org. Lett. 23, 7270-7273 (2021).

Bai, B.; Arutyunova, E.; Khan, M.B.; Lu, J.; Joyce, M.A.; Saffran, H.; Shields, J.S.; Kandadai, A.S.; Belovodskiy, A.; Hena, H.; Vuong, W.; Lamer, T.; Young, H.; Vederas, J.C.; Tyrrell, D.L.; Lemieux, M.J.; Nieman, J. Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors. RSC Med. Chem. 12, 1722-1730  (2021).

Vuong, W.; Vederas, J.C. Improved Synthesis of a Cyclic Glutamine Analog Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 Mpro. J. Org. Chem. 86, 13104-13110 (2021).

Fernandez, K.X; Fischer, C.; Vu, Gheblawi, M.; Wang, W.; Gottschalk, S.; Iturrioz, X.; Llorens-Cortès, C.; Oudit, G.A.; Vederas, J.C. Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators RSC Med. Chem. 12, 1402–1413 (2021).

Bai, B.; Belovodskiy, A.; Hena, M.; Kandadai, A. S.; Joyce, M.A.; Saffran, H.A.; Shields, J.A.; Khan, M.B.; Arutyunova, E.; Lu, J.; Bajwa, S.K.; Hockman, D.; Fischer, C.; Lamer, T.; Vuong, W.; Van Belkum, M.J.; Gu, Z.; Lin, F.; Du, Y.; Xu, J.; Rahim, M.; Young, H.S.; Vederas, J.C.; Tyrrell, D.L.; Lemieux, M.J.; Nieman, J. Peptidomimetic ?-acyloxymethylketone warheads with 6-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity and in vitro biological stability. J. Med. Chem. 65, 2905-2925 (2022).

Vuong, W.; Fischer, C.; Khan, M.B.; van Belkum, M. J.; Lamer, T.; Willoughby, K. D.; Lu, J.; Arutyunova, E.; Joyce, M.A.; Saffran, H.A.; Shields, J.A.; Young, H.S.; Nieman, J.A.; Tyrrell, L.D.; Lemieux, M.J.; Vederas, J.C. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: structural enhancements, increased solubility, and micellar studies. Eur. J. Med. Chem. 222, 113584, 1-11 (2021).

Arutyunova, E.; Khan, M.B.; Fischer, C.; Lu, J.; Lamer, T.; Vuong, W.; van Belkum, M.J.; McKay, R.T.; Tyrrell, D.L.; Vederas, J.C.; Young, H.S.; Lemieux, M.J. N-Terminal finger stabilizes the S1 pocket for the reversible feline drug GC376 in the SARS-CoV-2 Mpro dimer J. Mol. Biol. 433 167003, 1-17 (2021).

de Oliveira Pimentel, P. M. ; Rodrigues de Assis, R.; Gualdrón-Lopez, M.; Barroso, A.; Brant, F.; Leite, P.G.; Carbral de Lima Oliveira, B.; Esper, L.;. McKinnie, S.M.K.; Vederas, J.C.; do Nascimento Cordeiro, M.; Mendes dos Reis, P.V.; Martins Teixeria, M.; Monteiro de Castro Pimenta, A.; Borges, M.H.; de Lima, M.E.; Simão Machado, F. Tityus serrulatus scorpion venom as a potential drug source for Chagas’ disease: trypanocidal and immunomodulatory activity. Clinical Immunol. 226, 108713, 1-12 (2021).

Rosana, A.R.R.; Pokorny, S.; Klutsch, J.G.; Ibarra Romero, C.; Sanichar, R.; Engelhardt, D.; van Belkum, M.J.; Erbilgin, N.; Bohlmann. J.; Carroll, A.L.; Vederas, J.C. Selection of entomopathogenic fungus Beauveria bassiana (Deuteromycotina: Hyphomycetes) for the biocontrol of Dendroctonus ponderosae (Coleoptera: Curculionidae, Scolytinae) in Western Canada. Appl. Microbiol. Biotechnol. 105, 2541–2557 (2021).

Fischer, C.; Lamer, T.; Fernandez, K.; Gheblawi, M.; Wang, W.; Pascoe, C.; Lambkin, G.; Iturrioz, X.l; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. PEG-extended apelin-17 analogues as cardioprotective drug leads: importance of the KFRR motif and aromatic head group for improved physiological activity. J. Med. Chem. 63, 12073−12082 (2020).

Goméz-Mendoza, D.P.; Pereira Lemos, R.; Jesus, I.C.G.; Gorshkov, V.; McKinnie, S.M.K.; Vederas, J.C.; Kjeldsen, F.; Guatimosim, S.; Santos, R.A.; Pimenta, A.M.C.; Verano-Braga, T. Moving pieces in a cellular puzzle: a cryptic peptide from the scorpion toxin Ts14 activates AKT and ERK signaling and decreases cardiac myocyte contractility via dephosphorylation of phospholamban. J. Proteome Res. 19, 3467-3477 (2020).

Vuong, W.; Khan, M.B; Fischer, C.; Arutyunova, E.; Lamer, T.; Shields, J.; Saffran, H.A.; McKay, R.T.; van Belkum, M.J.; Joyce, M.; Young, H.S.; Tyrrell, D.L.; Vederas, J.C.; Lemieux, M.J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Comm. 11, Article 4282, 1-8 (2020).

Bernardo, S.P.C.; Rosana, A.R.R.; de Souza, A.N.; Chiorean, S.; Martins, M.L.L.; Vederas, J.C. Draft Genome Sequence of Thermophilic Bacterium Bacillus licheniformis SMIA-2, an Antimicrobial- and Thermostable Enzyme-Producing Isolate from Brazilian Soil. Microbiol. Res. Announc. 9, 1-3, e00106-20 (2020).

Antwi, I.; Chiorean, S.; van Belkum, M.J.; Vederas, J.C. Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production. RSC Med. Chem. 11, 528-531 (2020).

Chiorean, S.; Antwi, A.; Carney, D.W.; Kotsogianni, I.; Giltrap, A.M.; Alexander, F.M.; Cochrane, S.A.; Payne, R.J.; Martin, N.I.; Henninot, A.; Vederas, J.C. Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. ChemBioChem 21, 789-792 (2020).

Masoud, A. G. T.; Lin, J. X.; Farhan, M. A.; Fischer, C.; Zhu, L. F.; Anderson, C. C.; Sis, B.; Kassiri, Z.; Moore, R. B.; Kim, D.; Vederas, J. C.; Adam, B. A.; Oudit, G. Y.; Murray, A. G. Vascular repair is regulated by apelin through endothelial tip cell differentiation following immune-mediated injury. J. Clinical Investig. 130, 94-107 (2020). 

Vuong, W.; Mosquera-Guagua, F.; Sanichar, R.; McDonald, T.R.; Ernst, O.P.; Wang, L.; Vederas, J.C. Synthesis of Chiral Spin-Labeled Amino Acids. Org. Lett. 21, 10149−10153 (2019).

Wang, W.; Shen, M.; Fischer, C.; Basu, R.; Hazra, S.; Couvineau, P.; Paul, M.; Wang, F.; Toth, S.; Mix, D.S.; Poglitch, M.; Gerard, N.P.; Bouvier, M.; Vederas, J.C.; Penninger, J.M.; Kassiri, Z.; Oudit, G.Y. Apelin protects against abdominal aortic aneurysm: therapeutic role of neutral endopeptidase resistant apelin analogues. Proc. Natl. Acad. Sci. USA, 11, 13006–13015 (2019)

Fischer, C.; Ahn, Y.-C.; Vederas, J.C. Catalytic Mechanism and Properties of Pyridoxal 5’-Phosphate Independent Racemases: How Enzymes Alter Mismatched Acidity and Basicity. Nat. Prod. Rep. 36, 1697-1705 (2019).

Fischer, C.; Lamer, T.; Wang, W.; McKinnie, S.M.K.; Iturrioz, X.; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. Plasma Kallikrein Cleaves and Inactivates Apelin-17: Palmitoyl- and PEG-extended Apelin-17 Analogs as
Metabolically Stable Blood Pressure-Lowering Agents. Eur. J. Med. Chem. 166, 119-124 (2019).

Daas, M.S.; Rosana, A.R.R.; Acedo, J.Z.; Malika, D.; Nateche, F.; Kebbouche-Gana, S.; Vederas, J.C. Insights into the draft genome sequence of bioactives-producing Bacillus thuringiensis DNG9 isolated from Algerian soil-oil slough. Standards Genomic Sci. 13:25, 1-10 (2018).

Acedo J.Z.; Chiorean, S.; Vederas, J.C.; van Belkum, M.J. The expanding structural variety among bacteriocins from Gram-positive bacteria. FEMS Microbiol. Rev., 42, 805–828 (2018).

Fischer, C.; Kwon, M.; Ro, D.K.; van Belkum, M.J.; Vederas, J.C. Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea – tuning the scopolamine production. MedChemComm 9, 888–892 (2018).

Daas, M.S.; Rosana, A.R.R.; Acedo, J.Z.; Malika, D.; Nateche, F.; Kebbouche-Gana, S.; Vederas, J.C. Draft genome sequence of Bacillus paralicheniformis F47 isolated from Algerian salty lake. Genome Announcements 6, e00190-18 (2018).

Ahn, Y.-C.; Fischer C.; van Belkum, M.J.; Vederas, J.C. PLP-independent racemization: mechanistic and mutational studies of O-ureidoserine racemase (DcsC). Org. Biomol. Chem. 16, 1126 - 1133 (2018).

Sanichar, R.; Carroll, C.; Kimmis, R.; Reiz, B.; Vederas, J.C. Dess-Martin Periodinane Oxidative Rearrangement for Preparation of α-Keto Thioesters. Org. Biomol. Chem. 16, 593-597 (2018).

Chiorean, S.; Vederas, J.C.; van Belkum, M.J. Identification and Heterologous Expression of the sec-Dependent Bacteriocin Faerocin MK from Enterococcus faecium M3K31. Probiotics and Antimicrobial Proteins 10, 142–147 (2018).

Daas, M.S.; Acedo, J.Z.; Rosana, A.R.R.; Orata, F.D.; Reiz, B.; Zheng, J.; Nateche, F.; Case, R.J.; Kebbouche-Gana, S.; Vederas, J.C. Bacillus amyloliquefaciens ssp. plantarum F11 isolated from Algerian salty lake as a source of biosurfactants and bioactive lipopeptides. FEMS Lett. 365, fnx248, 1-9 (2018).

Bakhtiary, A.; Cochrane, S.A.; Mercier, P.; McKay, R.T.; Miskolzie, M.; Sit, C.S.; and Vederas, J.C. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147. J. Am. Chem. Soc. 139, 17803−17810 (2017).

Booman, M.; Forster, I.; Vederas, J.C.; Groman, D.B.; and Jones, S.R.M. Soybean meal-induced enteritis in Atlantic salmon (Salmo salar) and Chinook salmon (Oncorhynchus tshawytscha) but not in pink salmon (O. gorbuscha) Aquaculture 483, 238-243 (2017).

Acedo, J.Z; Ibarra Romero, C.; Miyata, S.T.; Blaine A.H.; McMullen L.M.; Vederas, J.C.; and van Belkum, M.J. Draft genome sequence of Enterococcus canintestini 49, a potential probiotic that produces multiple bacteriocins. Genome Announcements 5, e01131-17 (2017).

Caldo, K.M.P.; Acedo, J.Z.; Panigrahi, R.; Vederas, J.C.; Weselake, R.J.; and Lemieux, M.J. Brassica napus diacylglycerol acyltransferase 1 is regulated by its hydrophilic N-terminal domain in response to allosteric effectors. Plant Physiol. 175, 667-680 (2017).

McKinnie, S.M.K.; Wang, W.; Fischer, C.; McDonald, T.; Kalin, K.R.; Iturrioz, X.; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. Synthetic modification within the ‘RPRL’ region of apelin peptides: Impact on cardiovascular activity and stability to neprilysin and plasma degradation. J. Med. Chem. 60, 6408-6427 (2017).

Sanichar, R.; Vederas, J.C. One Step Transformation of Coenzyme A Into Analogues by Transamidation. Org. Lett. 19,1950-1953 (2017).

Acedo, J.Z; Towle, K.M.; Lohans, C.T.; Miskolzie, M.; McKay, R.T.; Doerksen, T.A.; Vederas, J.C.; Martin-Visscher, L.A. Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria. FEBS Lett. 591, 1349-1359 (2017).

Daas, M.S.; Rosana, A.R.R.; Acedo, J.Z.; Nateche, F.; Kebbouche-Gana, S.; Vederas, J.C.; Case, R.J. Draft Genome Sequences of Bacillus cereus E41 and Bacillus anthracis F34 from Algerian Salt Lakes. Genome Announcements 5, (genomeA.00383-17) May, 2017. doi:10.1128/genomeA.00383-17.

Towle, K.M.; and Vederas, J.C. Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides. MedChemComm 8, 276-285 (2017).

Zhong, J.-C.; Zhang, Z.-Z.; Wang, W.; McKinnie, S.M.K.; Vederas, J.C.; and Oudit, G.Y. Targeting the Apelin Pathway as a Novel Therapeutic Approach for Cardiovascular Diseases. (Biochimica et Biophysica Acta) BBA - Molecular Basis of Disease, 1863, 1942-1950 (2017).

Cochrane, S.A.;  Findlay, B.;  Bakhtiary, A.; Acedo, J.Z.; Rodriguez-Lopez, E.M.;  Mercier, P.; and Vederas, J.C. The Antimicrobial Lipopeptide Tridecaptin A Selectively Binds to Gram-Negative Lipid II. Proc. Natl. Acad. Sci. USA 113, 11561-11566 (2016).

Towle, K.M.; Lohans, C.T.; Miskolzie, M.; Acedo, J.Z.; van Belkum, M.J.; and Vederas, J.C. Solution Structures of Phenol-Soluble Modulins α1, α3 and β2, Virulence Factors from Staphylococcus aureus. Biochemistry 55, 4798-4806 (2016).

Cochrane, R.V.K.;. Norquay, A.K.; and Vederas, J.C. Natural Products and Their Derivatives as tRNA Synthetase Inhibitors and Antimicrobial Agents. MedChemComm 7, 1535-1545 (2016).

McKinnie, S.M.K.; Fischer, C.; Tran, K.M.H.; Wang, W.; Mosquera, F.; Oudit, G.Y.; and Vederas, J.C. The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides. ChemBioChem 17, 1495-1498 (2016).

Wang, W.; McKinnie, S.M.K.; Farhan, M.; Paul, M.; McDonald, T.; McLean, B.; Llorens-Cortes, C.; Hazra, S.; Murray, A.G.; Vederas, J.C. and Oudit, G.Y. Angiotensin Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System. Hypertension 68, 365-377 (2016).

Arbulu, S.; Frantzen, C.; Lohans, C.T.; Cintas, L.M. Herranz, C.; Holo, H.; Diep, D.B.; Vederas, J.C.; and Hernández, P.E. Draft Genome Sequence of the Bacteriocin Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subspecies fulvus). Genome Announcements 4, e00055-16 (2016).

Acedo, J.Z.; van Belkum, M.J.; Lohans, C.T.; Towle, K.M.; Miskolzie, M.; and Vederas, J.C. NMR Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved Among Leaderless Bacteriocins with Broad-Spectrum Activity. Biochemistry 55, 733-742 (2016).

Cochrane, R.V.K.; Sanichar, R.; Lambkin, G.R.; Reiz, B.; Xu, W.; Tang, Y.; and Vederas, J.C. Production of new cladosporin analogues by reconstitution of the polyketide synthases responsible for the biosynthesis of this antimalarial agent. Angew. Chemie Int. Ed. 55, 664-668 (2016).

Cochrane, S.A.; and Vederas, J.C. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates. Medicinal Res. Rev. 36, 4–31 (2016).

Cacho, R.A.; Thuss, J.; Xu, W.; Sanichar, R.; Gao, Z.; Nguyen A.; Vederas, J.C.; and Tang, Y. Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin LovB Megasynthase. J. Am. Chem. Soc. 137, 15688-15691 (2015).

Arbulu, S.; Lohans, C.T.; van Belkum, M.J.; Cintas, L.M.; Herranz, C.; Vederas, J.C; and Hernández, P.E. Solution structure of enterocin HF, an antilisterial bacteriocin produced by Enterococcus faecium M3K31. J. Agric. Food Chem. 63, 10689-10695 (2015).

Cochrane, S.A.; Li, X.; He, S.; Yu, M.; Wu, M.; and Vederas, J.C. Synthesis of tridecaptin-antibiotic conjugates with in vivo activity against gram-negative bacteria. J. Med. Chem. 58, 9779-9785 (2015).

Cochrane, S.A.; Surgenor, R.R.; Khey, K.M.W.; and Vederas, J.C. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1. Org Lett. 17, 5428-5431 (2015).

Cochrane, R.V.K.; Gao, Z.; Lambkin, G.R.; Xu, W.; Winter, J.M.; Marcus, S.L.; Tang, Y.; and Vederas, J.C. Comparison of 10,11-dehydrocurvularin polyketide synthases from Alternaria cinerariae and Aspergillus terreus highlights key structural motifs. ChemBioChem 16, 2479-2483 (2015).

Winter, J.M.; Cascio, D.; Dietrich, D.; Sato, M.; Watanabe, K.; Sawaya, M.R.; Vederas, J.C. and Tang, Y. Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. J. Am. Chem. Soc. 137, 9885-9893 (2015).

Cochrane, S.A.; Lohans, C.T.; van Belkum, M.J.; Bels, M.A.; and Vederas, J.C. Studies on Tridecaptin B1, a New Tridecaptin Analogue with Activity Against Multidrug Resistant Gram-Negative Bacteria. Org. Biomol. Chem. 13, 6073-6081 (2015).

Van Belkum, M.J.; Lohans, C.T.; and Vederas, J.C. Draft Genome Sequences of Paenibacillus polymyxa NRRL B-30509 and Paenibacillus terrae NRRL B-30644, Strains from a Poultry Environment that Produce Tridecaptin A and Paenicidins. Genome Announcements 3, 1-2, e00372-15 (2015).

Li, J.; Chaytor, J.L.; Findlay, B.; McMullen, L.M.; Smith D.C.; and Vederas, J.C. Identification of Didecyldimethylammonium Salts and Salicylic Acid as Antimicrobial Compounds in Commercial Fermented Radish Kimchi. J. Agric. Food Chem. 62, 3053-3058 (2015).

Acedo, J.Z.; van Belkum, M.J.; Lohans, C.T.; McKay, R.T.; Miskolzie, M. and Vederas, J.C. Solution Structure of Acidocin B, a Circular Bacteriocin Produced by Lactobacillus acidophilus M46. Appl. Environ. Microbiol. 81, 2910-2918 (2015).

Lin, X.B; Lohans, C.T.; Duar, R.; Zheng, J.; Vederas, J.C.; Walter, J.; and Gänzle, M. Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri. Appl. Environ. Microbiol. 81, 2032-2041 (2015).

Lohans, C.T.; van Belkum, M.J.; Li, J.;and Vederas, J.C. Characterization of Bacterial Antimicrobial Peptides Active Against Campylobacter jejuni. Can. J. Chem. 93, 381–388 (2015).

Bai, Y.; Findlay, B.; Sanchez-Maldonado, A.F.; Schieber, A.; Vederas, J.C.; and Gänzle, M.G. Novel pyranoanthocyanidins and vinylphenol adducts of deoxyanthocyanidins in sorghum sourdough. J. Agric. Food. Chem. 62, 11536-11546 (2014).

Kwon, M.; Cochrane, S.A.; Vederas, J.C.; and Ro, D.-K. Molecular cloning and characterization of drimenol synthase from Valerian plant (Valeriana officinalis). FEBS Lett. 588, 4597-4603 (2014).

Cochrane, R.V.K.; and Vederas, J.C. Highly selective but multifunctional oxygenases in secondary metabolism. Accts. Chem. Res. 47, 3148-3161 (2014).

Lohans, C.T; Li, J.L.; and Vederas, J.C. Structure and Biosynthesis of Carnolysin, a Homolog of Enterococcal Cytolysin with D-Amino Acids. J. Am. Chem. Soc. 136, 13150-13153 (2014).

Cochrane, S.A.; and Vederas, J.C. Unacylated Tridecaptin A1 Acts as an Effective Sensitizer of Gram-Negative Bacteria to Other Antibiotics. Int. J. Antimicrobial Agents 44, 493-499 (2014).

Vederas, J.C. Explorations of Fungal Biosynthesis of Reduced Polyketides. Nat. Prod. Rep. 31, 1253-1259 (2014).

Hu, Y.; Dietrich, D.; Xu, W.; Patel, A.; Thuss, J.A.J.; Wang, J; Yin, W.-B.; Qiao, K; Houk, K.N.; Vederas, J.C.; and Tang, Y. A Carbonate-Forming Baeyer-Villiger Monooxygenase. Nature Chem. Biol. 10, 552-554 (2014).

Cochrane, S.A.; Findlay, B.; Vederas, J.C.; and Ratemi, E.S. Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane. ChemBioChem 15, 1295-1299 (2014).

Cochrane, S.A.; Lohans, C.T.; Brandelli, J.R.; Mulvey, G.; Armstrong, G.D.; and Vederas, J.C. Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin
A1. J. Med. Chem. 57, 1127-1131 (2014).

Tulini, F.L.; Lohans, C.T.; Bordon, K.C.F.; Zheng, J.; Arantes, E.C.; Vederas, J.C.; and De Martinis, E.C.P. Purification and characterization of antimicrobial peptides from fish isolate Carnobacterium maltaromaticum C2: carnobacteriocin X and carnolysins A1 and A2. Int. J. Food Microbiol. 173, 81-88 (2014).

Lohans, C.T.; van Belkum, M.J.; Cochrane, S.A.; Huang, Z.; Sit, C.S.; McMullen, L.M.; and Vederas, J.C. Biochemical, Structural, and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni. ChemBioChem 15, 243-249 (2014) .

McKinnie, S.M.; Rodriguez-Lopez, E.M; Vederas, J.C.; Crowther, J.M.; Suzuki, H.; Dobson, R.C.; Leustek, T.; Triassi, A.J.; Wheatley, M.S.; and Hudson, A.O. Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds. Bioorg. Med. Chem. 22, 523-530 (2014).

Dietrich, D.; and Vederas, J.C. Lovastatin, compactin and related
anticholesterolemic agents. In Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Martín, J.F.; García-Estrada, C.; Zeilinger, S. (Eds) Springer Science: NY, Chapter 12, 263-287 (2014).

Lohans, C.T.; and Vederas, J.C. Structural characterization of thioether-bridged bacteriocins. J. Antibiot. 67, 23–30 (2014).

Pandya, K.; Dietrich, D.; Seibert, J.; Vederas, J.C.; and Odermatt, A. Synthesis of sterically encumbered 11-beta-aminoprogesterone derivatives and evaluation as 11-beta-hydroxysteroid dehydrogenase inhibitors and mineralcorticoid receptor antagonists. Bioorg. Med. Chem. 21, 6274-6281 (2013).

Wang, W.; McKinnie, S.M.K.; Patel, V.B.; Haddad, G.; Wang, Z.; Zhabyeyev, P.; Das, S.K.; Basu, R.; McLean, B.; Kandalam, V.; Penninger, J.M.; Kassiri, Z.; Vederas, J.C.; Murray, A.G.; and Oudit, G. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J. Am. Heart Assoc. e000249, Jul 1, 1-17 (2013).

Lohans, C.T.; Towle, K.M.; Miskolzie, M.; McKay, R.T.; van Belkum, M.J.; McMullen, L.M; and Vederas, J.C. Solution Structures of the Linear Leaderless Bacteriocins Enterocin 7A and 7B Resemble Carnocyclin A, a Circular Antimicrobial Peptide. Biochemistry 52, 3987-3994 (2013).

Xu, W.; Chooi, Y.-H.; Choi, J.W.; Li, S.; Vederas, J.C.; Da Silva, N.A. and Tang, Y. Finding the Missing Link in Lovastatin Biosynthesis: LovG is the Esterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover. Angew. Chemie Int. Ed. 52, 6472-6475 (2013).

Gao, Z.; Wang, J.; Norquay, A.K.; Qiao, K.; Tang, Y.; Vederas, J.C. Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. J. Am. Chem. Soc. 135, 1735-1738 (2013).

Towle, K.M.; Chaytor, J.L.; Liu, H.; Austin, P.; Roberge, M.; Roskelley, C.D.; and Vederas, J.C. Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion. Org. Biomol. Chem. 11, 1476–1481 (2013).

Cochrane, S.A.; Huang, Z.; and Vederas, J.C. Investigation of the Ring-Closing Metathesis of Peptides in Water. Org. Biomol. Chem. 11, 630-639 (2013).

Arnison, P.G.; Bibb, M.J.; Bierbaum, G.; Bowers, A.A.; Bugni, T.S.; Bulaj, G.; Camarero, J.A.; Campopiano, D.J.; Challis, G.L.; Clardy, J.; Cotter, P.D.; Craik;, D.J.; Dawson, M.; Dittmann, E.; Donadio, S.; Dorrestein, P.C.; Entian, K.D.; Fischbach, M.A.; Garavelli, J.S.; Göransson, U.; Gruber, C.W.; Haft, D.H.; Hemscheidt, T.K.; Hertweck, C.; Hill, C.; Horswill, A.R.; Jaspars, M.; Kelly, W.L.; Klinman, J.P.; Kuipers, O.P.; Link, A.J.; Liu, W.; Marahiel, M.A.; Mitchell, D.A.; Moll, G.N.; Moore, B.S.; Müller, R.; Nair, S.K.; Nes, I.F.; Norris, G.E.; Olivera, B.M.; Onaka, H.; Patchett, M.L.; Reaney, M.T.J.; Rebuffat, S.; Ross, R.P.; Sahl, H.G.; Schmidt, E.W.; Selsted, M.E.; Severinov, K.; Shen, B.; Sivonen, K.;Smith, L.; Stein, T.; Süssmuth, R.E.; Tagg, J.R.; Tang, G.L; Truman, A.W.; Vederas, J.C.; Walsh, C.T.; Walton, J.D.; Wenzel, S.C.; Willey, J.M.; and van der Donk, W.A. Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products: Overview and Recommendations for a Universal Nomenclature, Nat. Prod. Rep. 30, 108-160 (2013).

Lohans, C.T.; Huang, Z.; van Belkum, M.J.; Giroud, M.; Sit, C.S.; Steels, E.M.; Zheng, J.; Whittal, R.M.; McMullen, L.M.; and Vederas, J.C. Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy. J. Am. Chem. Soc. 134, 19540-19543 (2012).

Van Belkum, M.J.; and Vederas, J.C. The ABC transporter CclEFGH Facilitates the Production of the Circular Bacteriocin Carnocyclin A, Probiotics and Antimicrobial Proteins 4, 273-278 (2012).

Pyle, B.W.; Tran, H.T.; Pickel, B.; Haslam, T.M; Gao, Z.; MacNevin, G.; Vederas, J.C.; Kim, S.-U.; and Ro, D.-K. Enzymatic synthesis of a sedative terpene, valerena-4,7(11)-diene, by a unique sesquiterpene synthase from valerian plant (Valeriana officinalis). FEBS J 279, 3136–3146 (2012).

Li, J.; van Belkum M. J.; and Vederas, J. C. Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna. Bioorg. Med. Chem. 20, 4356–4363 (2012).

Ames, B; Nguyen, C; Bruegger, J.; Smith, P.; Xu, W.; Ma, S.; Wong, E.; Wong, S.; Xie, X.; Li, J. W.-H.;  Vederas, J.C.; Tang, Y.; and Tsai, S.-C. Crystal Structure and Biochemical Studies of Trans-acting Polyketide Enoyl Reductase LovC During Lovastatin Biosynthesis. Proc. Natl. Acad. Sci. USA, 109, 11144-11149 (2012).

Lama, A.; Pané-Farré, J.; Chon, T.; Wiersma, A.M.; Sit, C.S.; Vederas, J.C.; Hecker, M.; and Nakano, M.M. Response of Methicillin-resistant Staphylococcus aureus to Amicoumacin A. PLoS ONE 7, issue 3, 1-13 (2012). 10.1371/journal.pone.0034037

McKinnie, S.M.K.; Ross, A.C.; Little; M.J.; and Vederas, J.C. The Solid Phase Supported Peptide Synthesis of Analogues of the Lantibiotic Lactocin S. MedChemComm, 3, 971-975 (2012).

Fan, C.; and Vederas, J.C. Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT). Org. Biomol. Chem. 10, 5815-5819 (2012).

Ross, A.C.; McKinnie, S.M.K.; and Vederas, J.C. The Synthesis of Active and Stable Diaminopimelate Analogues of the Lantibiotic Peptide Lactocin S. J. Am. Chem. Soc. 134, 2008-2011 (2012).

Dietrich, D.; van Belkum, M.J.; and Vederas, J.C. Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Org. Biomol. Chem. 10, 2248-2254 (2012).

Zhou, H.; Gao, Z.; Qiao, K.; Wang, J.; Vederas, J.C.; and Tang, Y. A fungal ketoreductase that displays substrate-dependent stereospecificity. Nature Chem. Biol. 8, 331-333 (2012).

Sit, C.S.; Lohans, C.T.; van Belkum, M.J.; Campbell, C.D.; Miskolzie, M.; and Vederas, J.C. Substitution of a conserved disulfide in the type IIa bacteriocin, leucocin A, with L-leucine and L-serine residues: effects on activity and three-dimensional structure. ChemBioChem 13, 35-38 (2012).

Lohans, C.T.; and Vederas, J.C. Development of Class IIa Bacteriocins as Therapeutic Agents. Int. J. Microbiol. Volume 2012, Article ID 386410, doi:10.1155/2012/386410 (2012).

Shaheen, M.; Li, J.; Ross, A.C.; Vederas, J.C.; and Jensen, S.E. Paenibacillus polymyxa PKBI Produces Novel Variants of Polymyxin B-type Antibiotics. Chem. Biol. 18, 1640-1648 (2011).

Liu, W.; Chan, A.S.H.; Liu, H.; Cochrane, S.A.; and Vederas, J.C. Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147. J. Am. Chem. Soc. 133, 14216-14219 (2011).

Sit, C.S.; Van Belkum, M.J.; McKay, R.T.; Worobo, R.W.; and Vederas, J.C. The 3D solution structure of thurincin H, a bacteriocin with four sulfur to α-carbon crosslinks. Angew. Chemie Int. Ed., 123, 8718-8721 (2011).

Watanabe, N.; Clay, M.D.; van Belkum, M.J.; Fan, C.; Vederas, J.C.; and James, M.N.G., The Structure of LL-Diaminopimelate Aminotransferase from Chlamydia trachomatis: Implications for Its Broad Substrate Specificity. J. Mol. Biol. 411, 649-660 (2011).

Van Belkum, M.J.; Martin-Visscher, L.M.; and Vederas, J.C., Structure and genetics of circular bacteriocins.  Trends Microbiol. 19, 411-418 (2011).

Barriuso, J.; Nguyen, D.T.; Li, J. W.-H; Roberts, J.N.; MacNevin, G.; Chaytor, J.L.; Marcus, S.L.; Vederas, J.C.; and Ro, D.-K. Double Oxidation of the Cyclic Nonaketide Dihydromonacolin L to Monacolin J by a Single Cytochrome P450 Monooxygenase, LovA. J. Am. Chem. Soc. 133, 8078-8081 (2011).

Sit, C.S.; McKay, R.T; Hill; C.; Ross, R.P.; and Vederas, J.C. The 3D Structure of Thuricin CD, a Two-Component Bacteriocin with Cysteine Sulfur to α-Carbon Crosslinks. J. Am. Chem. Soc. 133, 7680-7683 (2011).

Liu, X.; Vederas, J.C.; Whittal, R.M.; Zheng, J.; Stiles, M.E.; Carlson, D.; Franz, C.M.A.P.; McMullen, L.M.; and Van Belkum, M.J.; Identification of an N-Terminal Formylated, Two-Peptide Bacteriocin from Enterococcus faecalis 710C. J. Agric. Food Chem. 59, 5602–5608 (2011).

Sit, C.S.; Yoganathan, S.; and Vederas, J.C. Biosynthesis of aminovinyl-cysteine containing peptides and its application in the production of potential drug candidates. Accts. Chem. Res. 44, 261-268 (2011).

Martin-Visscher, L.A.; Yoganathan, S.; Sit, C.S.; Lohans, C.T.; and Vederas, J. C. The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against Gram-negative bacteria in combination with EDTA treatment. FEMS Microbiol. Lett. 317, 152-159 (2011).

Yoganathan, S.; Sit, C.S.; and Vederas, J.C. Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Org. Biomol. Chem., 9, 2133-2141 (2011).

Ross, A.C.; and Vederas, J.C. Fundamental Functionality - Recent Developments in Understanding the Structure Activity Relationships of Lantibiotic Peptides. J. Antibiot., 64, 27-34 (2011).

Martin-Visscher, L.A.; van Belkum, M.J. and Vederas, J.C. Class IIc or circular bacteriocins. In Prokaryotic Antimicrobial Peptides from Genes to Applications. D. Drider and S. Rebuffat (Eds), Chapter 12, pp 213-236, 2011, Springer Verlag.

Zhou, H.; Qiao, K.; Gao, Z.; Vederas, J.C.; and Tang, Y. Insights Into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs. J. Biol. Chem., 285, 41412-41421 (2010).

Van Belkum, M.J.; Martin-Visscher, L.A. and Vederas, J.C. Cloning and Characterization of the Gene Cluster involved in the Production of the Circular Bacteriocin Carnocyclin A. Probiotics & Antimicrobial Proteins, 2, 218-225 (2010).

Yamamoto, K.; Xu, J.; Kawulka, K.E.; Vederas, J.C. and Ramamoorthy, A. Use of a Copper-Chelated-Lipid Speeds Up NMR Measurements From Membrane Proteins. J. Am. Chem. Soc. 132, 6929–6931 (2010).

Huang, Z.; Derksen, D.J. and Vederas, J.C. Preparation and Use of Cysteine Orthoesters for Solid Supported Synthesis of Peptides. Org. Lett. 12, 2282-2285 (2010).

Rea, M.C.; Sit, C.S.; Clayton, E.; O'Connor, P.M.; Whittal, R.M.; Zheng, J.; Vederas, J.C.; Ross, R.P. and Hill, C. Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc. Natl. Acad. Sci. USA 107, 9352-9357 (2010).

Zhou, H.; Qiao, K.; Gao, Z.; Meehan, M.J.; Li, J.W-H.; Zhao, X.; Dorrestein, P.C.; Vederas, J.C. and Tang, Y. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J. Am. Chem. Soc. 132, 4530–4531 (2010).

Campbell, C.D. and Vederas, J.C. Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers, 93, 755-763 (2010).

Fan, C.; Clay, M.D.; Deyholos, M.K. and Vederas, J.C. Exploration of Inhibitors for Diaminopimelate Aminotransferase. Bioorg. Med. Chem.18, 2141–2151 (2010).

Liu, H.; Boudreau, M.A.; Zheng, J.; Whittal, R.M.; Austin, P.; Roskelley, C.D.; Roberge, M.; Andersen, R.J. and Vederas, J.C. Chemical Synthesis and Biological Activity of the Neopetrosiamides and Their Analogues: Revision of Disulfide Bond Connectivity. J. Am. Chem. Soc. 132, 1486–1487 (2010).

Ross, A.C.; Liu, H.; Pattabiraman, V.R. and Vederas, J.C., Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase, J. Am. Chem. Soc. 132, 462-463 (2010).

Vederas, J.C. (Ed) Amino Acids, Peptides & Proteins, Volume 5 of Comprehensive Natural Products II Chemistry and Biology; Mander, L. and Liu, H.-W., Eds.; Elsevier: Oxford, 2010; 752 pages, ISBN 978-0-08-045381-1.

Yoganathan, S.; and Vederas, J.C. Nonprotein L-alpha-Amino Acids. In Comprehensive Natural Products II Chemistry and Biology; Mander, L. and Liu, H.-W., Eds.; Elsevier: Oxford, 2010; volume 5, pp 5-73.

Liu, H.; Pattabiraman, V.R. and Vederas, J.C., Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen, Org. Lett. 11, 5574-5577 (2009).

Ma, S.M.; Li, J.W.-H.; Choi, J.W.; Zhou, H.; Lee, M.K.K.; Moorthie, V.A.; Xie, X.; Kealey, J.T.; Da Silva, N.A.; Vederas, J.C. and Tang, Y., Complete Reconstitution of a Highly-Reducing Iterative Polyketide Synthase, Science 326, 589-592 (2009).

Martin-Visscher, L.A.; Gong, X.; Duszyk, M. and Vederas, J.C., The 3D structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif, J. Biol. Chem. 284, 28674-28681 (2009).

Huang, T.; Geng, H.; Miyyapuram, V.R.; Sit, C. S.; Vederas, J.C; and Nakano, M.M. Isolation of a Variant of Subtilosin A with Hemolytic Activity, J. Bacteriol. 191, 5690–5696 (2009).

Li, J. W.-H.; and Vederas, J.C. Drug Discovery and Natural Products: End of An Era or An Endless Frontier?, Science 325, 161-165 (2009).

Gong, X.; Martin-Visscher, L.A.; Nahirney, D.; Vederas, J.C.; and Duszyk, M. The circular bacteriocin, carnocyclin A, forms anion-selective channels in lipid bilayers, Biochim. Biophys. Acta (Biomembranes), 1788, 1797–1803 (2009).

Spantulescu, M.D.; Boudreau, M.A.; and Vederas, J.C. Retention of Configuration in Photolytic Decarboxylation of Peresters to Form Chiral Acetals and Ethers, Org. Lett. 11, 645-648 (2009).

Pillai, B.; Moorthie, V.A.; van Belkum, M.J.; Marcus, S.L.; Cherney, M.M.; Diaper, C.M.; Vederas, J.C.; and James, M.N.G. Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis, J. Mol. Biol., 385, 580-594 (2009).

Watanabe, N.; Clay, M.D.; van Belkum, M.J.; Cherney, M.M.; Vederas, J.C.; and James, M.N.G., Mechanism of Substrate Recognition and PLP-induced Conformational Change in LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana, J. Mol Biol., 384, 1314-1329 (2008).

Yoganathan, S.; and Vederas, J.C., Fracturing Rings to Understand Lantibiotics, Chem. Biol., 15, 999-1001 (2008).

Pattabiraman, V.R.; McKinnie, S.M.K.; and Vederas, J.C., Solid Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide, Bis-desmethyl Lacticin 3147 A2, Angew. Chemie Int. Ed., 47, 9472-9475 (2008).

Martin-Visscher, L.A.; van Belkum, M.J.; Garneau-Tsodikova, S.; Whittal, R.M.; Zheng, J.; McMullen. L.M.; and Vederas, J.C., Isolation and characterization of carnocyclin A, a novel circular bacteriocin, produced by Carnobacterium maltaromaticum UAL307, Appl. Environ. Microbiol., 74 , 4756-4763 (2008).

Derksen, D.J.; Boudreau, M.A.; and Vederas, J.C., Hydrophobic Interactions as Substitutes for a Conserved Disulfide Linkage in the Type IIa Bacteriocins, Leucocin A and Pediocin PA-1, ChemBioChem, 9, 1898-1901 (2008).

Martin-Visscher, L.A.; Sprules, T.; Gursky, L.J.; and Vederas, J.C., NMR Solution Structure of PisI, a Group B Immunity Protein that Provides Protection Against the Type IIa Bacteriocin Piscicolin 126, PisA, Biochemistry, 47, 6427-6436 (2008).

Huitema, C.; Zhang, J.; Yin, J.; James, M.N.G.; Vederas, J.C.; and Eltis, L.D., Heteraromatic ester inhibitors of hepatitis A virus 3C protease: evaluation of mode of action, Bioorg. Med. Chem., 16, 5761-5777 (2008).

Zhang, J.; Huitema, C.; Niu, C.; Yin, J.; James, M.N.G.; Eltis, L.D.; and Vederas, J.C., Aryl methylene ketones and fluorinated ketones as reversible inhibitors for severe acute repiratory syndrome (SARS) 3C-like proteinase, Bioorg. Chem., 36, 229-240 (2008).

Sit, C.S.; and Vederas, J.C., Approaches to the discovery of new antibacterial agents based on bacteriocins, Biochem. Cell Biol., 86, 116-123 (2008).

Silkin, L.; Hamza, S.; Kaufman, S.; Cobb, S. L.; and Vederas, J. C., Spermicidal Bacteriocins: Lacticin 3147 and Subtilosin A, Bioorg. Med. Chem. Lett., 18, 3103-3106 (2008) .

Niu, C.; Yin, J.; Zhang, J.; Vederas, J. C.; and James, M. N. G., Molecular docking identifies binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro, Bioorg. Med. Chem., 16, 293-302 (2008).

Pillai, B.; Cherney, M. M.; Diaper, C. M.; Sutherland, A.; Blanchard, J. S.; Vederas, J. C.; and James, M. N. G., Dynamics of Catalysis Revealed From Crystal Structures of Mutants of Diaminopimelate Epimerase, Biochem. Biophys. Res. Commun., 363, 547-553 (2007).

Liu, H.; Pattabiraman, V.R.; Vederas, J.C., Stereoselective Syntheses of 4-Oxa Diaminopimelic Acid and Its Protected Derivatives via Aziridine Ring Opening, Org. Lett., 9, 4211-4214 (2007).

van Belkum, M.J.; Derksen, D.J.; Franz, C.M.A.P.; and Vederas, J.C., Structure function relationship of inducer peptide pheromones involved in bacteriocin production in Carnobacterium maltaromaticum and Enterococcus faecium, Microbiology, 153, 3660-3666 (2007).

Watanabe, N.; Cherney, M.M.; van Belkum, M.J.; Marcus, S.L.; Flegel, M.D.; Clay, M.D.; Deyholos, M.K.; Vederas, J.C.; and James, M.N.G., Crystal Structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana: a Recently-Discovered Enzyme in the Biosynthesis of L-Lysine by Plants and Chlamydia, J. Mol. Biol., 371, 685-702 (2007).

Yin, J.; Niu, C.; Cherney, M.M.; Zhang, J.; Huitema C.; Eltis, L.D.; Vederas, J.C.; and James, M.N.G., A Mechanistic view of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-Like peptidase , J. Mol Biol., 371, 1060-1074 (2007).

Zhang, J.; Pettersson, H. I.; Huitema, C.; Niu, C.; Yin, J.; James, M.N.G.; Eltis, L.D.; and Vederas, J.C., Design, Synthesis and Evaluation of Inhibitors for Severe Acute Respiratory Syndrome 3C-like Protease Based on Phthalhydrazide Ketones or Heteroaromatic Esters, J. Med. Chem., 50, 1850-1864 (2007).

Cobb, S. L.; and Vederas, J. C., A concise stereoselective synthesis of orthogonally protected lanthionine and beta-methyllanthionine, Org. Biomol. Chem., 5, 1031-1038 (2007).

Pattabiraman, V. R.; Stymiest, J. L.; Derksen, D. J.; Martin, N. I.; and Vederas, J. C., Multiple On-Resin Olefin Metathesis to Form Ring-Expanded Analogues of the Lantibiotic Peptide Lacticin 3147 A2, Org. Lett., 9, 699-702 (2007).

Boudreau, M. A.; and Vederas, J. C., Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates, Org. Biomol. Chem., 5, 627-635 (2007).

Burr, D. A.; Chen, X. B.; and Vederas, J. C., Syntheses of Conjugated Pyrones for the Enzymatic Assay of Lovastatin Nonaketide Synthase, an Iterative Polyketide Synthase, Org. Lett., 9, 161-164 (2007).

Derksen, D. J.; Stymiest, J. L.; and Vederas, J. C., Antimicrobial Leucocin Analogues with a Disulfide Bridge Replaced by a Carbocycle or by Non-Covalent Interactions of Allyl Glycine Residues, J. Am Chem. Soc., 128, 14252-14253 (2006).

Pollard, M. M.; and Vederas, J. C., A convenient preparation of thioether functionalized porphyrins, Tetrahedron, 62, 11908-11915 (2006).

Bushman, B. S.; Scholte, A. A.; Cornish, K.; Scott, D. J.; Brichta, J. L.; Vederas, J. C.; Ochoa, O.; Michelmore, R. W.; Shintani, D.; and Knapp, S. J., Identification and Comparison of Natural Rubber from Two Lactuca Species, Phytochemistry, 67, 2590-2596 (2006).

Gursky, L. J.; Martin, N. I.; Derksen, D. J.; vanBelkum, M. J.; Kaur, K.; Vederas, J. C.; Stiles, M. E.; and McMullen, L. M., Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration, Arch. Microbiol., 186, 317-325 (2006).

Yin, J.; Cherney. M. M.; Bergmann, E. M.; Zhang, J.; Huitema, C.; Pettersson, H. I.; Eltis, L. D.; Vederas. J. C.; and James, M. N. G., An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors, J. Mol. Biol., 361, 673-686 (2006).

Pillai, B.; Cherney, M. M.; Diaper, C. M.; Sutherland, A.; Blanchard, J. S.; Vederas, J. C.; and James, M. N. G., Structural insights into stereochemical inversion by diaminopimelate epimerase: an anti-bacterial drug target, Proc. Natl. Acad. Sci. USA, 103, 8668-8673 (2006).

Vederas, J.C.; 2005 Alfred Bader Award Lecture: Diaminopimelate and lysine biosynthesis - An antimicrobial target in bacteria, Can. J. Chem., 84, 1197-1207 (2006).

Scholte, A.A.; and Vederas, J.C., Incorporation of Deuterium-labelled Analogs of Isopentenyl Diphosphate for the Elucidation of the Stereochemistry of Rubber Biosynthesis, Org. Biomol. Chem., 4, 730-742 (2006).

Diaper, C.M.; Sutherland, A.; Pillai, B.; James, M.N.G.; Semchuk, P.; Blanchard J.S.; and Vederas, J.C.; The Stereoselective Synthesis of Aziridine Analogues of Diaminopimelic Acid (DAP) and Their Interaction with DAP Epimerase, Org. Biomol. Chem., 3, 4402-4411 (2005).

Yin, J.; Bergmann, E.M.; Cherney, M.M.; Lall, M.S.; Jain, R.P.; Vederas, J.C.; and James, M.N.G., Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-Derived Beta-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site, J. Mol. Biol., 354, 854-871 (2005).

Thennarasu, S.; Lee, D.; Poon, A.; Kawulka, K.E.; Vederas, J.C.; and Ramamoorthy, A., Membrane Permeabilization, Orientation, and Antimicrobial Mechanism of Subtilosin A, Chem. Phys. Lipids, 137, 38-51 (2005).

Stymiest, J.L.; Mitchell, B.F.; Wong, S.; and Vederas, J.C., Synthesis and Biological Evaluation of Antagonist Analogs of the Peptide Hormone Oxytocin, In Understanding Biology Using Peptides, Blondelle, S., Ed., American Peptide Society, 94-95.

Stymiest, J.L.; Mitchell, B.F.; Wong, S.; and Vederas, J.C., Synthesis of Oxytocin Analogues with Replacement of Sulfur by Carbon Gives Potent Antagonists with Increased Stability, J. Org. Chem., 70, 7799-7809 (2005).

Hutchinson, C.R.; Kennedy, J.; Park, C.; Auclair, K.; and Vederas, J.C., The Molecular Genetics of Lovastatin Biosynthesis, Handbook of Industrial Mycology, An, Z., Ed., Chapter 17, Marcel Dekker Inc. New York, pp. 479-492 (2005).

Jain, R. P.; Pettersson, H. I.; Zhang, J.; Aull, K. D.; Fortin, P. D.; Huitema, C.; Eltis, L. D.; Parrish, J. C.; James, M. N. G.; Wishart, D. S.; and Vederas, J. C., Synthesis and Evaluation of Keto-Glutamine Analogs as Potent Inhibitors of Severe Acute Respiratory Syndrome (SARS) 3CLpro, J. Med. Chem., 47, 6113-6116 (2004).

Klinge, M.; Diaper, C. M.; and Vederas, J. C.; Di-tert-Butyl Dicarboxylate In Online Database 'Encyclopedia of Reagents for Organic Synthesis'; Wiley InterScience, 2005, DOI: 10.1002/047084289X.rd056.

Garneau, S.; Qiao, L.; Chen, L.; Walker, S.; and Vederas, J. C., Synthesis of Mono- and Disaccharide Analogs of Moenomycin and Lipid II for Inhibition of Transglycosylase Activity of Penicillin-Binding Protein 1b, Bioorg. Med. Chem., 12, 6473-6494 (2004).

Sprules, T.; Kawulka, K. E.; and Vederas, J. C., NMR Solution Structure of ImB2, a Protein Conferring Immunity to Antimicrobial Activity of the Type IIa Bacteriocin, Carnobacteriocin B2, Biochemistry, 43, 11740-11749 (2004).

Kaur, K.; Andrew, L. C.; Wishart, D. S.; and Vederas, J. C., Dynamic Relationships among Type IIa Bacteriocins: Temperature Effects on Antimicrobial Activity and on Structure of the C-Terminal Amphipathic alpha-Helix as a Receptor Binding Region, Biochemistry, 43, 9009-9020 (2004).

Jain, R. P. and Vederas, J. C., Structural Variations in Keto-Glutamines for Improved Inhibition against Hepatitis A Virus 3C Proteinase, Bioorg. Med. Chem. Lett., 14, 3655-3658 (2004).

Sprules, T.; Kawulka, K.E.; Gibbs, A.C.; Wishart, D. S.; and Vederas, J.C., NMR Solution Structure of the Precursor for Carnobacteriocin B2, an Antimicrobial Peptide from Carnobacterium piscicola. Implications of the alpha-Helical Leader Section for Export and Inhibition of Type IIa Bacteriocin Activity, Eur. J. Biochem., 271, 1748-1756 (2004).

Kawulka, K. E.; Sprules, T.; Diaper, C. M.; Whittal, R. M.; McKay, R. T.; Mercier, P.; Zuber, P., and Vederas, J. C., Structure of Subtilosin A, a Cyclic Antimicrobial Peptide from Bacillus subtilis with Unusual Sulfur to alpha-Carbon Crosslinks: Formation and Reduction of alpha-Thio-alpha-Amino Acid Derivatives, Biochemistry, 43, 3385-3395 (2004).

Martin, N. I.; Sprules, T.; Carpenter, M. R.; Cotter, P. D.; Hill, C.; Ross, R. P.; and Vederas, J. C., Structural Characterization of Lacticin 3147, a Two-Peptide Lantibiotic with Synergistic Activity, Biochemistry, 43, 3049-3056 (2004).

Scholte, A.A.; Eubanks, L.M.; Poulter, C.D.; and Vederas, J.C., Synthesis and Biological Activity of Isopentenyl Diphosphate Analogues, Bioorg. Med. Chem., 12, 763-770 (2004).

Lall, M.S.; Jain, R. P.; and Vederas, J.C., Inhibitors of 3C Cysteine Proteinases from Picornaviridae, Curr. Top. Med. Chem., 4, 1239-1253 (2004)

Jain, R. P.; and Vederas, J.C. Synthesis of beta-Cyclopropylalanines by Photolysis of Diacyl Peroxides, Org. Lett., 5, 4669-4672 (2003).

Mau, C.; Garneau, S.; Scholte; A., van Fleet J; Vederas, J.C., and Cornish, K., Protein Farnesyl Transferase Inhibitors Interfere with Farnesyl Diphosphate Binding by Rubber Transerase, Eur. J. Biochem., 270, 3939-3945 (2003)

Spantulescu, M.D.; Jain, R.P.; Derksen, D. J.; and Vederas, J.C., Photolysis of Diacyl Peroxides: A Radical Based Approach for the Synthesis of Functionalized Amino Acids, Org. Lett., 5, 2963-2965 (2003)

Sorensen, J. L.; and Vederas, J. C., Monacolin N, a Compound Resulting from Derailment of Type I Iterative Polyketide Synthase Function Enroute to Lovastatin, Chem. Commun., 1492-1493 (2003).

Martin, N.I., Hu, H., Moake, M.M., Churey, J.J., Whittal, R., Worobo, R., and Vederas, J.C., Isolation, Structural Characterization and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced by Paenibacillus kobensis M, J. Biol. Chem., 278, 13124-13132 (2003).

Kawulka, K.; Sprules, T.; McKay, R. T.; Mercier, P.; Diaper, C. M.; Zuber, P. and Vederas, J. C., Structure of Subtilosin A, an Antimicrobial Peptide from Bacillus subtilis with Unusual Post-translational Modifications Linking Cysteine Sulfurs to alpha-Carbons of Phenylalanine and Threonine, J. Am. Chem. Soc., 125, 4726-4727 (2003).

Garneau, S., Ference, C. A., van Belkum, M.J., Stiles, M.E. and Vederas, J. C., Purification and Characterization of Brochocin A and Brochocin B(10-43), a Functional Fragment Generated by Heterologous Expression in Carnobacterium piscicola. Appl. Environ. Microbiol., 69, 1352-1358 (2003).

Stymiest, J. L., Mitchell, B.F., Wong, S., and Vederas, J.C., Synthesis of Biologically Active Dicarba Analogs of the Peptide Hormone Oxytocin Using Ring Closing Metathesis, Org. Lett., 5, 47-49 (2003).

Sorensen, J.L.; Auclair, K.; Kennedy, J.; Hutchinson, C.R., and Vederas, J.C., Transformations of Cyclic Nonaketides by Aspergillus terreus Mutants Blocked for Lovastatin Biosynthesis at the lovA and lovC Genes, Organic and Biomolec. Chem. (Formerly J. Chem. Soc. Perkin Trans. 1), 1, 50-59 (2003).

Sprules, T.; Kawulka, T. E.; McKay, R. T.; Mercier, P.; Diaper, C. M.; Zuber, P., and Vederas, J. C., Solution Structure of a Cyclic Peptide, Subtilosin A, with Unusual Post-translational Modifications, Peptide Revolution: Genomics, Proteomics & Therapeutics, Chorev, M. & Sawyer, T. K. (Eds) American Peptide Society, 2003.

Lopaschuk, G. D.; Vederas, J. C.; Dyck, J. R., Preparation of Cyclopropanecarboxylic and Cyclobutanecarboxylic Acid Derivatives for Stimulation of Glucose Utilization. PCT Int. Appl. (2003), 82 pp. CODEN: PIXXD2 WO 2003082800 A1 20031009 Chem Abstr 139:276659 AN 2003:796644

Garneau, S.; Martin, N.I.; and Vederas, J.C. Two Peptide Bacteriocins Produced by Lactic Acid Bacteria, Biochimie, 84, 577-592 (2002).

Ramtohul, Y.K.; Martin, N.I.; Silkin, L.; James, M.N.H.; and Vederas, J.C., Synthesis of Pseudoxazolones and Their Inhibition of the 3C Cysteine Proteinases from Hepatitis A Virus and Human Rhinovirus-14, J. Chem. Soc. Perkin Trans. 1, 1351-1359 (2002).

Ramtohul, Y.K.; James, M.N.G.; and Vederas, J.C., Synthesis and Evaluation of Keto-Glutamine Analogues as Inhibitors of Hepatitis A Virus 3C Proteinase, J. Org. Chem., 67, 3169-3178 (2002).

Lall, M.S.; Ramtohul, Y. K.; James, M.N.G.; and Vederas, J.C., Serine and Threonine beta-Lactones: A New Class of Hepatitis A Virus 3C Cysteine Proteinase Inhibitors, J. Org. Chem. 67, 1536-1547 (2002).

Sutherland, A.; and Vederas, J.C., Conjugate Addition of Radicals Generated from Diacyloxyiodobenzenes to Dehydroamino Acid Derivatives; a Synthesis of Diaminopimelic Acid Analogues, J. Chem. Soc. Chem. Commun., 224-225 (2002).

Ramtohul, Y.K., Martin, N.I., Silkin, L., James, M.N.G., and Vederas, J.C., Pseudoxazolones, a New Class of Inhibitors for Cysteine Proteinases: Inhibition of Hepatitis A Virus and Human Rhinovirus 3C Proteinases, J. Chem. Soc. Chem. Commun., 2740-2741 (2001).

Caplan, J.F.; Sutherland, A., and Vederas, J.C., The First Stereospecific Synthesis of L-Tetrahydrodipicolinic Acid; A Key Intermediate of Diaminopimelate Metabolism, J. Chem. Soc. Perkin Trans. 1, 2217-2220 (2001).

Auclair, K.; Kennedy, K.; Hutchinson, C.R., and Vederas, J.C., Conversion of Cyclic Nonaketides to Lovastatin and Compactin by lovC Deficient Mutant of Aspergillus terreus, Bioorg. Med. Chem. Lett. 11, 1527-1531 (2001).

Sutherland, A.; Auclair, K., and Vederas, J.C., Recent Advances in the Biosynthetic Studies of Lovastatin, Current Opinion in Drug Discovery and Development, 4, 229-236 (2001).

Caplan, J.F.; Zheng, R.; Blanchard, J.S., and Vederas, J.C., Vinylogous Amide Analogues of Diaminopimelic Acid (DAP) as Inhibitors of Enzymes Involved in Bacterial Lysine Biosynthesis, Org. Lett. 2, 3857-3860 (2000).

Yan, L.Z.; Gibbs, A.C.; Stiles, M.E.; Wishart, D.S., and Vederas, J.C., Analogs of Bacteriocins: Antimicrobial Specificity and Interactions of Leucocin A with Its Enantiomer, Carnobacteriocin B2 and Truncated Derivatives, J. Med. Chem., 43, 4579-4581 (2000).

Auclair, K.; Sutherland, A.; Kennedy, J.; Witter, D.J.; Van den Heever, J.P.; Hutchinson, C.R., and Vederas, J.C., Lovastatin Nonaketide Synthase (LNKS) Catalyzes an Intramolecular Diels Alder Reaction of a Substrate Analog, J. Am. Chem. Soc., 122, 11519-11520 (2000).

Cirilli, M.; Scapin, G.; Sutherland, A.; Vederas, J.C., and Blanchard, J.S., The Three-Dimensional Structure of the Ternary Complex of Corynebacterium glutamicum Diaminopimelate Dehydrogenase NADPH L-2-amino-6-methylenepimelate, Protein Sci., 9, 2034-2037 (2000).

DeBlassio, J.L.; DeLong, M.A.; Glufke U.; Kulathila, R.; Merkler, K.A.; Vederas, J.C., and Merkler, D.J., The Amidation of Salicyluric Acid and Gentisuric Acid. A Possible Role for Petidylglycine alpha-Amidating Monooxygenase (PAM) in the Metabolism of Aspirin, Arch. Biochem. Biophys., 383, 46-55 (2000).

Hutchinson, C.R.; Kennedy, J.; Park, C.; Kendrew, S.; Auclair, K., and Vederas, J.C., Aspects of the Biosynthesis of Non-Aromatic Fungal Polyketides by Iterative Polyketide Synthases, Antonie van Leeuwenhoek, 78, 287-295 (2000).

Koo, C.W., Sutherland, A., Vederas, J.C., and Blanchard, J.S., Identification of Active Site Cysteine Residues that Function as General Bases: Diaminopimelate Epimerase, J. Am. Chem. Soc., 122, 6122-6123 (2000).

Leeper, F.J., and Vederas, J.C., Eds., Aromatic Polyketides, Isoprenoids and Alkaloids, Volume II - Topics in Current Chemistry, Springer-Verlag, Vol 209, 247 pages, ISBN 3-540-66573-0 (2000).

Cox, R.J.; Sutherland, A., and Vederas, J.C., Bacterial Diaminopimelate Metabolism as a Target for Antibiotic Design, Bioorg. Med. Chem. 8, 843-872 (2000).

Leeper, F.J., and Vederas, J.C., eds., Biosynthesis - Polyketides and Vitamins - Desktop Editions in Chemistry, Springer-Verlag, Berlin, 193 pages, ISBN 3-540-66969-8 (2000).

Franz, C.M.A.P.; van Belkum, M.J.; Vederas, J.C.; Stiles, M.E., and Worobo, R.W., Genes Responsible for Production and Immunity of Carnobacteriocin A: The Immunity Protein Confers Cross-Protection to Enterocin B, Microbiology, 146, 621-631 (2000).

King III, L.; Barnes, S.; Glufke, U.; Henz, M.E.; Kirk, M.; Merkler, K.A.; Vederas, J.C.; Wilcox, B.J., and Merkler, D.J., The Enzymatic Formation of Novel Bile Acid Primary Amides. A Possible New Class of Mammalian Hormones, Arch. Biochem. Biophys., 374, 107-117 (2000).

Vederas, J.C., Enzymes, Enzyme Mechanisms, Proteins, and Aspects of NO Chemistry, C.D. Poulter, Ed. - Book Review, Nat. Prod. Rep., 16, 638-639 (1999).

Hill, R.D., and Vederas, J.C., Azodicarboxamides: A New Class of Cysteine Proteinase Inhibitor for Hepatitis A Virus and Human Rhinovirus 3C Enzymes, J. Org. Chem., 64 , 9538-9546 (1999).

Zheng, G.; Yan, L.Z.; Vederas, J.C., and Zuber P., The Genes of the sbo-alb Locus of Bacillus subtilis are Required for the Production of the Anti-Listerial Bacteriocin, Subtilosin are Regulated by abrB, J. Bacteriol., 181, 7346-7355 (1999).

Wang, Y.; Henz, M.E.; Fregeau Gallagher, N.L.; Chai, S.; Yan, L.Z.; Stiles, M.E.; Wishart, D.S., and Vederas, J.C., Solution Structure of Carnobacteriocin B2 and Implications for Structure-Activity Relationships Among Type IIa Bacteriocins from Lactic Acid Bacteria, Biochemistry, 38, 15438-15447 (1999).

Bergmann, E.M; Cherney, M.M.; McKendrick, J.; Frormann, S.; Luo, C.; Malcolm, B.A.; Vederas, J.C., and James, M., Crystal Structure of an Inhibitor Complex of the 3C Proteinase from Hepatitis A Virus and Implications for the Polyprotein Processing in HAV, Virology, 265, 153-163 (1999).

Lall, M.S.; Karvellas, C., and Vederas J.C., beta-Lactones as a New Class of Cysteine Proteinase Inhibitors: Inhibition of Hepatitis A Virus 3C Proteinase by N-Cbz-Serine beta-Lactone, Org. Lett., 1, 803-806 (1999).

Sutherland A., and Vederas J.C., The First Isolation of an Alkoxy-N,N-Dialkylamino-Difluorosulfurane from the Reaction of an Alcohol and DAST: An Efficient Synthesis of (2S,3R,6S)-3-Fluoro-2,6-Diaminopimelic Acid, J. Chem. Soc., Chem. Commun., 1739-1740 (1999).

Kennedy, J.; Auclair, K.; Kendrew, S.G.; Park, C; Vederas, J.C., and Hutchinson, C.R., Accessory Proteins Modulate Polyketide Synthase Activity During Lovastatin Biosynthesis, Science, 284, 1368-1372 (1999).

Merkler, D.J.; Glufke, U.; Ritenour-Rodgers, K.J.; Baumgart, L.E.; DeBlassio, J.L; Merkler, K.A., and Vederas, J.C., Formation of Nicotinamide from Nicotinuric Acid by Peptidylglycine a-Amidating Monooxygenase (PAM): A Possible Alternative Route from Nicotinic Acid (Niacin) to NADP in Mammals, J. Am. Chem. Soc., 121, 4904-4905 (1999).

Huang, Y.; Malcolm, B.A., and Vederas, J.C., Synthesis and Testing of Azaglutamine Derivatives as Inhibitors of Hepatitis A Virus (HAV) 3C Proteinase, Bioorg. Med. Chem., 7, 607-620 (1999).

Sutherland, A.; Caplan, J.F., and Vederas, J.C., Unsaturated alpha-Aminopimelic Acids as Potent Inhibitors of meso-Diaminopimelic Acid (DAP) D-Dehydrogenase, J. Chem. Soc., Chem. Commun., 555-556 (1999).

Franz, C.M.A.P.; Worobo, R.W.; Quadri, L.E.N.; Schillinger, U.; Holzapfel, W.H.; Vederas, J.C., and Stiles, M.E., Atypical Genetic Locus for Enterocin B Production in Enterococcus faecium BFE 900, Appl. Environ. Microbiol., 65, 2170-2178 (1999).

Wilcox, B.J; Ritenour-Rodgers, K.J.; Asser, A.S.; Baumgart, L.E.; Baumgart, M.A.; Boger, D.L.; DeBlassio, J.L.; deLong, M.A.; Glufke, U.; Henz, M.E.; King III, L.; Kulathila, R.; Merkler, K.A.; Robleski, J.J.; Vederas, J.C., and Merkler, D.J., N-Acylglycine Amidation: Implications for the Biosynthesis of Fatty Acid Primary Amides and a Lead for the Development of Novel Anti-Cancer and Anti-Inflammatory Therapeutics, Biochemistry, 38, 3235-3245 (1999).

McCormick, J.K.; Poon, A.; Sailer, M.; Gao, Y.; Roy, K.L.; McMullen, L.M.; Vederas, J.C; Stiles, M.E., and Van Belkum, M.J., Genetic Characterization and Heterologous Expression of Brochocin-C, an Antibotulinal, Two-Peptide Bacteriocin Produced by Brochothrix campestris ATCC 43754, Appl. Environ. Microbiol., 64, 4757-4766 (1998).

Liu, Y.; Li, Z., and Vederas, J.C., Biosynthetic Incorporation of Advanced Precursors into Dehydrocurvularin, a Polyketide Phytotoxin from Alternaria cinerariae, Tetrahedron, 54, 15937-15958 (1998)..

Glufke, U., and Vederas, J.C., Peptidylglycine alpha-Amidating Monooxygenase (PAM): An Enzyme which Forms C-Terminal Amides in Peptides and Fatty Acid Amides, BIOforum International, 03/98, 117-120 (1998).

McKendrick, J.E.; Frormann, S.; Luo, C.; Semchuck, P.; Vederas, J.C., and Malcolm, B.A., Rapid Mass Spectrometric Determination of Preferred Irreversible Proteinase Inhibitors in Combinatorial Libraries, Int. J. Mass. Spectrom., 176, 113-124 (1998).

Merkler, K.A.; Baumgart, L.E.; DeBlassio, J.L.; Glufke, U.; King III, L.; Ritenour-Rodgers, K.; Vederas, J.C; Wilcox, B.J., and Merkler, D.J., A Pathway for the Biosynthesis of Fatty Acid Amides, Adv. Exp. Med. Biol., 469, 519-525 (1999); In "Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury", Honn, K.V.; Nigam, S.; Marnett, L.J., and Dennis, E., eds., Plenum: New York, 4, 1999, pp. 519-526.

Harris, J.M.; Liu, Y.; Chai, S.; Andrews, M.D., and Vederas J.C., Modification of the Swern Oxidation: Use of a Soluble Polymer-Bound, Recyclable and Odorless Sulfoxide, J. Org. Chem., 63, 2407-2409 (1998).

Gao, Y.; Lane-Bell, P., and Vederas, J.C., Stereoselective Synthesis of meso-2,6-Diaminopimelic Acid and Its Selectively Protected Derivatives, J. Org. Chem., 63, 2133-2143 (1998).

Scapin, G.; Cirilli, M.; Reddy, S.G.; Gao, Y.; Vederas, J.C., and Blanchard, J.S., The Substrate and Inhibitor Binding Sites in Corynebacterium glutamicum Diaminopimelate Dehydrogenase, Biochemistry, 37, 3278-3285 (1998).

Leeper, F.J., and Vederas, J.C., eds., Biosynthesis of Polyketides and Vitamins - "Topics in Current Chemistry", Springer-Verlag, Vol 195, 205 pages and 76 figures, ISBN 3-540-63418-5 (1998).

Fregeau Gallagher, N.L.; Sailer, M.; Niemczura, W.P.; Nakashima, T.T.; Stiles, M.E., and Vederas, J.C., Three Dimensional Structure of Leucocin A in Trifluoroethanol and Dodecylphosphocholine Micelles: Spatial Location of Residues Critical for Biological Activity in Type IIa Bacteriocins from Lactic Acid Bacteria, Biochemistry, 36, 15062-15072 (1997).

Quadri, L.E.N.; Kleerebezem, M.; Kuipers, O.P; de Vos, W.M.; Roy, K.L.; Vederas, J.C., and Stiles, M.E., Genes from Carnobacterium pisicola LV17B Involved in Bacteriocin Production and Immunity: Evidence for Global Transcriptional Regulation Mediated by Different Exported Peptides, J. Bacteriology, 179, 6163-6171 (1997).

Stiles, M.E.; Vederas, J.C.; Van Belkun, M.; McCormick, J.K.; Greer, G.G.; McMullen, L.M.; Leismer, J.J.; Poon, A., and Franz, C.M.A.P., Novel Bacteriocins, Transport and Bactrosystem and Method of Use Thereof, U.S. Patent Application September 5, 1997 07254/051001.

Andrews, M.D.; O'Callaghan, K.A., and Vederas, J.C., Synthesis of Tripeptide Inhibitors of Peptidylglycine alpha-Amidating Monooxygenase (PAM) Containing D- and L-Styrylglycine, Tetrahedron, 53, 8295-8306 (1997).

Quadri, L.E.N.; Yan, L.Z.; Stiles, M.E. , and Vederas, J. C., Effect of Amino Acid Substitutions on the Activity of Carnobacteriocin B2: Overproduction of the Antimicrobial Peptide, its Engineered Variants, and its Precursor in Escherichia Coli, J. Biol. Chem., 272, 3384-3388 (1997).

Morris, T.S.; Frormann, S.; Shechosky, S.; Lowe, C.; Lall, M.S.; Gauss-Müller, V.; Purcell, R.H.; Emerson, S.U.; Vederas, J.C., and Malcolm, B.A., In Vitro and Ex Vivo Inhibition of Hepatitis A Virus 3C Proteinase by a Peptidyl Monofluoromethyl Ketone, Bioorg. Med. Chem., 5, 797-807 (1997).

Frormann, S.; Huang, Y.; Lall, M.; Lowe, C., and Vederas, J.C., Design, Synthesis and Testing of Inhibitors of Viral Cysteine Proteinases, In "Recent Advances in the Chemistry of Anti-Infective Agents", Bentley, P.H. and O'Hanlon, P.J., Eds., Royal Society of Chemistry, Vol 198, 298-315 (1997).

Liu, Y., and Vederas, J.C., Modification of the Swern Oxidation: Use of Stoichiometric Amounts of an Easily Separable, Recyclable, and Odorless Sulfoxide That Can be Polymer-Bound, J. Org. Chem., 61, 7856-7859 (1996).

Harris, J.M.; McDonald, R., and Vederas J.C., Synthesis of a Chiral Azodicarboxamide Containing a Bridging Binaphthyl Moiety: Electrophilic Amination Reactions of Achiral Ester Enolates, J. Chem. Soc., Perkin Trans. 1, 2669-2674 (1996).

Wagschal, K.; Yoshizawa, Y.; Witter, D.J.; Liu, Y., and Vederas, J.C., Biosynthesis of ML-236C and the Hypocholesterolemic Agents Compactin by Penicillium aurantiogriseum and Lovastatin by Aspergillus terreus: Determination of the Origin of Carbon, Hydrogen, and Oxygen Atoms by 13-C NMR Spectrometry and Observation of Unusual Labeling of Acetate-Derived Oxygens by 18-O2, J. Chem. Soc., Perkin Trans. 1, 2357-2363 (1996).

Ratemi, E.S.; Dolence, J.M; Poulter, C.D., and Vederas, J.C., Synthesis of Protein Farnesyltransferase and Protein Geranylgeranyl-transferase Inhibitors: Rapid Access to Chaetomellic Acid A and Its Analogues, J. Org. Chem., 61, 6296-6301 (1996).

Cox, R.J.; Sherwin, W.A.; Lam, L.K.P., and Vederas, J.C., Synthesis and Evaluation of Novel Substrates and Inhibitors of N-Succinyl-LL-Diaminopimelate Aminotransferase (DAP-AT) from E. Coli, J. Am. Chem. Soc., 118, 7449-7460 (1996).

Auger, G.; van Heijenoort, J.; Vederas, J.C., and Blanot, D., Effect of Analogues of Diaminopimelic Acid on the meso-Diaminopimelate-Adding Enzyme from Escherichia coli, FEBS Letters, 391, 171-174 (1996).

Witter, D.J. and Vederas, J.C., Putative Diels-Alder Catalyzed Cyclization During the Biosynthesis of Lovastatin, J. Org. Chem., 61, 2613-2623 (1996).

Malcolm, B.A.; Lowe, C.; Shechosky, S.; McKay, R.T.; Yang, C.C.; Shah, V.J.; Simon, R.J.; Vederas, J.C., and Santi, D.V., Peptide Aldehyde Inhibitors of Hepatitis A Virus 3C Proteinase, Biochemistry, 34, 8172-8179 (1995).

Worobo, R.W.; Van Belkum, M.J.; Sailer, M.; Roy, K.L.; Vederas, J.C., and Stiles, M.E., A Signal Peptide Secretion-dependent Bacteriocin from Carnobacterium divergens, J. Bacteriology, 177, 3143-3149 (1995).

Harris, J.M.; Bolessa, E.A.; Mendonca, A.J.; Feng, S.-C.; Vederas, J.C., Synthesis of Chiral Diazanedicarboxylate and Diazenedicarboxylate Esters: Electrophilic Amination Reactions of Achiral Ester and Amide Enolates, J. Chem. Soc., Perkin Trans. 1, 1945-1950 (1995).

Harris, J.M.; Bolessa, E.A.; Vederas, J.C., Synthesis of Macrocyclic Diazanedicarboxylate and Diazenedicarboxylate Esters Containing a Steroid Skeleton: An Unusual Oxidation of Bromide to Bromine by a Strained Diazenedicarboxylate Ester. X-ray molecular structure of 3 -alpha-(3-hydroxypropyl)-24-nor-5-beta-cholan-7-alpha-ol Diazane-1,2-Dicarboxylate Cyclic Diester, J. Chem. Soc., Perkin Trans. 1, 1951-1959 (1995).

Lowe, C. and Vederas, J.C., Naturally Occurring Beta-Lactones: Occurrence, Syntheses and Properties. A Review, Org. Prep. Proc. Int., 27, 305-346 (1995).

Quadri, L.E.N.; Sailer, M.; Terebiznik, M.R.; Roy, K.L.; Vederas, J.C.; Stiles, M.E., Characterization of the Protein Conferring Immunity to the Antimicrobial Peptide Carnobacteriocin B2 and the Expression of Carnobacteriocins B2 and BM1, J. Bacteriology, 177, 1144-1151 (1995).

Klinge, M.; Vederas, J.C., Di-t-butyl Azodicarboxylate, In Encycl. Reagents Org. Syn., Vol. III, Coates, R.M., Ed., Wiley: Chichester, UK, 1995, pp 1586-1590.

Klinge, M.; Vederas, J.C., N-Benzyloxycarbonyl-L-serine-beta-Lactone, In Encycl. Reagents Org. Syn., Vol. I, Liebeskind, L.S., Ed., Wiley: Chichester, UK, 1995, pp 358-360.

Ratemi, E.S. and Vederas, J.C., Reaction of Trimethylsilylamines with N-Cbz-L-Serine-beta-Lactone: A Convenient Route to Optically Pure alpha-Amino-L-alanine Derivatives, Tetrahedron Lett., 35, 7605-7608 (1994).

Song, Y.H.; Niederer, D.; Lane-Bell, P.; Lam, L.K.P.; Crawley, S.; Palcic, M.M.; Pickard, M.A.; Pruess, D.L.; Vederas, J.C., Stereospecific Synthesis of Phosphonate Analogues of Diaminopimelic Acid (DAP), Their Interaction with DAP Enzymes, and Antibacterial Activity of Peptide Derivatives, J. Org. Chem., 59, 5784-5793 (1994).

Abbott, S.D.; Lane-Bell, P.; Sidhu, K.P.S.; Vederas, J.C., Synthesis and Testing of Heterocyclic Analogues of Diaminopimelic Acid (DAP) as Inhibitors of DAP Dehydrogenase and DAP Epimerase, J. Am. Chem. Soc., 116, 6513-6520 (1994).

Pu, Y.; Lowe, C.; Sailer, M.; Vederas, J.C., Synthesis, Stability, and Antimicrobial Activity of (+)-Obafluorin and Related beta-Lactone Antibiotics, J. Org. Chem., 59, 3642-3655 (1994).

Klinge, M.; Cheng, H.; Zabriskie, T.M.; Vederas, J.C., Irreversible Inhibition of Mammalian and Insect Peptidylglycine alpha-Hydroxylating Monooxygenases (PHMs), Peptide Amidating Enzymes, by N-Formyl Amides, J. Chem. Soc., Chem. Commun., 1379-1380 (1994).

Quadri, L.E.N.; Sailer, M.; Roy, K.L.; Vederas, J.C.; Stiles, M.E., Chemical and Genetic Characterization of Bacteriocins Produced by Carnobacterium piscicola LV17B, J. Biol. Chem., 269, 12204-12211 (1994).

Vederas, J.C., Murder, Magic, and Medicine - A Review, Nat. Prod. Rep., 11, 333-334 (1994).

Yoshizawa, Y.; Witter, D.J.; Liu, Y.; Vederas, J.C., Revision of the Biosynthetic Origin of Oxygens in Mevinolin (Lovastatin), a Hypocholesterolemic Drug from Aspergillus terreus MF 4845, J. Am. Chem. Soc., 116, 2693-2694 (1994).

Worobo, R.W.; Henkel, T.; Sailer, M.; Roy, K.L.; Vederas, J.C. and Stiles, M.E., Characteristics and Genetic Determinant of a Hydrophobic Peptide Bacteriocin, Carnobacteriocin A, Produced by Carnobacterium piscicola LV17A, Microbiology, 140, 517-526 (1994).

Zabriskie, T.M.; Klinge, M.; Szymanski, C.M.; Cheng, H. and Vederas, J.C., Peptide Amidation in an Invertebrate: Purification, Characterization, and Inhibition of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) from the Heads of Honey Bees (Apis mellifera), Arch. Insect Biochem. Physiol., 26, 27-48 (1994).

Niederer, D.A.; Kapron, J.T. and Vederas, J.C., Amination with N-Benzyloxycarbonyl-3-phenyloxaziridine as a Route to Sensitive Chiral alpha-Hydrazino Acids: Synthesis of L-Hydrazino Serine, Tetrahedron Lett., 34, 6859-6862 (1993).

Kapron, J.T.; Santarsiero, B.D., and Vederas, J.C., N-Phthalimidoaziridines by Diastereoselective Addition to alpha,beta-Unsaturated Amides: a Route to Chiral beta-Substituted alpha-Hydrazino Acid Derivatives, J. Chem. Soc., Chem. Commun., 1074-1076 (1993).

Qiao, L.; Vederas, J.C., Synthesis of a C-Phosphonate Disaccharide as a Potential Inhibitor of Peptidoglycan Polymerization by Transglycosylase, J. Org. Chem., 58, 3480-3482 (1993).

Sailer, M.; Helms, G.L.; Henkel, T.; Niemczura, W.P.; Stiles, M.E. and Vederas, J.C., 15-N and 13-C Labeled Media from Anabaena sp. for Universal Isotopic Labeling of Bacteriocins: NMR Resonance Assignments of Leucocin A from Leuconostoc gelidum and Nisin A from Lactococcus lactis, Biochemistry, 32, 310-318 (1993).

Li, Z.; Martin, F.M.; Reese, P.B.; Yoshizawa, Y. and Vederas, J.C., Intact Incorporation of Partially Assembled Intermediates into Acetate Derived Polyketide Antibiotics, In "Biosynthesis and Metabolism of Secondary Metabolite Natural Products", Petroski, R. J. and McCormick, S. P. Eds., Plenum: New York, 1992, pp 27-39.

Arnold, L.D.; Vederas, J.C., Polymer-Supported Alkyl Azodicarboxylates and Their Use in Mitsunobu Reactions, British Informal Patent Filed April 23, 1987, Can. Appl. April 25, 1988, U.S. Patent Application 189,410; EPO Patent Application 88 303818.4, Eur. Pat 291199, Issued 17 November 1988, Chem. Abstr. 111, 78892x (1991). US 4960832 Issued 2 October 1990; CA 1,297,447 Issued 17 March 1992.

Li, Z.; Martin, F.M. and Vederas, J.C., Biosynthetic Incorporation of Labeled Tetraketide Intermediates Into Dehydrocurvularin, a Phytotoxin from Alternaria Cinerariae, with Assistance of beta-Oxidation Inhibitors, J. Am. Chem. Soc., 114, 1531-1533 (1992).

Zabriskie, T.M.; Cheng, H. and Vederas, J.C., Mechanism-Based Inactivation of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) by a Substrate Analogue, D-Phenylalanyl-L-Phenylalanyl-D-Vinylglycine: Inhibition of Formation of Peptide C-Terminal Amides, J. Am. Chem. Soc., 114, 2270-2272 (1992).

Henkel, T.; Sailer, M.; Helms, G.L.; Stiles, M.E. and Vederas, J.C., NMR Assignment of Leucocin A, a Bacteriocin from Leuconostoc gelidum, Supported by a Stable Isotope Labeling Technique for Peptides and Proteins, J. Am. Chem. Soc., 114, 1898-1900 (1992).

Lowe, C.; Pu, Y. and Vederas, J.C., Synthesis of (+)-Obafluorin, a beta-Lactone Antibiotic, J. Org. Chem., 57, 10-11 (1992).

Hastings, J.W.; Sailer, M.; Johnson, K.; Roy, K.L.; Vederas, J.C. and Stiles, M.E., Characterization of Leucocin A-UAL 198 and Cloning of the Bacteriocin Gene from Leuconostoc gelidum, J. Bacteriology, 173, 7491-7500 (1991).

Johnson, L.B.N.; Griffiths, W.J.; Roberts, E.V.; Lam, L.K.P.; Vederas, J.C.; Reid, C.J. and Ballantine, J.A., A Mass Spectral Analysis of Some Cucurbitacins Isolated from Fevillea cordifolia, J. Chem. Soc., Perkin Trans. 1, 2583-2588 (1991).

Pansare, S.V.; Huyer, G.; Arnold, L.D. and Vederas, J.C., Synthesis of N-Protected alpha-Amino Acids From N-(Benzyloxycarbonyl)-L-Serine Via its beta-Lactone: N-(Benzyloxycarbonyl)-beta-(Pyrazol-1-yl)-L-Alanine, Org. Syn., 70, 1-9 (1991).

Pansare, S.V.; Arnold, L.D. and Vederas, J.C., Synthesis of N-tert-butoxycarbonyl-L-serine beta-Lactone and the P-Toluenesulfonic Acid Salt of (S)-3-amino-2-oxetanone, Org. Syn., 70, 10-17 (1991).

Zabriskie, T.M.; Cheng, H. and Vederas, J.C., Incorporation of Aerobic Oxygen into the Hydroxyl-glycyl Intermediate during Formation of C-Terminal Peptides Amides by Peptidylglycine alpha-Amidating Monooxygenase (PAM), J. Chem. Soc., Chem. Commun., 571-572 (1991).

O'Sullivan, M.C.; Schwab, J.M.; Zabriskie, T.M.; Helms, G.L. and Vederas, J.C., Reevaluation of the Stereochemical Courses of the Allylic Rearrangement and the Double Bond Reduction Catalyzed by Brevibacterium ammoniagenes Fatty Acid Synthase, J. Am. Chem. Soc., 113, 3997-3998 (1991).

Scaman, C.H.; Palcic, M.M.; McPhalen, C.; Gore, M.P.; Lam, L.K.P. and Vederas, J.C., Inhibition of Cytoplasmic Aspartate Aminotransferase from Porcine Heart by R and S Isomers of Aminooxy-succinate and Hydrazinosuccinate, J. Biol. Chem., 266, 5525-5533 (1991).

Pu, Y.; Martin, F.M. and Vederas, J.C., Synthesis and Acylation of Salts of L-Threonine beta-Lactone: A Route to beta-Lactone Antibiotics, J. Org. Chem., 56, 1280-1283 (1991).

Gelb, M.H.; Lin, Y.; Pickard, M.A.; Song, Y. and Vederas, J.C., Synthesis of 3-Fluorodiaminopimelic Acid Isomers as Inhibitors of Diaminopimelate Epimerase: Stereocontrolled Enzymatic Elimination of Hydrogen Fluoride, J. Am. Chem. Soc., 112, 4932-4942 (1990).

Yoshizawa, Y.; Li, Z.; Reese, P.B. and Vederas, J.C., Intact Incorporation of Acetate-Derived Di- and Tetraketides During Biosynthesis of Dehydrocurvularin, a Macrolide Phytotoxin from Alternaria cinerariae, J. Am. Chem. Soc., 112, 3212-3213 (1990).

Johnson, L.B.; Reese, P.B.; Roberts, E.V.; Lam, L.K.P. and Vederas, J.C., Structure Elucidation of Cordifolin A, a Novel Cucurbitacin from Fevillea cordifolia, Using 1- and 2-Dimensional NMR Techniques, J. Chem. Soc., Perkin Trans. 1, 2111-2116 (1989).

Oikawa, H.; Yokota, T.; Abe, T.; Ichihara, A.; Sakamura, S.; Yoshizawa, Y. and Vederas, J.C., Biosynthesis of Solanapyrone A, a Phytotoxin of Alternaria solani, J. Chem. Soc., Chem. Comm., 1282-1284 (1989).

Pansare, S.V. and Vederas, J.C., Synthesis and Reactivity of beta-Lactones Derived from L-Threonine and Related Amino Acids, J. Org. Chem., 54, 2311-2316 (1989).

McIntyre, C.R.; Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Application of Stable Isotope Labelling Methodology to the Biosynthesis of the Mycotoxin, Terretonin, by Aspergillus terreus: Incorporation of 13C Labelled Acetates and Methionine, 2H and 13C, 18O Labelled Ethyl 3,5-Dimethylorsellinate and Oxygen-18 Gas, Tetrahedron, 45, 2307-2321 (1989).

Rawlings, B.J.; Reese, P.B.; Ramer, S.E. and Vederas, J.C., Comparison of Fatty Acid and Polyketide Biosynthesis. Stereochemistry of Cladosporin and Oleic Acid Formation in Cladosporium cladosporioides, J. Am. Chem. Soc., 111, 3382-3390 (1989).

Arai, K.; Rawlings, B.J.; Yoshizawa, Y. and Vederas, J.C., Biosynthesis of Antibiotic A26771B by Penicillium turbatum and Dehydrocurvularin by Alternaria cinerariae. Comparison of Stereochemistry of Polyketide and Fatty Acid Enoyl Thiol Ester Reductases, J. Am. Chem. Soc., 111, 3391-3399 (1989).

Arnold, L.D.; Assil, H.I. and Vederas, J.C., Polymer Supported Alkyl Azodicarboxylates for Mitsunobu Reactions, J. Am. Chem. Soc., 111, 3973-3976 (1989).

Li, Z.; Rawlings, B.J.; Harrison, P.H. and Vederas, J.C., Production of New Polyene Antibiotics by Streptomyces cellulosae After Addition of Ethyl (Z)-16-Phenylhexadec-9-enoate, J. Antibiot., 42, 577-584 (1989).

Ahmed, S.A.; Scott, F.E.; Stenzel, D.J.; Simpson, T.J.; Moore, R.N.; Trimble, L.A.; Arai, K. and Vederas, J.C., Studies on the Biosynthesis of the Mycotoxin Austin, a Meroterpenoid Metabolite of Aspergillus ustus, J. Chem. Soc., Perkin Trans. 1, 807-816 (1989).

Ramer, S.E.; Cheng, H. and Vederas, J.C., Investigations of Polypeptide Biosynthesis: Formation of Peptide Amides, Pure Appl. Chem., 61, 489-492 (1989).

Arnold, L.D.; Vederas, J.C., Synthesis of Optically Pure alpha-Amino Acids from 3-Amino-2-Oxetanone Salts, British Informal Patent Filed April 23, 1987, European Appl. 88 303818.4, April 27, 1988, Can. Appl. April 25, 1988, U.S. Patent Application 189,405, US Patent 5,200,526 issued April 6, 1993.

Ramer, S.E.; Cheng, H.; Palcic, M.M. and Vederas, J.C., Formation of Peptide Amides by Peptidylglycine alpha-Amidating Monooxygenase; A New Assay and Stereochemistry of Hydrogen Loss, J. Am. Chem. Soc., 110, 8526-8532 (1988).

Lam, L.K.P.; Arnold, L.D.; Kalantar, T.H.; Kelland, J.G.; Lane-Bell, P.M.; Palcic, M.M.; Pickard, M.A. and Vederas, J.C., Analogs of Diaminopimelic Acid as Inhibitors of meso-Diaminopimelate Dehydrogenase and LL-Diaminopimelate Epimerase, J. Biol. Chem., 263, 11814-11819 (1988).

Noguchi, H.; Harrison, P.H.; Arai, K.; Nakashima, T.T.; Trimble, L.A. and Vederas, J.C., Biosynthesis and Full NMR Assignment of Fungichromin, a Polyene Antibiotic from Streptomyces cellulosae, J. Am. Chem. Soc., 110, 2938-2945 (1988).

Arnold, L.D.; May, R.G. and Vederas, J.C., Synthesis of Optically Pure alpha-Amino Acids via Salts of alpha-Amino-beta-Propiolactone, J. Am. Chem. Soc., 110, 2237-2241 (1988).

Townsend, C.A.; Brobst, S.W.; Ramer, S.E. and Vederas, J.C., Stereochemical Features of Enoyl Thiolester Reductase in Averufin and Fatty Acid Biosynthesis in Aspergillus parasiticus, J. Am. Chem. Soc., 110, 318-319 (1988).

Reese, P.B.; Rawlings, B.J.; Ramer, S.E. and Vederas, J.C., Comparison of Stereochemistry of Fatty Acid and Cladosporin Biosynthesis in Cladosporium cladosporioides Using 2H Decoupled 1H, 13C NMR Shift Correlation, J. Am. Chem. Soc., 110, 316-318 (1988).

Pansare, S.V. and Vederas, J.C., Reaction of beta-Hydroxy-alpha-Amino Acid Derivatives with Diethylamino-sulfur Trifluoride (DAST). Synthesis of beta-Fluoro Amino Acids, J. Org. Chem., 54, 4804-4810 (1987).

Vederas, J.C., Use of Stable Isotopes in Biosynthetic Studies, Nat. Prod. Rep., 4, 277-337 (1987).

Holker, J.S.E.; Kaneda, M.; Ramer, S.E. and Vederas, J.C., Biosynthesis of Multicolosic Acid, A Polyketide Metabolite from Penicillium multicolor: Occurrence of Large 18O-Induced beta-Isotope Shifts in 13C NMR Spectra, J. Chem. Soc., Chem. Comm., 1099-1100 (1987).

Arnold, L.D.; Drover, J.G. and Vederas, J.C., Conversion of Serine beta-Lactones to Chiral alpha-Amino Acids by Copper-Containing Organolithium and Organomagnesium Reagents, J. Am. Chem. Soc., 109, 4649-4659 (1987).

Gore, M.P. and Vederas, J.C., Oxidation of Enolates by Dibenzyl Peroxydicarbonate to Carbonates of alpha-Hydroxy Carbonyl Compounds, J. Org. Chem., 51, 3700-3704 (1986).

Kelland, J.G.; Arnold, L.D.; Palcic, M.M.; Pickard, M.A. and Vederas, J.C., Analogs of Diaminopimelic Acid as Inhibitors of meso-Diaminopimelate Decarboxylase from Bacillus sphaericus and Wheat Germ, J. Biol. Chem., 261, 13216-13223 (1986).

Trimble, L.A. and Vederas, J.C., Amination of Chiral Enolates by Dialkyl Azodiformates. Synthesis of alpha-Hydrazino and alpha-Amino Acids, J. Am. Chem. Soc., 108, 6397-6399 (1986).

Hogg, A.M.; Kelland, J.G; Vederas, J.C. and Tamm, C., Investigation of Ribo- and Deoxyribonucleo-sides and -nucleotides by Fast Atom Bombardment Mass Spectroscopy, Helv. Chim. Acta, 69, 908-917 (1986).

Harrison, P.H.; Noguchi, H. and Vederas, J.C., Biosynthesis of Polyene Antibiotics: Intact Incorporation of 13C-Labelled Octanoate into Fungichromin by Streptomyces cellulosae, J. Am. Chem. Soc., 108, 3833-3834 (1986).

Vederas, J.C., Biosynthetic Studies on Mycotoxins Using Multiple Stable Isotope Labelling and NMR Spectroscopy, Mycotoxins and Phycotoxins, P.S. Steyn, (Ed.), Elsevier, Amsterdam, 1986, pp 97-108.

Regenstreif, C.A.; Kelland, J.G.; Pansare, S.V.; Vederas, J.C. and Pickard, M.A., Inhibition of L-lysine uptake by alpha-methyl lysine in Escherichia coli and Bacillus sphaericus, Can. J. Microbiol., 32, 522-524 (1986).

Reese, P.B.; Trimble, L.A. and Vederas, J.C., Detection of Deuterium Labelling by Two Dimensional 1H, 13C NMR Shift Correlation with 2H Decoupling, Can. J. Chem., 64, 1427-1434 (1986).

McIntyre, C.R.; Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Biosynthesis of the Meroterpenoid Metabolite, Andilesin A, by Aspergillus Variecolor: Origin of the Oxygen Atoms, J. Chem. Soc., Chem. Comm., 501-503 (1986).

Ramer, S.E.; Moore, R.N. and Vederas, J.C., Mechanism of Formation of Serine beta-Lactones by Mitsunobu Cyclization: Synthesis and Use of L-Serine Stereospecifically Labelled with Deuterium at C-3, Can. J. Chem., 64, 706-713 (1986).

He, X.G.; Chang, C.C.; Chang, C.J.; Vederas, J.C.; McInnes, A.G.; Walter, J.A. and Floss, H.G., Further Studies on Biosynthesis of Granaticin, Z. Naturforsch., 41c, 215-221 (1986).

Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Biosynthesis of the Meroterpenoid Austin by Aspergillus ustus: Synthesis and Incorporation of 13C, 18O-Labelled Ethyl 3,5-Dimethyl-orsellinate, J. Chem. Soc., Chem. Comm., 214-215 (1986).

Ahmed, S.A.; Simpson, T.J.; Staunton, J.; Sutkowski, A.C.; Trimble, L.A. and Vederas, J.C., Biosynthesis of Aspyrone and Asperlactone, Pentaketide Metabolites of Aspergillus melleus: Incorporation Studies with [1-13C, 18O2]Acetate and 18O2 Gas, J. Chem. Soc., Chem. Comm., 1685-1687 (1985).

Arnold, L.D.; Kalantar, T.H. and Vederas, J.C., Conversion of Serine to Stereochemically Pure beta-Substituted alpha-Amino Acids Via beta-Lactones, J. Am. Chem. Soc., 107, 7105-7109 (1985).

Hartman, N.R.; Trimble, L.A.; Vederas, J.C. and Jardine, I., An Acid Metabolite of Cyclosporine, Biochem. Biophys. Res. Comm., 133, 964-971 (1985).

Kelland, J.G.; Palcic, M.M.; Pickard, M.A. and Vederas, J.C., Stereochemistry of Lysine Formation by meso-Diaminopimelate Decarboxylase, Biochemistry, 24, 3263-3267 (1985).

Trimble, L.A.; Reese, P.B. and Vederas, J.C., An NMR Method to Detect Stereospecific Deuterium Labeling at Diastereotopic Methylene Hydrogens: Selective 1H, 13C Heteronuclear Shift Correlation, J. Am. Chem. Soc., 107, 2175-2177 (1985).

Moore, R.N.; Bigam, G.; Chan, J.K.; Hogg, A.M.; Nakashima, T.T. and Vederas, J.C., Biosynthesis of the Hypocholesterolemic Agent Mevinolin, J. Am. Chem. Soc., 107, 3694-3701 (1985).

McIntyre, C.R.; Simpson, T.J.; Moore, R.N.; Trimble, L.A. and Vederas, J.C., Biosynthesis of the Meroterpenoid Metabolite, Andibenin B, J. Chem. Soc., Chem. Comm., 1498-1499 (1984).

Bardshiri, E.; McIntyre, C.R.; Simpson, T.J.; Moore, R.N.; Trimble, L.A. and Vederas, J.C., Biosyn-thesis of Tajixanthone and Shamixanthone, J. Chem. Soc., Chem. Comm., 1404-1406 (1984).

Simpson, T.J.; Stenzel, D.J.; Moore, R.N.; Trimble, L.A. and Vederas, J.C., Biosynthesis of the Meroterpenoid, Austin, J. Chem. Soc., Chem. Comm., 1242-1243 (1984).

McIntyre, C.R.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Biosynthesis of LL-D253alpha in Phoma pigmentivora. Incorporation of 13C, 2H and 18O Enriched Precursors, J. Chem. Soc., Chem. Comm., 706-709 (1984).

Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Biosynthesis of Monocerin. Incorporation of 2H, 13C and 18O Labelled Acetates by Drechslera ravenelii, J. Chem. Soc., Chem. Comm., 756-758 (1984).

Chan, J.K.; Moore, R.N.; Nakashima, T.T. and Vederas, J.C., Biosynthesis of Mevinolin, Spectral Assignment by Double Quantum Coherence NMR after High Carbon-13 Incorporation, J. Am. Chem. Soc., 105, 3334-3336 (1983).

Holker, J.S.E.; O'Brien, E.; Moore, R.N. and Vederas, J.C., The Distribution of Acetate-Derived Oxygens in the Tetronic Acids of Penicillium multicolor, J. Chem. Soc., Chem. Comm., 192-194 (1983).

Hill, J.G.; Nakashima, T.T. and Vederas, J.C., Fungal Xanthone Biosynthesis; Distribution of Acetate-Derived Oxygens in Ravenelin, J. Am. Chem. Soc., 104, 1745-1748 (1982).

Lane, M.P.; Nakashima, T.T. and Vederas, J.C., Biosynthetic Source of Oxygens in Griseofulvin; Spin-Echo Resolution of 18O Isotope Shifts in 13C-NMR, J. Am. Chem. Soc., 104, 913-915 (1982).

Nakashima, T.T. and Vederas, J.C., Biosynthesis of the Aflatoxin Precursor Sterigmatocystin by Aspergillus versicolor; Spin-Echo Resolution of 18O Isotope Shifts in 13C-NMR , J. Chem. Soc., Chem. Commun., 206-208 (1982).

Vederas, J.C., Biosynthetic Studies using 18O Isotope Shifts in 13C Nuclear Magnetic Resonance, Can. J. Chem., 60, 1637-1642 (1982).

Floss, H.G. and Vederas, J.C., Pyridoxal Phosphate Catalyzed Reactions, in New Comprehensive Biochemistry, Vol. 3 (Ch. Tamm, Ed.) Elsevier, Amsterdam, 1982, pp. 162-199.

Hutchinson, C.R.; Sherman, M.M.; Vederas, J.C. and Nakashima, T.T., Regiochemistry of Labelling of Lasalocid A by [13C, 18O]-labeled Precursors, J. Am. Chem. Soc., 103, 5953-5956 (1981).

Hutchinson, C.R.; Sherman, M.M.; McInnes, A.G.; Walter, J.A. and Vederas, J.C., The Mechanism of Stereocontrol During Formation of Lasalocid A, J. Am. Chem. Soc., 103, 5956-5959 (1981).

Ayer, W.A.; Pena-Rodriguez, L. and Vederas, J.C., Identification of Sterigmatocystin as Metabolite of Monocillium nordinii, Can. J. Microbiol., 27, 846-847 (1981).

Moore, R.N.; Diakur, J.; Nakashima, T.T.; McLaren, S.L. and Vederas, J.C., Isotope Shifts in 13C-NMR Spectra of 18O-labelled Acetals; Multiple Labelling Effects at beta-Carbons, J. Chem. Soc., Chem. Commun., 501-502 (1981).

Vederas, J.C. and Floss, H.G., Stereochemistry of Pyridoxal Phosphate-Catalyzed Enzyme Reactions, Acc. Chem. Res., 13, 455-463 (1980).

Wyss, R.; Tamm, Ch. and Vederas, J.C., Differential Hydrogen Exchange During Biosynthesis of Cytochalasins B and D, Helv. Chim. Acta, 63, 1538-1541 (1980).

Diakur, J.; Nakashima, T.T. and Vederas, J.C., Magnitudes of 18O Isotope Shifts in 13C-NMR Spectra of Ketones and Alcohols, Can. J. Chem., 58, 1311-1315 (1980).

Vederas, J.C.; Nakashima, T.T. and Diakur, J., Detection of 18O-label in Cytochalasin B by 13C-NMR, Planta Medica, 39, 201-202 (1980).

Vederas, J.C., Structural Dependence of 18O Isotope Shifts in 13C-NMR Spectra, J. Am. Chem. Soc., 102, 374-376 (1980).

Vederas, J.C. and Nakashima, T.T., Biosynthesis of Averufin by Aspergillus parasiticus; Detection of 18O-label by 13C-NMR Isotope Shifts, J. Chem. Soc., Chem. Commun., 183-185 (1980).

Brown, R.S.; Tse, A. and Vederas, J.C., Photoelectron-Determined Core Binding Energies and Predicted Gas-Phase Basicities for the 2-Hydroxypyridine 2-Pyridine System, J. Am. Chem. Soc., 102, 1174-1176 (1980).

Vederas, J.C.; Reingold, I.D. and Sellers, H.W., Stereospecificity of Sodium Borohydride Reduction of Tyrosine Decarboxylase from Streptococcus faecalis, J. Biol. Chem., 254, 5053-5057 (1979).

Vederas, J.C.; Schleicher, E.; Tsai, M.D. and Floss, H.G., Stereochemistry and Mechanism of Reactions Catalyzed by Tryptophanase from Escherichia coli, J. Biol. Chem., 253, 5350-5354 (1978).

Floss, H.G.; Schleicher, E.; Vederas, J.C.; Tatum, C.M. and Benkovic, S.J., Stereochemistry of Thymidylate Synthetase, J. Chem. Soc., Chem. Commun., 218-220 (1977).

Vederas, J.C. and Tamm, Ch., Biosynthesis of Cytochalasans, Part VI, Helv. Chim. Acta, 59, 558-566 (1976).

Buchi, G.H. and Vederas, J.C., 2-Butenoylcyclohexenes, SWISS 553187, 30 Aug. 1974, CA 82 72572d (1975).

Buchi, G.H. and Vederas, J.C., Isoxazoles as Perfume and Aroma Ingredients, SWISS 553249, 30 Aug. 1974, CA 82 21734a (1975).

Vederas, J.C.; Graf, W.; David, L. and Tamm, Ch., Biosynthesis of Cytochalasans, Part IV, Helv. Chim. Acta, 58, 1886-1898 (1975).

Altman, L.J.; Semmelhack, M.F.; Hornby, R.B. and Vederas, J.C., Synthesis of Dimethyl 1,2-Dihydropyridazine-1,2-dicarboxylate, Organic Preparations and Procedures Int., 7, 35-37 (1975).

Vederas, J.C. and Buchi, G.H., Nitrogen Containing Heterocyclic Compounds, Ger. Offen., 2315639, 11 Oct. 1973, CA 80 14914g (1974).

Graf, W.; Robert, J.L.; Vederas, J.C.; Tamm, Ch.; Solomon, P.H.; Miura, I. and Nakanishi, K., Biosynthesis of Cytochalasans, Part III, Helv. Chim. Acta, 57, 1801-1815 (1974).

Buchi, G.H. and Vederas, J.C., Interchange of Functionality in Conjugated Carbonyl Compounds Through Isoxazoles, J. Am. Chem. Soc., 94, 9128-9132 (1972).

Altman, L.J.; Bramwell, M.R. and Vederas, J.C., Synthesis and Stereochemical Assignments of Some Trifluoromethyl-phenylcyclopropanes, Can. J. Chem., 49, 968-971 (1971).

Altman, L.J. and Vederas, J.C., Configurational Equilibrium of alpha-Trifluoromethylcyclopropyl Radicals, J. Chem. Soc., Chem. Commun., 895-896 (1969).

Altman, L.J.; Semmelhack, M.F.; Hornby, R.B. and Vederas, J.C., Photochemical Isomerization of Dimethyl-1,2-dihydropyridazine-1,2-dicarboxylate, J. Chem. Soc., Chem. Commun., 686-687 (1968).