![]() |
---|
![]() |
![]() |
![]() |
![]() |
![]() |
---|
|
Synthetic MethodologyWe are interested in novel processes that form strategic carbon-carbon or carbon-heteroatom bonds, assemble challenging ring systems, and establish new stereo centres. A related goal is to link two or more sequenced bond-forming reactions in tandem, leading to "domino processes" that accomplish a large build-up in molecular complexity in a single synthetic transformation. While pursuing these objectives, we try to identify underutilized classes of high-energy reactive intermediates that may be harnessed for novel types of reactions. Currently, we are working within three different areas of synthetic methodology: Further development of the Nazarov reaction as well as different approaches to trap its oxy-allyl cation intermediate. Metallocarbenes and the cyclic ylides derived from their addition to pendant heteroatoms are reactive intermediates that attract our interest as useful synthetic intermediates. Finally, photochemical reactions for accomplishing otherwise elusive synthetic transformations, were the photochemical crossed [4+4]-cycloaddition has been in particular focus. Target-Directed Synthesis
For a more details se links to the left or, please contact us ( frederick.west@ualberta.ca ). |
---|
![]() |
---|
Frederick G. West. Professor of Chemistry
|
---|