2017/2016/2015/2014
2013/2012/2011/2010/2009/2008
2007/2006/2005/2004/2003/2002
2001/2000/1999/1998/1996/1995
1994/1993/1991/1990/1989/1988
2017
- Prados-Rosales*, R.; Carreńo, L.; Weinrick, B.; Lowary, T.
L.; Baena, A.; Joe, M.; Bai, Y.; Chow, S.-K.; Kalscheuer, R.;
Batista-Gonzalez, A.; Saavedra, N. A.; Chen, T.; Blanc, C.; Xu, J.;
Jacobs Jr., W. R.; Chan, J.; Porcelli, S. A.; Achkar, J. M. Casadevall,
A. “Arabinomannan-protein conjugates induce a protective response in mice that controls Mycobacterium tuberculosis dissemination” PLoS Pathogens. 2017, 13, e1006250.
- Angala, S. K; McNeil, M. R.; Shi, L.; Pham, H.;
Zuberogoitia, S.; Nigou, J.; Boot, C. M.; Lowary, T. L.; Gilleron, M.;
Jackson, M. “Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis” ACS Chem. Biol. 2017, 12, 682–691.
- Williams, D. M.; Ovchinnikova, O. G.; Koizumi, A.; Mainprize, I. L.; Kimber, M. S.; Lowary, T. L.; Whitfield, C. “A single polysaccharide assembly protein that integrates polymerization, termination and chain-length quality control” Proc. Natl. Acad. Sci. U.S.A., 2017, 114, E1215–E1223.
2016
- Poulin, M. B.; Lowary, T. L. “Chemical Insight Into the Mechanism and Specificity of GlfT2, a Bifunctional Galactofuranosyltransferase from Mycobacteria” J. Org. Chem. 2016, 81, 8123–8130.
- Lowary, T. L. “Twenty Years of Mycobacterial Glycans. Furanosides and Beyond.” Acc. Chem. Res. 2016, 49, 1379–1388.
- Joe, M.; Lowary, T. L. “Synthesis of a homologous series of galactofuranose-containing mycobacterial arabinogalactan fragments” Can. J. Chem. 2016, 94, 976–988.
- Frédéric, C.; Tikad, A.; Jian, F.; Pan, W.; Zheng, R. B.; Koizumi, A.; Xue, X.; Lowary, T. L.; Vincent, S P. “Synthesis
of unprecedented sulfonylated phosphono-exo-glycals designed as
inhibitors of the three mycobacterial galactofuranose processing enzymes” Chem. Eur. J. 2016, 22, 15913–15920.
- Ovchinnikova, O. G.; Doyle, L.; Huang, B.-S.; Kimber, M. S.; Lowary, T. L.; Whitfield, C. “Biochemical
characterization of bifunctional 3-deoxy-β-D-manno-oct-2-ulosonic acid
(β Kdo) transferase KpsC from Escherichia coli involved in capsule
biosynthesis” J. Biol. Chem. 2016, 291, 21519–21530.
- Liu, L.; Siuda, I.; Richards, M. R.; Renaud, J.; Kitova, E. N.; Mayer, P. M.; Tieleman, D. P.; Lowary, T. L.; Klassen, J. S. “Structure and Stability of Carbohydrate–Lipid Complexes” ChemBioChem 2016, 17, 1571–1578.
- Li, J., Lowary, T. L. “Synthesis
and evaluation of bicyclo[3.1.0]hexane-based UDP-Galf analogues as
inhibitors of the mycobacterial galactofuranosyltransferase GlfT2” Molecules 2016, 21, 1053.
- Harrison, J.; Lloyd, G.; Joe, M.; Lowary, T. L. Reynolds,
E.; Walters-Morgan, H.; Bhatt, A.; Lovering, A. L.; Besra, G. S.;
Alderwick, L. J. “PagL is a phosphotransferase responsible for ligating arabinogalactan to peptidoglycan in Mycobacterium tuberculosis” mBio, 2016, 7, e00972-16.
- Chen, T.; Blanc, C.; Eder, A. Z.; Prados-Rosales, R.;
Oliveira-Souza, A. C.; Kim, R. S.; Joe, M.; Bai, Y.; Lowary, T. L.;
Tanner, R.; Brennan, M. J.; Fletcher, H. A.; McShane, H.; Casadevall,
A.; Achkar, J. M. “Association of
Human Antibodies to Arabinomannan with Enhanced Mycobacterial
Opsonophagocytosis and Intracellular Growth Reduction” J. Infect. Dis. 2016, 214, 300–310.
- Lin, S.; Ashmus, R. A.; Lowary, T. L. “An oxidation–amidation approach for the synthesis of glycuronamides” Eur. J. Org. Chem. 2016, 2653–2644.
- Angala, S. K.; McNeil, M. R.; Zou, L.; Liav, A.; Zhang, J.; Lowary, T. L.; Jackson, M. “Identification of a novel mycobacterial arabinosyltransferase activity which adds an arabinosyl residue to α-D-mannosyl residues" ACS Chem. Biol. 2016, 11, 1518–1524.
- Ovchinnikova, O. G.; Mallette, E.; Koizumi, A.; Lowary, T. L.; Kimber*, M. S.; Whitfield, C. “The structure and function of a prototype bacterial β-Kdo glycosyltransferase reveals a new glycosyltransferase family” Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E3120–E3129.
- Jeyakanthan, M.; Meloncelli, P. J.; Zou, L.; Lowary, T. L.;
Larsen, I.; Maier, S; Tao, K.; Rusch, J.; Chinnock, R.; Shaw, N.;
Burch, M.; Beddows, K.; Addonizio, L.; Zuckerman, W.; Pahl, E.;
Rutledge, J.; Kanter, K. R. Cairo, C. W.; Buriak, J. M.; Ross, D.;
Rebeyka, I.; West, L. J. “ABH-glycan
microarray characterizes ABO subtype antibodies: fine specificity of
immune tolerance after ABO-incompatible transplantation” Am. J. Transplant. 2016, 16, 1548–1558.
- Ashmus, R. A.; Jayasuriya, A. B.; Lim, Y. J.; O’Doherty, G. A. Lowary, T. L. “De
novo asymmetric synthesis of a
6-O-methyl-D-glycero-L-gluco-heptopyranose-derived thioglycoside for
the preparation of Campylobacter jejuni NCTC11168 capsular
polysaccharide fragments” J. Org. Chem. 2016, 81, 3058–3063.
- Slaney, A.; Dijke, I. E.; Jeyakanthan, M.; Li, C.; Zou, L.;
Plaza-Alexander, P. M.; Meloncelli, P. J.; Bau, J.; Allan, L.; Lowary,
T.L.; West, L. J.; Cairo, C. W.; Buriak*, J. M. “Conjugation of A and B Blood Group Structures to Silica Microparticles for the Detection of Antigen-Specific B Cells” Bioconjug. Chem. 2016, 27, 705–715.
- Schieck, E.; Lartigue, C.; Frey, J.; Vozza, N.; Miller, R.; Nene, V.; Muriuki, C.; Naessens, J.; Lowary, T.
L.; Vashee, S.; Feldman, M. F.; Jores*, J. “Genome editing of Mycoplasma mycoides
via genome transplantation and mutagenesis in yeast provides insights
into the functional role of UDP-galactopyranose mutase and capsular
galactan” Mol. Microbiol. 2016, 99, 55–70.
2015
- Jeyakanthan, M.; Tao, K. S.; Zou, L.; Meloncelli, P. J.; Lowary, T.
L.; Suzuki, K., Boland, D.; Larson, I.; Burch, M.; Shaw, N.;
Beddows, K.; Addonizio, L.; Zuckerman, W.; Afzali, B.; Kim, D. H.;
Mengel, A. M.; Shapiro, A. M. J.; Burch, M.; West, L. J. “Chemical basis for qualitative and quantative differences between ABO blood groups: implications for organ transplantation” Am. J. Transplant. 2015, 15, 2602–2615.
- Gagnon, S. M. L.; Meloncelli, P. J.; Zheng, R. B.; Haji-Ghassemi, O.; Johal, A. R.; Borisova, S.; Lowary, T. L.; Evans, S. V. “High
resolution structures of the human ABO(H) blood group enzymes in
complex with donor analogs reveal that the enzymes utilize multiple
donor conformations to bind substrates in a step-wise manner” J. Biol. Chem. 2015, 290, 428–437.
- Sahloul, K.; Lowary, T. L. “Development of an Orthagonal Protection Startegy for the Synthesis of Mycobacterial Arabinomannan Fragments” J. Org. Chem. 2015, 80, 11417-11434.
- Poopari, M. R.; Dezhahang, Z.; Shen, K.; Wang, L.; Lowary, T. L.; Xu, Y. “Absolute
Configuration and Conformation of Two Fráter–Seebach Alkylation
Reaction Products by Film VCD and ECD Spectroscopic Analyses” J. Org. Chem. 2015, 80, 428–437.
- Zhang, D.; Huang, P.; Zou, L.; Lowary, T. L.; Tan, M.; Jiang X. “Tulane virus recognizes the A-type III and B histo-blood group antigens” J. Virol. 2015, 89, 1419–1427.
- Lak, P.; Makeneni, S.; Woods, R. J.; Lowary, T. L. “Specificity of Furanoside–Protein Recognition through Antibody Engineering and Molecular Modeling” Chem. Eur. J. 2015, 21, 1138–1148.
- Liston, S. D.; Clarke, B. R.; Greenfield, L. K.; Richards, M. R.; Lowary, T. L.; Whitfield, C. “Domain interactions control complex formation and polymerase specificity in the biosynthesis of the Escherichia coli O9a antigen” J. Biol. Chem. 2015, 290, 1075–1085.
- Wang L.; Dong, M.; Lowary, T. L. “Synthesis of Unusual N-Acylated Aminosugar Fragments of Mycobacterium marinum Lipooligosaccharide IV” J. Org. Chem. 2015, 80, 2767–2780.
- Elsaidi, H. R. H.; Lowary, T. L. “Effect
of phenolic glycolipids from Mycobacterium kansasii on proinflammatory
cytokine release. A structure–activity relationship study” Chem. Sci. 2015, 6, 3161–3172.
- Conde, P.; Rodriguez, M.; van der Touw, W.; Jimenez, A.; Burns, M.;
Miller, J.; Brahmachary, M.; Chen, H.-M.; Boros, P.; Rausell-Palamos,
F.; Yun, T. J.; Riquelme, P.; Rastrojo, A.; Aguado, B.;
Stein-Streilein, J.; Tanaka, M.; Zhou, L.; Zhang, J.; Lowary, T. L.;
Ginhoux, F.; Park, C. G.; Cheolho, C.; Brody, J.; Turley, S.; Lira, S.;
Bronte, V.; Gordon, S.; Heeger, P.; Merad, M.; Hutchinson, J.; Chen, S-
H.; Ochando, J. “DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance” Immunity, 2015, 42, 1143–1158.
- Bai, B.; Chu, C.-J.; Lowary, T. L. “Lipooligosaccharides from Mycobacteria. Structure, Function and Synthesis” Isr. J. Chem. 2015, 55, 360–372.
2014
- Arutyunov, D.; Singh, U.; El-Hawiet, A.; Dos Santos Seckler, H.; Nikjah, S.; Joe, M.; Bai, Y.; Lowary, T. L.; Klassen, J.S.; Evoy*, S.; Szymanski*, C. M. “Application of mycobacteriophage cell binding proteins for the detection of mycobacteria” Bacteriophage 2014, 4, e960346.
- Backus, K. M.; Dolan, M. A.; Barry, C. S.; Joe, M.; McPhie,
P.; Boshoff, H. I. M.; Lowary, T. L.; Davis, B. G.; Barry III; C. E. “The
Three Mycobacterium Tuberculosis Antigen 85 Isoforms have Unique
Substrates and Activities Determined by Non-active Site Regions” J. Biol. Chem. 2014, 289, 25041-25053.
- Zhai, Y.; Dasog, M.; Snitynski, R. B.; Purkait, T. K.;
Aghajamali, M.; Hahn, A. H.; Sturdy, C. B.; Lowary, T. L.; Veinot, J.
G. C. “Water-soluble Photoluminescent
D-Mannose and L-Alanine Functionalized Silicon Nanocrystals and Their
Application to Cancer Cell Imaging” J. Mater. Chem. 2014, 2, 8427-8433.
- Ashmus, R. A.; Lowary, T. L. “Synthesis of Carbohydrate Methyl Phosphoramidates” Org. Lett. 2014, 16, 2518-2521.
- Elsaidi, H. R. H.; Lowary, T. L. “Inhibition of Cytokine Release by Mycobacterium tuberculosis Phenolic Glycolipid Analogs” ChemBioChem 2014, 15, 1176-1182.
- Li, J.; Lowary, T. L. “Sulfonium Ions as Inhibitors of the Mycobacterial Galactofuranosyltranserase GlfT2” Med. Chem. Comm. 2014, 5, 1130-1137.
- van Alphen, L.; Wenzel, C. Q.; Richards, M. R.; Fodor, C.;
Ashmus, R. A.; Stahl, M.; Karlyshev, A. V.; Wren, B. W.; Stintzi, A.;
Miller, W. G.; Lowary, T. L.; Szymanski, C. M. “Biological roles of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni” PLoS ONE 2014, 9, e87051.
- Poulin, M. B.; Shi, Y.; Protsko, C.; Dalrymple, Sanders, D. A. R.; Pinto, B. M.; Lowary, T. L. “Specificity of a UDP-GalNAc pyranose-furanose mutase. A potential therapeutic target for Campylobacter jejuni infections” ChemBioChem 2014, 15, 47-56.
- Snitynsky, R. B.; Lowary, T. L. “Synthesis of nitrogen-containing furanose sugar nucleotides for the use as enzymatic probes” Org. Lett. 2014,16, 212-215.
2013
- Lowary, T. L. “Context and Complexity: The Next Big Thing in Synthetic Glycobiology” 2013, 17, 990-996.
- Zhang, J.; Zou, L.; Lowary, T. L. “Synthesis of the tolerance inducing oligosaccharide lacto-N-fucopentaose III bearing an activated linker” ChemistryOpen, 2013, 2, 156-163.
- Elsaidi, H. R. Barreda, D. R.; Cairo, C. W.; Lowary, T. L. “Simplified mycobacterial phenolic glycolipid analogs modulate cytokine levels via Toll-Like receptor 2” ChemBioChem 2013, 14, 2153-2159.
- Xia, L.; Lowary, T. L. “Amphiphilic cytosolic glycans from mycobacteria. Occurence, lipid-binding properties, biosynthesis and synthesis” Biopolymers 2013, 99, 697-712.
- Ahmed, M. F.; Lowary, T. L. “Glycosylations with 2,3-Aziridinofuranose Derivatives” Tetrahedron 2013, 69, 4276-4284.
- Richards, M. R.; Bai, Y.; Lowary, T. L. “Comparison between DFT- and NMR-based conformational analysis of methyl galactofuranosides” Carbohydr. Res. 2013, 374, 103-114.
- Willis, L. M.; Stupak, J.; Richards, M. R.; Li, J.; Lowary, T. L.; Whitfield*, C. “Structure
of a conserved glycolipid terminus for capsular polysaccharides
synthesized by the ABC transporter-dependent pathway in Gram-negative
pathogens” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 7868-7873.
- Taha, H. A.; Richards, M. R.; Lowary, T. L. “Conformational Analysis of Furanoside-Containing Mono- and Oligosaccharides” Chem. Rev. 2013, 113, 1851-1876.
- Xia, L.; Lowary, T. L. “Regioselective Polymethylation of α-(1-4)-linked Mannopyranose Oligosaccharides” J. Org. Chem. 2013, 78, 2863-2880.
- Plaza-Alexander, P.; Lowary T. L. “Synthesis of trisaccharides incorporating the α-Gal antigen functionalized for neoglycoconjugate preparation” ARKIVOC 2013, ii, 112-122. Invited contribution to special issue in tribute to Professor Richard R. Schmidt.
2012
- Peng, W.; Zou, L.; Bhamidi, S.; McNeil, M. R.; Lowary T. L. “The galactosamine residue in mycobacterial arabinogalactan is α-linked” J. Org. Chem. 2012, 77, 9826-9832.
- Greenfield, L. K.; Richards, M. R.; Vinogradov, E.; Wakarchuk, W. W.; Lowary T. L.; Whitfield, C. “Domain Organization of the Polymerizing Mannosyltransferases Involved in Synthesis of the Escherichia coli O8 and O9a Lipopolysaccharide O Antigens” J. Biol. Chem. 2012, 287, 38135-38149.
- Liu, L.; Bai, Y.; Sun, N.; Xia, L.; Lowary T. L.; Klassen, J. S. “Carbohydrate-Lipid Interactions. Affinities of Methylmannose Polysaccharides for Lipids in Aqueous Solution” Chem. Eur. J. 2012, 18, 12059-12067.
- Greenfield, L. K.; Richards, M. R.; Li, J.; Wakarchuk, W. W.; Lowary T. L. “Biosynthesis of the Polymannose Lipopolysaccharide O Antigens from Escherichia coli Serotypes O8 and O9a Requires a Unique Combination of Mannosyltransferase Modules in Single- and Multi-Active Site Enzymes” J. Biol. Chem. 2012, 287, 35078-35091.
- Zou, L.; Zheng, R. B.; Lowary T. L. “Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica.” Beilstein J. Org. Chem. 2012, 8, 1219-1226. Invited contribution to "Synthesis in the Glycosciences" Thematic Issue.
- Wheatley, R. W.; Zheng, R. B.; Richards, M. R.; Lowary T. L.; Ng, K. K. S. “Tetrameric structure of GlfT2 reveals a scaffold for the assemble of mycobacterial arabinogalactan” J. Biol. Chem. 2012, 287, 28132-28143.
- Xia, L; Zheng R. B.; Lowary T. L. “Revisiting the specificity of an α-(1,4)-mannosyltransferase involved in mycobacterial methylmannose polysaccharide biosynthesis” ChemBioChem 2012, 13, 1139-1151.
- Poulin, M. B.; Zhou, R.; Lowary T. L. “Synthetic
UDP-galactofuranose analogs reveal critical enzyme-substrate
interactions in GlfT2-catalyzed mycobacterial galactan assembly” Org. Biomol. Chem. 2012, 10, 4074-4087.
- Sarkar, S.; Tang, X. L.;
Das, D.; Lowary, T. L.; Suresh, M. R. “A bispecific antibody based assay shows
potential for detecting tuberculosis in resource constrained laboratory
settings” PLOS One. 2012, 7,
e32340.
2011
-
Clarke, B. R.; Richards, M. R.; Greenfield, L. K.; Hou, D.;
Lowary, T. L.; Whitfield, C. In vitro
“Reconstruction of the Chain Termination
Reaction in Biosynthesis of the
Escherichia coli O9a O-polysaccharide;
the Chain-length Regulator, WbdD, Catalyzes the Addition of Methyl Phosphate to
the Non-reducing Terminus of the Growing Glycan” J. Biol. Chem. 2011, 286, 41391–41401.
- Peng, W.; Jayasuriya, A. B.; Imamura, A.; Lowary, T. L. “Synthesis
of the 6-O-methyl-D-glycero-α-L-gluco-heptopyranose moiety present in
the capsular polysaccharide from Campylobacter jejuni NCTC 11168” Org. Lett. 2011, 13, 5290-5293.
- Islam, S. M.; Richards, M. R.; Taha, H. A.; Byrns, S. C.; Lowary, T. L.; Roy, P. N. “Conformational analysis of oligoarabinofuranosides: overcoming torsional barriers with umbrella sampling” J. Chem. Theor. Comput. 2011, 7, 2989-3000.
- Higgins, M. A.; Ficko-Blean, E.; Meloncelli, P. J.; Lowary, T. L.; Borastan*, A. B. “The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate Antigen Hydrolyzing Enzymes” J. Mol. Biol. 2011, 411, 1017-1036.
- Imamura, A.; Lowary, T. L. “Methods for the Chemical Synthesis of Furanose Glycosides” Trends Glycosci. Glycotech. 2011, 23, 134-152.
- Slaney, A. M.; Wright, V. A.; Meloncelli, P. J.; Harris, K. D.; West, L. J.; Lowary, T. L.; Buriak, J. M. “Biocompatible Carbohydrate-Functionalized Stainless Steel Surfaces: A New Method for Passivating Biomedical Implants” ACS App. Mater. Interfaces. 2011, 3, 1601-1612.
- Meloncelli, P. J.; West, L. J.; Lowary, T. L. “Synthesis and NMR Studies on the ABO Histo-Blood Group Antigens: Synthesis of Type III and IV Structures and NMR Characterization of Type I–VI Antigens” Carbohydr. Res. 2011, 346, 1406–1426.
- Shi, W.; Lowary, T.L. “Effect of Carbohydrate Amino Group Modifications on the Cytotoxicity of Glycosylated 2-Phenyl benzo-β-thiophenes and 2-Phenyl benzo-β-furans” Bioorg. Med. Chem. Lett. 2011, 21, 2591-2596.
- Shi, W.; Lowary, T.L. “Structure-Activity Relationships in Glycosylated 2-Phenyl-indoles, 2-Phenyl-benzo-β-thiophenes and 2-Phenyl-benzo-β-furans as DNA Binding and Potential Anti-tumor Agents” Bioorg. Med. Chem. 2011, 19, 1779-1789.
- Taha,
H. A.; Roy, P. N. Lowary, T. L. “Theoretical Investigations on the
Conformation of the β-Arabinofuranoside Ring” J. Chem. Theory
Comput. 2011, 7, 420-432.
- Harrison, J.
A.; Ravindranathan Kartha, K. P.; Fournier, E.
J. L.; Lowary, T. L.; Malet, C.; Nilsson, U. J.; Hindsgaul, O.; Schenkman, S.;
Naismith, J. H.; Field, R. A. “Probing the acceptor substrate binding
site of Trypanosoma cruzi trans-sialidase with systematically modified
substrates and glycoside libraries” Org. Biomol. Chem. 2011,
9, 1653-1660.
- Frigell,
J.; Pearcey, J. A.; Lowary, T. L. Cumpstey, I. “Carbasugar analogues of
galactofuranosides: Pseudodisaccharide mimics of fragments of mycobacterial
arabinogalactan” Eur. J. Org. Chem. 2011,
1367-1375.
- Liu, C.;
Richards, M. R.; Lowary, T. L. “Synthesis and NMR Spectroscopic Analysis of
Acylated Pentasaccharide Fragments of Mycobacterial Arabinogalactan” Org.
Biomol. Chem. 2011, 9, 165–176.
- Vembaiyan, K.;
Pearcey, J. A.; Bhasin, M.; Lowary, T. L.; Zou, W. “Synthesis of sugar–amino
acid–nucleosides as potential glycosyltransferase inhibitors” Bioorg. Med.
Chem. 2011, 19, 58–66.
- Shi, W.; Marcus, S. L.; Lowary, T. L. “Cytotoxicity and
topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles,
2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” Bioorg. Med. Chem.
2011, 19, 603–612.
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2010
- Peltier, P.; Beláňová, M.; Dianišková, P.; Brennan, P. J.;
Zhou, R.; Zheng, R. B.; Pearcey, J. A.; Joe, M.; Nugier-Chauvin, C.;
Ferričres, V.; Lowary, T. L.; Daniellou, R.; Mikušová, K. “Synthetic UDP-furanoses as potent
inhibitors of mycobacterial galactan biogenesis” Chem. Biol. 2010, 17, 1267–1366.
- Meloncelli, P.
J.; Lowary, T. L. “Synthesis of ABO Histo-blood Group Type I
and II Antigens” Carbohydr. Res. 2010, 345, 2304–2321.
- Tam,
P.-H., Lowary, T. L. “Mycobacterial
lipoarabinomannan fragments as haptens for potential anti-tuberculosis
vaccines” RSC
Specialist Periodical Reports, Carbohydrates 2010, 36,
38–58.
- Poulin,
M. B.; Lowary, T. L. “Methods to Study
the Biosynthesis of Bacterial Furanosides” Methods Enzymol. 2010,
478, 389–411.
- Oppenheimer, M.; Poulin, M. B.; Lowary, T. L. Helm, R. R.;
Sobrado, P. “Characterization of
recombinant UDP-galactopyranose mutase from Aspergillus fumigatus”
Arch. Biochem. Biophys. 2010,
502, 31–33.
-
Yang, G.;
Li, J.; Liu, Y.; Lowary, T. L.; Xu, Y. “Determination of the Absolute
Configurations of
Bicyclo[3.1.0]hexane Derivatives via Electronic Circular Dichroism,
Optical
Rotation Dispersion and Vibrational Circular Dichroism Spectroscopy and
Density
Functional Theory Calculations” Org. Biomol. Chem. 2010, 8,
3777–3783.
-
Imamura,
A.; Lowary, T. L. “β-Selective
Arabinofuranosylation Using a 2,3-O-Xylylene-protected Donor” Org.
Lett. 2010, 12,
3686–3689.
-
Liu, C.;
Richards, M. R.;
Lowary, T. L. “Probing
the Effect
of Acylation on Arabinofuranose Ring Conformation in Di- and
Trisaccharide
Fragments of Mycobacterial Arabinogalactan” J. Org.
Chem. 2010, 75,
4992–5007.
- Szczepina, M. G.; Zheng, R.
B.; Completo, G. C.; Lowary, T. L.; Pinto, B. M. “STD-NMR Studies of
Two Acceptor Substrates of GlfT2, a
Galactofuranosyltransferase from M. tuberculosis: Epitope Mapping Studies”
Bioorg. Med. Chem. Lett. 2010,
18, 5123–5125.
- Yang, G.; Tran, H.; Fan, E.; Shi, W.; Lowary, T. L.; Xu, Y.
“Determination of the Absolute Configurations of
Synthetic Daunorubicin Analogues Using Vibrational Circular Dichroism Spectroscopy
and Density Functional Theory” Chirality, 2010,
22, 734–743.
- Taha, H. A.; Castillo, N. C.; Sears, D. N. Wasylishen, R.
E.: Lowary, T. L. Roy, P.-N. “Conformational
analysis of arabinofuranosides: Prediction of 3JH,H
using MD Simulations with DFT-derived Spin–Spin Coupling Profiles”
J. Chem. Theory Comput. 2010,
6, 212–222.
- Tam, P.-H.; Lowary, T. L. “Epimeric
and amino disaccharide analogs as probes of an
alpha-(1,6)-mannosyltransferase involved in mycobacterial
lipoarabinomannan biosynthesis” Org. Biomol. Chem. 2010, 8, 181–192.
- Poulin, M. B.; Nothaft, H.; Hug, I.; Feldman, M. F.
Szymanski, C. M.; Lowary, T. L. “Characterization
of a Bifunctional Pyranose–Furanose Mutase from Campylobacter jenuni
11168” J. Biol. Chem. 2010,
285, 493–501.
- Shi, W.; Marcus, S. L.; Lowary, T. L. “Synthesis and Antibacterial Activity of
Aminosugar-Functionalized Intercalating Agents” Carbohydr. Res. 2010, 345, 10–22.
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2009
- Pan, Y.; Lowary, T. L.; Tykwinksi, R.R. “Naturally Occurring and Synthetic Polyyne
Glycosides” Can. J. Chem. 2009,
87, 1565–1582.
- Tam, P.-H., Lowary, T. L. “Recent
Advances in Mycobacterial Cell Wall Glycan Biosynthesis” Curr.
Opin. Chem. Biol. 2009, 13,
618–625.
- Szczepina, M. G.; Zheng, R. B.; Completo, G. C.; Lowary, T.
L.; Pinto, B. M. “STD-NMR
Studies Suggest that Two Acceptor Substrates for GlfT2, a Bifunctional
Galactofuranosyltransferase Required for the Biosynthesis of
Mycobacterium tuberculosis Arabinogalactan, Compete for the Same
Binding Site” ChemBioChem 2009, 10, 2052–2059.
- Shi, W.; Coleman, R. S. Lowary, T. L. “Synthesis
and DNA-Binding Affinity Studies of Glycosylated Intercalators Designed
as Functional Mimics of the Anthracycline Antibiotics” Org.
Biomol. Chem. 2009, 3709–3722.
- Murase, T.; Zheng, R. B.; Joe, M.; Bai, Y.; Marcus, S. L.;
Lowary, T. L.; Ng, K. K. S. “Structural insights into host
recognition of mycobacterial polysaccharides” J. Mol.
Biol. 2009, 392, 381–392.
- Hou, D.; Taha, H. A.; Lowary, T. L. “2,3-Anhydrosugars
in Glycoside Bond Synthesis. Mechanism of 2-Deoxy-2-Thioaryl Glycoside
Formation” J. Am. Chem. Soc. 2009, 131, 12937–12948.
- Richards, M. R.; Lowary, T. L. “Chemistry and
Biology of Galactofuranose-Containing Polysaccharides” ChemBioChem
2009, 10, 1920–1938.
- Hou, D.; Lowary, T. L. “Recent Advances in the
Synthesis of 2-Deoxy-glycosides” Carbohydr. Res.
2009, 344, 1910–1939.
- Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in
Glycoside Bond Synthesis. Application to Furanosyl Azides and
C-glycosides” Tetrahedron 2009, 65, 5916–5921.
- Meloncelli, P. J.; Lowary, T. L. “Synthesis of ABO
Type V and VI Antigens” Aust. J. Chem. 2009, 62,
558–574.
- Meloncelli, P. J.; Martin, A. D.; Lowary, T. L. “Glycosyl
iodides. History and recent advances” Carbohydr. Res.
2009, 344, 1110-1122.
- Carapito, R.; Imberty, A.; Jeltsch, J.-M.; Byrns, S. C.;
Tam, P.-H.; Lowary, T. L.; Varrot, A.; Phalip, V. “Molecular
basis of arabinobio-hydrolase activity in phytopathogenic fungi.
Crystal structure and catalytic mechanism of Fusarium graminearum GH93
α-L-arabinofuranosidase” J. Biol. Chem. 2009, 284,
12285–12296
- Hou, D.; Lowary, T. L. “2,3-Anhydrosugars in
Glycoside Bond Synthesis. Application to 2,6-Dideoxy-pyranosides”
J. Org. Chem. 2009, 74, 2278–2289. Selected as a
Feature Article by JOC editor.
- Taha, H. A.; Castillo, N.; Roy, P.-N.;Lowary, T. L."Conformational
Studies of Methyl β-D-Arabinofuranoside Using the AMBER/GLYCAM Approach"
J. Chem. Theory Comput. 2009, 5, 430-438.
back to top
2008
- Phillips, R. L.; Kim, I.-K.; Bradley E. Carson, B. E.;
Tidbeck, B.; Bai, Y.; Lowary, T. L.; Bunz, U. H. F. “Sugar-substituted
poly(para-phenyleneethynylenes) and their interaction with concanavalin
A and bacteria” Macromolecules 2008, 41, 7316–7320.
- Rose, N. L.; Zheng, R. B.; Pearcey, J.; Zhou, R.; Completo,
G. C.; Lowary, T. L. “Development of a coupled
spectrophotometric assay for GlfT2, a bifunctional mycobacterial
galactofuranosyltransferase” Carbohydr. Res. 2008,
343, 2130–2139.
- Completo, G. C.; Lowary, T. L. “Synthesis of
galactofuranose-containing acceptor substrates for mycobacterial
galactofuranosyltransferases” J. Org. Chem. 2008,
73, 4513–4525.
- Shi, L.; Zhou, R.; Liu, Z.; Lowary, T. L.; Seeberger, P.
H.; Stocker, B. L.; Crick, D. C.; Khoo, K.-H.; Chatterjee, D. “Transfer
of the first arabinofuranose residue to galactan is essential for
mycobacterial viability” J. Bacteriol. 2008, 190,
5248–5255.
- Birch,
H. J.; Alderwick, L. J.; Bhatt, A.; Rittmann, D.; Krumbach, K.; Singh,
A.; Bai, Y.; Lowary, T. L. Eggeling, L.; Besra, G. S.“Biosynthesis
of mycobacterial arabinogalactan: identification of a novel alpha-(1,3)
arabinofuranosyltransferase” Mol. Microbiol. 2008,
69, 1191–1206.
- Hou, F.; Skogman, F.; Lowary, T. L. “Synthesis
of 8-azidooctyl glycoside derivatives of the O-chain repeating unit of
Escherichia coli O9a lipopolysaccharide and a methylated analogue”
Carbohydr. Res. 2008, 343, 1779–1790.
- Li, J.; Lowary, T. L. “Synthesis
of Bicyclo[3.1.0]hexane Derivatives as Conformationally-Restricted
Analogues of beta-Arabinofuranosyl and arabino-Galactofuranosyl Rings”
Org. Lett. 2008, 10, 881–884.
- Alfaro, J. A.; Zheng, R. B.; Persson, M.; Letts, J. A.;
Polakowski, R.;
Bai, Y.; Borisova, S. N.; Seto, N. O. L.; Lowary, T. L.; Palcic, M. M.;
Evans, S. V. “ABO(H) blood group A and B glycosyltransferases
recognize substrate via specific conformational changes” J.
Biol. Chem. 2008, 283, 10097–10108.
- Appelmelk,
B. J.; den Dunnen, J.; Ummels, R.; Pak, M.; Larrouy-Maumus, G.; Nigou,
J.; Gurcha, S. S.; Movahedzadeh, F.; Brown, E. J.; Eysink Smeets, M.
M.; Besra, G. S.; Willemsen, P. T. J.; Lowary, T. L.; van Kooyk, Y.;
Maaskant, J. J.; Stoker, N.; Ley, P. v. d.; Puzo, G.;
Vandenbroucke-Grauls, C. M. J. E.; Wieland, C. W.; van der Poll, T.;
Geijtenbeek, T.; van der Sar, A M.; Bitter. W. “The mannose cap
of lipoarabinomannan is not important for mycobacterial virulence.”
Cell. Microbiol. 2008, 10, 930–944.
- Tam, P.-H.; Besra, G. S.; Lowary, T. L. “Exploring
the substrate specificity of a mycobacterial polyprenol
monophosphomannose-dependent alpha-(1,6)-mannosyltransferase” ChemBioChem
2008, 267–278.
- Seo, M.; Castillo, N.; Ganzynkowicz, R.; Daniels, C. R.;
Woods, R. J.; Roy, P.-N.; Lowary, T. L. “An
approach for the simulation and modeling of flexible rings. Application
to the alpha-D-arabinofuranoside ring, a key constituent of
polysaccharides from Mycobacterium tuberculosis” J. Chem.
Theory Comput. 2008, 4, 184–191.
- Belánová, M.; Dianišková, P.; Brennan, P. J.; Completo, G.
C.; Rose, N. L. Lowary, T. L.; Mikušová, K. “Galactosyl
Transferases in Mycobacterial Cell Wall Synthesis” J.
Bacteriol. 2008, 190, 1141–1145.
back to top
2007
- Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.;
Schriemer, D. C.; Lowary, T. L. “Studies Toward the Development
of Anti tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan”
ACS Symp. Ser. 2007, 989, 184–197.
- Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis
of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9
and O9a lipopolysaccharide” Carbohydr. Res. 2007,
342, 2818–2825.
- Hou, D.; Lowary, T. L. “Stereoselective synthesis
of 2-Deoxy-furanosides from 2,3-Anhydro-furanosyl Thioglycosides”
Org. Lett. 2007, 9, 4487–4490.
- Liu, C.; Skogman, F.; Cai, Y.; Lowary, T. L. “Synthesis
of the ‘primer-adaptor’ trisaccharide moiety of Escherichia coli O8, O9
and O9a lipopolysaccharide” Carbohydr. Res. 2007,
342, 2818–2825.
- Sefzik, T.; Houseknecht, J. B.; Clark, T. M.; Prasad, S.;
Lowary, T. L.; Gan, Z.; Grandinetti, P. J. “Solid State 17O-NMR
in Carbohydrates” Chem. Phys. Lett. 2007, 434,
312–315.
- Fan, E.; Shi, W.; Lowary, T. L. “Synthesis of
daunorubicin analogs containing truncated aromatic cores and unnatural
monosaccharide residues” J. Org. Chem. 2007, 72,
2917–2928.
- Voehringer, D.; Stanley, S. A.; Cox, J. S.; Lowary, T. L.;
Locksley*, R. M. “Identification of Intelectin-1 and -2 as
Novel Stat6-dependent Genes Expressed in Lung and Intestine During
Helminth Infection” Exp. Parasitol. 2007, 116,
458-466.
- Tam, P.-H.; Lowary, T. L. “Synthesis of a Panel of
Deoxy and Methoxy Analogs of the alpha-Manp-(1,6)-a-Manp-O(CH2)7CH3
Acceptor Substrate for a Polyprenolphosphomannose-Dependent
Mycobacterial Mannosyltransferase” Carbohydr. Res.
2007, 342, 1741-1772.
- Rademacher,
C.; Shoemaker, G. K.; Kim, H.-S.; Zheng, R. B.; Taha, H.; Liu, C.;
Nacario, R. C.; Schriemer, D. C.; Klassen, J. S.; Peters, T.; Lowary,
T. L. “Ligand specificity of CS-35, a monoclonal antibody that
recognizes mycobacterial lipoarabinomannan. A model system for
oligofuranoside-protein recognition” J. Am. Chem. Soc.
2007, 129, 10489–10502.
- Joe, M.; Bai, Y.; Nacario, R. C.; Lowary, T. L. “Synthesis
of the Docosanasaccharide Arabinan Domain of Mycobacterial
Arabinogalactan and a Proposed Octadecasaccharide Biosynthetic
Precursor” J. Am. Chem. Soc. 2007, 129, 9885–9901.
back to top
2006
- Joe, M.; Lowary, T. L. “Synthesis of
2-Deoxy-2-fluoro Analogs of Polyprenyl beta-D-Arabinofuranosyl
Phosphates” Carbohydr. Res. 2006, 341, 2723–2730.
- Bai, Y.; Lowary, T. L. “2,3-Anhydrosugars in
Glycoside Bond Synthesis. Application to alpha-D-Galactofuranosides”
J. Org. Chem. 2006, 71, 9658-9671.
- Bai, Y.; Lowary, T. L. “Synthesis of a
Pentasaccharide Fragment of Varianose, a Cell Wall Polysaccharide from
Penicllium varians” J. Org. Chem. 2006, 71,
9672-9680.
- Mendlik, M. T.; Tao, P.; Hadad, C. M.; Coleman, R. S.;
Lowary, T. L.
"Synthesis of L-Daunosamine and L-Ristosamine Glycosides Via
Photoinduced Aziridination. Conversion to Thioglycosides for Use
in Glycosylation Reactions" J. Org. Chem. 2006,
71, 8059-8070.
- Joe, M.; Sun, D.; Taha, H.; Completo, G. C.; Croudace, J.
E.; Lammas, D. A.; Besra, G. S.; Lowary, T. L. "The
5-Deoxy-5-Methylthio-Xylofuranose Residue in Mycobacterial
Lipoarabinomannan. Absolute Stereochemistry, Linkage Position,
Ring Conformation and Immunomodulatory Activity" J. Am.
Chem. Soc. 2006, 128, 5059-5072.
- Rose, N. L.; Completo, G. C.; Lin, S.-J.; McNeil, M. R.;
Palcic, M. M.; Lowary, T. L. "Expression, Purification and
Characterization of a Galactofuranosyl-transferase Involved in Mycobacterium
tuberculosis Arabinogalactan Biosynthesis"
J. Am. Chem. Soc. 2006, 128,
6721-6729.
- Ridgway, K. M.; Shi, W.; Lin, S.-J.; Palcic, M. M.; Lowary,
T. L. "Chemical and Chemoenzymatic Synthesis of a Trisaccharide
Fragment of Tsukamurella paurometabola Lipoarabinomannan"
Can J. Chem. 2006, 84,
642-649.
- Bai, Y.; Lin, S.-J.; Qi, G.; Palcic, M. M.; Lowary, T. L. "Synthesis
of n-octyl 2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1,2)-3-amino-3-deoxy-beta-D-galactopyranoside,
an analog of the H-disaccharide antigen" Carbohydr. Res.
2006, 341, 1702-1707.
- Chang, G. X.; Lowary, T. L. " An Olefin Cross
Metathesis Approach to C -Disaccharide
Analogs of the alpha-D-arabinofuranosyl-(1,5)-alpha-D-arabinofuranoside
Motif Found in the Mycobacterial Cell Wall "
Tetrahedron Lett. 2006, 47, 4561-4564.
- Kim, H.-S.; Ng, E. S. M.; Zheng, R. B.; Whittal, R.;
Schriemer, D. C.; Lowary, T. L. "Studies Toward the Development
of Anti-tuberculosis Vaccines Based on Mycobacterial Lipoarabinomannan"
ACS Symposium Series, 2006
back to
top
2005
- Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. "Modified
Mannose Disaccharides as Substrates and Inhibitors of a Polyprenol
Monophosphomannose-Dependent alpha-(1,6)-Mannosyltransferase Involved
in Mycobacterial Lipoarabinomannan Biosynthesis" Bioorg.
Med. Chem. 2005, 13, 1083-1094.
- Cociorva, O. M.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L.
"Oligosaccharides
as Inhibitors of Mycobacterial Arabinosyltransferases. Di- and
Trisaccharides Containing C-3 Modified Arabinofuranosyl Residues "
Bioorg. Med. Chem. 2005,
13, 1369-1379.
- Subramaniam V.; Gurcha, S. S.; Besra, G. S.; Lowary, T. L. "Synthetic
Disaccharide Analogs as Potential Substrates and Inhibitors of a
Mycobacterial Polyprenol Monophosphomannose-Dependent
alpha-(1,6)-Mannosyltransferase" Tetrahedron:
Asymmetry 2005, 15, 553-567.
- Completo, G. C.; Ponto, J. A.; Lowary, T. L. "Synthesis
of Oligosaccharide Fragments of the Lipoarabinomannan from Rhodocuccus
ruber" J. Carbohydr. Chem. 2005,
24, 517-527.
- Tong,
M.; Jacobi, C. E.; van de Rijke, F. M.; Kuijper, S.; van de Werken, S.;
Lowary, T. L.; Hokke, C. H.; Appelmelk, B. J.; Nagelkerke, N. J. D.;
Hans J. Tanke, van Gijlswijk, R. P. M.; Kolk, A. H. J.; Raap, A. K. "A
Multiplexed and Miniaturized Serological Tuberculosis (TB) Assay
Identifies Antigens that Discriminate Maximally Between TB and non-TB
Sera" J. Immunol. Meth. 2005,
30, 154-163.
- Luu, T.; Shi, W.; Lowary, T. L.; Tykwinski, R. R. "A
Divergent Synthesis of Triyne Natural Products and Glycosylated
Analogues Using a Carbenoid Rearrangement" Synthesis 2005,
3167-3178.
- Fan, E.; Lowary, T. L.; McDonald, R. "(3S,1S)-3-Hydroxyl-3-isopropenyl-1-tert-butyldiphenylsiloxy-1,2,3,4
-tetrahydronaphthalene" Acta Cryst E 2005,
61, o4295-o4297.
back to
top
2004
- Cociorva, O. M.; Lowary, T. L. "2,3-Anhydrosugars
in Glycoside Bond Synthesis. Application to the Preparation of
C-2 Functionalized alpha-D-Arabinofuranosides"
Tetrahedron 2004, 60, 1481-1489.
- Cociorva, O. M.; Lowary, T. L. "Synthesis
of Oligosaccharides as Potential Inhibitors of Mycobacterial
Arabinosyltransferases. Di- and Trisaccharides Containing C-5
Modified Arabinofuranosyl Residues" Carbohydr.
Res. 2004, 339, 853-865.
- Centrone, C. A.; Lowary, T. L. "Sulfone and
Phosphinic Acid Analogs of Decaprenolphosphoarabinose as Potential
Anti-tuberculosis Agents" Bioorg. Med. Chem. 2004,
12, 5495-5503.
- Koppel.
E. A.; Ludwig, I. S.; Sanchez-Hernandez, M.; Lowary, T. L.; Gadikota,
R. R.; Bovin, N.; Vandenbroucke, C. M. J. E, van Looyk, Y.; Appelmelk,
B. J.; Geijtenbeek, T. B. H. "Identification of the
Mycobacterial Carbohydrate Structure That Binds the C-type Lectins
DC-SIGN, L-SIGN, and SIGNR1 " Immunobiol. 2004,
209, 117-127.
- Tilekar, J. N.; Lowary, T. L. "An Efficient Route
to Thioglycosides with the 2,3-Anhydro-D-ribo
Stereochemistry" Carbohydr.
Res. 2004 , 339 , 2895-2899.
- Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. "5,6,7,9-Tetra-O
-acetyl-4,8-anhydro-1,2,3-trideoxy-D-glycero-D-gulo-non-1-enitol
" Acta Cryst E. 2004,
60, o1939-o1941.
- Rhoad, J. S.; Lowary, T. L.; Ferguson, M. J. "4,8-Anhydro-1,2,3,5-tetradeoxy-D-allo-non-1-enitol
" Acta Cryst E. 2004, 60,
o1942-o1944.
- Bai, Y.; Lowary, T. L.; Ferguson, M. J. "p -Tolyl
2,3-anhydro-5,6- O-isopropylidene-1-thio-beta-D-gulofuranoside"
Acta Cryst E, 2004, 60,
o2201-o2203.
back to
top
2003
- Houseknecht,
J. B.; Lowary, T. L.; Hadad, C. M. "Improved Karplus Equations
for 3 J C1,H4 in Aldopentofuranosides.
Application to the Conformational Preferences of the Methyl
Aldopentofuranosides" J. Phys. Chem. A. 2003,
107, 372-378.
- Han, J.; Gadikota, R. R.; McCarren, P. R.; Lowary, T. L. "Synthesis
of Octyl Arabinofuranosides as Substrates for Mycobacterial
Arabinosyltransferases" Carbohydr. Res. 2003,
338, 581-588.
- Gadikota, R. R.; Keller, A. I.; Callam, C. S.; Lowary, T.
L. "Efficient syntheses of trans -(+)-laurediol
from carbohydrate precursors" Tetrahedron:
Asymmetry 2003, 14, 737-742.
- Gadikota, R. R.; Callam, C. S.;
Appelmelk, B. J.; Lowary, T. L. "Synthesis
of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan
Appropriately Functionalized for Neoglycoconjugate Preparation"
J. Carbohydr. Chem. 2003, 22,
459-480.
- Gadikota, R.
R.; Callam, C. S.; Wagner, T.; Del Fraino, B.; Lowary, T. L. "2,3-Anhydrosugars in Glycoside Bond
Synthesis. Highly Stereocontrolled Synthesis of Oligosaccharides
Containing alpha and beta Arabinofuranosyl
Linkages" J. Am. Chem. Soc. 2003, 125,
4155-4165.
- Han, J.; Lowary, T. L. "Total Synthesis of
Buergerinin F and Buergerinin G" J. Org. Chem. 2003,
68, 4116-4119.
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. "An
Efficient Route to Pyrimidine Nucleosides with the 2,3-Anhydro-beta-Dlyxofuranosyl
Stereochemistry " Synlett, 2003,
1271-1274.
- Houseknecht, J. B.; Lowary, T. L.; Hadad, C. M. "Gas
and Solution Phase Energetics of the Methyl alpha and
beta-D -aldopentofuranosides " J. Phys. Chem. A. 2003,
107, 5763-5777.
- Centrone, C. A.; Lowary, T. L. "An Efficient Route
for the Synthesis of Glycosyl Phosphinic Acids" J. Org.
Chem. 2003, 68, 8115-8119.
- Callam, C. S.; Gadikota, R. R.; Krein, D. M.; Lowary, T. L.
"2,3-Anhydrosugars
in Glycoside Bond Synthesis. NMR and Computational Investigations into
the Mechanism of Glycosylations with 2,3-Anhydrofuranosyl Glycosyl
Sulfoxides" J. Am. Chem. Soc. 2003, 125,
13112-13119.
- Darwish, O.; Callam, C. S.; Hadad. C. M.; Lowary, T. L. "Regioselectivity
in Alkylation Reactions of 1,2-O-Stannylene
Acetals of D-Arabinofuranose"
J. Carbohydr. Chem. 2003, 22,
955-973.
- Lowary, T. L. "Recent Progress Towards the
Identification of Inhibitors of Mycobacterial Cell Wall Polysaccharide
Biosynthesis" Mini-Rev. Med. Chem. 2003,
3, 694-707.
- Lowary, T. L. "Synthesis and Conformational
Analysis of Arabinofuranosides, Galactofuranosides, and
Fructofuranosides" Curr. Opin. Chem. Biol. 2003,
7, 749-756.
- Wagner, T.; Gadikota, R. R.; Callam, C. S.; Lowary, T. L. "1-(2´,3´-anhydro-5´-O-benzoyl-beta-D-lyxofuranoyl)-5-fluoro-uracil
" Acta Cryst E. 2003, 59,
o1063-o1065.
back to
top
2002
- Lowary, T. L.; Eichler, E., Bundle, D. R. "Oligosaccharide
Recognition by Antibodies: Synthesis and Evaluation of Talose
Oligosaccharide Analogues" Can. J. Chem. 2002,
80, 1112-1130.
- Yin, H.; D'Souza, F. W.; Lowary, T. L. "Arabinofuranosides
from Mycobacteria: Synthesis of a Highly Branched Hexasaccharide and
Related Fragments Containing beta-Arabinofuranosyl
Residues" J. Org. Chem. 2002, 67,
892-903.
- Lowary, T. L. "D-Arabinofuranosides
from Mycobacteria: Synthesis and Conformation" J.
Carbohydr. Chem. 2002, 21, 691-722.
- Houseknecht, J. B.; Lowary, T. L. "Oligofuranosides
Containing Conformationally-Restricted Residues: Synthesis and
Conformational Analysis" J. Org. Chem. 2002,
67, 4150-4164.
- Houseknecht, J. B.; Altona, C.; Hadad, C. M.; Lowary, T. L.
"Conformational Analysis of Furanose Rings with PSEUROT:
Parameterization for Rings Possessing the Arabino-,
Lyxo-, Ribo-
and Xylo- Stereochemistry and Application
toArabinofuranosides " J. Org. Chem. 2002,
67, 4647
-4651.
- Krein, D. M.; Lowary, T. L. "An Efficient Route to
2-(Alkylamino)pyridines" J. Org. Chem.
2002, 67, 4965-4967.
- Kaur, D.; Lowary, T. L.; Vissa, V. D.; Crick, D. C.;
Brennan, P. J. "Characterization
of the Epitope of Anti-lipoarabinomannan Antibodies as the Terminal
Hexaarabinofuranosyl Motif of Mycobacterial Arabinans" Microbiology
UK, 2002, 148, 3059-3067.
- Basak, P.; Lowary, T. L."Synthesis of Conjugates of
L -Fucose and ortho-Carborane
as Potential Agents for Boron Neutron Capture Therapy" Can.
J. Chem. 2002, 80, 943-948.
- Centrone, C.
A.; Lowary, T. L. "Synthesis
and Anti-tuberculosis Activity of C-Phosphonate Analogs of
Decaprenolphosphoarabinose, A Key Intermediate in the Biosynthesis of
Mycobacterial Arabinogalactan and Lipoarabinomannan" J. Org. Chem. 2002,
67, 8862-8870.
back to
top
2001
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. "An
Efficient Synthesis of Methyl 2,3-anhydro-alpha-D-ribofuranoside"
Carbohydr. Res. 2001,
330, 267-270.
- Callam, C. S.; Lowary, T. L. "Synthesis of Methyl
2,3,5-tri-O-benzoyl-alpha-D-arabinofuranoside in the Organic
Laboratory " J. Chem. Educ. 2001,
78, 73-74.
- Gadikota, R. R.; Callam, C. S.; Lowary, T. L. "Stereocontrolled
Synthesis of 2,3-Anhydro-beta-D-lyxofuranosyl Glycosides" Org.
Lett. 2001, 3, 607-610.
- McGurk, P.; Chang, G. X.; Lowary, T. L.; McNeil, M.; Field,
R. A. "Stereospecific Synthesis of 5-Phospho-alpha-D-arabinosyl-C-
phosphonophosphate (pAC pp): A Stable Analogue of the
Putative Mycobacterial Cell Wall Biosynthetic Intermediate
5-Phospho-D-arabinosyl Pyrophosphate" Tetrahedron
Lett. 2001, 42, 2231-2234.
- McCarren, P. R.; Gordon, M. T.; Lowary, T. L.; Hadad, C. M.
"Computational Studies of the Arabinofuranose Ring:
Conformational Preferences of Fully Relaxed Methyl alpha-D
-arabinofuranoside " J. Phys. Chem. A. 2001,
105, 5911-5922.
- Callam, C. S.; Lowary, T. L. "Suzuki
Cross Coupling Reactions: Synthesis of Unsymmetrical Biaryls in the
Organic Laboratory" J. Chem. Educ. 2001,
78, 947-948.
- Callam, C. S.; Gadikota, R. R.; Lowary, T. L. "Sensitivity
of 1JC1-H1
Magnitudes to Anomeric Stereochemistry in 2,3-Anhydro-O-furanosides"
J. Org. Chem. 2001,
66, 4549-4558.
- Lowary, T. L. "Mycobacterial Cell Wall
Polysaccharides: Structure, Function, Biosynthesis and New
Opportunities for Drug Design" Invited Chapter in Glycoscience:
Chemistry and Chemical Biology Fraser-Reid, B; Thiem, J.;
Tatsuta, K. Eds. Springer-Verlag, 2001.
- Lowary, T. L. "D-Arabinofuranosides
from Mycobacteria: Synthesis and Conformation" Invited Chapter
in Glycochemistry: Synthesis and Applications Bertozzi, C.
R.; Wang, P. Eds. Marcel-Dekker, 2001.
- Houseknecht, J. B.; Lowary, T. L. " Chemistry and
Biology of Arabinofuranosyl and Galactofuranosyl-Containing
Polysaccharides " Curr. Opin. Chem. Biol. 2001
, 5 , 677-682.
- Yin, H. F.; Lowary, T. L. "Synthesis
of arabinofuranosides via low-temperature activation of thioglycosides"
Tetrahedron Lett. 2001,
42, 5829-5832.
- Houseknecht, J.
B.; McCarren, P. R.; Lowary, T. L.; Hadad, C. M. "
Conformational Studies of Methyl 3-O-Methyl-alpha-D-Arabinofuranoside:
An Approach for Studying the Conformation of Furanose Rings" J.
Am. Chem. Soc. 2001, 123, 8811-8824.
- Callam, C. S.; Singer, S. J.; Lowary, T. L.; Hadad, C. M. "Computational
Analysis of the Potential Energy Surfaces of Glycerol in the Gas and
Aqueous Phases. Effects of Level of Theory and Basis Set on
Strongly Intramolecular Hydrogen-Bonded Systems " J.
Am. Chem. Soc. 2001, 123, 11743-11754.
- Callam, C. S.; Lowary, T. L. "Synthesis and
Conformational Investigations of Methyl 4a-carba-D-arabinofuranosides"
J. Org. Chem. 2001,
66, 8961-8972.
- Gadikota, R. R.; Callam, C. S.; Lowary, T. L. "Total
Synthesis of (6S,7S,9S,10S)-6,9-epoxynonadec-18-ene-7,10-diol
and Formal Total Synthesis of (+)- trans-Kumausyne
from D-Arabinose" J.
Org. Chem. 2001, 66, 9046-9051.
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top
2000
- Laferté, S.; Chan, N. W. C.; Sujino, K.; Lowary, T. L.;
Palcic, M. M. "Intracellular Inhibition of Blood Group A
Glycosyltransferase" Eur. J. Biochem. 2000,
267, 4840-4849.
- Callam, C. S.; Lowary, T. L. "Total
Synthesis of Methyl 4a-carba-D-arabinofuranosides"
Org. Lett. 2000, 2,
167-169.
- Davis, T. M.; Lowary, T. L. "Unexpected Formation
of Glycals Upon Attempted C-alkylation of
Protected Glycosylacetylenes" Carbohydr. Res. 2000,
324, 210-217.
- D'Souza, F. W.; Ayers, J. D.; McCarren, P. R.; Lowary, T.
L. "Arabinofuranosyl
Oligosaccharides from Mycobacteria: Synthesis and Effect of
Glycosylation on Ring Conformation and Hydroxymethyl Group Rotamer
Populations" J. Am. Chem. Soc. 2000,
122, 1251-1260.
- D'Souza, F. W.; Lowary, T. L. "The
First Total Synthesis of a Highly Branched Arabinofuranosyl
Hexasaccharide Found at the Nonreducing Termini of Mycobacterial
Arabinogalactan and Lipoarabinomannan" Org. Lett.
2000, 2, 1493-1495.
- Chang, G. X.; Lowary, T. L. "A Glycosylation
Protocol Based on Activation of Glycosyl 2-Pyridyl Sulfones with
Samarium Triflate" Org. Lett.
2000, 2, 1505-1508.
- Gordon, M. T.; Lowary, T. L.; Hadad, C. M. "Probing
Furanose Ring Conformation by Gas-Phase Computational Methods: Energy
Profile and Structural Parameters in Methyl beta-D-arabinofuranoside
as a Function of Ring Conformation" J.
Org. Chem. 2000, 65, 4954-4963.
- Gallucci, J. C.; Gadikota, R. R.; Lowary, T. L. "
p-Cresyl
2,3-anhydro-5-deoxy-5-phthalimido-1-thio-alpha-D-lyxofuranoside
" Acta. Cryst. C. 2000,
56, e365.
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top
1999
- Subramaniam, V.; Lowary, T. L. "Synthesis of
Oligosaccharide Fragments of Mannosylated Lipoarabinomannan from Mycobacterium
tuberculosis" Tetrahedron, 1999,
55, 5965-5976.
- Gordon, M. T.; Lowary, T. L.; Hadad, C. M. "A
Computational Study of Methyl alpha-D-Arabinofuranoside:
Effect of Ring Conformation on Structural Parameters and Energy Profile"
J. Am. Chem. Soc. 1999,
121, 9682-9692.
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top
1998
- Lowary, T. L.; Meldal, M. Helmboldt, A.; Vasella, A.; Bock,
K. "Novel Rigid Type of C-linked Glycosylacetylene
Phenylalanine Building Blocks for Combinatorial Syntheses of C-Linked
Glycopeptides" J. Org. Chem. 1998,
63, 9657-9668.
- St. Hilaire, P. M.; Lowary, T. L.; Meldal, M.; Bock, K. "Oligosaccharide
Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded
Glycopeptide Libraries" J. Am. Chem. Soc. 1998,
120, 13312-13320.
- Ayers, J. D.; Lowary, T. L.; Morehouse, C. B.; Besra, G. S.
"Recognition of Synthetic Synthetic Arabinofuranosyl
Oligosaccharides by Mycobacterial Arabinosyltransferases " Bioorg.
Med. Chem. Lett. 1998, 8, 437-442.
- D'Souza, F. W.; Lowary, T. L. "A New Route to
Carbohydrates Enriched with Oxygen Isotopes" J. Org.
Chem. 1998, 63, 3166-3167.
- Bausch, C.; Peekhaus, N.; Utz, C.; Blais, T.; Murray, E.;
Lowary, T. L.; Conway, T. "Post-Genomic
Analysis of the GntII (Subsidiary) System for Gluconate Metabolism
Reveals a Novel Pathway for L-Idonic Acid Catabolism in E. coli"
J. Bacteriol. 1998, 180,
3704-3710.
- D'Souza, F. W.; Cheshev, P. E.; Ayers, J. D.; Lowary, T. L.
"Conversion of Pyranose Glycals to Furanose Derivatives: A New
Route to Oligofuranosides" J. Org. Chem. 1998,
63, 9037-9044.
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top
1996
- Greis, K. D.; Hayes, B. K.; Comer, F. I.; Kirk, M.;
Barnes, S.; Lowary, T. L.; Hart, G. W. "Selective Detection of
Glycopeptides and Site Mapping by Electrospray Mass Spectrometry"
Anal. Biochem. 1996, 234,
38-49.
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top
1995
- Deng, S.-J.; McKenzie, C. R.; Hirama, T.; Brousseau, R.;
Young, N. M.; Lowary, T. L.; Bundle, D. R.; Narang, S. A. "A
Synthetic Gene Library Approach to the Enhancement of Antibody Affinity"
Proc. Natl. Acad. Sci. USA 1995, 92,
4992-4996.
- Lowary, T. L.; Eichler, E.; Bundle, D. R. "Preparation
of a Pentasaccharide Antigen for the Investigation of
Carbohydrate-Protein Interactions" J. Org. Chem. 1995,
60, 7316-7327.
- Peters, S.; Lowary, T. L.; Hindsgaul, O.; Meldal, M.; Bock,
K. "Solid Phase Synthesis of a Fucosylated Glycopeptide of
Human Factor IX with a Fucose-alpha-(1,O)-Serine
Linkage" J. Chem. Soc. Perkin Trans. 1 1995,
3017-3022.
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top
1994
- Lowary, T. L.; Hindsgaul, O. "Recognition of
Synthetic O-methyl, Epimeric and Amino
Analogs of the Acceptor alpha-L-Fucp-(1,2)-beta-D-Galp-OR
by the Blood-Group A and B Gene-Specified Glycosyltransferases"
Carbohydr. Res. 1994, 251,
33-67.
- Lowary, T. L.; Hindsgaul, O. "Recognition of
Synthetic Analogs of the Acceptor beta-D-Galp-OR
by the Blood-Group H Gene-Specified
Glycosyltransferase" Carbohydr. Res. 1994,
256, 257-273.
- Lowary, T. L.; Bundle, D. R. "Nucleophile Induced
Rearrangements of Thioglycosides: Formation of 6-Thio Glycosides and
1,6 Thioanhydrosugars" Tetrahedron:Asymmetry
1994, 12, 2397-2404.
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top
1993
- Lowary, T. L.; Hindsgaul, O. "Recognition of
Synthetic Deoxy and Deoxyfluoro Analogs of the Acceptor alpha-L-Fucp-(1,2)-
beta-D-Galp-OR by the Blood-Group A
and B Gene-Specified Glycosyltransferases" Carbohydr.
Res. 1993, 249, 163-195.
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top
1991
- Lowary, T. L.; Richards, G. N. "Cycloheptaamylose
as a Model for Starch in the Pyrolysis of Polysaccharides" Carbohydr.
Res. 1991, 218, 157-166.
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top
1990
- Lowary, T. L.; Richards, G. N. "Mechanisms
of Pyrolysis of Polysaccharides: Cellobiitol as a Model for Cellulose"
Carbohydr. Res. 1990, 198,
79-89.
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top
1989
- Lowary, T. L.; Richards, G. N. "Analysis
of a Hydroxystilbene Glucoside in Several Softwood Barks" J.
Wood Chem. and Tech. 1989, 9, 333-340.
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1988
- Lowary, T. L.; Richards, G. N. "Effects
of Impurities on the Hydrolysis of Sucrose in Concentrated Aqueous
Solution" Int. Sugar J. 1988, 90,
164-167.
- Lowary, T. L.; Richards, G. N. "Vacuum
Pyrolysis of Bark from Pinus ponderosa" J. Wood
Chem. and Tech. 1988, 8,
393-412.
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