200mL X 1 vs 100mL X 2. Which is more effective?

Use a distribution coefficient to prove it!

Can you see that you can extract more of a compound from one medium to another by repeating the extraction? And when you use the same amount of solvent, say 200 mL, if you do extraction twice with 100 mL portions, will you extract more effectively than doing once with 200 mL?

Learning and using the distribution coefficient K will help you to see the answers and the reasons why.

A. Distribution coefficient "K"

When a compound is shaken in a separatory funnel with two immiscible solvents, the compound will distribute itself between the two solvents.
Normally one solvent is water and the other solvent is a water-immiscible organic solvent.

Most organic compounds are more soluble in organic solvents, while some organic compounds are more soluble in water.