Our Research

Our Approach

To understand how the structure of model solid/liquid interfaces influences interfacial molecular recognition, we combine synthesis with a variety of powerful surface characterization methods. In particular second harmonic generation (SHG) and sum frequency generation (SFG) are uniquely able to monitor specific molecular signatures in real-time at the solid/liquid interface. With our combined synthetic and spectroscopic approach, we can address outstanding questions in research areas ranging from chemical biology and biomaterials to green chemistry.

Understanding How Interfaces Influence Cooperativity and Multivalency

How does the confined environment of the interface influence the strength and specificity of interfacial binding? Answering this question with a focus on cooperativity and multivalency will improve our understanding of biological processes at cell surfaces and provide design strategies for biomimetic applications including targeted drug delivery.

Amplifying and Detecting DNA in One Step

In this project, we are developing a nonenzymatic DNA replication strategy as means to amplify and detect the presence of a target DNA sequence. Using artificial DNA strands tethered to a DNA chip, we can control the replication process and interface it with common chip-based detection platforms. This strategy requires a multidisciplinary approach involving DNA chemistry, surface modification methods, electrochemistry, fluorescence, and nonlinear optical spectroscopy.

Improving Green Chemistry with Insights from Surface Spectroscopy

With resonantly enhanced nonlinear optical spectroscopic methods, we are determining the molecular environment of solid-supported Lewis Acid catalysts. The ability to characterize not only the organization but also the binding behavior of these “green catalysts” will enable us to strategically design future systems based on our understanding of how surface immobilization influences catalyst performance.