Group Publications
University
of Alberta
PEER
REVIEWED PUBLICATIONS
23. "Glycoform remodeling generates a synthetic T cell phenotype," C. Zou, R.S. Loka, Y. Zhang, and C.W. Cairo*, Bioconjugate Chemistry, in press. [epub June 6, 2013; DOI]
22. "Identification of Selective Nanomolar Inhibitors
of the Human Neuraminidase, NEU4," A. Albohy, Y. Zhang, V. Smutova,
A.V. Pshezhetsky, and C.W. Cairo*, ACS Medicinal Chemistry Letters, in press. [epub May 7, 2013; DOI]
21. "Positive Regulation of Insulin Signaling by
Neuraminidase 1," L. Dridi, V. Seyrantepe, A. Fougerat, X. Pan, E.
Bonneil, P. Thibault, A. Moreau, G.A. Mitchell, N. Heveker, C.W. Cairo, T. Issad, A. Hinek, and A.V. Pshezhetsky*, Diabetes, in press [accepted Mar 18, 2013; link]
20. "Identification of selective inhibitors of human sialidase isoenzymes using C4, C7-modified-2-deoxy-2,3-didehydro-N-acetylneruaminic acid (DANA) analogs," Y. Zhang, A. Albohy, V. Smutova, A.V. Pshezhetsky, and C.W. Cairo*, Journal of Medicinal Chemistry, 56(7), 2948-2958 [epub Mar 26, 2013; DOI]
19. "Protein-glycosphingolipid interactions
revealed using catch-and-release mass spectrometry," Y. Zhang, L. Liu,
R. Daneshfar, E.N. Kitova, C. Li, F. Jia, C.W. Cairo, and J.S.
Klassen*, Analytical Chemistry, 2012, 84(18), 7618-7621. [epub Aug 24,
2012; DOI]
18. "Detection of cellular sialic acid content
using nitrobenzoxadiazole carbonyl-reactive chromophores," J.A. Key, C.
Li, and C.W. Cairo*, Bioconjugate Chemistry, 2012, 23(3), 363-371. [epub Jan 30,
2012; DOI]
17. "Substituted benzoxadiazoles as fluorogenic
probes: A computational study of absorption and fluorescence," A.
Brown*, T.Y. Ngai, M. Barnes, J.A. Key, and C.W. Cairo, Journal of Physical Chemistry A, 2012, 116(1), 46-54. [epub Dec 2, 2011; DOI]
16.
"Substrate recognition of the membrane-associated sialidase NEU3
requires a hydrophobic aglycone," M. Sandbhor, N. Soya, A. Albohy, R.B.
Zheng, J. Cartmell, D.R. Bundle, J.S. Klassen, and C.W. Cairo*, Biochemistry, 2011, 50(32), 6753-6762. [epub Jun 15, 2011; DOI]
15. "Selectivity
of a new class of oseltamivir analogs for viral neuraminidase over
human neuraminidase enzymes," A. Albohy, S. Mohan, R.B. Zheng, B.M.
Pinto, and C.W. Cairo*, Bioorganic
and Medicinal Chemistry, 2011, 19(9), 2817-2822. [accepted
Mar 18, 2011; epub Mar 23, 2011; DOI].
14. "Analysis
of molecular diffusion by first-passage time variance identifies the
size of confinement zones," V. Rajani, G. Carrero, D.E.
Golan, G.
de Vries*, and C.W.
Cairo*, Biophysical
Journal, 2011, 100(6),
1463-1472. [accepted
Jan 28, 2011; epub Mar 17, 2011; DOI].
13. "Inhibition of
human neuraminidase 3 (NEU3) by C9-triazole
derivatives of 2,3-didehydro-N-acetylneuraminic
acid," Y. Zou, A. Albohy, M. Sandbhor, and C.W. Cairo*, Bioorganic and Medicinal
Chemistry Letters, 2010, 20(24), 7529-7533. [accepted Sep
22, 2010; epub Sep 29, 2010; DOI]
12. "A
protected L-bromophosphonomethylphenylalanine amino acid derivative
(BrPmp) for synthesis of irreversible protein tyrosine phosphatase
inhibitors," N.S. Tulsi,
A.M. Downey, and C.W. Cairo*, Bioorganic and Medicinal
Chemistry, 2010, 18(24), 8679-8686. [accepted Sep 15, 2010;
epub: Sep 29, 2010; DOI]
11.
"Immobilization of carbohydrate epitopes for surface plasmon resonance
using the Staudinger Ligation," R.S.
Loka and C.W. Cairo*,
Carbohydrate Research,
2010, 345(18), 2641-2647. [accepted
Sep 15, 2010; epub: Sep 21, 2010; DOI]
10.
"Conjugation of synthetic N-acetyl-lactosamine
to azide-containing proteins using the Staudinger Ligation," R.S. Loka, C.M. Sadek, N.A. Romaniuk, and C.W. Cairo*, Bioconjugate Chemistry,
2010, 21(10), 1842-1849. [accepted
Aug 30, 2010; epub: Sep 15, 2010; DOI]
9. "A
monomeric photoconvertible fluorescent protein for imaging of dynamic
protein localization," H. Hoi, N.C. Schaner, M.W. Davidson, C.W. Cairo, J. Wang, and
R.E.
Campbell*, Journal
of Molecular Biology, 2010, 401(5), 776-791. [accepted Jun 25, 2010;
epub: Jul 5, 2010; DOI]
8.
"Insight
into substrate recognition and catalysis by the human neuraminidase 3
(NEU3) through molecular modeling and site directed mutagenesis," A. Albohy, M.D. Li,
R.B. Zheng, C. Zou, and C.W.
Cairo*, Glycobiology,
2010, 20(9), 1127-1138. [accepted May 17, 2010; epub: May
28, 2010; DOI]
7.
“Identification of fluorogenic
and quenched benzoxadiazole reactive chromophores,” J.A. Key and C.W. Cairo*, Dyes & Pigments, 2011, 88(1),
95-102.
[accepted May 13, 2010; epub: Jun
18, 2010; DOI]
6.
“A fluorogenic SNAr reaction for
demonstrating normal-phase chromatography and isolation of
nitrobenzoxadiazole
chromophores,” J.A. Key,
M.D. Li, and C.W. Cairo*,
Journal of
Chemical Education, 2011, 88(1), 98-100.
[accepted
May 4, 2010; epub: Oct 14, 2010; DOI]
5.
"Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin
cytoskeleton of T cells," C.W.
Cairo*, R. Das., A.
Albohy, Q.J. Baca, D. Pradhan, J.S. Morrow, D. Coombs, and D.E.
Golan, Journal
of Biological Chemistry, 2010, 285(15), 11392-11401.
[epub: Feb 17, 2010; Abstract;
DOI]
Also see our highlight on EurekAlert!
4.
"A modular synthesis of alkynyl-phosphocholine headgroups for labeling
of sphingomyelin and phosphatidyl choline," M.S. Sandbhor,
J.A. Key, I.S. Strelkov, and C.W. Cairo*, Journal of Organic Chemsitry, 2009, 74(22),
8669-8674. [epub: Oct 27, 2009; DOI]
3.
"A hidden Markov model for single particle tracks quantifies
dynamic interactions between LFA-1 and the 
actin
cytoskeleton", R. Das*,
C.W. Cairo, and D. Coombs,
PLoS Computational Biology, 2009, 5(11): e1000556. [epub: Nov 6,
2009; DOI]
2.
"Photophysical
characterization of triazole substituted coumarin fluorophores", J.A. Key, S. Koh, Q.
Timerghazin, A. Brown and C.W.
Cairo*, Dyes
& Pigments, 2009, 82, 196-203. [epub: Jan 3,
2009; DOI] [A top 25 hottest article for July-Sep 2009, and April-June 2009]
1.
“T Cell Adhesion Mechanisms Revealed by
Receptor Lateral Mobility”, C.W.
Cairo*
and
D.E. Golan*, Biopolymers,
2008, 89, 409-419. [epub: Nov 26,
2007; DOI]
OTHER REFEREED PUBLICATIONS
4. “5-(4-Hexyl-1H-1,2,3-triazol-1-yl)-2,1,3-benzoxadiazole,” Key, J.A.; Cairo, C.W. and Ferguson, M.J.*, Acta Cryst 2012, E68, o3128-o3129. [epub: Oct 13, 2012, DOI]
3. “5-(1-Benzyl-1H-1,2,3-triazol-4-yl)-2,1,3-benzoxadiazole.” Key, J.A.; Cairo, C.W. and McDonald, R.*, Acta Cryst 2012, E68, o3130-o3131. [epub: Oct 13, 2012; DOI]
2. “1-[1-(2,1,3-Benzoxadiazol-5-ylmethyl)-1H-1,2,3-triazol-4-yl]hexan-1-one,”
Key, J.A.; Cairo, C.W. and McDonald, R.*, Acta Cryst. 2012, E68, o3132. [epub: Oct 13, 2012; DOI]
1. “7,7'-(3,3'-Dibenzyl-3H,3'H-4,4'-bi-1,2,3-triazole-5,5'-diyl)bis(4-methyl-2H-chromen-2-one)”,
J.A. Key,
C.W. Cairo
and M.F. Ferguson*, Acta Cryst. 2008,
E64, o1910. [epub Sept 13, 2008; PDF; DOI]
REVIEWS
& BOOK
CHAPTERS
2. "Fluorescent small-molecule
probes of biochemistry at the plasma membrane," C.W. Cairo*, J.A. Key, and C.M. Sadek, Current Opinion in Chemical
Biology, 2010,
14(1), 57-63. [epub: Nov 4, 2009; DOI] [A top 25 hottest article for Jan-Mar 2010]
1.
"Signaling by Committee:
Receptor Clusters Determine
Pathways of Cellular Activation," C.W.
Cairo*, ACS-Chemical
Biology,
2007, 2, 652-655. [epub: Oct 19, 2007; DOI]
GRADUATE STUDENT THESIS
7. Downey, A. M., M.Sc., "Design and synthesis of
alpha-bromo phosphonates as analogs of glucose-6-phosphate", 274 pgs,
2012, University of Alberta.
6. Zou, Y., M.Sc., "Design and synthesis of
inhibitors for the human neuraminidase 3 enzyme", 235 pgs, 2011,
University of Alberta.
5. Loka, R.S., Ph.D., "Exploration of
carbohydrate epitopes in their native habitat with the Staudinger
ligation", 327 pgs, 2011, University of Alberta.
4.
Key, J.A., Ph.D., "Fluorogenic and fluorescent bioorthogonal lablling
strategies for examining glycoproteins and phospholipids", 437 pgs,
2011, University of Alberta.
3. Sadek, C.M., M.Sc., "Exploring the role of
sialic acid in the glycoprotein LFA-1 using bioconjugate chemistry",
127 pgs, 2011, University of Alberta.
2.
Ebesoh, N.G., M.Sc., "Probing the function of LFA-1 using fluorescent
proteins that target the beta-2 integrin transmembrane domain", 157 pgs,
2011, University of Alberta.
1. Tulsi, N.S., M.Sc.,
"Synthesis of BrPmp, a
phosphotyrosine analog, and its incorporation into peptides", 113 pgs,
2011, University of Alberta.
PATENTS
2.
T.L. Lowary; C.W. Cairo; L.J. West; J.M. Buriak; P.J. Meloncelli; M.
Jeyakanthan; and A.M. Slaney, "Method and system for ABO compatible
blood type matching," W.I.P.O., The Governors of the University of
Alberta, WO/2011/106898. [Link]
1.
C.W. Cairo; N.S. Tulsi; and A.M. Downey, "Methods and systems for
preparing irreversible inhibitors of protein tyrosine phsophatases,"
W.I.P.O., The Governors of the University of Alberta, WO/2011/106898. [Link]
Graduate
and Postdoctoral Work
PEER
REVIEWED PUBLICATIONS
- “Analysis
of a Two-Dimensional Dissociation Constant for Laterally Mobile
Cell-Cell
Adhesion Molecules within a Contact Area”, D.M. Zhu, M.L.
Dustin, C.W. Cairo,
D.E. Golan*,
2007, Biophys. J., 92,
1022-1034. [PDF]
- “Mechanisms
of Cellular Avidity Regulation in CD2/CD58 Mediated Adhesion of T
Cells”, D.M.
Zhu, M.L. Dustin, C.W. Cairo, H. Thatte, D.E.
Golan*, 2006, ACS-Chemical
Biology, 1, 649-658. [PDF]
[Supporting]
- “Cytoskeletal
Regulation Couples LFA-1 Conformational Changes to Receptor Lateral
Mobility
and Clustering”, C.W. Cairo, R. Mirchev,
D.E. Golan*, 2006, Immunity,
25, 297-308. [PDF]
[Supporting 1]
[Supporting
2] [Supporting
3]
- “Visualization
and Characterization of Receptor Clusters by Transmission Electron
Microscopy”,
J.E. Gestwicki, C.W. Cairo, M.J. Borrok, L.L.
Kiessling*, 2003, Methods
in Enzymology, 362, 301-312. [PDF]
- “Influencing
Receptor-Ligand Binding Mechanisms with Multivalent
Architecture”, J.E.
Gestwicki, C.W. Cairo, L.E. Strong, K.A. Oetjen,
and L.L. Kiessling*,
2002, J. Am. Chem. Soc., 124, 14922. [PDF]
[Supporting]
- “Control
of Multivalent Interactions by Binding Epitope Density”, C.W.
Cairo,
J.E. Gestwicki, M. Kanai, and L.L. Kiessling*, 2002, J. Am.
Chem. Soc.,
124, 1615-1619. [PDF]
[Supporting]
- “Selective
Immobilization of Multivalent Ligands for Surface Plasmon Resonance and
Fluorescence Microscopy”, J.E. Gestwicki, C.W. Cairo,
D.A. Mann, R.M.
Owen, L.L. Kiessling*, 2002, Anal. Biochem., 305,
149-155. [PDF]
- “Affinity-Based
Inhibition of b-Amyloid
Toxicity”, C.W. Cairo, A. Strzelec, R.M.
Murphy,
L.L. Kiessling*, 2002, Biochemistry, 41, 8620-8629.
[PDF]
- "Cell
Aggregation By Scaffolded Receptor Clusters”, J.E. Gestwicki,
L.E. Strong, C.W.
Cairo, F.J. Boehm, L.L. Kiessling*, 2001, Chem. Biol.,
9, 163-169. [Journal
Cover] [PDF]
- “Designed
Potent Multivalent Chemoattractants for Escherichia coli”,
J.E.
Gestwicki, L.E. Strong, S.L. Borchardt, C.W. Cairo,
A.M. Schnoes, L.L.
Kiessling*, 2001, Biorg. Med. Chem., 9, 2387-2393. [PDF]
REVIEWS
& BOOK CHAPTERS
- “Drug-receptor
interactions,” C.W. Cairo, J.B. Simon,
D.E. Golan, in Principles of
Pharmacology, 2nd Ed., D.E. Golan Ed.,
Lippincott, Williams & Wilkins, Baltimore, MD, 2007. [link]
- “Immobilized
amyloid-b
protein experiments using SPR technology”, C.W.
Cairo and
L.L. Kiessling*, 2002, Biacore Journal, 3, 4-7. [PDF]
- “Hitting
the Sweet Spot”, L.L. Kiessling* and C.W. Cairo,
2002, Nat. Biotech.,
20, 234-235. [PDF]
THESIS
- Cairo,
C.W., Ph.D., “Promoting
Receptor Clustering using Multivalent Ligands and Identifying Ligands
for the b-Amyloid
Peptide”, 279 pgs, 2002, University of Wisconsin-Madison. [PDF low res]
[PDF
high res]
![[Journal Cover]](pubs/kiessling_cb_02.jpg){kind=link}