Faculty Research
Alphabetical · By research area

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area being studied in my group:

• The synthesis of structurally complex natural products that have important biochemical and medicinal properties.
• The development of new strategy and methodology for making complicated structures.

A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).

The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.

Synthetic Targets:

Methodology:

Selected Publications

Synthesis of the Potent Anticancer Agents Ottelione A and Ottelione B in Both Racemic and Natural Optically Pure Forms. Clive, D.L.J.; Liu, D. J. Org. Chem. 2008, 73, 3078-3087.

Generation of Carbocycles by Intramolecular Conjugate Displacement: Scope and Mechanistic Insights. Wang, L.; Prabhudas, B.; Clive, D.L.J. J. Am. Chem. Soc. 2009, 131, 6003-6012.

Total Synthesis of the Marine Alkaloid Halichlorine — Development and Use of a General Route to Chiral Piperidines. Liu, D.; Acharya, H. P.; Yu, M.; Wang, J.; Yeh, V.S.C.; Kang, S.; Chiruta, C.; Jachak, S. M.; Clive, D.L.J. J. Org. Chem. 2009, 74, 7417-7428.

Desymmetrization of 4-Hydroxy-2,5-cyclohexadienones by Radical Cyclization: Synthesis of Optically Pure γ-Lactones. Sunasee, R.; Clive, D.L.J. Chem. Commun. 2010, 46, 701-703.